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SSN8

Victor ID 5370
Gene Name SSN8
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23884246
NCBI Protein GI 799314820
Locus Tag CNAG_00440
Genbank Accession CP003820
Protein Accession XP_012046717
Taxonomy ID 235443
Chromosome No 1
Gene Starting Position 1143871
Gene Ending Position 1145518
Gene Strand (Orientation) +
Protein pI 7.8
Protein Weight 46973.36
Protein Length 438
DNA Sequence 
>gi|799350543:1143871-1145518 Cryptococcus neoformans var. grubii H99 chromosome 1, complete sequence
ATTTACATTGTATCTATCATCTTACCTGTCTAGTTGATCAAAGAGCAAAGACACACCAATAAAAGCTGCA
GTTAGATGTCTTCCAACTTCTATACCTCCTCTCATAACCGCTATTGGCTCCTGACTCGGCCGTCTCTTCT
GGAATCTCGTCAAACAGACCTCAAATACTGCACTTCTCGCCAGCTATATTGCCTCTTCATCTTCTTCTCT
CAGCTCATCCAAAAACTCGGTAAACGCCTGTTGCTGAGGCAAATACCGATAGCCACGGCATGTGTGTTTT
TCAAGCGGTTCTACTTCAAGAACAGTTTGTGCGAGACGAATCCATATTTAGTGCTCGCCGCTTGCATTTA
TGTGGCAGCCAAAGTAGAGGAGACTCCGGTACATATCAAGAGTGTTGTAAGCGAGGCCAAGTTGGTTTTC
CATGGTGGGATTCTCCCTTTGGATTAATGTGTTACATTTGCTGAAGTCAGGCGATCAATAAAATAGAACA
CAACATCAAAATGTTCCCTGCTGAGACCAATAAGCTTGGAGAAATGGAGTTTTATCTACTAGAGGATCTC
GATTTCCACTTAGTAGTCTTCCACCCATATCGGGCGTTACTTCATCTCACCGGGAGGGAGTCTGCAGACA
TGGGAAGATTTGAGAAGTCTAGAGTTCAAGAAGATATGGAAATACGGAAAAAAGAAGGAGATGCCAAAAA
GATGCGAGAAGAGGAGGCGAAGAAGGCCAGCAGTAAGGGACAGCAACCAACAGTCGGACAGGCGCTTGAG
AAAGAAGGGGAGCGCCTCGAAGAGACTGAGGAGACCAGGATAAGGCGTCTAATGAGTAGAGGGACAGGCG
AAGGTGTGATGGAAGTGGACGAGGGTGTTCTGCAAATATCATGGTGAGTGTGATTATTGACATCAATTTG
ACATCTATTTGATACGTCCCAATAGGTTCATCCTCAACGACTCCTATCGCACGGATGCGCCTCTGCTATA
TCCTCCTTATATAATCGCTCTTTCGGCAATATATATCGCCTTCTGCCTAACATCCATGTCGAATTCCTCT
GCCCGCACCCGTGCGTCTTCCACTCAGCGGCCGGAACTCTTGCAATCGATTTCGATCAATGAAGGATTGA
ATTTGCTCCCACCGCCTAAAAATGCCGCAGAGTTTCTGGCTGGGTTTCAAGTCAGTTTACCAATGCTTTT
TGGTTGCGTGCAGGAGATTATTGGACTGTATCCCGTATGGGAGGCATTCGAGCCAACGGTGATGAGGAAT
TCCCAAGCACAAGCCAAGGGGGGAAATGCAACAGCGCCTGTCGCAGCTGCTGCAGGTACAAACCCCGGGC
AGAATGATTTAGCCCAAGACAAAAAGGAGAAGTTCGGTTTGGAGGAGGCTGAATCACTGGTACGGAAAAT
GATCGAGGAAAGGATGATAGATTTAGGTCATCCAGACAGTGGGGGTGTTGAAAAGGCTGCAGGTACCGGC
CCGTCCAATGTAGCGGGTAAGAAGCGGGCAAGATAGCATAGGTCATGCCTTGATCATTTTCAAGTGCACA
ATACATTGCTTGTCATATTAAACCATAGCATATTGTATGAGACTATATTAAATTATAATTATGAATGCCA
AAAAGCCATTGCATGCGTACATGTACACTTTCAAATAA
Protein Sequence 
>gi|799314820|ref|XP_012046717.1| cyclin C [Cryptococcus neoformans var. grubii H99]
MSSNFYTSSHNRYWLLTRPSLLESRQTDLKYCTSRQLYCLFIFFSQLIQKLGKRLLLRQIPIATACVFFK
RFYFKNSLCETNPYLVLAACIYVAAKVEETPVHIKSVVSEAKLVFHEHNIKMFPAETNKLGEMEFYLLED
LDFHLVVFHPYRALLHLTGRESADMGRFEKSRVQEDMEIRKKEGDAKKMREEEAKKASSKGQQPTVGQAL
EKEGERLEETEETRIRRLMSRGTGEGVMEVDEGVLQISWFILNDSYRTDAPLLYPPYIIALSAIYIAFCL
TSMSNSSARTRASSTQRPELLQSISINEGLNLLPPPKNAAEFLAGFQVSLPMLFGCVQEIIGLYPVWEAF
EPTVMRNSQAQAKGGNATAPVAAAAGTNPGQNDLAQDKKEKFGLEEAESLVRKMIEERMIDLGHPDSGGV
EKAAGTGPSNVAGKKRAR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Ssn8 functions as a global regulator which negatively regulates diverse physiological and developmental processes and is required for virulence in C. neoformans (Wang et al., 2011).
References
Wang et al., 2011: Wang LI, Lin YS, Liu KH, Jong AY, Shen WC. Cryptococcus neoformans mediator protein Ssn8 negatively regulates diverse physiological processes and is required for virulence. PloS one. 2011; 6(4); e19162. [PubMed: 21559476 ].