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STE50

Victor ID 5371
Gene Name STE50
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23890345
NCBI Protein GI 799320432
Locus Tag CNAG_07507
Genbank Accession CP003822
Protein Accession XP_012047827
Taxonomy ID 235443
Chromosome No 3
Gene Starting Position 312753
Gene Ending Position 315956
Gene Strand (Orientation) -
Protein pI 5.37
Protein Weight 72160.72
Protein Length 700
DNA Sequence 
>gi|799350639:312753-315956 Cryptococcus neoformans var. grubii H99 chromosome 3, complete sequence
ATGGCAAAATAGTTGAACATCCATGCAAAAAGCTACCCCAAATCCCAGAAGGTAGCGAAACATACCATGC
TAGCATTGCGGGCGATCACAAAAACAGGTTTACGATAGGGAGCTATATCTCCGGAAATGCTCTACATCAT
CGATCGCTATATACGACACCGCACTCAAAAGCCTCATGTATTCTTCGACGTTCCGCCCATTCCTCGCTTA
CTTTTCCCCAGCTTCACCTTTGCTTTTATCCTCGTTTGCCTCACCATCAGCTGTTCCTTGGTCTAGATTT
ATGTTTGTAACCTTTGATCCTGAAGACGGCTTGGGTTTAACAGCAGTTTCGGCTTCGCGCATGCCAACTG
AAATGGTAACGGAAGTCTTCCCAACAAACCAGGCAGGCACCCAGCCTCGCTCTCCAGTGTCATTACGAAT
TCTACGAGATTCGTCAGCGGATCTCACCCATTAGGGCAGTTTGTACAGTTACTCACACATAACTCCTATT
ATCGGTAAACAAGAATCTGGTCAGCATCCTACATACTTCGTCTAGACTGCGAAACTCACCAATGACAATA
CTTCTTGTAGACCCTCACCTTCTCTCCCTCTTTCAGCGTCAACTCGTCATCTCCCTTTGAGTCATAATCC
ATGAGCACGAACCCAGCATAACTACTCGAGATGATATGAGAGGGTGGAAGAGGAGCTAAACCGGGGTAGG
GAGCAATTTGTCCGTCAGGTGAAGGTGAGATGATTGACATGGGTTGGCTGAGCTCGAGTAGACATCCTAC
AACGCTTATTTAAATATTTATACGAGGAGATCAACCAAACCGCTTACCTGCTGGTACCCAGCCTTGAGTA
TAGCTATTGGGTATACCTGTCGCATCAGGATCTCGATTGACAATATACCAACCCTTATTTTTAGAACGAA
TGACATATGTCGATCCACTATCTCCACGTTTCAGCTCGAACGACTTTCAAAAACACCGGCAAAGATGGCA
CTTACACAGGCACGTCAAACTCATCTTCTCTATCTCGACAGTATCTAAAAATCATCAGCTCTGTTGCTAC
GGCGTCACAGTTCGTTAACATACGGGTAGATAGCCACTCCATATGTCACATTTACCACCGAACCATCTGG
ATCGACCAGCTGCCCATTTGATGTGCGTCCTCCACCGTCTCCATCTCTAAGCCCCGGGCTCGGTAGTTCC
GGGAAAGCTGTGCCGTTCGGTGTTTGCCCATCTTCTGTACGAGGAACATCAGGTTTGAGGGCGTTGGGTT
TCGTTGGGGACAAGGAGGTGTCAGTGGCAGGTTTGATTTTTGGGAGGAGAGTAGCTGTCGTATTGGGAGG
AAGGCCAAGCTTTTGGGCTTGTTTTGTATGGGCGACGTATACTGGTGATTTTATATCTTTCTGAAGGAAA
ATTAGCCACTCCCTAAAGTTCGCAGAAGGTGACTGACAATGTGACGAAGCATGAAGACCGGCTTGTGACC
TGTTTCTTTCAGTTTCTGAAACAGTAACAGCGGCTTCTCATCATAACTTAGGCACCGTTCTGCAATTGAG
TTAAACAAGCCCCTACTTGTGAGGATATTGCTCACCCGTAGATTCTCCGGTATTGTCATAACAAATGAAT
AACGCATATAGCCGCCAGTCATCATTAATCTTATATTTTTTCAAAGCTGCAGGCAACACTTTCCAGCAGG
GATCCTCTAAAGTCACTCTGAAAGATTTGGCGGCACTTCTCGCCGCATCCTTTGCTCTCGATCTCTCTTT
ATCTGATGGGTTTGCAGAATGACTTGACGGTCCTGGAGCAGGGGCCGAAGACGATACAGAAGGATATGGC
GAGGGTTTGGTGGAAGAGACGGAGAGGGATTGTGATGACAATGCAGGTGGAGTCATGCTGGGAGAGCTGG
AGGTACTGCCGGCTAAATTTGACGATTCCATGAGGACTCTATTTATTGATCGACCATCTCTTCTGTCAGC
GCTACTTGCTACGGGAGAGTCCGCATAGTTGTGATTAGAGGTTGTTGGGGTGAAGCTATCTTGGAAAGTG
GCAGAGTTTGATGAAAGAGGTGCGTTGAGGGATGAGGCAAGGGCGGAGGATGCTAAAGATGCTGGGAAAA
GCTGTTCAGGCCGCGGTCTTGAGGTGCTCTACGGACATGATCAGGGACTCATCAAGATCATCAGCAATAA
TTTGACCCACCGGAGCAGGCTCTACACTGTCACTATCCTTGAAATCTCTCCACTCGTAGCTGTTCGACCT
TCCGAGCTCATCCGGCCTTTTCCGTATAGACCCCGCTAAAGCGTCCTCAGACCCATACTGAGCATGCGGT
ATAGATATCCCTCTTTCCTCCAAAGCAACTCTCAATAAATCATGATCTCTTTCTATCAGGGATAGCCTTT
CCTCTATCTCACAAGACATTAGCAGTTGTTCACGTCTGTTGCATACTACTTACGTTGTTGCCGCACGATC
TCCAGCAGTCTCCCTGCCTCCAGGCGGTCGCGATCTTCTATTTCTATTTACAGTCAGAAGAATCAGCTCT
TCATTGCACCTTACTCGTCCTTCTCCAAAAAAGCCATACCTGGTGGTCTCCATTCGTCCTCTCCTATTTC
TAGACCTTGCTCCATTTTTAATTCATAGACGGCCCGTAGGAGCCTTAGTCGATGCCCGATGCTGGACATT
CCCATATCTTGAAGAGTTTCATGATCGAGCGCAACCAGGACATCACCGGCAATTCCATGTTCTACAAAAT
GGCCCATTAGTCCAAGCATTGTGTCGATAAAGGACACGACACAGCTAACCATGTATCTCAGCCTCATATT
GTCCAAGGCCAATGCTGGAAAGGTATGATACGACAGCGTCCTCGTCCCATTGTAGTACAGAAACAGGTGG
TGAAGCCGCTGTAGGAGAGGTGACTGTCGCGGCCATGCCTTGCGTAGGTTACTGGAAGCTTGATGTCCAG
GCGGCCAGTATAATTGAGATGGACAAGGAGGCGGTGGACAGACTGGAAAGGAAAAGGGATGATTAGCTAT
ATAAAAGTATTGATTTTGTTGTTATGGTGTGGCCATCTTTCTTTGCTTCACTTTGCGTTCAACTGCCGAC
GCATTTGTTTTCCTGTTTCACCGGTTTCATCTCGCTTCTTCTTTTCGCCACGTATTATTGGGAGCTGACC
AGTTACACTCTCCTACTTTCAATGCGTCCTAAATTTTGATGTCTAGGTTGCGCG
Protein Sequence 
>gi|799320432|ref|XP_012047827.1| protein kinase regulator [Cryptococcus neoformans var. grubii H99]
MAATVTSPTAASPPVSVLQWDEDAVVSYLSSIGLGQYEAEIHEHGIAGDVLVALDHETLQDMGMSSIGHR
LRLLRAVYELKMEQGLEIGEDEWRPPEIEDRDRLEAGRLLEIVRQQQERLSLIERDHDLLRVALEERGIS
IPHAQYGSEDALAGSIRKRPDELGRSNSYEWRDFKDSDSVEPAPSTSRPRPEQLFPASLASSALASSLNA
PLSSNSATFQDSFTPTTSNHNYADSPVASSADRRDGRSINRVLMESSNLAGSTSSSPSMTPPALSSQSLS
VSSTKPSPYPSVSSSAPAPGPSSHSANPSDKERSRAKDAARSAAKSFRVTLEDPCWKVLPAALKKYKIND
DWRLYALFICYDNTGESTERCLSYDEKPLLLFQKLKETGHKPVFMLRHIKDIKSPVYVAHTKQAQKLGLP
PNTTATLLPKIKPATDTSLSPTKPNALKPDVPRTEDGQTPNGTAFPELPSPGLRDGDGGGRTSNGQLVDP
DGSVVNVTYGVAIYPYCRDREDEFDVPVGSTYVIRSKNKGWYIVNRDPDATGIPNSYTQGWVPAGCLLEL
SQPMSIISPSPDGQIAPYPGLAPLPPSHIISSSYAGFVLMDYDSKGDDELTLKEGEKVRVYKKYCHWSYV
IRNDTGERGWVPAWFVGKTSVTISVGMREAETAVKPKPSSGSKVTNINLDQGTADGEANEDKSKGEAGEK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: C. neoformans STE50 gene has both conserved and novel functions during sexual reproduction and monokaryotic fruiting, and these functions are domain-dependent (Fu et al., 2011).
References
Fu et al., 2011: Fu J, Mares C, Lizcano A, Liu Y, Wickes BL. Insertional mutagenesis combined with an inducible filamentation phenotype reveals a conserved STE50 homologue in Cryptococcus neoformans that is required for monokaryotic fruiting and sexual reproduction. Molecular microbiology. 2011; 79(4); 990-991007. [PubMed: 21299652].