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UGD1

Victor ID 5380
Gene Name UGD1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23888330
NCBI Protein GI 799324327
Locus Tag CNAG_04969
Genbank Accession CP003823
Protein Accession XP_012048628
Taxonomy ID 235443
Chromosome No 4
Gene Starting Position 111115
Gene Ending Position 113863
Gene Strand (Orientation) -
Protein pI 5.59
Protein Weight 47724.41
Protein Length 468
DNA Sequence 
>gi|799350666:111115-113863 Cryptococcus neoformans var. grubii H99 chromosome 4, complete sequence
TATAATCCAGATAAAGCTGATTCATATGTTCTATATCAAGGCAACCAACACAGACAAAGATGTTTTGCAG
AAAACTAGCACGAATGTTGGGTATCGCTAGTTTTGTGACTGCTATATATATTCTAATGGGAGTATAATGG
TATACAAGGATCATGCACTCAAACAACGCCTTCGACTAACGCCTTAAACACGGTCGCCGGTACCGATAGT
GACGACCTTGAAACCGATGTTGGTGAGCTCCTGTCGGTTGAGGATGAGTCGACCATCGAAGACAAAAGCA
GGTCGGGGACAGTTGTCGTAGACTAATGGCAAATGTTAGCGTTATTTTTCAACGTTCAGCGACTCAGTAA
CTCACTCTTCTTCCAGTCAAGAGTCTTGAACTCGTCCCATTCAGTGCAGATGACGATGGCCTCGGCATTA
GCACAAGCCTCCTCGACACTCTTGCAGATTGTAAGGTGGGGCTGGACTGTGGATGAGGTCAGTGGATGAG
GTCAGTGGATGCATAATTTTCCAACACATACTGGGCTCAGCGGGGATCTCTCCGTAGCTGTGTACACTGT
CAATAGATGTTCTCAAAGAATTGATGGTTGTACTCACTCAGTCATGTCGAGCCAGATCTGAGACTCTGTG
ACTTGAGGGTCGTAGACAGCGATACGAGCCTTCTCCGACAAGAAGTGGTTGGCGATGCTGATGGAAGGAG
ACTCTCGGGCTGTTTACGCAATCAATAAAAGGCCAAATTTAGTAAACAATCATCGACTCACTGTCACCAG
TGTCCTTCTTGAAGGCCCAACCAAGAATGGCAATCTTCTTGCCGGTAATGGTGTTGAAGAGGGTGTCAAC
AACCTTTCGGGCGAATCGGCCCTTCTGGTATTCATTCTGTAGTCATATCAGCAAAACTCTTTTTACAGAG
CAAGCGGACTAGACACACCATCTCAACAACGGCACGCCAGTATTTGGCAACCTCGGGAAGATGGAGAGAC
TCAGAAAGGTAGACCAAGTTGAGAATGTCCTTCTGGAAACAAGAACCACCGAAACCCTACGACAAATTGC
GTGAGTTACATTCAAAGCCTGATCGATGGCACTTACGACAGACGCCTTGAGGAACTTGGAACCCATTCGG
GTGTCCTTACCGACAGCGTAGGAGACCTCGTCAATGTTGGCCCCAGTAGCCTCACAGATGGCAGAGAGGG
CGTTAACAGAGGAAATTCGCTGGGCCAACATAGCGTTGGCTGCGAGCTTGGAAAGCTCAGAAGACCAGAG
GCCGACGGTCAAAATTCGCTCCCTAGGAACCCAGTTGGCGTAGACGTCGGAAAGAGCCTGGCAAGCATTG
ATACCTTGTTGGGTCTGGAGAGAGCCAATAAGGACTCGATCAGGGTTGAAAAGATCGGAGATAGCGGTAC
CCTCGGCAAGGAACTCTGAATTATTATTAGAACAGTCTTTGTAACCATTGCAAAATAGCTTACCAGGGTT
AGAAAGAATGTCGAAGTGGCATCCGGGCCTGCAGTTGGCCTCGAGAATGGTTCGCATAGATCTGTAAATT
GTCAGTTTGGAATCTGGAAACAAGATTTGGTAGCTTACTCGGCAGTTCTGCAGGGGACGGTGGACTTTTC
AACGACGATCTTGGAAGAGGTAGCGACCTCAGCGATTCGTCGAGTGGCGAGCTGAAGGAACCTATCGAGA
TGTGAGCATGTAACGCAATATAAAGATAAAAAGGCCCTACTTCAAGTCAGCTGCATAGCCGGCACCGACA
CCAGACTTTTTGGTGGGGGTATTGACGGAAACAAAGATGAGGCTACTGTGTATTAGCTAACAGCTTTTTC
AAGGAAATCTAAATTGCTCACTCTGCCTCCTCAATACCCTTGTCAACATCAGTGCTGAAGAAGAGGTTCT
TGCCCCTGGTGGCCTTGACAACCTCATCGAGACCAGGTTCATAGATAGGGAGGTTGTCAGAGTTCCAGGC
GTCAATTCGCTGTTGGTTGAGGTCGACAATGGTGACTTGAATTTGGGGGCTGTGTAAAACTGGTCAGTCA
TTGATCTCGCAAAGGACCCACTATTGTGAATATGTTGTGGAGAGAATATGGCACGAGGATGGCAAAAGAT
GCAGAGACATGTGCACTACCAAGAAAAGAGACATGTACACTTACCACTTCAACGCGCTATTTGTAACGAA
CAAGGTGAAAAAAGCGTCAGCAAATGATCCACAAGGGTACAACAGAGATGCCAGGCGTACATAACAGCGC
AAGTGGGGCCGCCTGGAAGATAAACGGTCAGCGGGCGACGCGACGCGTCTTACAAAGAAAACGACTTACC
GACATAACCAGCGCCGACTAAAGAGGTTGAGAAGAGAAACGGTCAGCATGGTTCTTACCGCTGTAAGGAA
AGAGGAGGAAGAAAGGGATGGCAAATTATCCATAGAAGCTGTCCTCCGTCCTGCAACATATGGCAAGATC
GGAAGCAGCCATTGGGCAGGGAAGCGGTAAGAATGCTGATACTCACTACAGCAGATCTTCTTAACAGTGA
TGGGGGCCATTTTGAATGGGGTTGAGGGTATGGGTGGAGAGAGGAGTAAGCGTTTGGAGAAGGAGGAAGG
AAGGAAGAAAGAAAAGAGAAGGATGGACGAGGCTGATAAATCGGGAAGGAGCGTTGGCGTGGGTGAGAGT
AAGGTTAACAGCGAGCAACGAGCGAGCGTGTGAGGTTTAGATCCAGGGGATACAATTCAGAAATCTGGAC
TAGCCGCGGACAGAAACGT
Protein Sequence 
>gi|799324327|ref|XP_012048628.1| UDP-glucose 6-dehydrogenase [Cryptococcus neoformans var. grubii H99]
MAPITVKKICCIGAGYVGGPTCAVIALKCPQIQVTIVDLNQQRIDAWNSDNLPIYEPGLDEVVKATRGKN
LFFSTDVDKGIEEADLIFVSVNTPTKKSGVGAGYAADLKFLQLATRRIAEVATSSKIVVEKSTVPCRTAE
SMRTILEANCRPGCHFDILSNPEFLAEGTAISDLFNPDRVLIGSLQTQQGINACQALSDVYANWVPRERI
LTVGLWSSELSKLAANAMLAQRISSVNALSAICEATGANIDEVSYAVGKDTRMGSKFLKASVGFGGSCFQ
KDILNLVYLSESLHLPEVAKYWRAVVEMNEYQKGRFARKVVDTLFNTITGKKIAILGWAFKKDTGDTRES
PSISIANHFLSEKARIAVYDPQVTESQIWLDMTDYGEIPAEPIQPHLTICKSVEEACANAEAIVICTEWD
EFKTLDWKKIYDNCPRPAFVFDGRLILNRQELTNIGFKVVTIGTGDRV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Deletion of UGD1 blocked not only the synthesis of UDP-glucuronic acid but also that of UDP-xylose and modifications in the cell wall (Moyrand and Janbon, 2004).
References
Moyrand and Janbon, 2004: Moyrand F, Janbon G. UGD1, encoding the Cryptococcus neoformans UDP-glucose dehydrogenase, is essential for growth at 37 degrees C and for capsule biosynthesis. Eukaryotic cell. 2004; 3(6); 1601-1608. [PubMed: 15590833].