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sopA

Victor ID 54
Gene Name sopA
Sequence Strain (Species/Organism) Shigella flexneri 5a
NCBI Gene ID 876658
NCBI Protein GI 13449231
Locus Tag pWR501_p292
Protein Accession NP_085447.1
Taxonomy ID 623
Plasmid No pWR501
Gene Starting Position 220499
Gene Ending Position 221479
Gene Strand (Orientation) +
Protein Name outer membrane protease
DNA Sequence 
>gi|13448939:220499-221479 Shigella flexneri 5a virulence plasmid pWR501, complete sequence
CATGGACATTTCAACCAAAAAAGTAGAGTTCTCGATGAAATTAAAATTCTTTGTACTTGCACTTTGTGTA
CCTGCGATCTTTACTACACATGCTACCACTAACTATCCACTTTTCATACCGGACAACATCAGTACGGATA
TTAGTCTAGGATCTCTGAGTGGCAAAACAAAAGAACGCGTTTATCATCCCAAGGAAGGGGGGAGAAAAAT
TAGTCAACTGGACTGGAAATACAGTAATGCGACTATTGTTAGAGGTGGCATCGATTGGAAGCTAATTCCA
AAAGTGTCTTTCGGAGTTTCCGGTTGGACTACTTTAGGTAACCAGAAAGCAAGCATGGTTGATAAAGACT
GGAACAATTCCAATACCCCTCAGGTATGGACCGACCAGAGCTGGCATCCCAATACGCATCTCCGTGATGC
TAACGAATTCGAGCTGAATCTTAAAGGTTGGTTATTAAATAATTTGGATTATCGACTTGGACTAATAGCA
GGTTACCAAGAGAGTCGTTACAGTTTTAATGCAATGGGAGGGAGTTATATTTATAGTGAAAACGGGGGGA
GCAGGAATAAAAAAGGGGCACATCCTAGTGGTGAAAGAACAATAGGTTACAAACAGCTCTTCAAAATACC
TTATATTGGATTAACTGCTAATTACCGCCATGAGAATTTTGAGTTTGGAGCAGAACTGAAATATAGTGGT
TGGGTTCTTTCATCTGATACAGATAAACACTATCAGACTGAGACAATTTTTAAAGATGAAATAAAAAACC
AAAATTACTGCTCTGTTGCTGCGAATATTGGATACTATGTCACCCCCAGTGCAAAATTTTATATAGAAGG
CTCCAGAAATTACATTTCTAATAAAAAAGGTGATACATCTCTTTATGAGCAAAGTACCAATATATCTGGC
ACCATTAAAAATAGTGCAAGTATTGAATATATTGGTTTTCTCACTTCCGCAGGTATAAAGTATATTTTTT
G
Protein Sequence 
>gi|296100145|ref|NP_085447.3| VirG-specific protease [Shigella flexneri 5a str. M90T] MDISTKKVEFSMKLKFFVLALCVPAIFTTHATTNYPLFIPDNISTDISLGSLSGKTKERVYHPKEGGRKISQLDWKYSNATIVRGGIDWKLIPKVSFGVSGWTTLGNQKASMVDKDWNNSNTPQVWTDQSWHPNTHLRDANEFELNLKGWLLNNLDYRLGLIAGYQESRYSFNAMGGSYIYSENGGSRNKKGAHPSGERTIGYKQLFKIPYIGLTANYRHENFEFGAELKYSGWVLSSDTDKHYQTETIFKDEIKNQNYCSVAANIGYYVTPSAKFYIEGSRNYISNKKGDTSLYEQSTNISGTIKNSASIEYIGFLTSAGIKYIF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sopA mutant was able to infect HeLa cells, but was attenuated in its ability to spread to other cells compared to the wild type (Egile et al., 1997).
References
Egile et al., 1997: Egile C, d'Hauteville H, Parsot C, Sansonetti PJ. SopA, the outer membrane protease responsible for polar localization of IcsA in Shigella flexneri. Molecular microbiology. 1997; 23(5); 1063-1073. [PubMed: 9076742].