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CXT1

Victor ID 5384
Gene Name CXT1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. neoformans JEC 21
NCBI Gene ID 3254907
NCBI Protein GI 58261216
Locus Tag CNL04750
Genbank Accession AE017352
Protein Accession XP_568018
Taxonomy ID 214684
Chromosome No 12
Gene Starting Position 328062
Gene Ending Position 331018
Gene Strand (Orientation) -
Protein pI 5.16
Protein Weight 76486.46
Protein Length 694
DNA Sequence 
>gi|58271749:328062-331018 Cryptococcus neoformans var. neoformans JEC21 chromosome 12, complete sequence
ATCGAAAACGACGAAATATGCATAGAGACACGAAAACATGATGCTGTAACTGTAGGGAATGGAGAAAATC
TCAAAAGCACACAAATCGCAGACCAACCACCCATCCATTTAGGTCGGATCTCATCTACCACCCCTTGAGT
TTGTCTGAAACCCCTGTTACTTGCGGCAAAGCGTACACAAATATTCTTAAAATGTCCATCCAACCCTTCA
TCGCTCTGTAGCGTTCGCCGACGCTCTTTCTTGTTCCGCTATAACATCCTCGCTATACCTTTTTGAAAAC
CTACTGGTCGATGACAGGGGTCTCAATATCAGCAGCAGCGGGTACATCGTCGGCCTCTTTAGAGGCTTTC
TTTTGAGTGGAGACGTAGTCCTAAAGGAGAAAAAATTAGGCGTTATACCGGACAAATTGATGATAGACCT
ACCATTTTGCCATTGTCTCTGTCTGGACTGGTCAACCTCGCATATTCGAGGTACAACCTGAACATGTACG
CTTGAAGGTCCTCTCTTCTCCAGGCTAAACAGTTGTCTATCAGCGTCTAATCCTCCAGTTTATTTACGAA
AATCGACTCACTTCGCTCGACCCAGCACTGTCCGTTCAACGCAATTCTCCTAGCGACTTCATCATGAGCG
CCTCGACCGGATGGGGTTCCTCGGAAACTACCTATCGTTAGCCCTATCCTGAGGCGAAATGGGGATTGAT
ACGCACAAAGTCATGATGGAGAAGAGATCAGAGTAATCCATCTTGGATGGGACATAGGCATACCATTCCG
GAAGGGAGTTGGTATTCCACTCGGGGAAAACGGTAGACTTGATGACAACGCTAGGAAAGAAGTCAGTACG
GTAGAAGGACGCCTATTTGTAAAAGCTCACTTGTTGCTGGCCATTAACCGAGGGAAGCGGGAGCTCCAAG
CATTGCCATCAGTCTAGTGGATAGTCAGCACACAGATACTGGCGCTTGAGGTCGCAGAAGAACGACTCAC
GTCAAAGACATATTTGAAGTCATTACTCCTCTCAGAACTATCTTTTGGAGCGAAATCAATCTCCTTCTCC
ATCTCCTCACAAGTTCCGTCTCCCCAGTCACACTGCCAGTTTCCACCTGCAAGTTTTACATCCATATAAT
ACTGACCCAGCTCTCTCAACGGCATCCGAGCGAGCTCAGCCTCGCCAGAAGAACCCACAGGGGAGAGGAC
TTCAGTGTAGGTGTCCGACTTGTCGTTGGCGAGGAAATGCAGACGTTCGCGGTGGGATTGACGCCACTTG
GCACCAGCCTTCTTGTTGTGCTGCAATCCGGTAGCCAACCCACGCCAATATAGTTTGCCACTCTTCCGGT
TCCACTCGGGATCGTGGCCAATATCGTCACGCCTTCCGTCTTTACCAATAGGAGTGACGGGGATGTCGCC
GTTGAGAGCAGTTTTGGAAGGAACGAGAATGGGGTAAAGTTTGGTATGGGGTTTGGGATGGCTGTCGGAA
TTCTTCTCTTCGAGTAGCATCCCGTGGTTCTCCATGTAGGACGGATGCTGACAGATGTCCATGGCGGCGA
GATGCGAAGAGATGAAGGAATCGGGAGCCTCTGCAAAACGGGTCAAATTAGAGCGCCATTAAATCAGAAA
GGTTGCAACTTACCGAGCTCCTCTTCGCCTTTATTAAGAGGACTGTCGGGAGGACAGGCTTTTCTCCAAT
TTTGCTCGGCTCGATCCAGTTCGTTAGGATGTGTGGAGATTTTGCCATGTCGAGCAGCAGTAAGAAGCTC
TTCTTGACGCTCATGATCGAGAAGGATAGATGGTTGGTCGTGGATAGTAAAAGTCGCCCTGCCCAAATTA
TTCAATGATGATTCCAAACATCAAGCGTGTATACTTACCTGAAAGTCCCAATATGCTTGATAAAAGGTTC
CATCAAGTTGATCTGACTGTCAGCCCTAGGTCGACTAGCCCACCAAGTATCTCTGGAATAATCGTCGTTC
CACTTGAGCTCCACCTTGCCGTCGTGTACAATGAGAGTGAATGTTTCGGGAATCTTCTCAGCCTCGACTA
GGCGCTCCTTGAGGGTGTCTATAGGGAGGGCATAGAAAGGAAGAAGAGAGTTCATGATTCTGCAACTCGG
ATAAGTGGGATTCAAGCAGCAAACGTGACATACTCACGGGTCATACTCATCTGGGAGGAGGACGTTATTG
GCTTTGGCGAAATGCCACCTTGGAAGCGATATTAGCCCAAACATAACTCGTACTCAGGTAATCACGTCTT
ACCACTCGTCGAAACCCTTTGGCGGCCTTCTTCCCCATCTGTCCATGTACACATCCACGGCCTGCTCCAG
TGTCTGACTTTGCATTGTGACCATTGAGTTCCACTTGGCTTCACCGTCCCTCAGCAATCCCAAGATAGGG
TGCGTCAGTCCGGCAGGCATCTTTCGCGTAGCATTGCTGAGCTCGGAAAACTCGTCGTCAAAGTCCGGAT
CGGCATCAGTACCCTCGGCAGGAGGCGCGTCGGCGCGCACAATACCTGGAGAAATCTCATCGAGAGAGAG
CACTCGAGCGCGTGCCTTCTCCGCTGCTGAAAGAGCATCGAAGGGCGAGAGGAAAAGACACTGCCCGTCC
TCATCGAACTCTAATGGGCGCGTCGGGGCGTTGGGATTGAGGATTGGAGGGAGCCATTTGGAAGGAGAGA
AGTATGAGGCGTCCGGCTCGTGGTGCGGCAAGTTTGGAGTGAGGACGGGAGGAAGAGTCGAGGGTGCAAA
GGTGTGGAGGAAGAGGATGAGGATGGAGGCTGAGAGGATGAGGATGATGAACCTGCGGGGGAGGGGGAGC
TTGAGGGGGGAGGAGAAGGGCAAGTTGAGCGGCATCGCAGGCAGGGGGCCGTTGTGTGGAGGTGGGGGAG
GAGGCGGTGTTGTCCTGATCTCTGTGCGTGTCGAAAGTGTTCAGCCCGTCAGCCATGTACTCCACCACAA
GATGTTGCAGATCCTTT
Protein Sequence 
>gi|58261216|ref|XP_568018.1| cryptococcal xylosyltransferase 1 [Cryptococcus neoformans var. neoformans JEC21]
MPLNLPFSSPLKLPLPRRFIILILSASILILFLHTFAPSTLPPVLTPNLPHHEPDASYFSPSKWLPPILN
PNAPTRPLEFDEDGQCLFLSPFDALSAAEKARARVLSLDEISPGIVRADAPPAEGTDADPDFDDEFSELS
NATRKMPAGLTHPILGLLRDGEAKWNSMVTMQSQTLEQAVDVYMDRWGRRPPKGFDEWWHFAKANNVLLP
DEYDPIMNSLLPFYALPIDTLKERLVEAEKIPETFTLIVHDGKVELKWNDDYSRDTWWASRPRADSQINL
MEPFIKHIGTFRATFTIHDQPSILLDHERQEELLTAARHGKISTHPNELDRAEQNWRKACPPDSPLNKGE
EELEAPDSFISSHLAAMDICQHPSYMENHGMLLEEKNSDSHPKPHTKLYPILVPSKTALNGDIPVTPIGK
DGRRDDIGHDPEWNRKSGKLYWRGLATGLQHNKKAGAKWRQSHRERLHFLANDKSDTYTEVLSPVGSSGE
AELARMPLRELGQYYMDVKLAGGNWQCDWGDGTCEEMEKEIDFAPKDSSERSNDFKYVFDTDGNAWSSRF
PRLMASNNVVIKSTVFPEWNTNSLPEWYAYVPSKMDYSDLFSIMTFFRGTPSGRGAHDEVARRIALNGQC
WVERTWRREDLQAYMFRLYLEYARLTSPDRDNGKMDYVSTQKKASKEADDVPAAADIETPVIDQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: This gene (USX1) encodes the previously identified UDP-xylose synthase. We demonstrated that it is necessary for both capsule xylosylation and C. neoformans virulence (Moyrand et al., 2002).
References
Moyrand et al., 2002: Moyrand F, Klaproth B, Himmelreich U, Dromer F, Janbon G. Isolation and characterization of capsule structure mutant strains of Cryptococcus neoformans. Molecular microbiology. 2002; 45(3); 837-849. [PubMed: 12139628].