Victors

SRE1
Victor ID	5361
Gene Name	SRE1
Sequence Strain (Species/Organism)	Cryptococcus neoformans var. grubii H99
NCBI Gene ID	23888183
NCBI Protein GI	799340974
Locus Tag	CNAG_04804
Genbank Accession	CP003829
Protein Accession	XP_012052219
Taxonomy ID	235443
Chromosome No	10
Gene Starting Position	352127
Gene Ending Position	355791
Gene Strand (Orientation)	+
Protein pI	5.3
Protein Weight	105616.71
Protein Length	1026
DNA Sequence	>gi\|799350850:352127-355791 Cryptococcus neoformans var. grubii H99 chromosome 10, complete sequence CGCTCCGTTTGTTTTCGGGTAGTCTTTGAAAACTGATTCGTATCCACTTTCTTTCTTGCTCCTGCATTCT TTCTTCTTCCTTATTTACTTTATCCCCTGTGTACCTTCACACTCCAGTATATCTCCCCCATGGCCTCATT ACAGGACAAGATGCCGACCTCACTGTACCAGTTCGACCAAGAAGAACAAGACTCGAGCTTCGCGCCTTCT GATATTTCCCCGACAGACGCTCTTTTCCCTCCTGAACTCACTGCTATCTTCGTAGATAACCAGTTCCCCT TCGATAATTCCTCAGGTAACTTCGGAAGAAATTATCAACACCGAGGTTCCCTCTCTTCAAATGAGGATTC ACTTCCTTTCCTGTCACCGACCAACCCACAGTCAATGTCGTCGACCTCCCCACGTCTTTCCCTTTCTCCA TCGACAGGTGAACCTTCCTTTCATCTCGCATCACATTCTTCCTATGATCAATTGTCACACTCTCCGCATA GTCACAGTTCCGCCTCGCCTTCATCGAGTTCCGGAACGGATGATGTTCTTCTGGCTAGAAGTTTTGAAGG TGTGAGCGGTGGGGAGTTGGATATGTTCCTGCTTCCAGAGCCGATCAATGACTATCCTGTCAATTCAGAT GGGTTTGGAGGACAGAAGCCCGGACAATCGCTGTTTTTGCCCGGTCGAACAGAAGGATTCAATGGAATGG GTGATGAGTGGATCCAAGACCTCTTTAAGGACCCTGTTCAGGAAAATGGCTTTGATAACATTAGCCAACA ACCACAGCCACAGGCTGGTGGCCTTGATTTTGATCCGATACTAGCGGAGCTTCAACAACAGTCTCAGCAA CAACCAATGCAGCAACAGCAGCGGCAAGTTGGGCAAACCATCCAGCCTCAGATGGTGAAACAAGAACCAT TAATACAGCAAGACAGCTGGAGCCATGAGCAAAACATGGGCAACTCCCAACGCGGTAAGCATTATAATTT GATGTAATTTATCGTCAAAGAGAAGACGCTCACACTACACAGGCTTCACTTTTACTCACCATCCTTTTGC TCCCAGGAACCAAGCTCGGGATATCAAACCCGCTTCTATCCCTCTCACTGCGAGTGTGCGCCGTCCTACC GCTGTTAAAACTGAAGCAGTTCCTGCTGCTGGCCCCACCCCTACCATTGGCAAGCACAACAAAACTGAGC GCCGTTATCGCCAGAAGGTGCAAGCTGCTCAAGCCGACTTACGGGATGCCATACCTGCGTTACGTCTATT GTACGGAACTTCCACTCCTGAGCAGCTTGCCACTACCGATATTCGTGCACCTGACGGGACAGTTGACGGC CTCGGAGAGGTGACCAGGCCGAACGCCAGTGCAAAAGCCACCATTTTGATAGGGGCGAGAGTATATATTG AACTCTTGCAAAAACGCTCAGCAAAGCTTCAGAGGATGGTCAATGAACTTGAGACATTTAGAGAAGCGGT GGAAGGTGAAGCGGGCCTTGCCGCATGGAAGGAAGACTTTGGACGAAGAGAAGCAGAAATTGATAGGGTA GAAGCTGAACAAATGGCGGCCAAGCTCAAGGAAGAGGACGATGAGATTGAAGACGAAGATGATGGTGAGG ACGAGGAACCTTCTTCCAAAAAGCGTAAATGTACGGCCGCGCCAAAGACCAAACCCAAAACAACAGCCAA GACCAAAATCACCCCTCAGTCTACTGCCTCTGCTGGTGCTCGAGTGTTCGCAGCGTTTGCTATGTCATTC TCTTTCGTCCCTTCTGCTTCCACTGTCTTCCGCTCAGCTTCTCAGCCCCAAGCTCTGACAACCGATAAAG TTCTTGGGCATGCGACAGATCAACAAATCCTTGCCAGCGTACCGTTAATCATCGCTGAGCACATATCGCG CCTCCTTGCCCGTAGTCTTCCGAACGCCCTTGTTCCCGCCCCTGCAACCCTGCTCGAATGGACATGGAGA CTTCTTGTCGCTGTTGTTTTTGCTGTGGTCATGCGTCCGATCATCTCGAAATTGACCACCAAATCAGCCG AAAAGGTTAGACCAGGTACAATTGAGGGTGTTCTAAAAGATGTTGTCGGGATCGTTTCGAGAAAGAAGGC CCAAAAGACCGAATGGGAAAGATTTGCTGCAGGTGTCGTTGGTCGAGGTAAGCTTCCAAGTTTCCAAATG TGACACATTTTAATAATTGCGTAGCCGATAATGCGTCTGCACTGGCAAAGTGGCACACTATCTTACATCT TAATGTCACCGCCTCATCACCCTATTCTCTTGCACTCCTTGCGCTTCTTCAGCCTGAGTCTTCTCTTCTG CGTTCACCGCAGCAACTCTGGCTCACTGCCCAGTCACGTGTTGATGGAACTACACCTCCCGCTTTAGTTA CTGTGCTTGGATTGCCCTTGCACGAAGCCTTGCGTTGCCTTTCTTCTCTTCCCCCCACCTCCGCACCTCT TTCCGCCCTGGCCGAACAGATCACTCTCATTCATGTTCACGATCTGTACACTCGTTTATTCATTCACCTG GTCGAAGCTTCTACCGCCTCTCCCCTTTCCACCACGTCACTCAAATCCCTCCTTTCCGCTCTTGAATCTC ACAACTTGGGTGCCAACCTCAAAGCATCCGCTTTTGACAAGGAAATCAGAAGCGTGATGCAAAGTACTCA GAAGGGATCAGTGGTGCACGCTCTCGGCTTGGTATTGATTGGTCTTTGGGGGATCTTTACGGGGCCTAGC TCCTCAGCGCAAGCATCCCTTGCCGCGGCACTTGTAGCTGACCAGGTTTCAGGCACAACTCATGGACTCA ATTCAGTTTCAGCTTTGCTTGAACTCCTTTATCCCGGCTGTGTCCCCGTCTCTGAAACCCCCGTTTTCGT CAGTCCTCTTTCACCAAACGCTCAAAAAGTCGATACCCTTGCACTGTCAATCATTGAGTATCTTTCGCTT CTTCTCACCACTTCTCGTTCCACAGAGGCCATGAATATGGACCGAGAAGGTAGGAAAGAAGAAAGTCTCG GTGTTCAGCGAAAGGTAATCAAGTTGAGAGGCGTCTTGAACAAGACCGGATGGGTGGGTGTGGAATCTGA GCTCGATGCAGATGACTTTGAGGAAGTTTGCGATCAGCCAGAAGAATTCATACTAGGAGACGAAGCGGAT AAGCGTGATCTCAGACCTCACCAACTTGAGAGCGAGAGAATACATTATGAACGGGCGAAGGAGAGATTGG TAGACATTCTTGCCAGGATTGGCAGACGTGCTGCAGGAAGGGCCAATGGAAGAGATGAAGATTCGGGATT GGAGGGCGATTTAGATGAACTGTAGAATGTCGTCCTTATTTTCCGTCTTTGCTTTTGTTTTGTATGTTTT TTGGTTCCATCGTGTTGATTAATGTGTATAATACTCGTCATAAATGTACGTGCCATTGTTTGGAAATGAA GCTGTTTTTTCCCCGCTTAAGACACGTGTAGATGCTGCAGAAGACTTGTAAAGCCGTAGTAGGCAAACGC ACTCGGACATTTCTCAGCTGGTGCATTTACACGAATTGTTTAGGTCGCTGGCGCCTCCTTATTGATCAAT TTCCATAGCCCGGCATGAGCAATAGTTGTAAAGGTCGGATTCCGCGACAGCATATCAGACAAATACCATT GTATGCTGTATGTACGTACGTGATG
Protein Sequence	>gi\|799340974\|ref\|XP_012052219.1\| hypothetical protein CNAG_04804 [Cryptococcus neoformans var. grubii H99] MASLQDKMPTSLYQFDQEEQDSSFAPSDISPTDALFPPELTAIFVDNQFPFDNSSGNFGRNYQHRGSLSS NEDSLPFLSPTNPQSMSSTSPRLSLSPSTGEPSFHLASHSSYDQLSHSPHSHSSASPSSSSGTDDVLLAR SFEGVSGGELDMFLLPEPINDYPVNSDGFGGQKPGQSLFLPGRTEGFNGMGDEWIQDLFKDPVQENGFDN ISQQPQPQAGGLDFDPILAELQQQSQQQPMQQQQRQVGQTIQPQMVKQEPLIQQDSWSHEQNMGNSQRGF TFTHHPFAPRNQARDIKPASIPLTASVRRPTAVKTEAVPAAGPTPTIGKHNKTERRYRQKVQAAQADLRD AIPALRLLYGTSTPEQLATTDIRAPDGTVDGLGEVTRPNASAKATILIGARVYIELLQKRSAKLQRMVNE LETFREAVEGEAGLAAWKEDFGRREAEIDRVEAEQMAAKLKEEDDEIEDEDDGEDEEPSSKKRKCTAAPK TKPKTTAKTKITPQSTASAGARVFAAFAMSFSFVPSASTVFRSASQPQALTTDKVLGHATDQQILASVPL IIAEHISRLLARSLPNALVPAPATLLEWTWRLLVAVVFAVVMRPIISKLTTKSAEKVRPGTIEGVLKDVV GIVSRKKAQKTEWERFAAGVVGRADNASALAKWHTILHLNVTASSPYSLALLALLQPESSLLRSPQQLWL TAQSRVDGTTPPALVTVLGLPLHEALRCLSSLPPTSAPLSALAEQITLIHVHDLYTRLFIHLVEASTASP LSTTSLKSLLSALESHNLGANLKASAFDKEIRSVMQSTQKGSVVHALGLVLIGLWGIFTGPSSSAQASLA AALVADQVSGTTHGLNSVSALLELLYPGCVPVSETPVFVSPLSPNAQKVDTLALSIIEYLSLLLTTSRST EAMNMDREGRKEESLGVQRKVIKLRGVLNKTGWVGVESELDADDFEEVCDQPEEFILGDEADKRDLRPHQ LESERIHYERAKERLVDILARIGRRAAGRANGRDEDSGLEGDLDEL
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: Orthologs of mammalian SREBP and Scap.fission yeast Scp1 responds to 4-methyl sterols and thus shares properties with mammalian HMG-CoA reductase, a sterol-sensing domain protein whose degradation is regulated by the 4-methyl sterol lanosterol (Hughes et al., 2007).
References	*Hughes et al., 2007:* Hughes AL, Lee CY, Bien CM, Espenshade PJ. 4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress. The Journal of biological chemistry. 2007; 282(33); 24388-24396. [PubMed: 17595166 ].


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SRE1