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SAC6

Victor ID 5359
Gene Name SAC6
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23888121
NCBI Protein GI 799340789
Locus Tag CNAG_04738
Genbank Accession CP003829
Protein Accession XP_012052174
Taxonomy ID 235443
Chromosome No 10
Gene Starting Position 534005
Gene Ending Position 536915
Gene Strand (Orientation) +
Protein pI 5.47
Protein Weight 65399.24
Protein Length 624
DNA Sequence 
>gi|799350850:534005-536915 Cryptococcus neoformans var. grubii H99 chromosome 10, complete sequence
TGCCTCGCGCTGCAGCACACTTTATGCACGGAAAACAGATGCATACAACAGCACCCAACAGTCAATCCAC
TCTTCGCCGTATTACATTACTAAATTACGTAACGCACGCATGACGACGTAGCACCGCTGACGGCCGCCGT
CGAGCTGTCTCGCTGGTGCAGGTGAGCGTTCCTGTGAGTTCTGCCTGTCCATTTCCATGTTCACTTCTTC
TTTTACATCTTCGCGATCCTAGCTCTGCTAATCTACGGCCCACATCCTCCAGCTTACAACAATGCAAGCC
ATCAAACTCGGAAAGAAGTATCCCGATTTCAAGCAGGATGAGATCTTTGACCTCATCAACAAGTTCAAGT
GAGTGTCATAGTCTTCCCACACTTCTGCGACCTGGTTCAACCTTGTGCTTGGATTTGGATGACCCATGGA
CTCCATCCAGCTATTTTCTGCTAATGAGCAATTAATTCTTAGGCAAATCGATGTGGATGACAAGGGAAGC
TTGGACAAGGCCACTGTCATCTCTGCGCTCCAAGCGAACGGCGAAGCGGATTATGACTCAGTAAGTAGTC
TCTTCCTTCCCATCTGCAAGCCCTATGCGCTTTTTTGAAACCATTCCATAAACCATATAGCTCATCTTGT
GTACATAGGCTCGAGAGACCCTCAAAAACGTCAACATCGACGCTTCTGGACGAGTTGAACTGGAAGATTG
GGTGCAATTGCACTCATTGTTGAAGGCCGCCAAGAGTCAGCCTCTGTGGGTCCTCACTAGTATTATGATT
TATACCATGGCAAACTAACGTCAAGCCAGGCTGGAGCATAACAAAGGTCGTATCTCCGTTCGCGGTACGG
CCGGCACAAACGCTCAGCACACTATTAACGAGGATGAAAGACGGTCTTTCACTGATCACGTTAACACTGT
AAGCAATATATCTAACGTTCCAGAAAGCAAAGCTAAATGCATCATACATTAGGTCCTTGCTGCTGATAAG
GACGTTGGCCACCTTCTTCCTATCCCCACCGACACTATGCAACTGTTCGACGAATGCCGAGGTAAATTTA
TGGGTCATCACTAATAAGATCAGACTAACGCATGTTTAGACGGCCTTATCCTCTGTAAACTCATCAATGA
CGCTGTTCCCGAAACTATTGATGAACGAGTTCTCAACAAGCCCTCAGTCAAAGCCGGCAAGGCCCGTCCA
CTCAACGCTTTCCAAATGACTGAAAATAACAACATCGTTATCACCTCCGCCAAGGGTATCGGATGCTCTG
TAGTCAACATTGGTCCCCAGGACCTTATCGAAGGCAGGGAGCACTTGATTTTGGGTCTGATTTGGCAGAT
CATCAGAAGAGGTTTGCTCAGCAAGATCGACATCAAGATTCACCCCGAGTTGTACAGATTGTTGGAAGAT
GAAGAGACCATGGAGGAATTCTTGAGGTTACCTCCTGATCAGATCTTGTTGAGATGGTTCAATTACCATC
TTAAAGCTGCTGGATGGCATAGAAGGTGAGATCCTTTGGAGAAGAGAAAGTCAAAGACTGACATGTCACA
GAGTTGAGAACTTCACTAAAGATGTCTCTGATGGTGAAAACTACACCATCCTCCTTAACCAACTCAAACC
CGACCAATGCTCCAAATCCCCTCTTCAGATCTCTGACCTTCATAAGCGTGCTGAAGAGGTACTTCAGAAC
GCCGATCGAATTGGCTGCCGACGCTTCCTTACTCCCAACTCCCTTGTTAACGGTAACCCCAAGCTTAACT
TGGCCTTTGTTGCCAACCTTTTCAACACATGGCCCGGACTTGATCCTCTTGAGGAGACTGAGGCTCCGCC
ACCTGTGGAGGACTTTGATGCGGAAGGTGAGAGGGAGGCAAGAGTGTTCACTCTTTGGTTGAACTCTTTG
GATGTCGAGCCTGGAGTCTACAACTTGTTCGAAGATCTAAAAGACGGAACAGTCTTGTTGCAAGGATTCG
ACAAGGTCATTCCTGGTTCCGTTATCTGGCGTCGAGTTTCCAAGCCTCGAGAAGGTCAAGAGCTCTCTCG
ATTCAAGGCCGTCGAGAATACCAATTATTCTGTCGACCTTGCCAAGGCCAACGGCATGCACATTGTTGGT
ATCCAGGGTTCAGACATTGTCGATGGTACTCGTACTTTGGTCCTTGGTCTCGTGTGGCAACTGATGAGGT
TGAGCATCAATCAAACCCTTGCCAGCATTTCGAAAGACGGTAAGGGTGTAACTGATCAGGACATCATCAA
ATGGGCCAATGAGACGGTTAAGAAGGGAGGGAAGACTTCCACTATGAGGAGCTTCAAAGACCCCAGTCTC
TCGAACGCTGTTTTCTTCTTGGACCTTTTGAATGGTGTTAAGCCGGGCATCGTGGATTATTCTTTGGTCA
CTCAAGGCGTAGACGAGGAGGAGAAGAGGATGAATGGTAAATCTGTTGAATTAAAGTCAAAAGATTAGGT
GGCTAAAGCACTTTCGTAGCCAAGTTGGCCATTTCTATCGCGCGTAAGATGGGCGCGTTGATTTTCCTTG
TGCCAGAAGGTAAGTCGAGGATCTTGTGTATGGTGTTATTTTTTTCTAATGCCAGAATATCATTGCAGAT
ATTGTCGACGTCCGACCTCGACTTGTGCGTATCCGTCTCTATCTCCCATAAACAGATCGATGAGTGGCGC
TGACAATCACTTTGGTAGATCCTTACATTCGTTGGTGCACTTTGGAGCGCTTCCTTGAACCAATAATCAA
TAATATTCGCCGAAGCTACTGGCATAATGTACAAAGAAATAGGGGAACATGTCAATCCGCTGTGTTATGC
AAGATATCGAAAAATCTCTCTTAGTAATTGTTTGTCCAAACAAATCAGATAGTAATATAAGACAACACTT
CATTGGTAATACTTATGCATAATAAGTTATCAAGCATTCAT
Protein Sequence 
>gi|799340789|ref|XP_012052174.1| fimbrin [Cryptococcus neoformans var. grubii H99]
MQAIKLGKKYPDFKQDEIFDLINKFKQIDVDDKGSLDKATVISALQANGEADYDSARETLKNVNIDASGR
VELEDWVQLHSLLKAAKSQPLLEHNKGRISVRGTAGTNAQHTINEDERRSFTDHVNTVLAADKDVGHLLP
IPTDTMQLFDECRDGLILCKLINDAVPETIDERVLNKPSVKAGKARPLNAFQMTENNNIVITSAKGIGCS
VVNIGPQDLIEGREHLILGLIWQIIRRGLLSKIDIKIHPELYRLLEDEETMEEFLRLPPDQILLRWFNYH
LKAAGWHRRVENFTKDVSDGENYTILLNQLKPDQCSKSPLQISDLHKRAEEVLQNADRIGCRRFLTPNSL
VNGNPKLNLAFVANLFNTWPGLDPLEETEAPPPVEDFDAEGEREARVFTLWLNSLDVEPGVYNLFEDLKD
GTVLLQGFDKVIPGSVIWRRVSKPREGQELSRFKAVENTNYSVDLAKANGMHIVGIQGSDIVDGTRTLVL
GLVWQLMRLSINQTLASISKDGKGVTDQDIIKWANETVKKGGKTSTMRSFKDPSLSNAVFFLDLLNGVKP
GIVDYSLVTQGVDEEEKRMNAKLAISIARKMGALIFLVPEDIVDVRPRLILTFVGALWSASLNQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Endocytic processes were hampered in the sac6Ãâ mutant, but cell polarity and cytokinesis were not visibly disturbed however had no effect on virulence in mice (Chang et al., 2012).
References
Chang et al., 2012: Chang YC, Lamichhane AK, Kwon-Chung KJ. Role of actin-bundling protein Sac6 in growth of Cryptococcus neoformans at low oxygen concentration. Eukaryotic cell. 2012; 11(7); 943-951. [PubMed: 22562467 ].