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UBP5(Cryptococcus neoformans var. grubii H99)

Victor ID 5378
Gene Name UBP5(Cryptococcus neoformans var. grubii H99)
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23888948
NCBI Protein GI 799348958
Locus Tag CNAG_05650
Genbank Accession CP003833
Protein Accession XP_012053906
Taxonomy ID 235443
Chromosome No 14
Gene Starting Position 876022
Gene Ending Position 880938
Gene Strand (Orientation) -
Protein pI 6.07
Protein Weight 121019.86
Protein Length 1113
DNA Sequence 
>gi|799350995:876022-880938 Cryptococcus neoformans var. grubii H99 chromosome 14, complete sequence
GCTTGATACTTCTGTACTTTATCCATTTCTTTTCATACAGACACTACGCAACGTCTAGCAAAATGAAGAA
TCAGAGAAATATTTGGAGGGGACTACACCCCTTTCCTTGCAGGTCGAGTAGGGACTGAGGAGAAATGAGC
AGCTGATAGGCCAAATATGGAGGAAACGGTGACAAAGATGTATGGCACACGAGATGCGCGCATAGAAAGA
ATATGTCTAGTAGAGAAAATGGGAGAATGGAAACTTGAATTTGATATATATGTATCGATGAAGACAAAAG
ACAGAACGATAGATCACAACTTCGAACACCCAGAAGTACCTTGCAACAACGCCTCCTACCTCCCTTTTTG
TTTTCTCACGCGCACGACTCGAACTATCTCATTACAATACCCTTTTCGACGTTCGCCTTGTTTGGCCGCC
TATCGATATGATCGAGACCAAGAGCATCATCTGGTGCCCACTTATGATCATAAATGATGTCGTCTAGTTC
AACTGTGTCAGCATAAACAGTCAGAAACGTTTTTTTTTTCCTTTCTCGCCTATCAAAATATGATGGCACA
TGCTGCTACTCACTTTCTTCCACAATGGAGGGTTGTTTGAATACTGTTGAGGTAACTAAAGAGAACTTGT
ATTTGGCAAATTCCTTTTCAGAAACGCCGACCCTCTCTTGCAATCGTGCCTTGGTCTCAGAAAAGGGCTC
TCCCTGTGCGCGCAAACCGTAAGCCACCCTCTAATAAAATACAACGGATACGGCCAAGTAACTTACTTCG
TGCAGAACAAATTTGCAGGGAACACCATGGGTCCTGGAAGGGTCTCTGCTGTAGTGGAACACATTCACAA
TCTTGGTGCCCTCGCCAGCTTGTAATTCTTCAACGGGGATCTCCTCTGCATATAACTCAGCTGATTCAGG
AAGATTTCCAATCATTTCTGAACCAGTATGTTCACGTGGTGATCGACCAGAGGGTGAGACGTCGAAGATT
CTAATCTTGCCGCTGCCATTAGGTTCGAGTTTGACGAGTTTTGACATGTTATCGGCCACGTCATTGAACG
TGCAGGTTTTGGGCAGTAAGAATGAATGTGTGGCCTAGGCGCCAGATCAGTTTACGCTTCTTACTGTGTC
AAGAAGATGATTTCTTACTTCTTCTTTATTATGCCTTCCTGTCCAGACAACCTTTAACGATTTTTTCGTT
TCCAACTCAATGATACTGATATCCAGTAACTCGTAATAGATGCAGATATGAGCGTGCTGGTTGTAATAGC
TGGTCTGGGTAATATCCGCCACACTTTGATTCAGCGAACGCTTGACGATAGCTTTGGGGGCACCGTTTTG
GTTATGAGCCGAGGTAAATCTCAGCTTCAAAGGATCGTATTTTAGGAATTCCCCGACTCGGTGCGCCATC
TGAAATGGATTTAGACATCGTTCGCAAAAAAGAGGAGATTCGATATAAGACTTACAACATCATATGTCAT
CTTCTTACTCAGCATGAGATCGAATTCGGGCACGCTGGCGGCCCTGTCTTCATAACGAGGCTTGAAGTGA
ACAAGGATTCGGTTTTGGAGGAAGTCGTAGAATTGTGGAACGCTCGAGTACAATGATTGCGCTTCTAAAT
CGGCGATCCTGTCTACGAGTGAGTTTTCGCCGTCGACGGATATGTCATGAAGATAAACCTACTCTTTCTC
GGGAAGTTCTACCTGGTAGCAGATGATATCTCCGTCTTGAATTTCATTTTGAATGAAGGACTGCTTCAAC
TTCATTCCCTCGATCATACCCGCCTTGATTTCCTATTACGACATTAAGTATTAGTACTGAGCAATCCGCA
GACAGTCAAAACTTACCTCGTAGAGCTTGATGGGCGTTGAAGATGGCCAACCCATCCTTTCCTGTATGAT
ACCCAACAAGTCTGAAACTTTTTGGTGCTTGTCGACGAACACCTTCCCTTGACCTAACAGCGTCTGACGA
GAACAGTCAAACCACTTGAGGAAGATCATAATGGGGGGCTCTTTGCCCTCAGCATGCAGCTAAGAGAGGA
CGGAAAGTCAGATATCTGTTGCGACATCATTGTCTTTCCAAGCACGACACTCACTTCGTTAAATTTGGCA
TGATCAGGATTGTAGTCGAGGTATAATTTTAGATCAGAAGCTCGAGCGGCCATTGAATTACGGATATTTT
CCATTGCTGCAGAGAAAAAAGCGGATTATTAGCCAAAGCGTAAACTTTCTGAAAGATATACACATACTTT
GCGTGTTGTCGTTCTCGTGGATAGGGACATCGGGGCGTGTTGTCTTGTTTTGTCTATTTACAAGTACCCA
CAAACGGAAATCGCGCTCTGGAATCTTAAAGTGGGAAGCAATCCTGCTCTTGAACGTTGGATAGCTCTCG
TTCTTCAACACCCGGAAAGTGGGCAGATCGGTGGCTGGGATATTCTTGTCCTCAAAGGAGGCAAGATCGA
AACCTTGGTGCTTGGAGAAGATTTCGTCGGTGATGACTTTGGCTGTCAAGTACAGGTGCTGTTCATCCTT
CTCCCTCTTTTTAGCCTCGAGCTGCTCCCTCTCGTGATCCAAGCGAGCCTCTGTGAACATATGTCAATGG
CAAACTTTTGGACGATACCACGAGAAGACTTACTCAAATGAGGAGGTGTGTCACTTTCTGTAAAGGGTGC
CAACACTGTGTCAAGCTCTGTTTCCCTTATGTAAACCAACATATAGGCGTTGGTGAACTTTTTGAGAGTT
CTAGCCTGAGTCCTCTGATGAGGAGGAACAAGACCGTTCAACATGTCTCCGCCATAGTTGTCTTCTAAGA
CCTCCTTGTCTGTGACGGGCGTAACTCTGTCATCATCAAATTTGTACCAGCGACCATCCTTTTCAGGCTT
AATGAGAGCGAAATAGTGGCCGCCGTGAAGATCACCAGAATGCACCAGGACACCGTGTAGCTTGTAGACG
TGGGATTGGGCCCGATCGGCCGACTCATCGAGGAATTCTCCTAAATCAATCTCGAAAGGGAACTCGTGAC
GGTCATTAATCTTGACCAAAGCATCCTTCTCTACGTCATACTCAAAACGGCGCAACTGGAGATGAAGGAC
TGGAGGGAACGATTTGAAAATGACACCCTTTTTCGCAGCCTGCAAGCCGTGTCCCTCCGCTTGATACTTG
TTCTCGCCATCGAGTGTCTCAACGGACACATACTCCTTGAAGGAAGCCCGCAAATCCTTCAGTCCCTTGA
TGGTAAGTTGAATATCTATACATTTGATTAATGTCACCCTAAATAGAAAAAAAAAATCGACAAACCATAG
AAGTCTTCAATCACCGACGACTCAAAATCAACATCAATGCACTTGATGTAATTCTTCATCTGACCCTTGA
ACAGTTTCGGAATGGCGCCTTCGGCAGGAGTTCCCTTCATCTTGATTTCCAACTTGTCTTGAAGGATACG
GCTGAACTCTTGGACGTCGTGTTGCATGAAAGAATCGAGGGATTTCCATCCAAAAGATTTTGTGAGCTCA
GTGGTTCCTACTGGTTGGTTGGACGTCTGAAGGTGATAAAATACGCGTTGAAGAGCCAAAGCCAAACTTT
CGGATGGAATGTCGTCTTCGGTGGGTATTTGGTAGACAGCCTGATCAAAGGTTTTAGATAGGAACGACTT
GTGGCGGTCAGGGGCTTACCTTTCGGAAGTAGTTGGTACAGAAGAGAGACTGCAAGAGAGAGTTCATGTA
ACACGTAGCGCCTTGGTTCTTCAAACCAACATGACCAGTCTCCTTCTTGGAATCATAACTGGGAGAGCAA
TCAGTACGGGCCCTTCTTTGTTGATGCTCTACTCACTTGACAAAATTGTGCCACAAAACGCCCGTGGGAT
CCTTCAACACTCGCACGAAAGCTGTAATCTCCACTTCGTCATTCTCAATCGTCGGTCTATTCTTTCCGTT
GACAGGATCCGCTGTGTACAACTTTCGCAAGTCGACAAATCGAGTGAATCCCCAATCACACTCTTCAGCA
ACAAATCGATGATGCGCGTCTGAACAAAACAAAGTTTGCTATTTTAGTCATCTTTTTCGTTGCGATGCAG
GAGTAGACTCACGGCTAGATGTTTGAATCGTGGGATCCCATGGGTTCGAAATGGCCAGACAGAATTGTGC
ACAGGCATGCCATCCTTCGGGGGCTGTCTTTGGGTTCGCATAATCTAGGTAGACGGAGACCATGTCGTTG
GGCTGTCCGTTCGCGTTTCCTTGCGGAAACAACAAAATGCGCCTGAATCCTCAAATCAACATCTGCACAC
TGAACATAATATCTAGAGATCAACCTACCACTTGTGACCACCACAACTGAACTCTGGTCCGACTATTCTT
TTCGGCTGTTGACTCCAGTGCTCAATTCGCCATGTTTGGTACTGGAAATCTTCGATTTCTAAGCCTAAAT
CAGGCATGCACTTGGCGGCATACGCCTCATCTGAATGAAAGAAAGAGTGGCGTTAGTACTCTTATTTTTC
AATATTTCATAATCATTGTAAACAGTTTAATGACGTACAGTCATGAACATTTGGGATGTCATCGACTTCC
ATTGGAGCCGGACTTTCGTCTAAAATAATGTCCTGCACATCATTTACGGGTTGCTGCTATATGAAAATGG
TAAGCGCTTCGTCCAAATTGGAATAAACGGCCGACAGTGTGTCTGAAACACCAACGATGCCGATTGTCAC
TCACCATCTTGGATCAAGCCGCGTTGTTGGGCGGCAAGAAAGGCGGTAAAAGATGTCAGACGTCACGCTG
GTGTGGAGGGCGGTTGTGTTCTTGCGTGGCTCAGGGTCTAGCCGTAAGGTAACTGAGTGGCGGCTGGCTG
TATTCTTGTAGGAAGGAAAGAAAGGAAGAGGGGAATGGAGGCGAGAAAGATGCAGTCGTAGAGGAATAGA
CCACGCTCGAGATTGAC
Protein Sequence 
>gi|799348958|ref|XP_012053906.1| ubiquitin carboxyl-terminal hydrolase 7, variant [Cryptococcus neoformans var. grubii H99]
MQQPVNDVQDIILDESPAPMEVDDIPNVHDYEAYAAKCMPDLGLEIEDFQYQTWRIEHWSQQPKRIVGPE
FSCGGHKWRILLFPQGNANGQPNDMVSVYLDYANPKTAPEGWHACAQFCLAISNPWDPTIQTSSHAHHRF
VAEECDWGFTRFVDLRKLYTADPVNGKNRPTIENDEVEITAFVRVLKDPTGVLWHNFVNYDSKKETGHVG
LKNQGATCYMNSLLQSLFCTNYFRKAVYQIPTEDDIPSESLALALQRVFYHLQTSNQPVGTTELTKSFGW
KSLDSFMQHDVQEFSRILQDKLEIKMKGTPAEGAIPKLFKGQMKNYIKCIDVDFESSVIEDFYDIQLTIK
GLKDLRASFKEYVSVETLDGENKYQAEGHGLQAAKKGVIFKSFPPVLHLQLRRFEYDVEKDALVKINDRH
EFPFEIDLGEFLDESADRAQSHVYKLHGVLVHSGDLHGGHYFALIKPEKDGRWYKFDDDRVTPVTDKEVL
EDNYGGDMLNGLVPPHQRTQARTLKKFTNAYMLVYIRETELDTVLAPFTESDTPPHLKARLDHEREQLEA
KKREKDEQHLYLTAKVITDEIFSKHQGFDLASFEDKNIPATDLPTFRVLKNESYPTFKSRIASHFKIPER
DFRLWVLVNRQNKTTRPDVPIHENDNTQTMENIRNSMAARASDLKLYLDYNPDHAKFNELHAEGKEPPIM
IFLKWFDCSRQTLLGQGKVFVDKHQKVSDLLGIIQERMGWPSSTPIKLYEEIKAGMIEGMKLKQSFIQNE
IQDGDIICYQVELPEKEIADLEAQSLYSSVPQFYDFLQNRILVHFKPRYEDRAASVPEFDLMLSKKMTYD
VMAHRVGEFLKYDPLKLRFTSAHNQNGAPKAIVKRSLNQSVADITQTSYYNQHAHICIYYELLDISIIEL
ETKKSLKVVWTGRHNKEEATHSFLLPKTCTFNDVADNMSKLVKLEPNGSGKIRIFDVSPSGRSPREHTGS
EMIGNLPESAELYAEEIPVEELQAGEGTKIVNVFHYSRDPSRTHGVPCKFVLHEGEPFSETKARLQERVG
VSEKEFAKYKFSLVTSTVFKQPSIVEENDIIYDHKWAPDDALGLDHIDRRPNKANVEKGIVMR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ubp5Ãâ mutant exhibited severely attenuated virulence and many distinct phenotypes, including decreased capsule formation, hypomelanization, defective sporulation, and elevated sensitivity to several external stressors (Fang et al., 2012).
References
Fang et al., 2012: Fang W, Price MS, Toffaletti DL, Tenor J, Betancourt-Quiroz M, Price JL, Pan WH, Liao WQ, Perfect JR. Pleiotropic effects of deubiquitinating enzyme Ubp5 on growth and pathogenesis of Cryptococcus neoformans. PloS one. 2012; 7(6); e38326. [PubMed: 22719877 ].