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IpaH7.8 from Shigella flexneri 5a

Victor ID 56
Gene Name IpaH7.8 from Shigella flexneri 5a
Sequence Strain (Species/Organism) Shigella flexneri 5a
NCBI Gene ID 876715
NCBI Protein GI 13449022
Locus Tag pWR501_p083
Protein Accession NP_085238.1
Other Database IDs UniProtKB-ID: IPA7_SHIFL
UniRef100: UniRef100_P18014
UniRef90: UniRef90_P18014
UniRef50: UniRef50_Q31SH3
UniParc: UPI00000BEF77
EMBL: AF386526
EMBL: AF348706
EMBL: AY879342
EMBL: AL391753
EMBL: M32063
EMBL-CDS: AAL72346.1
EMBL-CDS: AAK18394.1
EMBL-CDS: AAW64892.1
EMBL-CDS: CAC05787.1
EMBL-CDS: AAA26526.1
RefSeq_NT: NC_002698.1
RefSeq_NT: NC_004851.1
EnsemblGenome: EBESCG00000093145
EnsemblGenome_TRS: EBESCT00000094101
EnsemblGenome_PRO: EBESCP00000090308
GenomeReviews: AF386526_GR
KEGG: sfl:CP00
Taxonomy ID 623
Plasmid No pWR501
Gene Starting Position 61750
Gene Ending Position 63447
Gene Strand (Orientation) +
Protein Name invasion plasmid antigen
DNA Sequence 
>gi|13448939:61750-63447 Shigella flexneri 5a virulence plasmid pWR501, complete sequence
TATGTTCTCTGTAAATAATACACACTCATCAGTTTCTTGCTCCCCCTCTATTAACTCAAACTCAACCAGT
AATGAACATTATCTGAGAATCCTGACTGAATGGGAAAAGAACTCTTCTCCCGGGGAAGAGCGAGGCATTG
CTTTTAACAGACTCTCCCAGTGCTTTCAGAATCAAGAAGCAGTATTAAATTTATCAGACCTAAATTTGAC
GTCTCTTCCCGAATTACCAAAGCATATTTCTGCTTTGATTGTAGAAAATAATAAATTAACATCATTGCCA
AAGCTGCCTGCATTTCTTAAAGAACTTAATGCTGATAATAACAGGCTTTCTGTGATACCAGAACTTCCTG
AGTCATTAACAACTTTAAGTGTTCGTTCTAATCAACTGGAAAACCTTCCTGTTTTGCCAAACCATTTAAC
ATCATTATTTGTTGAAAATAACAGGCTATATAACTTACCGGCTCTTCCCGAAAAATTGAAATTTTTACAT
GTTTATTATAACAGGCTGACAACATTACCCGACTTACCGGATAAACTGGAAATTCTCTGTGCTCAGCGCA
ATAATCTGGTTACTTTTCCTCAATTTTCTGATAGAAACAATATCAGACAAAAGGAATATTATTTTCATTT
TAATCAGATAACCACTCTTCCGGAGAGTTTTTCACAATTAGATTCAAGTTACAGGATTAATATTTCAGGG
AATCCATTGTCGACTCGCGTTCTGCAATCCCTGCAAAGATTAACCTCTTCGCCGGACTACCACGGCCCGC
AGATTTACTTCTCCATGAGTGACGGACAACAGAATACACTCCATCGCCCCCTGGCTGATGCCGTGACAGC
ATGGTTCCCGGAAAACAAACAATCTGATGTATCACAGATATGGCATGCTTTTGAACATGAAGAGCATGCC
AACACCTTTTCCGCGTTCCTTGACCGCCTTTCCGATACCGTCTCTGCACGCAATACCTCCGGATTCCGTG
AACAGGTCGCTGCATGGCTGGAAAAACTCAGTGCCTCTGCGGAGCTTCGACAGCAGTCTTTCGCTGTTGC
TGCTGATGCCACTGAGAGCTGTGAGGACCGTGTCGCGCTCACATGGAACAATCTCCGGAAAACCCTCCTG
GTCCATCAGGCATCAGAAGGCCTTTTCGATAATGATACCGGCGCTCTGCTCTCCCTGGGCAGGGAAATGT
TCCGCCTCGAAATTCTGGAGGACATTGCCCGGGATAAAGTCAGAACTCTCCATTTTGTGGATGAGATAGA
AGTCTACCTGGCCTTCCAGACCATGCTCGCAGAGAAACTTCAGCTCTCCACTGCCGTGAAGGAAATGCGT
TTCTATGGCGTGTCGGGAGTGACAGCAAATGACCTCCGCACTGCCGAAGCTATGGTCAGAAGCCGTGAAG
AGAATGAATTTACGGACTGGTTCTCCCTCTGGGGACCATGGCATGCTGTACTGAAGCGTACGGAAGCTGA
CCGCTGGGCGCAGGCAGAAGAGCAGAAGTATGAGATGCTGGAGAATGAGTACTCTCAGAGGGTGGCTGAC
CGGCTGAAAGCATCAGGTCTGAGCGGTGATGCGGATGCGGAGAGGGAAGCCGGTGCACAGGTGATGCGTG
AGACTGAACAGCAGATTTACCGTCAGCTGACTGACGAGGTACTGGCCCTGCGATTGTCTGAAAACGGCTC
ACGACTGCACCATTCATA
Protein Sequence 
>gi|13449022|ref|NP_085238.1| invasion plasmid antigen [Shigella flexneri 5a str. M90T] MFSVNNTHSSVSCSPSINSNSTSNEHYLRILTEWEKNSSPGEERGIAFNRLSQCFQNQEAVLNLSDLNLTSLPELPKHISALIVENNKLTSLPKLPAFLKELNADNNRLSVIPELPESLTTLSVRSNQLENLPVLPNHLTSLFVENNRLYNLPALPEKLKFLHVYYNRLTTLPDLPDKLEILCAQRNNLVTFPQFSDRNNIRQKEYYFHFNQITTLPESFSQLDSSYRINISGNPLSTRVLQSLQRLTSSPDYHGPQIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYSQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSRLHHS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaH7.8 mutants had a lower rate of exit from the endocytic vacuoles into the cytoplasm in mouse macrophages than the wild-type strain (Fernandez-Prada et al., 2000).
References
Fernandez-Prada et al., 2000: Fernandez-Prada CM, Hoover DL, Tall BD, Hartman AB, Kopelowitz J, Venkatesan MM. Shigella flexneri IpaH(7.8) facilitates escape of virulent bacteria from the endocytic vacuoles of mouse and human macrophages. Infection and immunity. 2000; 68(6); 3608-3619. [PubMed: 10816519].