Victors

VTC4
Victor ID	5388
Gene Name	VTC4
Sequence Strain (Species/Organism)	Cryptococcus neoformans var. grubii H99
NCBI Gene ID	23884995
NCBI Protein GI	799328003
Locus Tag	CNAG_01263
Genbank Accession	CP003824
Protein Accession	XP_012049426
Taxonomy ID	235443
Chromosome No	5
Gene Starting Position	754452
Gene Ending Position	757643
Gene Strand (Orientation)	-
Protein pI	4.84
Protein Weight	92977.14
Protein Length	864
DNA Sequence	>gi\|799350697:754452-757643 Cryptococcus neoformans var. grubii H99 chromosome 5, complete sequence TGAATCTGAAAGTGAATCCATGCATAATAGTCTAGCTTTCCTTTTGGGTTGAGAAATCAAAATTACGCCT TGGAACCTCAAGCAACCTGAGCCTTTTTTTTAGAGCTGTCGTAATCTTAGCACCAAATTGACCATTACAC TGGCTAACAACGCCGCGCAAAGCGCTGTGGGGCCCCATCTATCGTGATAGTCAACTGCTTCGCGTTTCCG CATCTTGCGAATTCTCCAAGCGTACATTCCTCCGCAGTAGAGGATGGCTGAGAGTGAAGTAAACGTGAAG CAGCCGGCAGAAACCATACCGACGGCATCGGTAGGGTCGATAAAATTGAGCAGACCGATAGACACTGCCG AGAGCAGAATTGCAAAATGAGCCCACTGCAAGTTTCACGGGTTAGTATTTAAAAAAAAAGTTTGGGCAAA GCAGTAGGGAGATTATCATTACCTTTAAGAATGTGCGCTCAGCAGCAAACACGACCTTTGGTTCAACTCG GACTGGAATGGCAATCTTCTTTCCTGGTGGGGCCCTGAATTGGTCCACATAGATGACCCTTTCATCATCA TCACCACCCTCCTCCTCCTCATCATCGTCTTCCTCCTCTCCCTCCTCTACCTGATCTTCTCGTCTATTCT TCGCCGCCTCTTGAAGCTTTTTCATACTCTTGTCATCAAGCAATTGCAGGTTCTTGTCAAAGCGATCGCT GGAAGCAAGAGGATCAATCCTGAGCGAGGCATCATACTGCTGCTGACTGCGGATTTCCCTGGCAGGACGC GAGGAGGAACCGTTTACCGCCCCCGCGGAGGATGACTCGGCTTCGTTTTCGCCATAGGTGGTGATCCCAA CCCGCCGAGCAGCCTCGTCCCTTATATGTTTCTCTCGATGCTCCCTTGCCGCTCTGGCTTGGGCGGCAAC ATCTGAAGGTAGTCTCAGATGGTCTTCTTCGTTTTTGGCCTTGTGAACGAGATATTCCTCGTCATCTTCA CCTTCCGAGATCGGTTCGTGGTAGCTGGCTTGAGATGTGGTGCTTTTCGCGGCAGGCGACGGGAGGGCGG ACCCCTCCATACTGGCGTTGGAGTGGATGTTGGACTGAGGTCGTTCGATGAGTATTTTGGATTTGGCAGT GACCGGCTTGCGGATATCCTGGTCCATCTGAGGAAGCCAGAAAGGTACGAGATCCACCCTTTCTGGAAGG AGACTGGCACATCCGTGGATAAATTTGGAGAATTTAGGGACTGCCTCTACCAGGTGAGAGTTGATCAGAT CCCGGATCCATTGAGGAGGTTCTTCTCCAACCTTGGTAGCTAATTTGACTTCGAGGACGCCATAAGGGAA AAGCTCCTTTTCTGAATTCGGGATAGAGTCAAACGGGTGGTTTATTCCAAGATCCATGCGGCGCCAGTTG CCATGGGTGCGATCGACTCCATCAAAGTTGTCTTCGCGAACCATCGTGAGCTCGGTATCGAGGGAGATGC GAACGGTGGCGTTCCCAGGAAGCTGGAAAGCTGTTCGGTTATAAAAAGTCCTCATGACTAAAAAGGAATT GTTGTTCAGACCAGGCTACATGGACCACAAGGACAATAAAACTTACCAGGCCTTAGCTTTCTTGTGATGA TGGCATACTGGACTTCATTTGCCAGCTGTTTCATGCCTTCCACTTCTTTCTCCGTCTTCTTATTCTTTTT GACTAGCTCATCAAACTCGTCGTCCATGGTGTATCGTCCACTTATGAAATCGTTCATTTTGCCTTCTTTG ATAGTAAACCGCTCTTTAACAGATTTTTCTCCTGTCCAATCTTCGCGATGCGTTTTCCGTTCTACAAATA TCTACGGTAACAACTGTTTAGCGACTGACTGGCTCAACAGGCGGTAAAGATGGGAATCTCGTGTGACCTA CTGTATTGCCGGTAACATCACCGTACCACCTCATACGGATAGCCTCTGCACCTTCAGTCTTCTCCAATCG ACCTAGATAAAGCTCCAGATCTTGATTATCGAAATAGATGGATGTGATGGCCGAGTCTGCCATGGAGAAC TCTTTGTTCGGGTTGAATACTTGGGTTCTCGGGTAAGCACCCGAAAAAAAAAAAACCCAGCAAGGAATGG CCAAGTGCTTACCTAGAACAGGTAGATGTTTCATAATTGCCAGCTTGAGCGGGACGATATTCTCGTCGTG AACCTTGTGATGACAAGTCAGTTACGCAGCGGCATGTATTCCCAGAAAGAAAAACCAACCCAGTATTTAG TTGTGCTCCTGACAAACGCATTCTGATTCCCACCGGCGGAAGCGTCACCTTCAATAGGATGCCCACGGGT GCGCACCAGGTCAAATAATTTTGACAACTTGACGATGAGAGGATCATAATTCATACGATAGAAGGGATGG GCTTCGAGAACTTGGCGATTAAAAGTGTTTTTTAGATTGAACCCGGTAAGTTTCTAGATCCAATGGTGGG TTTCGGTTTTCGTCAGTTCCAAGAAAAAAAAAGAATAAAAGTGAGCACATTTCAAGGCAACGTACATCAT GTTTCTTGACGATTTTGATAAATCCAGTGAAATTGAGTTTTGTAAACAGCGCGAGGTCATGTACGTCGGC TACCAAGACAGCGACTTCTTCTTCCAGCTCTCTAAACCGCTCCTCGATCGCATCGATTAACATGTCGCTG GACACATCTTCATCGTCATCATCATCGTCATCGTCATCACTGCCCGCATCATCGTCCCGACGATCTCTGA TATTTCTCTCTACATCACCGGGCGTCGTCGCCGTTGTCGCCGTCGTCGTTTCCATCGTCCCATCATCGCC TCTATCATCTTCTTCATCCGAAGTAGCTCCTTCGCTGTATCCAGCCTTTTCGACGAGCCCCTTGACTTCC TCCTCGAGCTGCTGGATCTTGCTCATGAGCTCATCGGATTTGTCATGCTGGAACGTCTCGCATTTCGTGA GCTGATCCTGCAAGGCTCGGACAAAGTCTGCTTCTGCGGTATCGTTCCAAGGCAGGTTGGCCTTGATCTG CTTTTTGAGGCCGCCATAGTCGATGTACTGGTCTGCCCATTCCGAGTAGAGGGTGTCCTGTATTTTGGAC GCGTCAGCAGGGGGGGTTTTCTAGAGATGGATAAAATGATGAACCTTTATGCGTCTTCCAAACTTCATGG TTTGTGGTGGGGAGGGAGAGAAGGGAAAAAGTGAGTTTATAT
Protein Sequence	>gi\|799328003\|ref\|XP_012049426.1\| vacuolar transporter chaperone 4 [Cryptococcus neoformans var. grubii H99] MKFGRRIKDTLYSEWADQYIDYGGLKKQIKANLPWNDTAEADFVRALQDQLTKCETFQHDKSDELMSKIQ QLEEEVKGLVEKAGYSEGATSDEEDDRGDDGTMETTTATTATTPGDVERNIRDRRDDDAGSDDDDDDDDD EDVSSDMLIDAIEERFRELEEEVAVLVADVHDLALFTKLNFTGFIKIVKKHDKLTGFNLKNTFNRQVLEA HPFYRMNYDPLIVKLSKLFDLVRTRGHPIEGDASAGGNQNAFVRSTTKYWVHDENIVPLKLAIMKHLPVL VFNPNKEFSMADSAITSIYFDNQDLELYLGRLEKTEGAEAIRMRWYGDVTGNTIFVERKTHREDWTGEKS VKERFTIKEGKMNDFISGRYTMDDEFDELVKKNKKTEKEVEGMKQLANEVQYAIITRKLRPVMRTFYNRT AFQLPGNATVRISLDTELTMVREDNFDGVDRTHGNWRRMDLGINHPFDSIPNSEKELFPYGVLEVKLATK VGEEPPQWIRDLINSHLVEAVPKFSKFIHGCASLLPERVDLVPFWLPQMDQDIRKPVTAKSKILIERPQS NIHSNASMEGSALPSPAAKSTTSQASYHEPISEGEDDEEYLVHKAKNEEDHLRLPSDVAAQARAAREHRE KHIRDEAARRVGITTYGENEAESSSAGAVNGSSSRPAREIRSQQQYDASLRIDPLASSDRFDKNLQLLDD KSMKKLQEAAKNRREDQVEEGEEEDDDEEEEGGDDDERVIYVDQFRAPPGKKIAIPVRVEPKVVFAAERT FLKWAHFAILLSAVSIGLLNFIDPTDAVGMVSAGCFTFTSLSAILYCGGMYAWRIRKMRKREAVDYHDRW GPTALCAALLASVMVNLVLRLRQL
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: Deletion of the VTC4 gene encoding a polyphosphate polymerase blocked the ability of C. neoformans to produce polyphosphate. The vtc4 mutant behaved like the wild-type strain in interactions with macrophages and in the mouse infection model (Kretschmer et al., 2014).
References	*Kretschmer et al., 2014:* Kretschmer M, Reiner E, Hu G, Tam N, Oliveira DL, Caza M, Yeon JH, Kim J, Kastrup CJ, Jung WH, Kronstad JW. Defects in phosphate acquisition and storage influence virulence of Cryptococcus neoformans. Infection and immunity. 2014; 82(7); 2697-2712. [PubMed: 24711572].


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VTC4