Victors

VCX1
Victor ID	5386
Gene Name	VCX1
Sequence Strain (Species/Organism)	Cryptococcus neoformans var. grubii H99
NCBI Gene ID	23886488
NCBI Protein GI	799320487
Locus Tag	CNAG_02940
Genbank Accession	CP003822
Protein Accession	XP_012047842
Taxonomy ID	235443
Chromosome No	3
Gene Starting Position	388041
Gene Ending Position	393383
Gene Strand (Orientation)	+
Protein pI	6.66
Protein Weight	145098.15
Protein Length	1424
DNA Sequence	>gi\|799350639:388041-393383 Cryptococcus neoformans var. grubii H99 chromosome 3, complete sequence AGGTGGATGCTGTCTCAGTAACGTACGGCACTCGGGACGGCAACGCACATATCGCAGCTCGACAACACGT ATCGATAGCTAATATTCAAAGACTTTAGCAAAGTATGTCTGCAGGTCGCAAGTCTTGCACATCTTCCAGC ATCCAAGAACAGCAGAAGTAAACGCAAATCGACCACCACCACGATCACACCTATTTATTGTGATGTCAAC TCCCATTCGCTCTGATAACCAAAGCCTCAAAGACGACTCTTCTTCTCCCTCTTCCCCTACACCGACTATC CGCAATACTACACCTGTCCAGCCGCCCAGCGCCTCGCAGGTTTTCGCCGCCGCGGTGGCCGCTTCTCCTG GGCCCGCCCCTGGACGCGCCGCAAGTCAGCCAGGGATGAATAGAAGACAAAGTGGGCAGCAACAGCAGCA AGAGCTCGGGAAGGGACGCCCAGGAAAGGATGATCTGGTAAGTGAAGGTGACCAAGAAGTGCTCGGTGAA TGGTATCATGGTGTTTCGGAATTTGGAGCAGGAACGTGTGTTTGCGCACAGACGTCGCTGGGCAGACGCA CTTCTGATCGATTTCCCTTGTGGTGATCCATCATTCTGTATTTCAGATGGCGTAATCCCCCTTGCCATTC CTTTCTCCCCCTTCGCCTCCATCACCTCGAGTAAGGGCGCCGCTAACGATCAGCATGCCTTCACCACAGC GCACTGCGGCCACACCCAGTCAACTCCGAGGCAACTACTCCCCAGCACGTGCCTCTATATCTTCCACGGA GGATGAGGACTACCTAAAGCCGAATTCTCTACCGCGAACAGCTGTTCCAGAAAACACCACCTTTGAATCC ACTCCTAGAGGCTGGGGCGGTGGCAGTAGTCGTGGGGTGCCGCAGACCGCTTTTGGAAGCAGTTTTGGTT CCCCGACGGCATTCTTCAGCCAGCCTGCGCGAGAAGCATCTAGCGGAGGAACACATCGCTTAGGCCGAAG TGCCCGGTTCGCCAATTCTCGGGACCCATCGCAAACTGTTACTAATCCGGGCGGCTCATCTTCCCGTTCG GCTTCTCGAGCCCGTCCGCCTTTGCAGCACCACCACAGTATCTTGAGAGATTCTCCCAACCTAGACGACG ATGAACTGCAAGACCGAGGGGCTGAACTTATCAAACAGCGGCAAAGAGAAAGGAAGGCAAAGAGGAAGAA GTTGGAGCTTGAGCAGCAGCGCCGACTTGCTGAGGAAGGAACGACACCAGAGACGAGTAACCCACCCAGT GGTGTACCAGAAGAAGGTTTTGCCGCTCAGCAAGGGGGGTTGAGCAGGGGACCAGTGCCCATGTCAAGGA TAAGGAATCCTAGTGCAACCCGCCGTCCTACGAGTGAGGGATTCTTCCCATACCCTCCAAGCATATCTGA TGGAGAAACTCCCCGAGATGGTGGGATGAGCCCAAAAGAGGATGCTCGCGCACCGTCCGTATATTCGTCT GTTGCCGATGACGAGGCAGAAGATCAATTAGACGAGCGTGTAAGTATAGTGGGAGAAATTGTTAATGATG TTGTTGAAGAAGAGACTGGCGGTGATGTTGATAAGTGCGGCTCTGACGAAGAAGAGGAGATTGGGCCGGA TGAAGGAGTCACGATGAGAGACCGTCAAGATGTAAGTGGATTCTAATGTCTTTTTATGCGTCATTTGCTC ATATACATTAGGCAATTAATATCGAACACCCGTTCGGTCTCCCAATTTGGAAACCCGCTCTTTATCGCAA ATCACGATCTGTAACCCGCAACGCCGAATCCGCGCTTCACTCAATTCCATCCGCAGCCGCTGAACGACAT CTATTACCGGGAAACATCCTTTGGACAGCCCTCTTTGGATGGTGGCTTGCTATTGCGTGCTTCATAGCAG CTGTTTTGGTAAGCGGTGCGGAAGTATTAGGTGGTGGTAGGGGTGGTTATGGAAAGACGTTACGCGGCCT GGCTTGGTATATCGGGTGGCCATTCGGAAAATATGTGGAAGGTGAAGGGGCACCGGACGATGATCATGAA CACGATGAACACGCAGCTGGGGACGAGGAGCAAGCGAATGGGAACTACCAAGCACTTGATGGTTCTTCGC CGATCAGCAAACGACAGAGAGGGAGAGAAGTATCGGACTCCTCATCTTCCAATGTCACCGTGAGACGTGC TCAAGATTCGGCACCAGTGAATGCCGCGGACTGCCCCGACGCAACTTCCGCGAGTACTGTGCGAGCCAAC AACGAACGTCCTGCAGTGTCATTCGCTTCTGGTATCAAGGGCAAAGGTCGCGACAGTGTCACTGAACGAT CTTCACTGTTGGGAAAGAACGGCTTCAGGAGGCCCAGAAACAAGCGAGCCAAAAAGCTCGGCCAAATAGT CTACTGGCCTGGATTCTGCGTCATCGTTGCACCTACAATGCTTTTGGTCTGCGTTCTTTGCTGGGGATTC GTGATAACTATTCCCATGGCAAAATTGACCTGGGAATTGTTGAATCTTTTATGGTACCGGCCACTTGAGA TTAATTTCCGACCTGCTCCGAGAGTCCCAGTACCGACACCCACCTGTTCTTCTGACAACGTTCACGATGA TACCAACGGTTCCGGATCGAGCACTGCTGTCGGAGACTCCCCTACCAACTTCACTCTCAAGCGCGCACGT CTTACGGCTGGTCAAGTTGCTCCGACGTCTGGACCTACATCCACTGTTTTGCTCTGCACCTATCGTGCAG TTGGCTTACAGTACTACAAGTACACAGTTGGTGGGGTCAATATCATGTTCATCAACCTCTTGCCTCTTGT GTTTTTTACTATCATTGATGGTCTCCTCCTTCTTCCAGCTGTGGAACGCAAAGAGCACCTCGGGAAACCA ATCACTCCACTCTTGCGTCTCCTCACATCTCAAGCCCTCCTCTTCGTCCTCGCGCTTGCTTCAGTCATCC CGCTCTCATACTTCATCGGCATGGCTGTCGCTTCCATCTCTGCGCAGTCCTCCATCGGCATGGGCGCTGT TATTAACGCTACCTTTGGTTCTATTATCGAAATCATTCTCTATAGCATTGCCCTTACGCAGGGCAAGGGC AGGTTGGTGGAAGGTTCTATTGTAGGCAGTATCTTGGCCGGTGTATTGCTCATGCCGGGAGCGAGTATGT GTTCAGGGGCTTTCAAAAGGAAAGAGCAAAAGTTTAACGCGAAGAGCGCCGGCGTGACGAGTACGATGTT GATCATGGCTATTATTGGGACTTTGACACCGACCATGTTCTATCAGACCTATGGTTCTGTGAGTTGTTCT ATTGACTTACCTACATTTGTATATAGGGAGCTAATAAGCGCCTTAGTTTGAGCTTCATTGCCAAGACTGC CCTTCTGGTCACCCCAACATGACCATCACCTTGCCAGAGGGCGGTATGAGTTTACAGCCTGGAGACATGT GGATGTGCGACCATTGCTACTATGAACATCCTGATCCAGAGCGTGATCCATTCTACCAGGAAAATGTCAA GACCTTAATGTATGCCTGTGCTGCCATCCTTCTCTTCGTAAGTCAACCTCAGTCCATGAATCGTGGTTTC AACGAAAAAAAAAAATTGACAGGTATGGTCTAGTCATACCTTATTGGTCTCTGGTTTTCTCTCCGCACTC ACGCCGCCCAGATATGGCAAAACCCGCAACAGCTCATGAAATCTGAGGATGCTCAAGCTGTTAGCGAAGT GCATCCTGCTCTCAAGACCACCCTCGCGCAACGCATTACTCCACAGGCTCTGATGCAGCATGTCCTCCCT TTGCACAAATCAAACAACCCCCCTGCCACCTCAACTACAAATCCTGTTGTACCTGTAGCCACCAACGAAG GTAGTATCCCCGCGACAGTGTCTCCTAAGACTGGCACGTTGCGTTTGGCGCCATCTGGCTTGACCAAAGA CGGAACTGATCAGACCGCAAACATCACTCCAGGACATTCTCAACAATCCTCTCATGCTAATGGAATCGAA ACTTCTCGTCCAAGCCCAAATACGAGCCAAGCCTTCACCCTCCCAGCTGGGTATACCCCGTACTTTGAGA GTATTGATCAAGCTACTAAGTCGAATCTCACTCCCATGCGTCTTCCTGGTACACTCACAACGGAGGACTT TACTCGTGCTGTGGCGGTTGCTACCGTTAGTGCGCTCAGGCATCAAGGGTCAATTGTTGAGTCTGAAAGG AAGCGCAGACACGTGGGAGGTGAAGGTCCAGCGGGCGGGGAGCAAGGAGGGGGAGTAAGTAAAGAGGAAG AAGGGCATGAGAAAGGTGGTGGACATGAAGCGCCAAGCTGGACCAGAGGGGCCAGTGCTGGGGTTTTGCT GGCTTGTACCATGTTGTACGCTATTATTGCTGGTGAGTTATACTGCGGATTGTAGTTGACGAAAGGATTC TGACGATTATCTGTAGAGATCTTGGTGGACGTGGTAGACGTTGTACTCCACGGATCCGGCATAGATGAAA AGTTTTTGGGTTTGACACTCTTTGCGCTAGTGCCCAACACGACCGAGTTCATGAACGCTATGTCATTTGC TCTCAATGGTAACATCGCTCTCAGGTAAGTTTATGGCTTGCGAGATAAACCATTGCGCAGAAATATTGAC GGTAATGATAGTATGGAAATCGGTTCCGCGTATGCTTTACAAGTGTGCCTGCTCCAAATACCGGCAATGG TCGCTTTCAGCGCATTGTATCAGCCGGAGAAAATGGGCGATGTCATCGACACATTCACGTAGGTCCAACT TCAATCCTTCAGTTCACACAAGTGAGATATTAACGATCGATAAAGCCTCATTTTCCCTCGCTGGGATGTA ATCGCCATTATTCTTTCTATTTTCTTGCTCACTTACACCTACATCGAGGCAAGGAGTAACTACCATCGTG GCTCAATTTTGGTCCTTGCGTAGGTTCTTCATTCTAGTCCCAGTACGCTTCATTGACCGCCGTTACAGCT ATATTGTACTCATAATGGGATTTTACTACGCTCCTCCAAGAGCCCAAGGAGGTACCGACCATGACACCAT CTTTGGACAGGAGAGCCTGGAAAGTTTTAACGCGGGCTGGACAACGGCATTGACGAAACTTTGGGTGTGA TAGGCTTGTCAGTGGATGTGGTATAGAGGTAGTTCTCTGACGGGTGTATAGGGTGAGAAGATTGTCGCCA AGTAGGTGGAGGTGCGAATTGTCCTCGTGTGTAATAAGAATATACGCTTCAACATATAGACCGATCAATG ATACATACATTTTTTTTTTTTTGATAGTACCAATTTACACCACCCCAGTAACGAAATAATTACGATGCGA TAGCGGCAATCCGAACAACCAGA
Protein Sequence	>gi\|799320487\|ref\|XP_012047842.1\| calcium/proton exchanger [Cryptococcus neoformans var. grubii H99] MSTPIRSDNQSLKDDSSSPSSPTPTIRNTTPVQPPSASQVFAAAVAASPGPAPGRAASQPGMNRRQSGQQ QQQELGKGRPGKDDLRTAATPSQLRGNYSPARASISSTEDEDYLKPNSLPRTAVPENTTFESTPRGWGGG SSRGVPQTAFGSSFGSPTAFFSQPAREASSGGTHRLGRSARFANSRDPSQTVTNPGGSSSRSASRARPPL QHHHSILRDSPNLDDDELQDRGAELIKQRQRERKAKRKKLELEQQRRLAEEGTTPETSNPPSGVPEEGFA AQQGGLSRGPVPMSRIRNPSATRRPTSEGFFPYPPSISDGETPRDGGMSPKEDARAPSVYSSVADDEAED QLDERVSIVGEIVNDVVEEETGGDVDKCGSDEEEEIGPDEGVTMRDRQDAINIEHPFGLPIWKPALYRKS RSVTRNAESALHSIPSAAAERHLLPGNILWTALFGWWLAIACFIAAVLVSGAEVLGGGRGGYGKTLRGLA WYIGWPFGKYVEGEGAPDDDHEHDEHAAGDEEQANGNYQALDGSSPISKRQRGREVSDSSSSNVTVRRAQ DSAPVNAADCPDATSASTVRANNERPAVSFASGIKGKGRDSVTERSSLLGKNGFRRPRNKRAKKLGQIVY WPGFCVIVAPTMLLVCVLCWGFVITIPMAKLTWELLNLLWYRPLEINFRPAPRVPVPTPTCSSDNVHDDT NGSGSSTAVGDSPTNFTLKRARLTAGQVAPTSGPTSTVLLCTYRAVGLQYYKYTVGGVNIMFINLLPLVF FTIIDGLLLLPAVERKEHLGKPITPLLRLLTSQALLFVLALASVIPLSYFIGMAVASISAQSSIGMGAVI NATFGSIIEIILYSIALTQGKGRLVEGSIVGSILAGVLLMPGASMCSGAFKRKEQKFNAKSAGVTSTMLI MAIIGTLTPTMFYQTYGSFELHCQDCPSGHPNMTITLPEGGMSLQPGDMWMCDHCYYEHPDPERDPFYQE NVKTLMYACAAILLFSYLIGLWFSLRTHAAQIWQNPQQLMKSEDAQAVSEVHPALKTTLAQRITPQALMQ HVLPLHKSNNPPATSTTNPVVPVATNEGSIPATVSPKTGTLRLAPSGLTKDGTDQTANITPGHSQQSSHA NGIETSRPSPNTSQAFTLPAGYTPYFESIDQATKSNLTPMRLPGTLTTEDFTRAVAVATVSALRHQGSIV ESERKRRHVGGEGPAGGEQGGGVSKEEEGHEKGGGHEAPSWTRGASAGVLLACTMLYAIIAEILVDVVDV VLHGSGIDEKFLGLTLFALVPNTTEFMNAMSFALNGNIALSMEIGSAYALQVCLLQIPAMVAFSALYQPE KMGDVIDTFTLIFPRWDVIAIILSIFLLTYTYIEARSNYHRGSILVLAYIVLIMGFYYAPPRAQGGTDHD TIFGQESLESFNAGWTTALTKLWV
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: The loss of VCX1 does not influence cell wall integrity or capsule size but decreases secretion of the major capsular polysaccharide glucuronoxylomannan (GXM) in culture supernatants.Vcx1 also influences C. neoformans phagocytosis by murine macrophages and is required for full virulence in mice (Kmetzsch et al., 2010).
References	*Kmetzsch et al., 2010:* Kmetzsch L, Staats CC, Simon E, Fonseca FL, de Oliveira DL, Sobrino L, Rodrigues J, Leal AL, Nimrichter L, Rodrigues ML, Schrank A, Vainstein MH. The vacuolar CaÃ‚Â²(+) exchanger Vcx1 is involved in calcineurin-dependent CaÃ‚Â²(+) tolerance and virulence in Cryptococcus neoformans. Eukaryotic cell. 2010; 9(11); 1798-1805. [PubMed: 20889719 ].


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VCX1