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SIN1

Victor ID 5363
Gene Name SIN1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23888078
NCBI Protein GI 799340073
Locus Tag CNAG_04693
Genbank Accession CP003829
Protein Accession XP_012052002
Taxonomy ID 235443
Chromosome No 10
Gene Starting Position 679717
Gene Ending Position 682835
Gene Strand (Orientation) +
Protein pI 7.17
Protein Weight 80092.95
Protein Length 796
DNA Sequence 
>gi|799350850:679717-682835 Cryptococcus neoformans var. grubii H99 chromosome 10, complete sequence
CGTCTGATCTCAGACCGGAGGAATGCCAGCTCGATTGTTGTTAGATGAGAGTCAGCCCTGTAATAATTAT
TGGTTAGACCTAATAATATAAGGGAGACGTAAGAGGGGTGAGTTGGACTTATAGACTCCGGTATTTTCTA
CATCGTGTGAATCTGTCACAAAGAACGACCCATTCCGTTTCTCCTAGGGATTTCGCTTTGAGCGAACATC
GAAGCCTTCAAAATGACTATGATATCCGACGTGGAGTGAGTGTTAGTAGTACTACATTGTAATGAATCTA
ACGAGACCATCTGCAGTTACATGCTGCAAGCAATACGTTTGTCATCCCTCCGAACAACAGACGACCATAT
AACCCCTCGCATCATCTCCCTCGACCCTACCTTTGCTGTGAACCCTTACATCAATGCTTCTGGCTTGTCG
GACATCGAACGGTGGCCGGAAATTAAGCGCGCACTTGAATCGCCACCTCTAGAAGAAGGATATCTCTCTG
GTTCAGCTCCTGGAATGAGGAACAGTGATACGGAAGGACCACGTAGAGGAAGTGGTTTGAATTATACTCA
GACTATTATGGGCCCAGGGAGGATGGGAGGGGCAGGCATGAGGGTATCTGGCCGACATGCAGTTCCGGGA
GAGTCTAGGAGAGGGCAGGCCGTTAGAGCCGACTCATCCAGCTCGATCACTGCCCCCCAATCTCCCACGT
CCAAAGGCAAAGAACAATTTAGCAGACTGCCAGAGGTAACTACCACTGGAGATGTTTTCTCACCTTCAGG
AAGGCCAAGGGCAGGCTCCGCTCCTGCTCCTGGGCCGTCACAAGGGTCCCCAAGGCATATAGCCTCGAGT
ATGCTCAGTACCGGAAGAGATCTTGGGGTAGATGGCCCCGGGGGCCTACTACATCGAGCGTTGTCGTCTA
GTCAAATGTCAAACGGGTCCGGCTTAGGCCAAGACGGGATACCCACAACGGCAACCCCAGAAGATAGGGG
CTCGTCTATAGGAATAGAACCCACAACTGGGACGCAAACGGTTGAACGTCGTTTGGTGGGTGGTCTAGAA
GATCAAGGAAGCGATGTGGACGAAGAGGAAGCTGCTGAGGCAGATGTTAGGGAAGGCGGTAGAGAAGCAA
CCGCTGTCCCCGACTCAAAGAGGGCTTCTGTCGATACAGTAAGCACAACGGAGCTTCTCGACTTCACTCC
GGTACCTCTTCCTCAAGGCCAAAGTGTTCCTTCGCAGCTCTCCGCTCTCACTGTTGCTTTGAACAAATTC
ATACCGCATGTAGTATCCACTGCGCCCCACGATTCCTCTGGACCCCTTTCCCCTATCCCCGCAACTACAA
TCAACCCATTTTATTCTCTCTATTCTACTGTCGCAGCCCCTCCAGGTGTGCCATCCGTGTCTCTCGAACT
GTACTTCCCACATTCTAAAAATCCTGGACAGCCCGTGGTCGCTAAAGTGAGAAAGGATGCCACTGTAGAA
GAAGTTACTGGATTTGGGCTCTGGAAGTACTGGGATGATGGAAGGGAGCCGAAGATGGAAGAGGAAAGAT
GGAGTACTGTTGGATGGGGACTGCGAATTGTCGAAGATGATGGAGAAGTCGACGAGGATTTCCCACGTAA
GTCTTAGTCTTAGACGAGAAATCGTCATATTAATATCTATGGCAGCGCTTGATCGAGAGAGCAAGATATC
GAAATTTTCGTATGGGCAGTTCGCCATAGTTGAAGCCACAGAAAACCAAAGTAAGTAATTGACATTGACT
AAAACCCGCTAACATGTATTGCAGTACAACAAAACGTCTTAAAGGCACCCACTATTACTCGTCGCACCTC
CCGTGTCCTTGCTGTTCCTTTCGCAGCACGGCCCATGGTACAAGCTGCACCTCGACCCAGCCTCGCACCG
CCACAGTCCAGCCAAGGGGGAAGCGTTGCGTCTTCTTTCTCATCTCCCGAATTCGCACCCCTCTCGACTA
CCGTTACCGCAGCTAATATGGGGCAGGGAAGAGGCATGGGCCCTACAGTGGGGTTAACCTCGACCCAAAG
CGATGTCGTGAGATTGAGAGTTAGAGTTACAGCAAGCGCAGATGTGCACTTTACTACCACCATCAATGTG
TAGGTAAATGCGACTTCATTCGGAATTGTTACTGACGATCTCTGGCAGACCTGCGGATATGTATATAGCA
GATCTCACTGAGGTTCTCTGCAAGAAAAAGCGTTTGCAGATGCCTGCTACGGACTGGGTGCTGTGCTTGG
CTGATCTGACGTTGGCTTTACCGCTTGACAGAACTGTTGCGAGTCTGGGAGTTCAGACGGATCTTGCGTT
AGTGAGAAGACAATGGGCGATGGAGCACGGCCTAAGGATCGATGACCGACGGGGAGGGGATCCATCAGGT
AAGTTTACAAAGTCGGCAATTGAAATCAGCTAAAGGCGATGGCGGGCCATAGCTTCCATCTTCAAAAGGC
AGTCGGAGCCTGCACCGATACAAAGATTTGGTCCTGGTCTTTCAGACTTCACCCAAACGTATAAGGTGAG
TGCTGTGACAGTTATGGAAGTCCTGATGCTCACTAGACGTGATCTTTAGAAATACACTGTGCAACGTAAG
ATTGCTATTGGCCGACACGAGCGTGTTCTGGCGATCGACGGAGATTATATTCATGTGAGTTTATCTCTTG
TATATTCCATATGTCCGCTTTCTGATATCATAATTAGATCATGCCCTCCGAGTCCCGAGCATTCTTCGAT
TCTATGAAAACAACGTCTTTCCACATATCCTTAGTAGCTGCATGTAAACTTACAGGGCGAGGAGGCGGTT
TCAAGATAAATGTATGGCGAGATGGTGCCCAGAAGAGATATGAGTTTGAAGCAGAGAACCAAAGACAGGC
TGTGGACATAGTATCCACTGTTAGACAGCTGTAAGTATTAGACCACCTGTCAAGCTGAAATGGTGAACTG
ATGACAATGATAAATAACAAAGGATGAAGACATACGCGGCCGAGAGAACATCAATGCTGCCACCACCAAG
AGTCACGCTTAGAAAATGATTCCGCGCGAAGGGTTTTTATATCTGTAGCAATAAACTGTTGTACAGCATT
ACTTGTGATTACGATACCAATGCATAAAATCTGAACAAC
Protein Sequence 
>gi|799340073|ref|XP_012052002.1| hypothetical protein CNAG_04693 [Cryptococcus neoformans var. grubii H99]
MTMISDVDYMLQAIRLSSLRTTDDHITPRIISLDPTFAVNPYINASGLSDIERWPEIKRALESPPLEEGY
LSGSAPGMRNSDTEGPRRGSGLNYTQTIMGPGRMGGAGMRVSGRHAVPGESRRGQAVRADSSSSITAPQS
PTSKGKEQFSRLPEVTTTGDVFSPSGRPRAGSAPAPGPSQGSPRHIASSMLSTGRDLGVDGPGGLLHRAL
SSSQMSNGSGLGQDGIPTTATPEDRGSSIGIEPTTGTQTVERRLVGGLEDQGSDVDEEEAAEADVREGGR
EATAVPDSKRASVDTVSTTELLDFTPVPLPQGQSVPSQLSALTVALNKFIPHVVSTAPHDSSGPLSPIPA
TTINPFYSLYSTVAAPPGVPSVSLELYFPHSKNPGQPVVAKVRKDATVEEVTGFGLWKYWDDGREPKMEE
ERWSTVGWGLRIVEDDGEVDEDFPPLDRESKISKFSYGQFAIVEATENQIQQNVLKAPTITRRTSRVLAV
PFAARPMVQAAPRPSLAPPQSSQGGSVASSFSSPEFAPLSTTVTAANMGQGRGMGPTVGLTSTQSDVVRL
RVRVTASADVHFTTTINVPADMYIADLTEVLCKKKRLQMPATDWVLCLADLTLALPLDRTVASLGVQTDL
ALVRRQWAMEHGLRIDDRRGGDPSASIFKRQSEPAPIQRFGPGLSDFTQTYKKYTVQRKIAIGRHERVLA
IDGDYIHIMPSESRAFFDSMKTTSFHISLVAACKLTGRGGGFKINVWRDGAQKRYEFEAENQRQAVDIVS
TVRQLMKTYAAERTSMLPPPRVTLRK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Deletion of SIN1 affected cell viability in the presence of sphingolipid biosynthesis inhibitors (Lee et al., 2012).
References
Lee et al., 2012: Lee H, Khanal Lamichhane A, Garraffo HM, Kwon-Chung KJ, Chang YC. Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in Cryptococcus neoformans. Molecular microbiology. 2012; 84(1); 130-146. [PubMed: 22339665 ].