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UVE1

Victor ID 5385
Gene Name UVE1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23886733
NCBI Protein GI 799335909
Locus Tag CNAG_03213
Genbank Accession CP003827
Protein Accession XP_012051101
Taxonomy ID 235443
Chromosome No 8
Gene Starting Position 359459
Gene Ending Position 362340
Gene Strand (Orientation) -
Protein pI 9.55
Protein Weight 68001.65
Protein Length 645
DNA Sequence 
>gi|799350780:359459-362340 Cryptococcus neoformans var. grubii H99 chromosome 8, complete sequence
ACAATATACGACATGGCGACACGCATGCATACCATCACAGACTTCTGGTGGTTCGCGCCTTTCGATTTGA
TTTGTTTGTTATATTTATTCCGTCGGGAGTCTACTACTAGAAGCGACACCTTTTTTGAGTTACGCCGCTT
TGAAACCTTCCGGTCCTCTTGCAGCGAAAATCATCTATTTTTTGTGGCTTCTCATTTTGCTTGTTTGCTT
GTTTGGGTGTCTGAAGTCACAAGATAACAAGATGCCAGATACGCCAATCGTCAATCAACATAAGTCTACC
GTTACTGTGCCACACAAATACGAACATATTCGCACATCCGGTGCTCCAAGGTCGAGAATCCATATAAAAA
TGCTTACTCTGCCGCCGCTTCTTTCTTTACCCTCCCTCTCTTCTTGGGCTTCTCCTTCGTCGCTTTCATA
TCTACCTCCATACCCACATCATCTACCGCCTCCACGACCTGTCCGTCTTTCTTGAAGCCCTCATCGCCCA
ACCCCCCATCGCCCTCCTTTTCGATATCTGACAGATGGACCGGTTCACCTTGAGAGTCGACATCCCCGGT
TTCTTTGGTCTTCCTATTGGTCATTGCCGCAATTAGTTTTCTGAGATGGAAATAAAAACACGATAGATAG
ACAACCTACTTCTTGAGATTGCTCTTTCTGCCCTTGGTCTGCATGCTGGGGTTGGGGTCAGGGGGGCGCA
GATTGTCATGGATGACATCTTCCAGACCGCTGTCAAGTAATGATCAGCTTTCCATGCTCACCGCGCTAGA
ATTGTACCTACTAGATTCGGTACAGCTCGAAGACTGCTTGCTCCTATGTTCACAATCAGCCAATGTTTTT
ACCATGAGATGGGGAAACCACGTACTTTGTCTTTGGCTTCAATCATCAAATCAACATCATCTGGCAACTC
CGCTGGGAGCGTTTGACATCGATCAGCATGCGCCCTTCTCTCCATTATGCTCTGTGCTCCCGGCCTAGGC
TCTGATAGATGTTGCTTCATCTTGATTCCCTTCTTGTTCCAGACCCCTGCAATCTTCGGGATAAGCTCTC
CGGGAGGGTCGGTGGAAGGGTTCAGGGCGTCGTGGTGATAATCAAAGATGATGGGGATGTCAAGCTCAGT
ACAAACTGGTAGAAGATCATCGACGTTGTAGCAAATCTATGCTTATGTCAGACCTTGCCCATAGATTTTA
AATCTATACACTTACTTCGTCATTCTCCAGGACAAGCCTTGCCTTCACTTTGTCGCTCGCAAGGGTGGTG
TAGTTTTCTTTGAACCTTGCCAAAGTACTTTCCTTATCCCCATAAACACCACCCATATGGATACTATTCT
TTATTAGGACTGGATTTTGGCTGCGATTTGTGCTGCTTACATCATGACACCATCTGGCCCAAGTCCCATC
CTGTCCATGATTTCACAGTGATATTCTAACTCTCTAATTGACGCATCTACTACAGCCTTTTTCGGTGACC
CTAATTGCGTAAACTACTCAAATCAGCCCTCCATGACTCTGGTGTTTGTGGTGTAACCATAGCTCACCTG
ACCAGGATGCATAGTCAATCTGTGCCCATACCTTCTTGCTAAATCTCCTGCGTCCTTCAACTCTGCATCT
GCAAAATCGAGAGAGTATCCGTACTTGGCGTGAGATGCGAACGGAAACATTTCAGAAGACATCCGCATGA
AACGAATCTTGTTGCCCTCATTCCACTGGATCAATGTCTTGAGGTCTCGAACGTTCATTAGCCCGAGCCC
TTTAGGCAACTCAAGCCCCTCTTCCTCTATACTGGCGATTCGACAAGTTCTTGAACAAAATATGCTATCG
GGCTTGTTGGCACGTAATACGGTATTCAGACAGGCGTATCCAAGGCGCCCTGTAAAGAATTGGGGCTGAG
CATTCATTAAGCCAAGCTATGAAACACCTACCTCTGAATGTTGTCGTCTTTCGCTCAACATCAGGAATTT
CGTATACCTTTTTGGGGTACTCCCTAAGCTTTCGTTTACGTTTCACGATCTCATTGCCTTCATCGTCGTG
TTGCAGTTCGTCTTTGGCTATTCGTGATTTCTTTACTACTTTCTTCTTTGGTTTTCCTTCTTGTTCCCCA
TTTTTCGCTGTGGTCGCTAACTCAACTTTGATTTTTCGTCTGTTTTTCTTGCCGTTCTCGGGTATTGCCA
ATTCTTCCTTGACATCGAGTTCTTCCTCACTCTCAGCTTCTTCCTTGGCGGTAGCAAGTTCAGCCTTACT
ATTCCCGCCTCTTTTTCTCCCATTCGTTGAACTAACTGTTCCAATTTTCACCTTTCCTGCTTCTTCTGCC
ACCACTTTTGAGCTCCTCTTACGTTTAGCCGTCCCCCGGTCTGCAGCGCCATTCACCGCCACTTTCCCGA
CCTGGTCATCCTCAACATCGGAAATCGGAGGAGGTGTAAGGTTATCTTCGTCCATGGCCATTGCTACCGC
CAGTAAAGTCGCTTTTGGTGGTCTGGATGGTGGGGACGGAGGGGGTTGCTCTAGACTTCTGGGAGAGGTG
ATGAAAGGCGCCCTGTTTGTTGAAGAGGGTTGGAGAGCTGTACGTGCACTTCTTCGGGGAGGCATACTAG
CTTGAATATGAGATGATGTGGGGAATGAGCCTGACAAGTAAGGCGAATATGGTCTCCGAAGAATTACTTT
TGTCGTGATTGCAGGTAGTCGTGGTTGTCGAAAAAGGAGCGATAAGCTCATGTATTCAATGCTGATGCGT
AGTTGGCAACAAAAGCAGACGAGTTTGTTGCAAAATCAGATGGAAGTATTCGCGACTGAGTTTTATACAT
ACCGGAAATGTCGAGTGTGGTGTCGTACTAGCGAACGATGGGTAGAGAGCTTGAAAAGGTGGAGATCGAG
ATGAAGATCGAC
Protein Sequence 
>gi|799335909|ref|XP_012051101.1| UV damage endonuclease UvdE, variant [Cryptococcus neoformans var. grubii H99]
MSLSLLFRQPRLPAITTKVILRRPYSPYLSGSFPTSSHIQASMPPRRSARTALQPSSTNRAPFITSPRSL
EQPPPSPPSRPPKATLLAVAMAMDEDNLTPPPISDVEDDQVGKVAVNGAADRGTAKRKRSSKVVAEEAGK
VKIGTVSSTNGRKRGGNKLDVKEELAIPENGKKNRRKIKVELATTAKNGEQEGKPKKKVVKKSRIAKDEL
QHDDEGNEIVKRKRKLREYPKKVYEIPDVERKTTTFRGRLGYACLNTVLRANKPDSIFCSRTCRIASIEE
EGLELPKGLGLMNVRDLKTLIQWNEGNKIRFMRMSSEMFPFASHAKYGYSLDFADAELKDAGDLARRYGH
RLTMHPGQFTQLGSPKKAVVDASIRELEYHCEIMDRMGLGPDGVMIIHMGGVYGDKESTLARFKENYTTL
ASDKVKARLVLENDEICYNVDDLLPVCTELDIPIIFDYHHDALNPSTDPPGELIPKIAGVWNKKGIKMKQ
HLSEPRPGAQSIMERRAHADRCQTLPAELPDDVDLMIEAKDKEQAVFELYRIYGLEDVIHDNLRPPDPNP
SMQTKGRKSNLKKKTKETGDVDSQGEPVHLSDIEKEGDGGLGDEGFKKDGQVVEAVDDVGMEVDMKATKE
KPKKRGRVKKEAAAE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The mutantation of UVE1 leads to a UV hypersensitive phenotype (Verma and Idnurm, 2013).
References
Verma and Idnurm, 2013: Verma S, Idnurm A. The Uve1 endonuclease is regulated by the white collar complex to protect cryptococcus neoformans from UV damage. PLoS genetics. 2013; 9(9); e1003769. [PubMed: 24039606 ].