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THR1

Victor ID 5375
Gene Name THR1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23887595
NCBI Protein GI 799338232
Locus Tag CNAG_04156
Genbank Accession CP003828
Protein Accession XP_012051624
Taxonomy ID 235443
Chromosome No 9
Gene Starting Position 152272
Gene Ending Position 153607
Gene Strand (Orientation) +
Protein Length 357
DNA Sequence 
>gi|799350821:152272-153607 Cryptococcus neoformans var. grubii H99 chromosome 9, complete sequence
CGATTTCTTGGACATTTGCAGGTAAACCCTCTTGTCTCTCCACCATATACTCAGCATGCCAGCCCGCAAG
TACAAGATTCACGTTCCGTGTACCTCCGCAAACATTGGCCCCGGGTTCGACGTCTGCGGTATCGCTCTTT
CCCTCTCTCTTTCCCTCGTTGTCACCATCCCTTCGGTTTCATCTGGTGCCGAGCCTTTGCCCAAGATCAT
CTACACCGGTCTCGACTCCGATAACGTTCCTCTCTCTCCCTATAAAAACCTTCTGACTAGAGTAGCCCTC
TATGTCCTCCGAGCAAACGGTATCACCACTTTTCCTCCTGGTGTGACCATTGAGGCTCGCAACGAAATCC
CTTTCGGACGTGGTCTTGGTTCCTCAGGAGCCGCCGTCATTGCCGGTGTTCTTCTCGGTGACTTGCTTGG
TAACCTCAGCCTCCCCAAATCTCGTTTGCTTGATTTTGCTCTCATGGTTGAGCGCCATCCGGACAATGTT
ACTGCTGCGCTTATGGGTGGTTTCGTCGGCTCTTACCTTCGTGAGCTTTCTCCTGAAGACATGTCCGCTG
CCAGCATCCCTCTCGCAGAGGTGCTCCCAGAGTATCCCCCTGATGCCGGACCCGACTGGGGTAAGAGCCC
TCCTCAGCCCCCACACGGTATTGGGCATTTTGTGAGGTTCGGATGGGCGAAGGAGATCAAGGCGATCGCC
GTGTCTCCTAGGTTTGAGTTGGCTACTGCCAAGGCTAGGGGTGTATTGCCAGAAAGCTACTCTAGGAAGG
ACATGGTGAGATTCATATTGCCTTTGACGTCTCCTCTATTCTGACTCCTTCGTAGATCTTCAACCTTCAA
AGATTAGCCGTGCTTACCACCGCTTTGGCTCGATCTCCGCCTGACCCTGACCTCATCTACGATGCCATGG
GTGACCGTGTCCATCAGCCTTACCGAATGACCCTCGTATGGCAATTCTTCCATCCTCATAACGGTGCTGA
TTATATGACATGGTGCAGATCCCAGGTCTTCCCAAAATTCTTTCTACGCTTACTCCCACTTCCCATCCCG
GTCTCCTAGGTATCTGTCTTTCGGGAGCTGGTCCCACCATTCTCGCCCTTGCCACGCACAACTTCGAGGC
TATCGCCAACGAGATTGAGAGAATATTCGGAGATGAGCAGGTTTTGGTCGACCACAAGGTTCTGAATATT
GATGAGAAGGGAAGCTGGGTTGAGGATATCACAGAAGCTTAGAGATTGGGATTGTTTCTGTATAAAACGC
GGATATATAAACATTGCATGGCTAATTACTGAGGCTGCGTTCCAAAATCTGAGTAATTGCGCTGAGAGTC
ATTCCT
Protein Sequence 
>gi|799338232|ref|XP_012051624.1| homoserine kinase [Cryptococcus neoformans var. grubii H99]
MPARKYKIHVPCTSANIGPGFDVCGIALSLSLSLVVTIPSVSSGAEPLPKIIYTGLDSDNVPLSPYKNLL
TRVALYVLRANGITTFPPGVTIEARNEIPFGRGLGSSGAAVIAGVLLGDLLGNLSLPKSRLLDFALMVER
HPDNVTAALMGGFVGSYLRELSPEDMSAASIPLAEVLPEYPPDAGPDWGKSPPQPPHGIGHFVRFGWAKE
IKAIAVSPRFELATAKARGVLPESYSRKDMIFNLQRLAVLTTALARSPPDPDLIYDAMGDRVHQPYRMTL
IPGLPKILSTLTPTSHPGLLGICLSGAGPTILALATHNFEAIANEIERIFGDEQVLVDHKVLNIDEKGSW
VEDITEA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: THR1 were essential for the growth of C. neoformans in rich media, when ammonium was the nitrogen source, or when threonine was supplied as an amino acid instead of a dipeptide (Kingsbury and McCusker, 2008).
References
Kingsbury and McCusker, 2008: Kingsbury JM, McCusker JH. Threonine biosynthetic genes are essential in Cryptococcus neoformans. Microbiology (Reading, England). 2008; 154(Pt 9); 2767-2775. [PubMed: 18757810 ].