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YPK1

Victor ID 5393
Gene Name YPK1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23888064
NCBI Protein GI 799340637
Locus Tag CNAG_04678
Genbank Accession CP003829
Protein Accession XP_012052138
Taxonomy ID 235443
Chromosome No 10
Gene Starting Position 712595
Gene Ending Position 715343
Gene Strand (Orientation) +
Protein pI 7.92
Protein Weight 59953.21
Protein Length 575
DNA Sequence 
>gi|799350850:712595-715343 Cryptococcus neoformans var. grubii H99 chromosome 10, complete sequence
TTCGCTTCGCTCTGTTCCATTTTTATTTTCTCATCTCCATCTTCACAACTGCTTCTTTTCAAACAAATTC
ACCTCGCAACCAGCGACAGAAACAGATCCGCATCGCCAGTCCGTGTCGGAAAACGCATAGACAAATCACT
CGCGACCACAAAGTCACCGGCCCCGACCCGACGACGCCACCAAACTCTGCTTCGATCTCCACCGGTCATT
ACGGCGCGTCCAAGAACTTCTACTTATATCCCTGCCCACAGCTCAAGGAGTCCATTGCCTTCCATGATGT
CCTGGAAATTTGGTAAAAGTGAGTGCATTTCTGTACCAAGCTCAAGAACGATCGCGTCTTTTGTCTGCTA
GTTTTTGGAAAGTCGTTGCTGACCAAGCCCTTGTTTGTTCTCTCATCGTCATGTTTTCTCTTATCATCCG
CGTTTATTATTCGCCGCACAGAATTCAAAGAAGGAGGGTTCCTATCGGGCAAACACCACAGCTCCAACAA
CAACAGCCCTTCCGATACCTCTCGTTCCACCACTCCTACCCCTGGCAACCCCCACCCTGAAGATGCAGTC
AAGCCGCCTGTGCCTAGGAGTGGTATGCTCAAGATCCGTGTGACTGCCGCAAAGGGACTTAGTTTGCCGC
AAGGAGGTGAGTGTTGCATTTCATATGGTTAACTGGAAAATCCTGACGCGACTGTAGTCTCTGTCCCTGC
CCCAGTCCAGGAAGCTCTTACCACCCATCCTACCCTTGCTTCCCGCATAGCTACATCTCCTCCCACCGCC
ATCGTCAAGGCGGCTGGTGCCAATCGTGACTCTCTCCAGCGTCGCCAAGTCTGGTGGCTTCCCTATCTCG
TTCTTGAGTTCGACAAAAATGAAGTCCTCGTCGATGCGCTTGGCGGTGACTTGGCATCGCCAGTATGGAT
GTACAGTGCGACTTTTGATGTTTCTAGGATAAGCGAGATTAGCGCTACTGTGTACTTGAGGACAAGGGAG
CCTCATGCAGAGGGCCGAGAAAAGTCTAACGGTGAAGGCGAGGGCGAGGATATGGGTAACTCAGACTTGT
GCTTGGGTAGCATCAGATTCACGCCCAACTTGGACTCTTTGGTGAGTATGGTTGATGTCCTCGAAGTAGG
ACTTGTGAGCTTGTGCTGATACGGTGTTCAGAGGGTGACAGACGACTGGGTGACTGTGCAAGGCGGTGGT
GGCTCAGGGTCTATTAATGTTCAAGTGTCCTTCAAGCCTGCTTCTGTGAATAACTTCTAATTTGAATTTC
CTTGGATATGGCTAATGAATTTCACCACAGGGGCAAATTCTTACGATTGATAGCTTTGAGCTTCTTAAAG
TTATTGGCAAGGGCAGTTTCGGTAAAGTCATGCAAGTCCGCAAGCGTGACACGCTCCGAATTTATGCTCT
CAAAACCATCCGAAAAGCCCACATTGTCTCCCGATCCGAAGTTACCCACACCTTGGCAGAACGTACCGTC
CTCGCCCAGGTTAACTGCCCTTTTATTGTGCCCTTAAAGTTCTCTTTCCAGTCCAAGGAAAAGCTGTACC
TGGTCTTGGCGTTCATCAACGGAGGAGAGTTGTTCCACCACTTGCAGAGGGAGGGCAAGTTCAACGAGAC
TAGGTCTAGGTTCTACTCGGCCCAACTACTGCTGGCGTTGGAGCATTTGCACTCCTTCAATGTGATCTAC
AGGTGAGTCTTCTTCAGCATGTATGGCGAAAGAGCTAATTAACAATTTGCAGAGATTTGAAGCCCGAAAA
CATTCTGTTAGATTACGCCGGGAATATTGCCCTTTGTGATTTTGGACTGTGTAAACTCAACATGTCCAAC
TCGGACACCACAAATAGTGGGTATCTTCCTGTACACTTGCGAGCTCAACTAATTTTCCACCGTAGCCTTC
TGTGGTACACCTGAATAGTATGTCGACCGCTTACCATCACTGTCAATATTAGCTGACATGACGTAGTCTT
GCTCCTGAACTTCTTTCTGGTCACGGCTATACTAAATGCGTTGACTGGTGGACTCTTGGTGTCCTCTTGT
ACGAAATGCTCACTGGTCTTCCTCCCTTTTACGACGAAAACACCAACGAAATGTACCGCAAGATTCTCAC
CGAACCTTTGCGCTTCCCCGATGGCGTTCGTTCTGAAGCCAGGTCTCTTCTGACCGGTTTGCTTAATCGA
GATCCTCGCCAAAGGCTTGGCGTCAACGGCGCCCAGGATATCAAGAATCACCCCTTCTTTGCCAAACACA
TCAACTTTACAAAACTCTGGAACAAGCAAATCCAACCACCTTTCAAGCCCGCTGTGGCGAGTGCTATTGA
CACTTCCAATTTCGATGAGGAGTTCACCAACGAGGTGCCCCTCGACTCGGTTGTTGACGACTCACATCTG
TCCCAGACTGTGCAACAGCAATTGTATGTACCCCATGTTGTTTTGTTATGTTTACTGACTCAACATTATA
GCGAGGGATTCTCCTGGAGTGTTTCGCCTCTTGGCGAATCTGTTGGCCGATATTAGAATACAGGGTTAGT
GGTGTAGAGAGGGCCACTGGTGTAGAATGGCAGAGCTAGTGGTGTACAATGATAGGGCAGTACAAATGTG
TCAAAGCCCATACCCTAAATAAACGTGAATCCGATTACAATTGGGCAGCGAATTGCCTTTTGTTTGCTCA
GCGTAACATCGGATGATGCCAGATGTATGATACGTTCCCCGTATAGCCCTTATTCCTCCTTCATGCATAT
ACAAATGAGCGTTACAGCA
Protein Sequence 
>gi|799340637|ref|XP_012052138.1| AGC/Akt protein kinase [Cryptococcus neoformans var. grubii H99]
MMSWKFGKKFKEGGFLSGKHHSSNNNSPSDTSRSTTPTPGNPHPEDAVKPPVPRSGMLKIRVTAAKGLSL
PQGVSVPAPVQEALTTHPTLASRIATSPPTAIVKAAGANRDSLQRRQVWWLPYLVLEFDKNEVLVDALGG
DLASPVWMYSATFDVSRISEISATVYLRTREPHAEGREKSNGEGEGEDMGNSDLCLGSIRFTPNLDSLRV
TDDWVTVQGGGGSGSINVQVSFKPASGQILTIDSFELLKVIGKGSFGKVMQVRKRDTLRIYALKTIRKAH
IVSRSEVTHTLAERTVLAQVNCPFIVPLKFSFQSKEKLYLVLAFINGGELFHHLQREGKFNETRSRFYSA
QLLLALEHLHSFNVIYRDLKPENILLDYAGNIALCDFGLCKLNMSNSDTTNTFCGTPEYLAPELLSGHGY
TKCVDWWTLGVLLYEMLTGLPPFYDENTNEMYRKILTEPLRFPDGVRSEARSLLTGLLNRDPRQRLGVNG
AQDIKNHPFFAKHINFTKLWNKQIQPPFKPAVASAIDTSNFDEEFTNEVPLDSVVDDSHLSQTVQQQFEG
FSWSVSPLGESVGRY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Deletion of PDK1, SIN1 or YPK1 but not MPK1 affected cell viability in the presence of sphingolipid biosynthesis inhibitors (Lee et al., 2012).
References
Lee et al., 2012: Lee H, Khanal Lamichhane A, Garraffo HM, Kwon-Chung KJ, Chang YC. Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in Cryptococcus neoformans. Molecular microbiology. 2012; 84(1); 130-146. [PubMed: 22339665 ].