Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

nsp4

Victor ID 5400
Gene Name nsp4
Sequence Strain (Species/Organism) Severe acute respiratory syndrome-related coronavirus
NCBI Protein GI 34555778
Other Database IDs CDD:292959
Taxonomy ID 694009
Gene Strand (Orientation) ?
Protein Name nsp4-pp1a/pp1ab
Protein Length 500
Protein Note cleaved from polyprotein by the PL2-PRO at the N-terminus and by 3CL-PRO at the C-terminus; contains transmembrane domain 2 (TM2)
Protein Sequence 
>NP_904322.1 nsp4-pp1a/pp1ab [Severe acute respiratory syndrome-related coronavirus]
KIVSTCFKLMLKATLLCVLAALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAG
FDAWFSQRGGSYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI
EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQFPNTYLEGSV
RVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDAMNLIANIFTPLVQPVGALDV
SASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANALLFLMSFTILCLVPAYSFLPGVYSVFYLYLT
FYFTNDVSFLAHLQWFAMFSPIVPFWITAIYVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTF
LLNKEMYLKLRSETLLPLTQYNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPP
QTSITSAVLQ
Molecule Role Virulence factor
Molecule Role Annotation Mutation in SARS-CoV nsp4 protein attenuated viral replication in 293T cell. (Sakai Y et al., 2017)
References
Sakai Y et al., 2017: . Two-amino acids change in the nsp4 of SARS coronavirus abolishes viral replication. . ; ; . [PubMed: 28738245].