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UGE

Victor ID 5381
Gene Name UGE
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23889297
NCBI Protein GI 799345213
Locus Tag CNAG_06050
Genbank Accession CP003831
Protein Accession XP_012053101
Taxonomy ID 235443
Chromosome No 12
Gene Starting Position 174226
Gene Ending Position 176763
Gene Strand (Orientation) -
Protein pI 7.18
Protein Weight 33672.76
Protein Length 322
DNA Sequence 
>gi|799350913:174226-176763 Cryptococcus neoformans var. grubii H99 chromosome 12, complete sequence
TTATTTCAACTGATTATATGTTCCACAGCTATTGCAATCTTGCACACTTGTGCAACTCAATGATCTCAAC
TGGGTGTCTTACGAGTCTGAACGGCAACTTACCGATCCATAGGTTACAATGTTGATGCATCTGTTCTCTG
CCTTGGATTTAGAGAACGTTTCTAATGCGAAATCAGACCACATGGAGTGAGTCTGATCGCGTTCAGCGGC
CTCCGACAACGTACTTACTGTTTTGCATAGCCGAGGGCTCGGTTTCACAGGTAACCAATGGAGCCTGATG
TTCACAATGTTTTTTTCATACCATGACGTTGCATGACATATCCAGGAGCTTGCTTGAGCAAGGAATTTGG
ACATAATCGCATGTTGCCATTTACATGGCAGGATAAATGCCAACGGGATTCCTCGAGATGCAAGGCTGAC
CGACATTGGAGATAAATGAGGCTCAACGACAATGATTAACGCGGCGTTAAGGATTTTGCATCATATCTCG
CCGTTCGTCTTTTGCGCGGTATTGTGAGTTGCTAACCATTGTAATAAAAGTTGCGCTAACAGCAATATAG
TTCGAAAGCTGCAACTATACTCAGACTGGGGCAAGACAGAGAAGAGCATAGCTGACTGTATAGTCATTGC
ATGAATGTAAGGAACCTTTTCATAAGCCTATAAATAAAGGCTCAGCGCTTATCAATGGGTGTTTCTGCTA
GGCCGTCAAGACGAATATCCGGCAACGTTTCTCGACTGGAATCGCCAAAGATCTTGGCACATCTCCTGCA
GACCTCTGCGCGCAATGAATCCAAGCTCTTCTTTCGCCAGTCGAGGGTCGGCTGTCAAGTCCGGAACGTC
ACCGGATCTAGAAAGCCCAATTTTAGCTTCATTCGGGAAAATGGTTGATTAACCTAACCTACCTTCGTTC
CACGATTTCGTACTGGTACCCATATCCTGTTGCGATTTTCATCTCGTTAATCATCTCAAGAACGGTGATA
CCCTTGCCTCTCCCCAGGTTGAATGCGCGGAAATACCCGTTTTTCTTCGTATCAACTGAGTGGAAGATAC
CTGAACTTTGAGTTGTGATTTCTGACTTGGCGAGAGCGTCAAGCCCGAGGAGATGGCCCTCAGCAAGGTC
CATGATGTGAAGATAATCCCGAAGACATGTGCCGTCTCTGTGATTACACATCGTCAGAATCGATTAAGAT
CAAACAGCACGCATAACCCACCTGGTAGGGTAGTCATTCCCAAAAACCTTGAGATCAGATGATGATCTCC
CCACCGCGATCTGAGCTAGAATTGGAAGTAGGTTACCTGGGCGGCCTTTAGGCTCTTCCCCTAGCTGGCC
GGACAGATGAGCCCCAGCCGGGCTGGGTGTGAGGTTTTAGCGGGCCTCCCAATGGCAAGGAAAATTCTCT
CACTTACTTAAAATATCTCACGCTTATCGCTTTGAGACCTTGAATGCCAGCCTTGGCTGCGTCAGCCCGG
CATACGTCTCGGATCACTTCCTCTGTGATCGCCTTGGTACGCCCATACACAGATTCAGGTATGATCTCAG
AGGTCTCGGGGATTGGAATCATCGCTGGGGTGCCGTAGACGGTGGCGGATGACGAGAAGACAAGGTTGTT
GGTTTGGAATCGTTGCATAATCTGGAAGCTGTCGATCAGAGTTGGTCAATAGCCTGGACAGTATGAACAT
ACCTTCAGGAGCGAGATTGACCCCCCGACGTTGACCTCGTAATAATCTAACGGAATCTCACTCGATTCTC
CGACTGCTTTGAGTGCAGCTAGGTGGATTACCGCCCATATGCCGCCTTTTGACTGATATTGCTTGAACAC
CTTGTCGATTTCTTCCGCGTTACGAATATCGCACTGGTGGTAAAGGGGTTTGGGAGCATGTGGGCTATTA
AAGATCGAAGATCAGCTATGCCGGTCCATGCCATGTATATGGACTTACCCTACTTCATTTTGGGCTATTT
GATTGCAGCGCTCGAGAGCTTGAGGGTATGCGTTGTGCGCATTGTCAATGATGATGGGCAAGTAGCGACC
AGAGACCAGAAGTGAGAGGACAACGTGAGATCCTATGTATCCGAGTCCACCGGTGACAAGGACGTTCTGT
AATGAGAATTAGCCTTGGTTTTGTTGTAATTGTAATAGAATGGTCCCACTTTCAAAGGCTGTCCATGGAC
AGACAAGCTTGATGTCGACGTTTGGTTCATGGTAACTCGAGTCTGTTCAAAAACCATAATGCAGGTGAGC
GGTTGAGTGTGTTATTGCGATTCAATGTTTGCTATCATAGCTCATGGTCATTGAGGCTGCATTCTACATC
TTTTATACTGGATGCTGACATCCTCTTCCCAACACCTATTAGGGAAAGTCGATGCAACAGAATCATGAAC
GGGAATACTCAGAATTGGACCCGAGCACGAACGGGAATCTTGCCCAAATAATGCTTTGTTCGAACGGGAA
TTTCGAGGATGGGCAATTCTGCGAACGGGAATGTGTAGTAGAGGAAGCGATGAACGGGAATTCTGCGAAC
GGGAATGTGTAGAAGAGA
Protein Sequence 
>gi|799345213|ref|XP_012053101.1| UDP-glucose 4-epimerase, variant [Cryptococcus neoformans var. grubii H99]
MNPHAPKPLYHQCDIRNAEEIDKVFKQYQSKGGIWAVIHLAALKAVGESSEIPLDYYEVNVGGSISLLKI
MQRFQTNNLVFSSSATVYGTPAMIPIPETSEIIPESVYGRTKAITEEVIRDVCRADAAKAGIQGLKAISV
RYFNPAGAHLSGQLGEEPKGRPGNLLPILAQIAVGRSSSDLKVFGNDYPTRDGTCLRDYLHIMDLAEGHL
LGLDALAKSEITTQSSGIFHSVDTKKNGYFRAFNLGRGKGITVLEMINEMKIATGYGYQYEIVERRSGDV
PDLTADPRLAKEELGFIARRGLQEMCQDLWRFQSRNVAGYSS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: UGE2 is necessary for C. neoformans cells to utilize galactose as a carbon source at 30 degrees C but is not required for virulence. In contrast, deletion of UGE1 does not affect cell growth on galactose at this temperature (Moyrand et al., 2008).
References
Moyrand et al., 2008: Moyrand F, Lafontaine I, Fontaine T, Janbon G. UGE1 and UGE2 regulate the UDP-glucose/UDP-galactose equilibrium in Cryptococcus neoformans. Eukaryotic cell. 2008; 7(12); 2069-2077. [PubMed: 18820075 ].