Victors

SCP1
Victor ID	5360
Gene Name	SCP1
Sequence Strain (Species/Organism)	Cryptococcus neoformans var. grubii H99
NCBI Gene ID	23885279
NCBI Protein GI	799342834
Locus Tag	CNAG_01580
Genbank Accession	CP003830
Protein Accession	XP_012052616
Taxonomy ID	235443
Chromosome No	11
Gene Starting Position	349199
Gene Ending Position	353973
Gene Strand (Orientation)	+
Protein pI	7.32
Protein Weight	145992.39
Protein Length	1449
Protein Note	The sterol-sensing domain of Scp1 is important for regulating Sre1 proteolysis. The conserved mutations Y247C, L264F, and D392N in Scp1 that render Scap insensitive to sterols cause constitutive Sre1 activation.
DNA Sequence	>gi\|799350881:349199-353973 Cryptococcus neoformans var. grubii H99 chromosome 11, complete sequence CGGGAGGAATATCGTGCGAGAAGCCAAGAAGCAAGTAGGAAGGAAGGACGAAGAGAAGGAAAGCACAATA ATCCGTCCTCAACTGTTAGGCAACACAGTCAACGATGGCTTACCTTTGAAAACATATTCCATCAGTCTAC GTCAACTTATTCTCCACTTGAGCAATGTCGTTCGTATCTTCGGAAACGCCAAACGCAATCGCGTCTTCAT CAACCGCCCATATTGGCTCTGCCAATCCGAGAGCAAGACACAGACTGGACAATGGGTTACAATATCATTC CAACCCTTTACCTAGTGATTGCCGACCGTTGCTAAGATCTGCGCCGCGGAAACGAAGGGTCGCCAGCAAG TCGAAAAAGCTCAGATGGAGGAAAGGGTTGGTTACGGAGGCTTTCCGCAAGTTTGGCGAGCATTGTGCGA GAAATCAAGTGGGTGAACAGAAGGATATATGTGCGATGCCATGCTGACTTGTATAAGATACGAACACTTC TCATTGACTGTCTTGTCATGACTAATTTGTTTTACCCTTCCCTGGCGCTCTATCTCCCGAAAAGATTTCC TCCACCGAGCCCACATGCCGCTCAGAACACTCACTGGCCACCTTTGGACAATGATGCCGCATCGTCATAT CGTACAAATACAGATCATCCGCTATCTTTCTCTACTTTAGGATGTCTTTTCCCCTCACCTCCGCCTTTAC TACCCCGTTTGACGTGGGCTGGTTGGTGGGGCAGCGGTACTCGGGGACGGGAAGATGAGGGATGGACGGC AACAAGGGCCATACCTGGCGCAACAGAAATAGGGGAAGGGCAAAATGATGAGGTTTGGGTTATGCGGATT GGATGGGCAGACGTTGAGGACGTCCTCGATCGACAAATTGAGGATGGCGAGCGGAAGTGGGAAGAGAGAG ATCATCATCTCTTGGAACTGGTACAAAATGTGGCCGAAAATTGGGAAAGACAAGTTCCTTCTAGCAGCCA GAGATGTGTCCGTCAGCTCAGATCATCGATTTCTGCCAGAGAGGACGGTGTTGACTCAGAGCCCCCGCCC TGCTATGTCCTGACGCCTTCTCCAGACGCTTTAGAGTCTGCGATACCAATATCAATGTCCGGTCTCGCTC ATTTCGACCATGGAGTGTCGGTCTCGCCGGATGGCCTACCTTTAGGACGGTCCCCCCACGCAGGCAACAT CTATCACACTTTTGCAGCGTTGTTCCATGTGCCACAAAATTCGACTTCCGCATTTGAACAACGGTGGCAG AGCGCCATGTTGGATGTTGCGAAAGAAGTAGAAGGAGAAGTATTTGTGGAGGCTAAAGGACCGAGAGTCG GTGACCAAATTGGCGAGTGGTTTGTCTCTGTAAAGCACTTCTCCTCTCGAACTGTTATAGCCAAGCTAAT TTTCGACATAGTACGCTTCATCCCCTCTTTCTCATCAAACAAACTTAACTGGTGCGATTTCATCTGACCG TTCTAAAATCTTTTCGTCATCGCCTCCCCCGATAATTATCGTTCTTTACATTATACTTTTCACCACTCTT ATCGTTCAACTCTCCAATGCTTCCAAAGCCCATTCCCGATTTGGTCTTGCTTTTACTGGAGTCGTGCAGC TGTGCTGTTCATCAGTTATGTCTTTCAGTGTCTTGGCCCTTCTAGGTTGGAATGGGTGGGGTGTACCTCA TGCCGAAAGTAGTTTGCCGACATACGTCTTACCCTTCGTCATCGTTGTAGTCGGTGCGGAGAACATGTCG ACCCTCGTGAGTGCTTGTTCCCTGCATCAATGCATCAAAAGATTCCATTGACACAACTTAGACGCAGGCC ATATTCTCAATACCCTTCACTCATTCTGTTCCCGTAAGAATAGGGCTTGGTCTGAGCAAAGTTGGAACTA CCATTGCACTCACTTCCTTAACGGATCTTGGTATCCTGAGTGTTGTCTGGCTCTGTGTCAACCTTCAGCC TGTTAGAGAGTTTTGCCTATTTGCGGCCGTTGTAATCGTGACCGATTGGTTCATGCTTCACACATTCTTC TTGACTGTAAGTCAAGATAAGTCATAAACATAAGGATGATGCTAAATATCGGGTCATAGGTCTTGTCCAT CGATGCTCAAAGACTCGAGCTAGCCGATGTTTTGGCGTCTAACAAGGTCGGCATGGTTTCTCCGGTGGAA TCTAAGGGAGAAAAGGACGCTCAGAATGAAAATCAAGGATTCCTATGGCGAAATATGCTGAGGGCTAGGA CAACTAAAAGTGGAAGTTTGTTACTAGTAAGCTTCTCCGTTTATGCAATAAACATGGCTGATTGAGACAT TTGATATAGCTCCTTTTTACTGTAGGGCTTCTATACTGGTTAACTGAACGGCATCGTTTACCCCTCAACA CCACTGCGAGTCTTTACGGATACACACCTACTGCGCGATCTACTTCTGTCAGTGTCCCCACTCCAACGGC GTCTCCCTTTATTAGTACTCCTGAAGCAATTTCCGTGTTGTCATCTGCGGAAAAGCTTTGGCGTGCCCTC AACCCAGAAGGATGGCCGTTCGCACATGTCATAGTCCCGCCCGCTTCGATACTTGTACTTCCCAAAGTCG GGCATTCTATGCGACCAGGGGACATTCGCAAACTCTCACTTCCAGCTAGCCGCCTTCTTATCCCTCGGCT GAAAGCTCTTCTCTACATCTTCAAGGTGTTGGTTCTTCCACAGGCAATTACAGCTGGCGCCTTGTATGCG CTTTTGTTGTACTTGCTCAAAGATTCTGATCTCCTTGACGCTCAACGGAACCGACTAGGGAGGACGGGCG ACGCGCATGACGATGAGTCTGACTTCCGAGGGTCGGCAAAGAATGCTAGCGGTTTGTCCAATTGTCTCCG AGCCCGAATGTTACCGTGCAGCCATGAAGCCGATGTGGATCTCATCGCATCGAGCTCTGACGGACGCATT GCTATATCAGTGGCCATTGATAACTCCGTATGTCTATGGAGGTTTTCAGATACCCCTGGAAGCGGAACTC GCGAGCCTCTGCCAACGGTTGGACTAGATCGCGGAGACGCTATTGTTGCAGCCGCTGTGAGCGAGGATGG TCAGCATGTTGCCGTGTGTACCAACATGGCGGTGTTACAGATATGGGAAGTGCCCAGAGAGGGTGCGATT GTGCCTCTGCAAGTTCGGAGGGCTGAGCAAACTTTCACCGCGAAGATTTTGGGGATAACATTCGATGAAA TTGCCCCTAGTGTCGATGACCCTTTTACGGCTAATGAGCCGACGGTGGATGAAGCGCGCAAGGCAACTTC TGTCATGGTCGGATATGGAGACGGTACCGTTGTGGCTATAAGCGAGGTGGGCGCCAAGGTGATCATTCCT GCACAGGATAAGGGCGCCTATTCCTCTTGTCGAGTCCTCTTTATGAGAAATATTGGCGGTTCCTTAAGCA TCTTAATCGCTAGACAACACGACATTGACATTTGGCGAAAATCTACTTTCGGATGGGAATCGTCCTCTCT TATTGCTGATCTCCCCGGCGAAGACCGTATTACTGCCGTTTCACCCCTCAACGCCGAGTTGCCTGGCGTC TTTGCTGTTGGCCATCGCTCTGGTAATATCACGATCTATGATGAATCTCACGGCCAGCTGGAATTGATGC CGCAAGGTTCGTCTGTAGAAGGTGTGCGCAAGCTCCAACTTGTAAGGCCTTCAAGCATGAAGTGTTTAGG GTGTGGCCTTCAGTCTGCGGAGGGTTACGCAGTCGTCTCGTCAACTTCGTCCCAAGTGTCCATTGATCGT ATCGCGCCTCGTACTTCGATCCCCACGTTCTGTCGTTGTACACGACGGGTGTCGTCTGCCGATGATGTTC CTGCTCTCATGCATCGCTCGGACTTGCCACAGCGTAGTAAGCCCAATACTCTTATTGTCCCTCCTGTTAC GTTTCGTCAACGCCCTACACCTGGATCATCCCCTCATAAGTCGACCTCCCTACTTTCTCCTGTCTCGAAT GGAGAATTTCCACTGTCCTCTCACGGCTCTGCTCGCCGATCGAGTAACTTTCATAGAGAAGATGATTCTC TCAAAATAATATCCTCTCCACACGATCGCTCTGCCTTGTCTAACATAGGCGGAGGTAGCGGCCTGGTTTC ACCAAGTGGTGATATGGAAGTAACCTCTCTAGGGGGCATCAGTGCTCAAGGCGCGAGCGATGGCGGTTGG GCGATACTCGATGGAGACGTGCTAGCAGGTGTTAGAAGAGGACGGGAAGGCATTGACGATGCGCAATGGC AGGTTTGGAGCGTAGACATGACCGCACCATGGGACACAGCCGGCTTGGTCGTGGATAGCATTGACTTGTC AGAGCTTCAACAGCGAACATTCGAGGTTGATTGTGTTATCCGAGGGCAGGCATCTGGAGGCGGAAGCACC AATGGAATTGTGTCGATGCGTGATAGAAGAACTGAAAGGCTTTTGAGTATGGATGGGCGAGCGAGCTTTC CAGAGCGGGTCGGTTCATTCGCTGTGCCCACATATGAGTCGCTAGGCTATGTTGAAGTCGTGGGGGTGGA TACCCTGGGTGCGAAAGGGATGATAGGTGGTTTTGGTAATAGATTGGGAACGATTAGTCTTGAGAGATGT GATGAAAAGAAAGTTATAGGGAGGAGTAGCATGGACGGTGTAGTGCTACCGGTCGTTCGGTACAGGAGTT GGGTATTACGTAAGGAAAAGGAGGAGCGAAGAGAGAGAGAGCGAGAGAGAGAGAGACAACGAGGAAGGAG CGGAGCATATAGCTA
Protein Sequence	>gi\|799342834\|ref\|XP_012052616.1\| hypothetical protein CNAG_01580 [Cryptococcus neoformans var. grubii H99] MSFVSSETPNAIASSSTAHIGSANPRARHRLDNGLQYHSNPLPSDCRPLLRSAPRKRRVASKSKKLRWRK GLVTEAFRKFGEHCARNQIRTLLIDCLVMTNLFYPSLALYLPKRFPPPSPHAAQNTHWPPLDNDAASSYR TNTDHPLSFSTLGCLFPSPPPLLPRLTWAGWWGSGTRGREDEGWTATRAIPGATEIGEGQNDEVWVMRIG WADVEDVLDRQIEDGERKWEERDHHLLELVQNVAENWERQVPSSSQRCVRQLRSSISAREDGVDSEPPPC YVLTPSPDALESAIPISMSGLAHFDHGVSVSPDGLPLGRSPHAGNIYHTFAALFHVPQNSTSAFEQRWQS AMLDVAKEVEGEVFVEAKGPRVGDQIGEWFVSYASSPLSHQTNLTGAISSDRSKIFSSSPPPIIIVLYII LFTTLIVQLSNASKAHSRFGLAFTGVVQLCCSSVMSFSVLALLGWNGWGVPHAESSLPTYVLPFVIVVVG AENMSTLTQAIFSIPFTHSVPVRIGLGLSKVGTTIALTSLTDLGILSVVWLCVNLQPVREFCLFAAVVIV TDWFMLHTFFLTVLSIDAQRLELADVLASNKVGMVSPVESKGEKDAQNENQGFLWRNMLRARTTKSGSLL LLLFTVGLLYWLTERHRLPLNTTASLYGYTPTARSTSVSVPTPTASPFISTPEAISVLSSAEKLWRALNP EGWPFAHVIVPPASILVLPKVGHSMRPGDIRKLSLPASRLLIPRLKALLYIFKVLVLPQAITAGALYALL LYLLKDSDLLDAQRNRLGRTGDAHDDESDFRGSAKNASGLSNCLRARMLPCSHEADVDLIASSSDGRIAI SVAIDNSVCLWRFSDTPGSGTREPLPTVGLDRGDAIVAAAVSEDGQHVAVCTNMAVLQIWEVPREGAIVP LQVRRAEQTFTAKILGITFDEIAPSVDDPFTANEPTVDEARKATSVMVGYGDGTVVAISEVGAKVIIPAQ DKGAYSSCRVLFMRNIGGSLSILIARQHDIDIWRKSTFGWESSSLIADLPGEDRITAVSPLNAELPGVFA VGHRSGNITIYDESHGQLELMPQGSSVEGVRKLQLVRPSSMKCLGCGLQSAEGYAVVSSTSSQVSIDRIA PRTSIPTFCRCTRRVSSADDVPALMHRSDLPQRSKPNTLIVPPVTFRQRPTPGSSPHKSTSLLSPVSNGE FPLSSHGSARRSSNFHREDDSLKIISSPHDRSALSNIGGGSGLVSPSGDMEVTSLGGISAQGASDGGWAI LDGDVLAGVRRGREGIDDAQWQVWSVDMTAPWDTAGLVVDSIDLSELQQRTFEVDCVIRGQASGGGSTNG IVSMRDRRTERLLSMDGRASFPERVGSFAVPTYESLGYVEVVGVDTLGAKGMIGGFGNRLGTISLERCDE KKVIGRSSMDGVVLPVVRYRSWVLRKEKEERRERERERERQRGRSGAYS
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: Orthologs of mammalian SREBP and Scap,, monitor oxygen-dependent sterol synthesis as a measure of cellular oxygen supply. Yeast Scp1 responds to 4-methyl sterols and thus shares properties with mammalian HMG-CoA reductase, a sterol-sensing domain protein whose degradation is regulated by the 4-methyl sterol lanosterol (Hughes et al., 2007).
References	*Hughes et al., 2007:* Hughes AL, Lee CY, Bien CM, Espenshade PJ. 4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress. The Journal of biological chemistry. 2007; 282(33); 24388-24396. [PubMed: 17595166 ].


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SCP1