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XRN1(Cryptococcus neoformans var. neoformans JEC 21)

Victor ID 5389
Gene Name XRN1(Cryptococcus neoformans var. neoformans JEC 21)
Sequence Strain (Species/Organism) Cryptococcus neoformans var. neoformans JEC 21
NCBI Gene ID 3257877
NCBI Protein GI 58267550
Locus Tag CNE03620
Genbank Accession AE017345
Protein Accession XP_570931
Taxonomy ID 214684
Chromosome No 5
Gene Starting Position 1024291
Gene Ending Position 1029766
Gene Strand (Orientation) -
Protein pI 7.33
Protein Weight 153997.05
Protein Length 1457
DNA Sequence 
>gi|58272422:1024291-1029766 Cryptococcus neoformans var. neoformans JEC21 chromosome 5, complete sequence
TTTCTTTTACATGTCGAAATCGATCTTCGACGCTGGTCATCGATTTACAAGTTCCCCACTAGCACTACTC
CTCAACTACTGCGCTACCGCCACTTCCAACCCCCCTGCCTCTAGTGAATCCTCTTGAACCACCCCTGAAA
CCCCCTCTTCCCCTTGGTCCACCGTTTGGAGCGCCTCCGCGAGCGGACGCAGGAACACCATTGTGGGTAC
CCCGATGAGCGAAGGGGGCGCCGTTCGCAGCACCTCTTCCCCTGACGGCACCGATACCAGACTTGTTGTT
CATGTTTTGTGCCTTTCCTCGAATAGGGGGATTGGTAGGTATTGCCTGGTGAACGGAAGCATGGGAATGG
ACCACCGGAAGGTTTCCCTGAGCCTGAACGTGAGTGACGTGACTGGAATCACGATTGTCATTGACCACAG
GACCAGGGCCCAGTCGCAAACCTCCAAGCAAGTTGGACAATTGATCTCGGTGACTAACGGGCTGTTGCTG
AACAGGCTGAGGTCGGACACCCTTCGCCACGCCGCTATACTTCAGATGGCCGTTGCTACCGACAACAGTG
GTGCTTTGAGTAGAGTGAACAGTCTTGGGTTTCTGCAAAATGTGATGTGTAGTTGTCGCAGTTTGCTGAC
GGCCCGGCACCGACGGCTGGTAATGCTGCATAGGTACAGCAGGGCGAGGTCCAAGTTGAGGTCTGAAGAC
ATTTTGAGGAACAGGCTTCGGTCCAGCTCTCTCGGAGACAGTGAATTGGGGACGAGTTAAATTGAGGCAG
GACGAGAATGGTACAGTTGACCCGCGGTAAGGCGAACACTTCCCCTGGAGAGTAGAACCACCCATGAAGC
CATTGTCCCAGATTACATCAACGGTCCTCATTCCAAGACCGACCACAACACCCCTCATGCCTGTTGGCAC
CCCTCCCGCGGCGGGGTCCTGCACCATAACGACTCGGTGGCCAGGTTCAAAAACTTGACCTTGAAGTCGA
TAAATGGCTTGTGCGGGCTTCAAAAGGGTCTGGCGTGGAACATTGTCCAAACGCTTCTTCTTGATCGATT
GGAAGGTTTTCTTAGACAAAATGTCGTCGGCAAGTTTTTCAACTATCTGGCAGGTTTCCTGAAAGGCGGA
CGCTCATTAGTGAAAAGTCTATACCATGCGCCTGTGCCTTAACTAGGCTTACCGCTTCAAGCTGATCGGC
AAACAACGACACGGATTCCAAATCATTCAGTCCTTCATCCTTCAACCACTTCTTCATGCCCTTGATAACA
GTATCAGGGTCCTCCGCAGTGGGGCAAAGTTCCTTGCTTTTGACCAGGTCTCCTCCCCTGTTCTCCAGAT
GCTTGAACACCTCAGGGAAAGCCTTCTTGTACGCCTCCAGCACTTGAGCAGTCTTCTCGCTGAACTCCCA
GCCTCGATCGTTTCTCTTCGAGTAACCGAGAACCTTAAGACCGCGAGACTCAAACTTGAGCGAAAGTCCA
ATATTGGTCTTCGAGCCATCACCGAGTTGAACGAGCAAAGTAGACGTGATGCGAGAAAGAGCGAGGGCGG
AGATACCAAGACGACGGGATAGGATTGGTGAAGGCCACCACTTGCCCGCAGGTCGATGGGCGACAGCCTT
CATGAATCTGAGGGTTTCCTCCGTTTCCTCTTCAAAGTACTATGTCATCTCGTAAGCACTATATAGACAT
GAAATAATGGAACTTGGAACTCACTGCAAGAATCACGCTTAACGTCTGAGCTTCCTCATTGACCGCCGAG
ACCTGCGCTGCGAGACCGTAATGCATATCACCGAGGAAAAGAACTTTTTCTCCAACAGGGAAGTCAACCT
TCAAGTCAGGCGGAGCTCGTTCCTGTTCAATACGGTCAAAAACCCATACTGCCCATAGACGGCGTAAACA
ACTCACCAGGAAACGTTCATCTTCAAATGTGACCTGTGAGACAGCCACCTGGTACGCTTGGACGATCTCC
TTTTCTGGGGTTTCGTAGTCCTTGACAAGTGCACCGTTATCGAGGTGTTTCAAGCCTTTTAATATTATCA
GCTAGATGTTACAGAGCCGATGATAGATACATACCCTTAAGCGGTCTGATATGCAACAATACTTCCACAC
CCCCAATAATCACGCCGTACCTCCTTGAATAATGCCTCTCCACATGGTCTGCCTGTCGCCTCCATTTGAC
CGCATCCTGATGGGGCATATGTACAACTCGAAGAGACTTGCCAACTTGCTGCAAGGTGTACTTGAACATA
TCATCTGAAACAGCAGCGACGATACCTTCCTGGAGATAAGGCCAAGAGTGGAAGGTCCTTTGGCCGAGAA
CGTTTCGAGCTATCTCAGAAGTCTTGGGAAGTTCATCTTTGCCAATGATGGTGATCACCATAGAAGGATT
CTTACTATCAGACTGGAAGACGTTGACACCATGGTAGTCAAGGGTACCATTGTGGGGAAGAGTGTCGAGA
GATGGGAAACCAGCAAGCGCGGAAACACCAAGTTGAACACCTTCAACTAGACCAAAGATGAGCTGGACGT
CGCCACCAAGGACTGGGAGATTAAATGGGGAAGCACGGCAATGGCTTCGAGTGAGCTCAGGGAAAACACC
CGGGAAAGATGATGGGTAATTTTCATCGATCTCAGGATCGTAAACAAATTGAGTACTGAGCACACCGCTC
TTGTTCCGCTCTCTCTCCTCGGGAGTGAGACGAACATCACGAGCTGATCATCAAAATTAGTTTGACATTA
TGTTTCTAAAACCTAAAATTACTTACCGGCCATGGCCTTCAACAACCTGTTTTGATCGATGAATGGGATC
TTTACCACAGCCTCCCAATCCTGCTTTTTGCCATTCATATCCAATTCAAAGTTCCGGGGATAAAAGTCGA
TGATCGGGGAGGTTTCCTCATACATGAGGTCCTGTCAAAAAGAATCAGAGATAACAACGGCTTATGATGC
GGAAATCACTGACTCTGTATGCCAATGGAACATGATCCATACTATCTACAGGCAAAACACCCATAAGTTG
TTGGAAAGGAGTGAAGGGTTTGCCATAGTCAAATTCAAACTTCATATCAGCAACTCCCTTCAAATCTGCG
TCCACTGATCAGCGGCAAGCAAACAACATTGAACAGTCGCATATACTTACCAGTGATACGGGGAGAGTAG
TGATATTTGTAGAACCAGCCCCAGCTTGAAACGCCCTTGTAGTAATAGTTGAGGATCCATTGAAGACCTT
CAATATAGTGGTGTACAAGGTCCTGCATTTGAGCTGGGTCGTTGTAGTTGATCTCAAGTTTATCCTAGGC
GAGCTATCAGTTACGGAAGTCAAGATAAGGACAATGACAACGCACGTGATAATATTGCCTCTTTATATCA
TCCATGGCTTCCTTCAGTTTCTCGTCCATCGACTTCTCAACATCTTCCGGATACGTATCGACGACTGCAG
CTTTGCTCCAGTTACGGAAAACTCTCTGAACTGCTAGCTTGCCTTCATCCTCCATTTCATCGCTTTCCCA
ATCTCCATCTTCCTCTTTGCCGTCCGCACTTCCATCTTGGCTCACACCTTCCATGTTGAAAGTGCAGACG
ATCAAGGATTGACCATAATCGTCAACTTCGTCCCATGTCGTGTGCAGGTGTAACTCGTCGGCAAGCTCTT
GGACGAAAGCGTTATCACGCTTGTCCTGAGTGTTGATGAGCTCAAGTCGGTGAGTGGGATTGGGTTGATT
TTGCTGCTTCTCGATAAAACTGCGTAACTGGTTCAGTACTTTTTGTTGATATTTGGTGATGACTGCGATA
ACGTCAGTATCAAAACAGCTTCACTACCGGTACGACTGACCCTTGCGGTTCTTCTTTCTAGCCTTCTCAA
TCACCATAGTGTCTCTAGTGTGGTTTCCAGAAAAGTGAACCTGGTCCAGGAGGTCATCTTCAAACCTCTT
GACCTCAAATTCGGCCAATTTGTCGAGCAAAAGTTGGAGTCTTGGCAATGAAATTGTGCCATGCTCGTTA
ATGTATCCGTCTACCAAATGTTCAGTAACGCATTCAGCGGCAGCCAGGTAGGGACTCACCAATTGTGGGC
AAAATGTCTTTATACATCCCCCAGATTCTTTCCAAGGCACCTTCGTTGATATGTAAATCCGGCAAATGAG
GCAAGAAATCATTCCCAACAAAGATTGCCATTAGAATGAAATCATCAATGATACGCTCGAGGTCGTACTC
GAAGGAGATCTGAGTCTGGAGGGACGAGAATTCAAGGTCGAGATATTCTCGCATGAGGGAAAGATGGAGT
AGGAAAAAATTAGTGTTCGCAAGTCTGCATCTCATTAGCTGCTATCCTAGTTTGAAGCAAGGAACCTACT
CGGTGTTCTGTCTAGACTTCCGTCCAAACGTCACTTCCTCACGCAAAAGACAGAAATGGGGGTCATGGCT
CAATAGACCCAACATTATCAGATCGGCATCAAGACCGTAGAGGCAATGCCTGGTGTTAGGGTTGTAATCC
GGCTGAGCCTTGTTCAGTCGGATGAATTCTTGGATCTTGTGTTCACCCTCTCCGGGGACCTGCAACAAGT
TAGTGACCGACTCCATTAGTAAGTGTAGGCTTACATCGTGACCGCTAAGAATAACTCTGATGCTGCGCCA
ATCGGCGTCTTCAGAAATTCTTTTTCGCACATAGTACTTGAGGTGTTGCGACAGCCTCGCCATAAAAGGT
GTACCTACAATTCCGTTAAACCTTTTCTGCGAAATGCAGCAGCTTCATTACATACCTGGCGTAATGGCAT
TGGAGTCAAATGCCTTTTCATCAGGCAGCTTTTCTCCATTCTTCTCCGCCTTTTCCCTTTGGTCCCTAGC
GTCCTTACCGGCCCTGAACCTTCGGCTACGCTGCTGGTTCATCTTTGCTCGAGGAGCTACACCGTCAATA
GCCATGAAAAATACTTTTTGAGGTTTTATTTTGGTGAAAAGATGGTCGATATAGGCGAAAATGGCCAAAA
TCATCTGCTCCTCCGTGATTCGAAAATGCGGGTCGTTCTCAGTCGATGGGGGGTGAGAACAGTTGTGAAT
GATACCGTTCTATGATAGGTCAGGAAAGCATGCTAGTCAACCTTGGAAATGCTAACCATATCCAGACTGA
AGTGACTTGGGTCAGCGCCATAATACAAAAGCAAGGTTCGAGCGGCAACTTACTAGAGATTATCGAACGT
GGGGATAGAGTTGGGTGTGATCAACTGAGAGGTAAGAGGATACCTCTCTGAGATCCATCTGAAGAACTAG
ATCGTATGGTCAGTACGAAAAATGTTTCCTGCATTCATTACGATGCAGACCAACCTTTGGGATACCTGGA
AGACAGTTAGCGACGGTTTCCAAAGAACGAGAAGAGACAGACATACCCATTGTCGTTAGTATATACTACT
GTCTTATTTATTGTACAGTCAAGAATGCAAGTTGATCAGTGTGTTGCTGTAAGGAGCGTAAACACTGTGG
CGGGCTGTGTAGAGAT
Protein Sequence 
>gi|58267550|ref|XP_570931.1| Exonuclease II [Cryptococcus neoformans var. neoformans JEC21]
MGIPKFFRWISERYPLTSQLITPNSIPTFDNLYLDMNGIIHNCSHPPSTENDPHFRITEEQMILAIFAYI
DHLFTKIKPQKVFFMAIDGVAPRAKMNQQRSRRFRAGKDARDQREKAEKNGEKLPDEKAFDSNAITPGTP
FMARLSQHLKYYVRKRISEDADWRSIRVILSGHDVPGEGEHKIQEFIRLNKAQPDYNPNTRHCLYGLDAD
LIMLGLLSHDPHFCLLREEVTFGRKSRQNTELANTNFFLLHLSLMREYLDLEFSSLQTQISFEYDLERII
DDFILMAIFVGNDFLPHLPDLHINEGALERIWGMYKDILPTIDGYINEHGTISLPRLQLLLDKLAEFEVK
RFEDDLLDQVHFSGNHTRDTMVIEKARKKNRKVITKYQQKVLNQLRSFIEKQQNQPNPTHRLELINTQDK
RDNAFVQELADELHLHTTWDEVDDYGQSLIVCTFNMEGVSQDGSADGKEEDGDWESDEMEDEGKLAVQRV
FRNWSKAAVVDTYPEDVEKSMDEKLKEAMDDIKRQYYHDKLEINYNDPAQMQDLVHHYIEGLQWILNYYY
KGVSSWGWFYKYHYSPRITDLKGVADMKFEFDYGKPFTPFQQLMGVLPVDSMDHVPLAYRDLMYEETSPI
IDFYPRNFELDMNGKKQDWEAVVKIPFIDQNRLLKAMAARDVRLTPEERERNKSGVLSTQFVYDPEIDEN
YPSSFPGVFPELTRSHCRASPFNLPVLGGDVQLIFGLVEGVQLGVSALAGFPSLDTLPHNGTLDYHGVNV
FQSDSKNPSMVITIIGKDELPKTSEIARNVLGQRTFHSWPYLQEGIVAAVSDDMFKYTLQQVGKSLRVVH
MPHQDAVKWRRQADHVERHYSRRYGVIIGGVEVLLHIRPLKGLKHLDNGALVKDYETPEKEIVQAYQVAV
SQVTFEDERFLERAPPDLKVDFPVGEKVLFLGDMHYGLAAQVSAVNEEAQTLSVILAYFEEETEETLRFM
KAVAHRPAGKWWPSPILSRRLGISALALSRITSTLLVQLGDGSKTNIGLSLKFESRGLKVLGYSKRNDRG
WEFSEKTAQVLEAYKKAFPEVFKHLENRGGDLVKSKELCPTAEDPDTVIKGMKKWLKDEGLNDLESVSLF
ADQLEAKTFQSIKKKRLDNVPRQTLLKPAQAIYRLQGQVFEPGHRVVMVQDPAAGGVPTGMRGVVVGLGM
RTVDVIWDNGFMGGSTLQGKCSPYRGSTVPFSSCLNLTRPQFTVSERAGPKPVPQNVFRPQLGPRPAVPM
QHYQPSVPGRQQTATTTHHILQKPKTVHSTQSTTVVGSNGHLKYSGVAKGVRPQPVQQQPVSHRDQLSNL
LGGLRLGPGPVVNDNRDSSHVTHVQAQGNLPVVHSHASVHQAIPTNPPIRGKAQNMNNKSGIGAVRGRGA
ANGAPFAHRGTHNGVPASARGGAPNGGPRGRGGFRGGSRGFTRGRGVGSGGSAVVEE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Deletion of XRN1 impairs uni- and bisexual mating (Wollschlaeger et al., 2014).
References
Wollschlaeger et al., 2014: Wollschlaeger C, Trevijano-Contador N, Wang X, Legrand M, Zaragoza O, Heitman J, Janbon G. Distinct and redundant roles of exonucleases in Cryptococcus neoformans: implications for virulence and mating. Fungal genetics and biology : FG & B. 2014; 73; 20-28. [PubMed: 25267175 ].