Victors

CXT1
Victor ID	5390
Gene Name	CXT1
Sequence Strain (Species/Organism)	Cryptococcus neoformans var. grubii H99
NCBI Gene ID	23888490
NCBI Protein GI	799324846
Locus Tag	CNAG_05148
Genbank Accession	CP003823
Protein Accession	XP_012048740
Taxonomy ID	235443
Chromosome No	4
Gene Starting Position	555968
Gene Ending Position	559102
Gene Strand (Orientation)	+
Protein pI	5.34
Protein Weight	74521.47
Protein Length	674
DNA Sequence	>gi\|799350666:555968-559102 Cryptococcus neoformans var. grubii H99 chromosome 4, complete sequence GGAGAAAGCGATCTGCAACATCTTGTTGGAGTCCCAACATGACCGGCTGAGGCTGACTGGCTGAACACTT TCGACACGCACACAGATCAGGACAACGCCGCCCCCTCCCCCCCACCTCCACAGAACGGCTGAATCGTCAT CCTTTGCCTGCGATGCCGCTCAATTTGCCCTTCTCCTCCCCCCTCAAGCTCCCCCTCCCGCGCAGGTTCA TCATCCTCATCCTCTCAGCCTCCATCCTCATCCTCTTCCTCCACACCTTTGCACCCTCAACTCTTCCACC AGTCTTTACTCCAAGCTTGCCACACCACGAGCCAGACGCCTCATACTTCTCCCCATCCAAATGGCTCCCT CCAATCCTCAATCCCAACGCCCCGACGCGCCCATTAGAGTTCGATGAAAATGGGCAATGTCTTTTCCTCT CGCCCTTCGATGCTCTTTCAGCAGCGGAGAAGGCACGCGCTCAAGTGCTCTCTCTCGATGAGGTTTCTCC AGGTATTGTGCGCGCCGACGCGCCTCCTGCCGAGGGTACTGATGCCGATCCGGACTTTGACGACGAGTTT TCCGAGCTCAGCAATGCTACGAGAAAGATGCCTGCTGGACTGACGCACCCCATCTTGGGCTTGCTGAGGG ACGGTGAAGCCAAATGGAACTCAATGCTCGCAAGGCAAAGTCAGACACTGGAGCAGGCCGTGGATGTGTA CATAGACAGGTGGGGAAGAAAGCCACCCAAGGGTTTCGACGAGTGGTAAGCCGTTATCACCAGAGTACGA GTTATGCTTGGGCTAATATTCCTTCCAAGGTGGCATTTCGCCAAAGCCAATAACGTCCTTCTCCCGGATG AGTATGACCCGTGAGTATGTCATGTCTGCTGTTTGAACCTCACTTACTTGATTTGCAGGATCATGAACTC TCTTCTTCCTTTCTATGCCCTCCCGATAGACACCCTCGAGGAGCGTCTGATCGAGGCTGAGAAGATTCCC GAAACATTCACTCTCATTGTACACGACGGCAAGGTGGAACTCAAATGGAACGACGATTACTCCAGAGATA CTTGGTGGGCTAGTCGACCTAGGGCTGATAGTCAGATTAACTTGATGGAACCTTTTATCAAGCATATTGG GACTTTCAGGTAAGTAATCATGCTTGATGTGTGGAACCATCGTTGAATAATTTGGGCAGGGCGACTTTTA CCATCCACGATCAACCATCTATCCTTCTCGACCATGAGCGTCATGAAGAGCTTCTTACTGCCGCTCGACA TGGCAAAGTCTCCACGCATCCTAACGAACTTGATCGAGCCGAACAAAACTGGAAAAAAGCCTGTCCTCCC GATAGTCCTCTTAACAAAGGCGAAGTAGAGCTTGGTAAGTTGCAGCCTTTCTGATTTAATGGCGCTCTGA TTTGACCCTTTTACAGAGGCTCCTGATTCCTTCATCTCTTCGCATCTCGCAGCCATGGACATCTGCCAAC ACCCGTCCTACATGGAGAACCACGGTATGCTACTTGAAGAGAAGAACTCTGACACCCATCCCAAACCCCA TACCAAACTTTACCCCATTCTCGTTCCTTCCAAGACTGCTCTCAACGGCGACATCCCCGTCACTCCTATT GGTAAAGACGGGAGGCGTGACGATATTGGCCACGATCCAGAGTGGAGCCGGAAAAGTGGCAAACTCTATT GGCGTGGGTTGGCCACCGGGTTGCAGCACAACAAGAAGGCTGGTGCCAAGTGGCGACAATCCCACCGCGA GCGTCTGCACTTCCTCGCAAACGACAAGTCGGACACCTACACTGAAGTCCTCTCTCCTGTGGGTTCTACT GGTGAGGCTGAGCTTGCTCAAATGCCATTGAGAGAGCTGGGTCAGTATTACATGGATGTAAAACTTGCAG GTGGAAACTGGCAGTGTGACTGGGGAGACGGAACTTGTGATGAAATGGAGAAAGAGATTGATTTCGCTCC AAAAGATAGTTCGGAGAGGAGCAATGACTTCAAATATGTCTTTGACGTGAGTCGTTCTTCTGCGACCTGA AGAGCCAATGTGTGTTTGCTGATTATCCATCAGACTGATGGCAACGCTTGGAGCTCCCGTTTCCCTCGGT TAATGGCTAGCAACAAGTGAGCTTTTACAAATAGGCGCCCTCCTATCTTACTGACTTCTTTCCTATAGCG TTGTCATCAAGTCCACCGTTTTCCCCGAGTGGAATACTAACTCTCTTCCGGAGTGGTATGCTTATGTCCC ATCCAAGATGGACTACTCTGATCTCTTCTCCATCATGACTTTGTGCGTACCAATCCCCATCTCACCTTAG GATGGGGCTAACAATAGGTAGTTTCCGAGGAACCCCATCCGGTCGAGGCGCTCATGATGAAGTCGCTAGG AGGATTGCGTTGAACGGCCAATGCTGGGTCGAGCGGAGTGGGTAGATTTTCATAAATAAACAGAAGGATT AGACGCTGATAGACGACTGCTAGCCTGGAGAAGAGAGGATCTTCAAGCGTACATGTTCAGGTTGTACCTC GAATATGCGAGATTGACCAGTCCAGACAGGGACAATGGCAAGATGGTATGTCTATTATTTATCTGAGTCT GGTATGGCGCCTAATTCTCCTTCTTTAGGACTACATCCCTTCTCAAGAGCGCCCCTAACGAGGACGAGGA TGAACCCATTGCTGCTGATGTTGAGCCCCTGTCATCGATCAGTAGGTTTTTGGAGAAGTATAGCGAGGTA GCAATGCTATAGCGGAGCAGAAAAGAGCGTCGGCGAACGCTATAGAGCGATGGAGGATGGACATTTCAAG AGGGTTCGTGTACGCTTTGCCGCAGGTGACAGGGGTTTCAGACAAATCTGTTAAAGAGGTGGTAAATGAG ATCCGGTCTGAATGGATGGGTGTTTGGTCTGCGATTTGTGTGCTTTTTAAGATTTTCTCCATTCCCTGCA GTTCACGGCATTACATTTTCATGTTTCTATGCATATTTCGTCGTTTTCGATACGGCTCTGGGCAACTCTA CATTTCCAGCTTTTTAATTTTATCTTAGCAAACAAATTTGCCTATGATACGGCACTTTCTTCATTGTTCG CACTTAACACAAGAAGATGGAATTCCATGCAGATATGCCAAATATGTAGATTAGT
Protein Sequence	>gi\|799324846\|ref\|XP_012048740.1\| beta-1,2-xylosyltransferase 1 [Cryptococcus neoformans var. grubii H99] MPLNLPFSSPLKLPLPRRFIILILSASILILFLHTFAPSTLPPVFTPSLPHHEPDASYFSPSKWLPPILN PNAPTRPLEFDENGQCLFLSPFDALSAAEKARAQVLSLDEVSPGIVRADAPPAEGTDADPDFDDEFSELS NATRKMPAGLTHPILGLLRDGEAKWNSMLARQSQTLEQAVDVYIDRWGRKPPKGFDEWWHFAKANNVLLP DEYDPIMNSLLPFYALPIDTLEERLIEAEKIPETFTLIVHDGKVELKWNDDYSRDTWWASRPRADSQINL MEPFIKHIGTFRATFTIHDQPSILLDHERHEELLTAARHGKVSTHPNELDRAEQNWKKACPPDSPLNKGE VELEAPDSFISSHLAAMDICQHPSYMENHGMLLEEKNSDTHPKPHTKLYPILVPSKTALNGDIPVTPIGK DGRRDDIGHDPEWSRKSGKLYWRGLATGLQHNKKAGAKWRQSHRERLHFLANDKSDTYTEVLSPVGSTGE AELAQMPLRELGQYYMDVKLAGGNWQCDWGDGTCDEMEKEIDFAPKDSSERSNDFKYVFDTDGNAWSSRF PRLMASNNVVIKSTVFPEWNTNSLPEWYAYVPSKMDYSDLFSIMTFFRGTPSGRGAHDEVARRIALNGQC WVERTWRREDLQAYMFRLYLEYARLTSPDRDNGKMDYIPSQERP
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: Xylbeta1,2-transferase (Cxt1p) that participates in capsular polysaccharide biosynthesis is also the sole transferase responsible for adding xylose to C. neoformans glycosphingolipids (Castle et al., 2008; Klutts et al., 2007).
References	*Castle et al., 2008:* Castle SA, Owuor EA, Thompson SH, Garnsey MR, Klutts JS, Doering TL, Levery SB. Beta1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids. Eukaryotic cell. 2008; 7(9); 1611-1615. [PubMed: 18676952 ]. *Klutts et al., 2007:* Klutts JS, Levery SB, Doering TL. A beta-1,2-xylosyltransferase from Cryptococcus neoformans defines a new family of glycosyltransferases. The Journal of biological chemistry. 2007; 282(24); 17890-17899. [PubMed: 17430900 ].


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CXT1