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STE6

Victor ID 5372
Gene Name STE6
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23884643
NCBI Protein GI 799326899
Locus Tag CNAG_00869
Genbank Accession CP003824
Protein Accession XP_012049160
Taxonomy ID 235443
Chromosome No 5
Gene Starting Position 1775289
Gene Ending Position 1781094
Gene Strand (Orientation) -
Protein pI 7.96
Protein Weight 160652.37
Protein Length 1529
DNA Sequence 
>gi|799350697:1775289-1781094 Cryptococcus neoformans var. grubii H99 chromosome 5, complete sequence
GTAGAGGAAGTTAACATGTATGGTACATCGAATGCAAGGTCATAAATCTTTCAGAGCGAATTATCCGGGC
TTCGATGATATGCTGTATCGACCAGAAGAAGTTGTTTCTTTGATGAGACTTGCTGCTCATGTACATATGA
ATACCAATGTCCACGCAGATATATAATCCCATAGATGAGAAAACTAAATACACGCGTACTCATTCTACTT
TCTAAAACCTTTAAAACATAAGATCATAATCTACTATTTCCTTCTTCCAATTTTACGCCGCGGTAGACTC
GGAGCCCCGAGATACCGACTCACGTTTCTTCTCACTAGACTGTGCAGGGACTAGCTTCTCCTGTACGCCC
TCTGGTTCAGACGCTTGTTCTTTGCCGGTGTTCTTGGGCTAATTAGACTGGTTATCAGCAATGAGGGGTA
GGTAAAGGGCCGAAAGGTACGCACTACACGAGCAAGCCAGTAGATACCTACAGCCGCAATGATGTTGAAC
ACGACGTACGCCCACAGGAGACCAAAATCTCTCCATCTATTTGCACATCAGCATTCATTACCCATGCAAA
GGAAACGATAAAACTCACTTGTTGCTGTAGTAAATGTTGAATTGCGCCAAGAAAGAGTTAGTACTGCTCA
TAGAACAGAACTCGCACGCCGTCGTTGCATTCTCATTCACCAAATATCCTCCGTAATTACTGATATAAGT
TGACATGTAGTCGCCACACGACTCCCCGGAAGGAGGATTCAAAGTGAGAAGCTCGATGTCGGAACAGACG
ACACTGGTTTCGGCGACAGCAGTACTGAGCATGCCGTCGACAAGGTAGGTGAATGGTGAGACACGATACA
TAAACATCCAGAAACCGGGGAGGGAGGAAGGAGGGGCTAAAACACTGAGCAAGAATCAGCGAATGTCCGA
TAAAAAGAGGCGGGAAGGAAGACTTACCCGCAGAAGATGAGACACATGGAGAACAAAAGGTTCGCAATGT
TACCAGCAGTTTCAGCCGTCGCGATACCCGCCACAATCATGATCGCAAAAGTAGCGTTGAAGATCAAGAA
CATCTCAATGTATAAAAACATGAGCGCGCCTCGAAGATGGACAGCGCCGGTAGGGATGGCGTTGCGGTAG
TAGCCAATGGGATAGTACCAGGTAAAGTAGATGACGGCGCCCATGAGAACTGAAAGATGTTAGCGCGAGC
ACAGGCAGGAAAAGAAAAGAGAAAACGCACTGGCCCAAGGAATTTCCGCGACGATGTTACTCAAAATAAA
GATCTTCCAAGAGTACGTTTTTGAAGGTCTTTCTCGGACCTCATACAAGCTTCGCTGAGTGGTAAAGTTG
GGCATGATTTGTTGGGTAAGTTGACCGAAGATTGTGAACATCTACATTAAAGTCAGCGTTTACTAAGAGA
ATGTCAGGGATTACTAACCATGAAAACAGAGAACAACTGGTTCTGCAAGCCTTGCTGGGAAGTACCGGAC
TTGAAGAAACTGAATCCAATGAAAAGGGCCTATGCAATGATTGGCACCCATTACTCGCGTAGAAAATCAT
TGAAGCAACTCACAGACAAAGCACACAAAGCAGCCTTGGACCAAATATAACTAGGCGTCCTCCAGTGTTG
TTGCCAAACCCTCGTCAACACAACATTAAACTGTTTCCACAAGGGTGACGCAAATTCTGCATATTCCGCC
TTGACTTCCGACTTGCTTTTTTCATGATCCTTGTTCTGCAGAGCTGCTTCACCCTTACCGCCTTGAGTCT
CCTTGATCCTTGCAAGCTCACGGCGCACTTCGACTCGCTCAGGGCTGTTAATCCATGCTTGGTGCCAATC
GACATCAGAATGGGAGCCGGGCGCAGCACCAATAGCAGCCAACATCCATTCTGCCGGGTTTTCGCCTTCC
GGGCACTTGGGAGCACCATTCTTCTCAAAGTAATCAATGAGGATATGAGATCCCTTGCCGACCTCGCCAA
AGTAGACCGTCTTACCACCTCTAGCGAGGAAGAGGAGACGGTCGAACTGTTCGAAAAGCATTGCCGAGGG
TTGGTGGATGGTACAGAGAATAGCTTGACCGTGTTCAGTGAGCTTTCGAAGGAGGAGAAGAATGTTCCAG
GAGGTTTGGGAATCGAGACCAGAGGTAGGTTCGTCGAGGAAGAGAAGAAGAGCAGGCTTGGCGACAAGCT
CAACACCAATGGTGAGCCGCTTTCTTTGTTCGACATTGAGACCTAGTAGGATGTTAGCATATAGTGTGAG
GAAGATGAGAGTTATTAAACTGACCAGTACCGGGCACACCAACGACAGCGTCGGCGTAACTTTCCATCTC
CAAAAGCTTCAATACTTCTTCCACATACTCATATTTCTCCTTGATGCTGATAGTGTTCGACTGTCGAAGA
ACAGCGCTGAACCGGAGCGCTTCTCGGACAGTACTAGTTTCAAGATGAAGATCTTGCTGTTGAACGTAGC
CGGTCTTTCGCTGGAACGAGACGTCTCTTTGTCGGCCGTCGACGAGCATTTCACCGGTAACTACACCCAT
AGTAACCCGCGTGGCCAACACATCGAGAAGAGTAGTTTTGCCCGCACCAGAAACACCCTAATCATCCATA
CGTGTTACCTCAACATCGCTCCGAGAAGAATAAAAGAGCTTACCATAAGAGCAGTCAAAGTACCAGGCTT
GACCCATCCATCCACGTGGTCCAAAATCCTTCTTGGTTCCTTCTTGATCTTGATATCATAAACCACATCT
TTCCAGGAGAAGATAGCGGTCTGCCTCTGGATGATCCCAGCGTCAGCTCGGTCAGCACCGGTGATTTGTT
TCTTCATTTTAGAACCACCGGCAAACTTGCCACCTTCAACGTCGTCGGATGAGCCGTGGGAGTGAGTGGA
CTGAGCAAGTAGGGCGCGGGGGATCTTGCCTCGAGGGAAGACGAGGATTTCACCTTTCGATTTCTTGGCG
GTAATAAATTCTGAAGGAGAATTAGCAGAAGCCGCTAAAGGGAATGACGAAAATACACTTACCAGTAGCA
GTCATGTAAATAGCGGTAAAAAAAAGGAAAAACCCGATCAGGATACCAAAGTTCCTCCACTTGTGCGCGT
GGTAGTATTCGTATGATAAGTTGATGTAGTCATCACCATTAACCACAGAAGAACCCGCAATAGCACCCGC
CGTGGAGCAAACGTGCTGTTGACCAGTTGCACCCTCGTATCCGGGACCCATCGGGATAAACGCCGAACAC
TCATACTCCCTATCATGAAACTCATTGATCATGAGAGATTCAAAGCCGTAAGCAATAGGATCAAGCCAGT
TCATCCATCGAGCCCAGCCACGCATGTTGGCCACGTTAACGGCAAAACCAGTGTACATGACGAGGCCAAG
GATGAGGAGAGCAGCAGGGGCAAGAGCTTGGGCGAGAGATCGACTGAGGGAGGCGATAGATCGGAAGAGC
ATGGACATGACCATCGTAAGGGTGAAACTGATGAGCATAAAGAAGAAGTACGGCCCTGTTTGGTTGTTAG
CGATGGGCCTTTCGGTGATAAATGGCATTACTCACCAGGTTCACGTCGGAGATTGGTCATGAAGTACAAG
GTCAAGCTGAAGATGATACAGTTGATGACCTTGTAAGGAATATCTGTAAGAGCAGAGGCGACGGCTTCGG
CGGAAGGGTGGTAGAAGGCGTAACGGGAGTGCTTCTCGACGATACCTCGTTGGGCGTAGAGGATAAGAAT
CTGCAATAGGTCAGCCGATGCTCACTTGTAATGAAGAGTGAATTGGCCTACTTCCAAAGCAGATCCGAAA
GCGCTCATCAAAATAGCAAAAAATAGCAAAGCACCTCGCGAGTAGAAACTGCTCGTAGTTGCAGCTACTC
AATGTCAGTCTTGAGACCTACCACATGTTAAAAAGACGGCTTACGAAGATTATAGAAGACTGAACCGATA
ATAAGAGCCATGATAAAATTACCAAACAGCTGAGTAAGAGTCAGACTGGGATCGGCACGCAGGCGATCGA
AACCTCTTCGAAGGCAAAGCTCGACTTGGCCGCCGTATGAAAGGGTGTAAGGAGATTTGGCTCGGAGACG
CTTGGACTGCTGAGCCCGTCTTGATTGCAAAAACTCTTGATAATTTTTGCCATGAACGGGGTACTTGTTC
TCAAACTCGGCAATCTGTGCCAAAAGCTCCTGATATTTGTCGCTCTGCTTCCATCGCGCGGCAAACTCCT
GCGGTGTGGTGGGTACCTTGCCTTCAAATCCTTCTCTTGGTGTACGTTCGCTTGCGCTGGTGAGTGATGT
AAGAAAGTCGGGCACGGTCTGCTGAGAAGGGCAGTGAAATCCCATATCGACAAAAAACTGCTTCGCATCA
GTGGTCTTGCCGAAAAAAATTTGCTCGCCTTCATAGAGGACGGAGACCTTGTCGAAACAGTCGTAAGCGG
CTTGAGGAGCTTGGTAGATGGCGACGGCGGAGGAGATGCCGATGTAGTCGGCGTTCAGACGGAGATTTTT
GCAGAATTCGATGGCGTTAGCAGAGTCGAGACCACGGGTGGAGTTGTCCCAGCATTGGAGAGGAGCGCCG
GCGAGGGAGGCCTCGGCAATAGTTACTCGTTTTCGCTCGCCACCTAGCGGATGTCAGCTTTGTAAATCTG
AGGAACAGACAAGTACGTACCACTGACACCACGAATGAAGTCATTGCCGACGATAGTGTTCAGAGTGTGG
GAAATGCCAAAGACAGACATGACGACATCTCGCATGTGCTTGGCGTATTCCTTCTTCGAAATACCTCCAG
GAGGATTTCGAGGAGCTCGAGCTTCAGCAGCGAAAGATAATGTTTGACCGACAGTAAGATTGGGGAAGTG
GACGTCGACTTCGGCAGTGTAGATAGCTTCGCCTCGGAATTGACCGTAAATTTGCTTCGGAGTGATACCT
GCTCGAAGTCAATTAGGTATCTAAAGTAAGACAAAGAGAATTGACCTCTATAATTAAGTGAAGAAGACTC
ATCCAAATAAATACCGTTCATCTCTCCAGCAATGGTCTTGAGCATTGTCGTACAACCGCTTCCGGGAGGA
CCAAGGACGACGAGCATTTCACCTGCCTCTAGTACACCGTCCATACTGTTCAAAATTTGGACCTTGCGTT
TACGGTTACTGATTAAGTCTCTGAGAGCGCCGATACCGACGAGTGGGAGGTTACCGACTGTCTTTTGGTA
GTCTATTTACAGTTAGTGCTGGTCTTATCATGTCTTGCCATCACACGGATGAATGGGTATGGCTCACCAG
CATCGGATCCAAAACCATGAACATCAAGATTCCTGAACGACAAACCAGCTTTCCTCGCCGGACCAGAAGT
CTGAAGGGCCTCAAACATCAATTTTGTCCATCTCCTAGCACAGAATTTGTCGGAAAAAGGATCAAGATCC
GAGCCTTGTTGGTACGAAAATAAAGCAGAGGAGTCATCGGTACCCCCTACAGATTGTCGAGTGAGTTGTC
GCGCGAGATGGCCGACTTCGCGAGCACGGTGTTCTTCAGTTTGAGCTGGAAGATCGTCGCTAGGGTGAGT
GTCTGTGAAATGGGCCCGGGATGCGACGCGGCCTAGTGAAGCGCCGGATGTTTGTTCGGTACGGTCGTAA
GTACCCAAACCTTGTCCTACACCTGCAAATGCCATCACGAGTAGATGGGAATGTGCGCTGGATAAGTTTT
TGTGAGATAAAGTAGTTTGTACAAATGAGAAAAAAGATGTTGTGAAAGAAGAAAATCGTGAGAGAGAGGT
AGTTATACGTATCTAGAAGGCGCCCATTGTTTGTGCGTCCATAGGACGAGAGTTTTGCGGGCGGCG
Protein Sequence 
>gi|799326899|ref|XP_012049160.1| ATP-binding cassette transporter [Cryptococcus neoformans var. grubii H99]
MAFAGVGQGLGTYDRTEQTSGASLGRVASRAHFTDTHPSDDLPAQTEEHRAREVGHLARQLTRQSVGGTD
DSSALFSYQQGSDLDPFSDKFCARRWTKLMFEALQTSGPARKAGLSFRNLDVHGFGSDADYQKTVGNLPL
VGIGALRDLISNRKRKVQILNSMDGVLEAGEMLVVLGPPGSGCTTMLKTIAGEMNGIYLDESSSLNYRGI
TPKQIYGQFRGEAIYTAEVDVHFPNLTVGQTLSFAAEARAPRNPPGGISKKEYAKHMRDVVMSVFGISHT
LNTIVGNDFIRGVSGGERKRVTIAEASLAGAPLQCWDNSTRGLDSANAIEFCKNLRLNADYIGISSAVAI
YQAPQAAYDCFDKVSVLYEGEQIFFGKTTDAKQFFVDMGFHCPSQQTVPDFLTSLTSASERTPREGFEGK
VPTTPQEFAARWKQSDKYQELLAQIAEFENKYPVHGKNYQEFLQSRRAQQSKRLRAKSPYTLSYGGQVEL
CLRRGFDRLRADPSLTLTQLFGNFIMALIIGSVFYNLPATTSSFYSRGALLFFAILMSAFGSALEILILY
AQRGIVEKHSRYAFYHPSAEAVASALTDIPYKVINCIIFSLTLYFMTNLRREPGPYFFFMLISFTLTMVM
SMLFRSIASLSRSLAQALAPAALLILGLVMYTGFAVNVANMRGWARWMNWLDPIAYGFESLMINEFHDRE
YECSAFIPMGPGYEGATGQQHVCSTAGAIAGSSVVNGDDYINLSYEYYHAHKWRNFGILIGFFLFFTAIY
MTATEFITAKKSKGEILVFPRGKIPRALLAQSTHSHGSSDDVEGGKFAGGSKMKKQITGADRADAGIIQR
QTAIFSWKDVVYDIKIKKEPRRILDHVDGWVKPGTLTALMGVSGAGKTTLLDVLATRVTMGVVTGEMLVD
GRQRDVSFQRKTGYVQQQDLHLETSTVREALRFSAVLRQSNTISIKEKYEYVEEVLKLLEMESYADAVVG
VPGTGLNVEQRKRLTIGVELVAKPALLLFLDEPTSGLDSQTSWNILLLLRKLTEHGQAILCTIHQPSAML
FEQFDRLLFLARGGKTVYFGEVGKGSHILIDYFEKNGAPKCPEGENPAEWMLAAIGAAPGSHSDVDWHQA
WINSPERVEVRRELARIKETQGGKGEAALQNKDHEKSKSEVKAEYAEFASPLWKQFNVVLTRVWQQHWRT
PSYIWSKAALCALSALFIGFSFFKSGTSQQGLQNQLFSVFMMFTIFGQLTQQIMPNFTTQRSLYEVRERP
SKTYSWKIFILSNIVAEIPWAILMGAVIYFTWYYPIGYYRNAIPTGAVHLRGALMFLYIEMFLIFNATFA
IMIVAGIATAETAGNIANLLFSMCLIFCGVLAPPSSLPGFWMFMYRVSPFTYLVDGMLSTAVAETSVVCS
DIELLTLNPPSGESCGDYMSTYISNYGGYLVNENATTACEFCSMSSTNSFLAQFNIYYSNKWRDFGLLWA
YVVFNIIAAVGIYWLARVPKNTGKEQASEPEGVQEKLVPAQSSEKKRESVSRGSESTAA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The ste6 mutants in either mating-type background showed partially impaired mating functions, and mating was completely abolished in a bilateral mutant cross (Hsueh and Shen, 2005).
References
Hsueh and Shen, 2005: Hsueh YP, Shen WC. A homolog of Ste6, the a-factor transporter in Saccharomyces cerevisiae, is required for mating but not for monokaryotic fruiting in Cryptococcus neoformans. Eukaryotic cell. 2005; 4(1); 147-155. [PubMed: 15643070].