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URA4

Victor ID 5382
Gene Name URA4
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23884513
NCBI Protein GI 799315752
Locus Tag CNAG_00734
Genbank Accession CP003820
Protein Accession XP_012046922
Taxonomy ID 235443
Chromosome No 1
Gene Starting Position 1918161
Gene Ending Position 1920984
Gene Strand (Orientation) +
Protein pI 6.89
Protein Weight 35479.84
Protein Length 353
DNA Sequence 
>gi|799350543:1918161-1920984 Cryptococcus neoformans var. grubii H99 chromosome 1, complete sequence
CCTTGCCGCTGTTTCTGCAACTGACTTGGGCTTTTTAAAGCATCTCTTGGTCGTCTATTGTTTGCCCTTT
TCTTCTCGAACACAGATATATCACGTAAAAATGCTACAAGAAATTGTTCTTCCCTCTCCTGCCGAGTAAG
TAATGCCTTGTCCCGTATCGAACACCGCCAATCTTTTCTTTCCAGCTTCCATGTCCATGTGAGACAAGGG
AAAATGTGCGAGCTCGTCACTCCTCAAGTTGCTAAGGGAGGTGTCCGCACCGCGTATGTAATGGTAAGGG
GTTTGTTGTGCATAGATGGCAGCAACTCATTGTAATCTGTAACAGCCCAACCTCGTCCCGCCTCTCACTT
CCACCGATGCTGTGGTATCCTATAGGGCCGAGCTTGAGAAAATTGATTCCTCTGTCCAGTGGCTCATGAC
CCTTTATTTGCATCCTGATGTAACCCCCGCTGAGATCCGCAAAGCTGCTAAAGCGGGCATCAAAGGTCAG
TCCTCAAGTTGTAGAGACTAAGCCGAGGGCGTAGGGTGGGTGCGAGGCGTATGATCGCTCGAACAGATGT
GCTTATATTCTTTACTACCATGCAGGTGTCAAGTCCTACCCTCGAGGGGTCACTACCAACTCCAATTCTG
GCATCGAAGACTACGAAGTCTACTACCCCGTCTTTAAGGCTATGGAGGAAGAAGGCATGGTCTTGAACTT
GCACGGAGAAGTCCCCAGTGACGCTCACAAGGTAAAGACCACTCAATTTGGAGAATATGAAGTACGTAAA
GCTCATCAGAAGAACAGAACATCTCAATCCTCAATGCCGAAGTTCACTTCCTCGAACATCTCCGTAAACT
CGCCACCGCTTTCCCCAAGCTTCGTATCGTTCTCGAGCATGCTACCACCTCTGCTGCGGTCGAGACTGTT
GCTTCCCTCCCTTCCAACGTCGCCTGTAGTATCACTGCTCACCATCTCTATCTTACCATCGACGAGGTCG
CTCCACAACCCCACCACTTTTGCAAGCCTCTTGCTAAGGAGCCCAAGGATAGAAAAGCCCTCCAAGACGC
CATCAAGAGCGGGAACGAGAAATTCTTCTTGGGCAGTGATAGTGCCCCCCACCCCTTGTCCAACAAGGCC
CCTGCTTTGACTGAAGAGGGTGCTGTGAGCGCTTGTGCCGCCGGTGTATACACCAGCCCCATTTTGATCC
CTCTAGTTGCAACCCTTTTGGAAGGTTTCGGCGCTTTGGATAAGCTTGAGGGATTCGTTAGTGGGCACGG
AAGGAAGTTCTATGGGGAACCCGCCAAGGAGGGACAGGAGTTAAGGTTGAGGAGGACGAAGGAGGATGAA
GGTTTCGTTAAGGGAACATTCAGGGGTGATGGCGTGGAGGTCATGCCTTTTTGGGCTGGCAAGAGGTTGG
GTTGGGAAATTGCTCAATAAACAGGATATCTATATTGATAGGATACCTCCCGGGATGTGAGTTGTAATAT
CCCAAATGATGCATATGCATGGAAATTGAAATGGTACAGTGATTTGACTCTTCTTACAGCTCCAATGGTT
ACGCTTCTTATTTTCTTATGCGTCAATCCCAAAAGTAACACCCTGCGCGAGAGAGACTTTGCTAGAATAG
TTGACAGTAGCAGCAGACCACCTTACGTATTGCTTCCAGGCGTCACCGCCAGACTCTCGTCCCCAACCAG
TGGACTTGTTACCTCCAAAACCAGCACCGATTTCAGCACCACTGGTACCAACGTTGACATTCACGATACC
GCAATCGGAACCTTCGGGACCCAGCCACTTGCCGAGAGACTTGAGATCACTAGTGAACAAGGCGCTCGAA
AGGCCTTGAGGGACAGAGTTGTTGATCTCAATGGCTTCTTCAAGAGTCTCGAATTCGGTAACATAGAGGA
TGGGGGCGAAGACCTCTTCCTTCCAGCAGGGATCATCCTTCTTTGGTCGAACGACAGTAGGCCAAACCCA
GTTACCGCCCTCGACCTCCTTGTCCATACCATTAATCCGCCCTGATCGCTTAGTAAGGATCTCACCACCG
CGGGATGTCACAGCTTGAAGCGTTTCCTCGTACTTCTTCACAGCGCCGTCGTTGTGAAGAGGACCGATAA
GGGTAGATGTCTGGAGAGGGTCACCCACCATCAAATGAGGGCTAGGTGCTTGGGCATCGTAGACAGGAAG
GAGCTTAGAAAGGAATTCTTGCGCAACGGATTTGTGTAGGATGAGACGACGAGTGGATGTGCATCGCTGT
CCGGCGGTACCCACGGCAGCGAAAAGAACGCTTTGAAGAGCGAGAGGAAGATCGGCGTCCTTGTCGACAA
TAACGGCATTGTTACCACCAAGTTCAAGGATAGTCTGTGAGGTAGAGTCAATCACAAACCGATAATACTT
GTATGAAAAACTTACCTTGCCGAATCGATCGCTTACAGCCTTACTGACCTCCTTACCGACCTTCTCACTT
CCTGTGAAACTCACTGCAAGAACAAATATCAGAGACGGATCAACCATACACAGTGGAAACCAATTTACCC
AAAGGGATATCCTCATTACCCACAATAGTCCTCCCGACATCGACACCTCCGCAGACGAGCGCAGCAGTTG
CTCCAGGAAGGCCGTTTTTCTCGAGAACGGGCTGGATTAGACGAGTGACAGCGATTGCCGTCAAAGGGGT
TGAGGGTGCGGGCTTCCAAATGGTAGAATTACCAGTAGCAAGGGCGACAGTGAGGTTCCTGTGATACCTT
TTAGCCAGGAGCCTTTAGTTGGACGAAGTATCAACTCACCAGCCCTATGTTAAGAAGAGTAAAATGGCAA
ACATATTAGATTATGCAAATTTCT
Protein Sequence 
>gi|799315752|ref|XP_012046922.1| dihydroorotase, homodimeric type [Cryptococcus neoformans var. grubii H99]
MLQEIVLPSPADFHVHVRQGKMCELVTPQVAKGGVRTAYVMPNLVPPLTSTDAVVSYRAELEKIDSSVQW
LMTLYLHPDVTPAEIRKAAKAGIKGVKSYPRGVTTNSNSGIEDYEVYYPVFKAMEEEGMVLNLHGEVPSD
AHKNISILNAEVHFLEHLRKLATAFPKLRIVLEHATTSAAVETVASLPSNVACSITAHHLYLTIDEVAPQ
PHHFCKPLAKEPKDRKALQDAIKSGNEKFFLGSDSAPHPLSNKAPALTEEGAVSACAAGVYTSPILIPLV
ATLLEGFGALDKLEGFVSGHGRKFYGEPAKEGQELRLRRTKEDEGFVKGTFRGDGVEVMPFWAGKRLGWE
IAQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Loss of the C. neoformans Ura4 protein, resulted in an expected uracil/uridine auxotrophy and an unexpected high temperature growth defect (de et al., 2014).
References
de et al., 2014: de Gontijo FA, Pascon RC, Fernandes L, Machado J Jr, Alspaugh JA, Vallim MA. The role of the de novo pyrimidine biosynthetic pathway in Cryptococcus neoformans high temperature growth and virulence. Fungal genetics and biology : FG & B. 2014; 70; 12-23. [PubMed: 25011011].