Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

SPE3-LYS9

Victor ID 5367
Gene Name SPE3-LYS9
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23886976
NCBI Protein GI 799336493
Locus Tag CNAG_03476
Genbank Accession CP003827
Protein Accession XP_012051284
Taxonomy ID 235443
Chromosome No 8
Gene Starting Position 1055845
Gene Ending Position 1059194
Gene Strand (Orientation) -
Protein pI 5.56
Protein Weight 75378.28
Protein Length 750
DNA Sequence 
>gi|799350780:1055845-1059194 Cryptococcus neoformans var. grubii H99 chromosome 8, complete sequence
GCCCTCGCTTGACTTGAGATCGTACATTTCCTGCAACACGCAGTTTGATACCATGCTAATAGCCAAAGAC
TTAACGACAATCCAAGACACCATAATCAATCATAATCACCCAATATCATACCTCTATAAACAACTGTTTA
AACGAGCTTCTCAACCATGGTGATACCCTCCTCCTTCTCCAGTCGCTCTCGGAATAACTTGCACGTCTCC
TCGTCGTAAGGAGCGAAGACACCGGGCTTGTTGAGGACACCCTCAAGGATGAACTGCACAGCCATACCGC
AAGGAACCTAACGGAACATCGTTTGGTCAGCATACTGCCGCAAAAACACACACGAAGTAAATCAAGTGAC
TAGAAAGTGACACGTACACCGACGAGCTTGGCCATGGCAGAGGGCCCACCGTTCCTGTCGCCGTAAGCCT
CGAGGGAGGAAGTGATGGTTTGCTAGCATATTTCCATCAGCATTTCTTTCCTTTCACGATCTAATCCGGG
GAGAACACACCTCGGAACCGTCGGCGTTGATAATCTCGAATGTGTGTTGCAGCAAGACAAGATCGACCTC
ACCCTCCTTGAAGGCACACTTCTCCTCGAGAAGAGCGGACAGAGCTCGCATAACGGAACCTCGCTGAGCG
ACCTGCTCCTCGGAGAAGAGACCGAGGTCTCGGAATTTGGTGATGAGGACCCTCGACTCAGTCTCGAAAG
ATTTGAGAGTCTTGAGCTTCTCAATGACGGCACTATTTATTGGTCAGCACATACTTCCAGATGTAATACG
ATAAACTTACGCCTCCTTGGCCTCAACGCCAAGCAACTGAGAGACGACCTTGATCCAAGTGATAGGAGCA
GCACCCTGGGCGAGGTAGTCGACTTGAGCGTCGGACATCAAACCAATTTCCTTCCAGGCAGTGATGACTT
CGCAGAAGCCAGCATACCTCATAGTACCTCGGCAAAGGTTCTGGACACCTTCCAAACCGTAGAACTCCCT
GAAGACAGTGGAGTCTCGGTTGGGGTAGGCGACGAGGTTGTACGCGGGAGTGAAGTAGTAAGGCTTGGCT
GTGCTCATGAGGTCTTTGCCGGCAACTTCGACGACCTTTCCGTCCTTGAGGTACTTGCCGTCGTTATTGA
GGGCCATGAGGACACCGACAGGGGACCAAGAGAACTTATAACCGAGGGCGTTGTCGGCGGCCTATACCAT
TGTAAGTGAATGCAATAACCAATGCAAAAAAAAAGATACGTACAGCAGGCTCAACAAGACCACCACAGAA
GCTGTAGAAGCTCTTGATCTTACCACCGGCCTTCTTGACTTCGTCAAAGACCTTGATGGCCCACAAGTGG
TCAACTCCGGGGTCGACGCCGATCTCGTTGAAACAGATCAAACCAGCATCCTTGAACTTCTGCTCGAGGG
CACGCATCTGGGGGTTGACGTAGGAGGTTGTGACAACGTGGACCTTCTCTTCAAGGGCAGCCTCCATGAC
CTGGGCGTGGTAGGTGTAAGGGATCAAGCTGACAACAACGTCGTGACCCTTGATAGCCTGTCGGAGAGCG
TCAGCCGAAGAGACGTCAACAGACATGGGGGTGGCGTTGGGGAGGCCGGAAGCGAGGTCCTGTGCACTAG
CAAGTGTTCGGCAAGCGATGGTGAGCTCATGGTTGTGTCGGGCAATGTAATCAGCAGCAGGGCCAGCAAC
AAGGCCGGAACCAAGGAGGAGCACCTTCTTCTTGGTCGTGGTAGGAGTGGGTCGAGCACCGCTGAACTTG
GGCAAGACGTTGACGCCGTCCTCGAGCATGGCACGACCGAACTCGGGGATGGTAAAAGCAGCTCGATGGA
CCTCAGAGTTGTAGTACCTGGTGTCGGGAACGGCACGGAGGGGAACAGTGAGGTCTCGGGTAGAGTCCTT
GCTGCAGACCATGATACCAATCTGACCGGCGGGGTAGGTGGGGATGGTGGTGAAACCGTACTTGACGACG
GGGAAGAGCTTGGAGCAAGTTTCCTTGAGGGTCTTGATGAGGGGGAGATGAACCCACAAGCACTCAGCCT
GGGTAGAGACAGAACCACCCTCCTTGAGAGCCTCCTTGAGGAGTTGGAAGTAAGGGGGCTGGAAAAGAGC
CTCGGCGGGACCGACGGGGTCAGAAGAGTCGGTGATGATAACGTCGTACTCGTTCTTGTGCTCGGGAAGG
AACTTAAAACCGTCACCAATGTGAACTTCAACTCGGGAGTCCTTGTAGCAGTCGGACATGAGAGGGAGCC
ATTGCTTAGAGACTCGGATGACAGCCTGGCGAAACGTGAGTTAGACGACGTGCGACAACGAGTACGAGCG
AAACCCACTTCGTCAATGTCGCAGAGAGTGACTTTCTTGACAGACTTGTGCTTGAGAACCTCTCGAATGA
CACCACCGTCACCACCGCCGATAACAAGGACGTTCTCGGGGTTAGGGTGTGAAGCCATAGGAAGGTGAGT
GATCATCTCCTGGTAACTGGTCGATGTCAACATTTCGTATTTCCGCATTAGGGTAGAAACGTCACTTACG
AGAATTCATCACGCTCGGTGGCCTGAATGACACCGTCGAGGACGAGAACATTACCGTAGGTCTCGGACTC
GAAGACAAGGACATCCTGGCAGACAAACCTCAGCGTTTTCTCCTCACATTACAACATATGACTCACCTGG
AAGAGGGACTTCTCCTGGTGCAAGATTTGCTTGACCCTGCAGACGCATTAGTACACTCGCAATTCCCTCC
ATAGCATCCAAGCTCACTTGAGAGTCATAGCCTGACCTGTTATCGGCTGTCAGTAAGAACTCTTCATGAA
AGGACTGACAATCGACTCACCGGGCCATTGGGTGTTGATCTCCCTGAACCAGCCGTCTGCAATATTTCAT
ATTAGTTCCATCTCTTCCAAGGATCTTATGAGAAGCATTTCGCAGAGTGCGTACCGACGATGTTGGGGTG
AGATTGAGAGACAGCCATGACGAATATCTTTTGCTTGGGAAAAGAGAAAAAGGTCAAGAAGAGAAACCAA
CAAGTCAAGTGTTGGTTCGGACCCCTCGACAAAGAAATTCCTCCTTTCTTTTTCTAGAGCGGCTTTCGCC
GCTATTACCTACATTCATTATTCGCTTCAAGCACGAGTCACGATCACGAGTACCAGTACTTGCTTGTTAA
CCGTAGAAATTTCAGTAATTGTTGTACCCTCTCTGCGTAGGTAGAAGCCGGTTTTAACCTATTCCTGAGT
TCCATTTTGTAAGTAAAACGAGTGTTTCGGACATGCGCCGAAGTCAAAAAAGACGAGTGATGACCCTTAG
TAGTAATGCCTTGCTGATCTCCTACAAGAGTATTTTGACTCAGTTAGGTTGAGCGGAAGC
Protein Sequence 
>gi|799336493|ref|XP_012051284.1| spermidine synthase [Cryptococcus neoformans var. grubii H99]
MAVSQSHPNIVDGWFREINTQWPGQAMTLKVKQILHQEKSLFQDVLVFESETYGNVLVLDGVIQATERDE
FSYQEMITHLPMASHPNPENVLVIGGGDGGVIREVLKHKSVKKVTLCDIDEAVIRVSKQWLPLMSDCYKD
SRVEVHIGDGFKFLPEHKNEYDVIITDSSDPVGPAEALFQPPYFQLLKEALKEGGSVSTQAECLWVHLPL
IKTLKETCSKLFPVVKYGFTTIPTYPAGQIGIMVCSKDSTRDLTVPLRAVPDTRYYNSEVHRAAFTIPEF
GRAMLEDGVNVLPKFSGARPTPTTTKKKVLLLGSGLVAGPAADYIARHNHELTIACRTLASAQDLASGLP
NATPMSVDVSSADALRQAIKGHDVVVSLIPYTYHAQVMEAALEEKVHVVTTSYVNPQMRALEQKFKDAGL
ICFNEIGVDPGVDHLWAIKVFDEVKKAGGKIKSFYSFCGGLVEPAAADNALGYKFSWSPVGVLMALNNDG
KYLKDGKVVEVAGKDLMSTAKPYYFTPAYNLVAYPNRDSTVFREFYGLEGVQNLCRGTMRYAGFCEVITA
WKEIGLMSDAQVDYLAQGAAPITWIKVVSQLLGVEAKEAAVIEKLKTLKSFETESRVLITKFRDLGLFSE
EQVAQRGSVMRALSALLEEKCAFKEGEVDLVLLQHTFEIINADGSEQTITSSLEAYGDRNGGPSAMAKLV
GVPCGMAVQFILEGVLNKPGVFAPYDEETCKLFRERLEKEEGITMVEKLV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SPE3-lys9 mutants grew slowly at 30 degrees C, were temperature sensitive in rich medium, and died upon lysine starvation (Kingsbury et al., 2004).
References
Kingsbury et al., 2004: Kingsbury JM, Yang Z, Ganous TM, Cox GM, McCusker JH. Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans. Eukaryotic cell. 2004; 3(3); 752-763. [PubMed: 15189996 ].