Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

SMT1

Victor ID 5366
Gene Name SMT1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23886342
NCBI Protein GI 799320701
Locus Tag CNAG_02784
Genbank Accession CP003822
Protein Accession XP_012047899
Taxonomy ID 235443
Chromosome No 3
Gene Starting Position 772634
Gene Ending Position 774990
Gene Strand (Orientation) -
Protein pI 8
Protein Weight 52998.95
Protein Length 482
DNA Sequence 
>gi|799350639:772634-774990 Cryptococcus neoformans var. grubii H99 chromosome 3, complete sequence
TCGACGATAAGGTGCAACCCATGGAGAAGACAATTGACGCGCTGAGTAGGACCAGTGGAGATCTCGTAAT
CGAAAGGGTTGAAGGGGCGGATCACGCATTCGATGAGGATCCAAAGGTTGAATGTCAAGCCTTCCAGGAG
TGGTTGGGCAAGACACTGCTTTAATGCTCACTGACTAGTCATCAAATGCATGCAGCGCATACTCGATTTC
AATTCAGACGGCTCTTTTGCTACTAGTCTTGCCATCCCACCCCTATTACACCGCCATGGGGCCCCTTGCC
CTGTTCCCCTGCGACCGGCTTCGTGAGCTTTTCAGGAGACGACCATCTGGTTCGGCCTCCGCTTGACGCT
TCCTGCTTAGCCCTAATTTGCTTAGTAAGAAATTGCAAAAACTTTCCCAAGCTTCTCGATCTTCTCGTCT
CCCTTCGACCCAATCAATCTCTAAAGATGGCGATCCATCTACTGGCCTCGAGTGGTTACAGATGTACTTA
ATTCTACAGCGAAAAAGTGTAGGTGGTTTGTTCACTTCCCCTTGACCTTCTGGCTCCGCTTTGTTTTCTT
GCCTTGCGGCCATTCGGCGAGCAGCCCGCGACCATGTATTGATCCTGGGCGCGATCAGTACGGAGTCCTG
CGTCTTTCCTTCATACTGTGAAGGATCCGGACTATCTTTCGACGGGTTTAAAGCGACGGTTCGAAGGACA
TCAAGCACATTGGCTTTCAATGTCGTAAGCGATATGTTCGATTGAGCATGGAATCGCACGGTATTTGAAG
ATGGTAAAAGCTGAGCAAATGTCGTATTTTCCATGATGTCGTAGGGTCTGGTTATGCTCTGCGACGGCGC
AGTACATATTAATTTCTCTTCTGCGATATCAAATAATAAGTACTTACATCAGGAAGTCGAGTCATGTTGT
GAGACCAGCCAAGTATCCATCGAGAAGTCCGGGATTGCTTAATATTGATGACAAAGTAGTTGTCAATCTG
GTTTTGACGTCAGTGTCTCACCATTGGCCACACATTATTTTAAATACCTTGAATTCCCCCAAAGTCTCTA
CGAGGGGCTGCAAAGACGAATACTTTCCCACTAGGGTTGTATACCACCTAACCTATGAGTATTAGCCTTG
ATCGACTTGCTCGTGCTTCTTGAGAAACGTACGTGCACCTTTGCCCTATGTCAATACTTTCTCGTATCAT
ACTCGTTATGAAAGCAAGTTCTCCCCCTCTGGTAATCAGTTCATTATCAGACGCAGTCGGGGCCTAAATG
GGTGCATGTTAGTAAATGTCGCTCATTTAGGAGCGTGCATGGGACTCACTGCATGAGGTTGTCTATCTTT
TTGTTCCATACCTTGCAGCATTTCCTGTGAGGACGCGAAAAAGGGGGGATTACATATTGTGAAGTCCCAG
TCCTCAGACTTGCCCTTGCATTCCAATAATGGAAAGAGGATTGGATCAGGTGTAGGCGAATTCAGTATGG
TGATCGAAGATGGAGGTATATTATTCTTCTCAAGTGTTGCCTTGGCATGGTTGTAGGAACTTTCGTCGAT
CTCTGACAGTAGTCAGCGCCTATCCTTAACCTATCCAAGTACAATCCACCTGTGGCAACAATACGAGAAT
CTGGCCGGAGTCGAGACAGTAAAATCGGGTAGATAGCCGTGGCTCCTGTTCCTCTATTTTAAGAATGGCG
TCAGCTTTTCTTAGTTCTATGATGGCTGCTAGTCCTCACATATCAAGAATTCGTAGGGGTCTCAAAGAAG
AGGATGGGAGGTGTGGTTCGAGGTCGAGCACATGGTAGATATAATCTAGTCTGTACTTTATTGAATAAAT
TCACTATCTGAAGTAAAGCAATACGACCCACCTATTGGGTATCTATCGTCGGGAGTAAGGTTGCTGTCGC
ATAATTCAGACTGACACAAAGCTCACAGTTGGGCAAAGCCTGTCCTCTCTCAAATCTACATCAAGACCCC
AATCTTCTTTCAACAAGCACTTGGTCAATTCCCTCAAAGCAGTTGGATCCTGAAAGTTGATAGAAGGGTA
TCCATCCTCGGAAACATTGACGCTTAGTGGTTTATTGATTAGTATCCTTCCGAATCACAGAAGACAAGAG
ACTTACAAGGGAGCAAATTTTGGGTATCTAGAAGCCAACCGGGCAAAATCTGGCTTCTGCTTCAGGTATG
GATTGTTTTGATGCATGGTCAAGTTTACCAAGCATGTGTGAGGCGCTGACGAATGGGTTGTTGAAAGAAG
AGACACGCTTTAAAAACAAGTCAAGGGTCAAGAAGGCTGAGTGACTCGAACGAAAGTGTCGTTGCGACGG
ACTGAAGAACCGATGTCTGGCGACTTGTTTGTGGTCAACCTCCACCA
Protein Sequence 
>gi|799320701|ref|XP_012047899.1| methyltransferase [Cryptococcus neoformans var. grubii H99]
MHQNNPYLKQKPDFARLASRYPKFAPFVNVSEDGYPSINFQDPTALRELTKCLLKEDWGLDVDLREDRLC
PTIPNRLDYIYHVLDLEPHLPSSSLRPLRILDIGTGATAIYPILLSRLRPDSRIVATEIDESSYNHAKAT
LEKNNIPPSSITILNSPTPDPILFPLLECKGKSEDWDFTICNPPFFASSQEMLQGMEQKDRQPHAAPTAS
DNELITRGGELAFITSMIRESIDIGQRCTWYTTLVGKYSSLQPLVETLGEFKIDNYFVINIKQSRTSRWI
LGWSHNMTRLPDSITRPYDIMENTTFAQLLPSSNTVRFHAQSNISLTTLKANVLDVLRTVALNPSKDSPD
PSQYEGKTQDSVLIAPRINTWSRAARRMAARQENKAEPEGQGEVNKPPTLFRCRIKYICNHSRPVDGSPS
LEIDWVEGRREDREAWESFCNFLLSKLGLSRKRQAEAEPDGRLLKSSRSRSQGNRARGPMAV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Ãˇâ€¯smt1 mutant loses more than 80% of its virulence compared with the wild type and the reconstituted strain (Singh et al., 2012).
References
Singh et al., 2012: Singh A, Wang H, Silva LC, Na C, Prieto M, Futerman AH, Luberto C, Del Poeta M. Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans. Cellular microbiology. 2012; 14(4); 500-516. [PubMed: 22151739 ].