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SEC 14

Victor ID 5362
Gene Name SEC 14
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23886679
NCBI Protein GI 799335732
Locus Tag CNAG_03153
Genbank Accession CP003827
Protein Accession XP_012051055
Taxonomy ID 235443
Chromosome No 8
Gene Starting Position 198228
Gene Ending Position 200021
Gene Strand (Orientation) +
Protein pI 6.36
Protein Weight 25037.56
Protein Length 225
DNA Sequence 
>gi|799350780:198228-200021 Cryptococcus neoformans var. grubii H99 chromosome 8, complete sequence
AATGGCCACCACAGACTTCCTCTCAGGACACCCAGGACACCTGTAAGAGCGCATAGTTCTATATCACACT
CATGCTGACAATCACACCCAGCTCAGAGGCCCAGCAATCCACCCTCGAAGCCTTCCGAACAGAGCTTCTC
TCCTCTGGCCTCATCCCCGACGGGGCCGACAAGGAAGCCTTTGTGCAACGTATCGGCTATGATCGTTTCG
ATGACCAGACCCTCTTGAGGTTCTTGAGGGCGCGCAAGTTTGATATCCCCAAGGCCAAGATCATGTGGGA
GGCGAATGAAAAGTGGAGAAAAGAGTTTGGCGCGGACGACATTGCTGCGTAAGTCGTTTTCTTTTGTTTT
TCCTGTTTTGAACGGTTTGCAATTCGCGAGAAGAGGAGAAAGAGGGAATGGAGGGGCGAAAGTGAGCATG
TTGGGTGTGCTTGGATGGAGAGACTCTTACACGGTGGATGCGCTTCGCCTGGATCCCCTTATTTAGACTT
TTAACCCCACTGACTCCTTGATGCTCGAATTAGCAACGGCTTTGACTATCCCGAATACGAAAAAGTCGCA
CAGTACTACCCGCAGTACTACCACAAGTCCGACAAGGAAGGCCGTCCCGTCTACATCGAGCAGCTCGGCA
AGCTCGACATCCCCAAGCTCTACGCGCTCACCACCCAGGAGAGACAGCTCAAGCGACTTGTTTCAGAGTA
TGAAAAGTTCCTCAGGGACCGATGCCCTGCCTGTTCCGAGGAGGTTGGACACCTTGTAGAGACTAGCTGT
ACTATTTTGGACTTGTACAATGCTGGTATCTCTAGCTTCTACAAGGGTAAGTCTTTGTTTTTCTTTTTTT
TTCTTCTAACGCGTCTGTTCGCATGCAAGAGATTTGTGCTGATCATGATTCTCGTCGTGGGTAAATAGTC
AAGGACTATGTCTCTGCCGCCTCTACCATTGGCCAAAACAACTGTAAGCTCGCTCTTATCTCGAATTCGA
ACAACCTCGACTAACCCTTTTTCAGACGTACGCCTCCTCACCCTTTTTGCCCACCTGCCCACCTGCCCAA
TTCGTCTTTTTAACTAACATTTTGCTTTCATTTTATAGCCCGAGACAATGGGCCACATGTTCATCATCAA
CGCCCCTTACCTCTTTTCCACCGTCTGGTCGCTCATCAAGCCCTGGCTGGACGAAGCTACCGTTCGCAAG
ATCCATATCCTTGGTAAATCCTACAAGGCCGAGTTGCAACAGTACATCTCTGCGGAGAACTTGCCAGTTG
AGTTGGGGGGCACTTGTAAGTGTCCTGGGGGGTGTAACTTGAGTGATGCCGGGCCTTGGAATAAGGCTGC
CGGAGGTGTTTAGGGTTGAGGAAAGTCTTGGCTTTTTTTTTAGGTGTGGGTGGATGGAAGGAGTTGAATG
AATCTTTTGGATCAGAGAGGAGGGAAAAGAAGGGCATTTTATTGTTGTAGAAGGGCGTGGGACGACAATA
GACTGGATGGATTGAAAATCTAGATTTGGGTGGCGGAGGGCACAAATTTCATACCCGTGGTTCAACACAC
AAAATATTAAATCGATGCTCGGAGCGAGCGCGGCGAATGAAAAAGTTGAAAGGGTTGGAGGGATTTGTCA
TTGGGAAAGGAAAAAGAGCTCAACCTTTTGGGTAATAGCGGGGATGGCGGATTAGAGATTACAGATATCT
ATATATATGGTTAGATGAGTCTTCTCCGAGAAATCTATGCTTCAAGTTTAAAAGCTTTCAGTGTCCCTTC
TCCATCATCGCTATACATCATATATGCACGGTGTTAAAATCTCG
Protein Sequence 
>gi|799335732|ref|XP_012051055.1| sec14 cytosolic factor, variant [Cryptococcus neoformans var. grubii H99]
MATTDFLSGHPGHLSEAQQSTLEAFRTELLSSGLIPDGADKEAFVQRIGYDRFDDQTLLRFLRARKFDIP
KAKIMWEANEKWRKEFGADDIAANGFDYPEYEKVAQYYPQYYHKSDKEGRPVYIEQLGKLDIPKLYALTT
QERQLKRLVSEYEKFLRDRCPACSEEVGHLVETSCTILDLYNAGISSFYKVKDYVSAASTIGQNNYVRLL
TLFAHLPTCPIRLFN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: CnÃˇâ€¯sec14-1 was hypovirulent in mice and did not disseminate to the CNS by day 14 post infection. Furthermore, macrophage expulsion of live CnÃˇâ€¯sec14-1was reduced (Chayakulkeeree et al., 2011).
References
Chayakulkeeree et al., 2011: Chayakulkeeree M, Johnston SA, Oei JB, Lev S, Williamson PR, Wilson CF, Zuo X, Leal AL, Vainstein MH, Meyer W, Sorrell TC, May RC, Djordjevic JT. SEC14 is a specific requirement for secretion of phospholipase B1 and pathogenicity of Cryptococcus neoformans. Molecular microbiology. 2011; 80(4); 1088-1101. [PubMed: 21453402 ].