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STE7

Victor ID 5373
Gene Name STE7
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23885419
NCBI Protein GI 799343243
Locus Tag CNAG_01730
Genbank Accession CP003830
Protein Accession XP_012052715
Taxonomy ID 235443
Chromosome No 11
Gene Starting Position 738451
Gene Ending Position 740413
Gene Strand (Orientation) -
Protein pI 8.45
Protein Weight 48332.88
Protein Length 461
DNA Sequence 
>gi|799350881:738451-740413 Cryptococcus neoformans var. grubii H99 chromosome 11, complete sequence
TAAACATTGCACGACTACTGCATAACGCCATTTCGCATGAGCCAAACATGCATCGTTTCTTTGTCTACAA
ATGATATTGTAATGAGTAATAAATATACACAGAACATATGATGGTTGGGGATATGCGAGACAATGATTAG
AGATATACAAAGAAGAGTATCAACATTGAAGAGTATACGAGGACGAAATATGATCTGCAGGACTGAAGTA
CGTCTATTCCTCGCGAGGGCCGGTCATGGATTGAGCCCAGGCTTGAAGGTCCTCTTTGGTGGGTTTGAGG
TTGGTCATCCATGGAGAAGACTGCAGAAAAGCACGGTAAGGAAAGAAGTTCGTCGTTGCGGTTGAATTAT
CACTTACCAGCAGCTCTTTAGGGCTCCTTCGTTGATCAGGATCCTTGATCAAGCAGCCTTCCACAAATGC
AACCGCCTCCTGGGGGAAGGTCCTCCGTCTGCTTGCCAATCTCGGAGCTGGTTCATTGACGATATGTTGC
AACAGGTCAAGGATAGACATGGCGTGCGGTCCACCGCTCTGACTGACACCGTTACGTCCGCTATTTGATT
CAATTTTAGGGCGTCGAACGGACCGAGGAAGTGTAGGATCAGGGTCAAAGTCGGAAACACTAGGTGAGAG
TTCTTCGGAGTCAGGTGAATCAGAGAATGGGAAACGGCCGACAGCCAACTCGATAAGGGAGATACCGAGA
GACCAGATGTCTGATTTGATTGTGTACGGTGCCCCCTGAATCCGCTCCGGCTACTCGAATATGATCAGAT
GACGATAAACAAACTACACTAGAGACAAACATACGCTCATATATGTGCTAGTGCCCACAAATGTATTGGC
GATCGAGTTAATTAACTCGCCAGAGACTCCAAAATCACATATCTTTATCTCCCCTCGGGTATTGGCTAAT
ACATTGGACGGCTTGATGTCTATTGGGTTTGAATGAATAATTAGTACACAAGTGTTCCTTTGGGTGTGGA
GCACGGGGTCGATTTCAATGATGGATGATCTACACATACCTCGATGTATGATGCGGTGTTTATCATAAAG
GTAAACGAGACCCTCTAGCACTGCTTCAGCGACCTTGCCAACGATATCAATGTCAATGGCGCCATGATGC
CTATAGATATAGTCCAGAGATCTATCATCGTTGCATCAGCAAGAGTTCTTCGAGTAATTTTTTTGACTTA
CCCAGCATCCATGAATTCCATGACAATACCTACATGGACGTCGACGGGGAAGCATCCATAATATGCGACG
ATGTATGGAGAATCACAGTCGTTCATGATTTGTAACTCTCGAAGGATCTGCTTTCTTATGGACGGTTTGG
CGTCTACTAGGATGAGCTTGATTTTTTATCAGCTGTATTTAAATCATCACGAAATAAGAACTATACCTTT
CGAGCCATAACGCATTTCCTCTTCTTGTTCCACACTTTGGTCACTGTCCCTCCGTTGCCCGCTCCTAAAT
CGTGCAGTATTTCTAGGTCTTCATCCCTGACCAAATCCTCTCCATCCTTGTCCTTGTGCTTCTTTTTCCT
CTTATTCTTATCTCCCCGTTCTTTACCGTCCCTGCTCTCCTTCTTTGCAGGACCCGACGCAACCGAACTG
TCGCTTTGGAAGGCTCTAGGGGAGTCGAATGCTTCCAGGGAGTGATTCGAGCCAGTTGATCGACTTGACA
GCTGGAGATTGGCAATATCATCTCTCAACTTGTCTGCTTCTGACATGAAGTTGCTAGGGAGGCTTCCATT
TGAAGGCAAAACTGGTGCTGTACGTGTGGGACGAAGGATCGATTTGGAGATGTCGAGTCCTGGAGGTTTC
TTCCGTGAAATGGAGGATTTGGGAAGAGAGAAGGTAGAAGAGGAGTTGGATGAGGGAGTTGAGGGATTTT
GTGGGTGCATCTTGAGGGCTGTGGAGATGGAAAGAGGAGATGAAAGTCAAGAAAGTTGTTGTTATGGCTT
GAG
Protein Sequence 
>gi|799343243|ref|XP_012052715.1| STE/STE7/MEK1 protein kinase [Cryptococcus neoformans var. grubii H99]
MHPQNPSTPSSNSSSTFSLPKSSISRKKPPGLDISKSILRPTRTAPVLPSNGSLPSNFMSEADKLRDDIA
NLQLSSRSTGSNHSLEAFDSPRAFQSDSSVASGPAKKESRDGKERGDKNKRKKKHKDKDGEDLVRDEDLE
ILHDLGAGNGGTVTKVWNKKRKCVMARKLILVDAKPSIRKQILRELQIMNDCDSPYIVAYYGCFPVDVHV
GIVMEFMDAGSLDYIYRHHGAIDIDIVGKVAEAVLEGLVYLYDKHRIIHRDIKPSNVLANTRGEIKICDF
GVSGELINSIANTFVGTSTYMSPERIQGAPYTIKSDIWSLGISLIELAVGRFPFSDSPDSEELSPSVSDF
DPDPTLPRSVRRPKIESNSGRNGVSQSGGPHAMSILDLLQHIVNEPAPRLASRRRTFPQEAVAFVEGCLI
KDPDQRRSPKELLSSPWMTNLKPTKEDLQAWAQSMTGPREE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Ste7 and Cpk1 kinases were found to act as a co-ordinate signalling module, whereas the Ste12alpha transcription factor functions with a redundant partner or in a branched or parallel signalling pathway (de et al., 2003).
References
de et al., 2003: de Jesús-Berríos M, Liu L, Nussbaum JC, Cox GM, Stamler JS, Heitman J. Enzymes that counteract nitrosative stress promote fungal virulence. Current biology : CB. 2003; 13(22); 1963-1968. [PubMed: 14614821].