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RPB4

Victor ID 5358
Gene Name RPB4
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23885158
NCBI Protein GI 799325943
Locus Tag CNAG_01444
Genbank Accession CP003824
Protein Accession XP_012048930
Taxonomy ID 235443
Chromosome No 5
Gene Starting Position 295675
Gene Ending Position 296598
Gene Strand (Orientation) +
Protein pI 4.65
Protein Weight 15282.97
Protein Length 147
DNA Sequence 
>gi|799350697:295675-296598 Cryptococcus neoformans var. grubii H99 chromosome 5, complete sequence
TATTAGAACGCCAGGCTGCATTACCGACATCCATCCGCATATTACAATGGCAGCCCTGCCCGCCCACCAC
CGCCGTCAGCAGGTCCGTGCCTTCCACGTCTCTCCCATCAGATACTGACTCACCTCTCCTCTAATCCAGA
TCCAGGAGGAAGACGCCACCAAGCTCCAGTTTGGAGGTCCGTTTCTTCCCTCCATCGGCGAGAAAATGCA
GAGATTACTTTGCGCTGACTTGTGGATCAAATAGACTTTGCGGAAGGAGAAGCTCTTACTTTGACCGAGG
TGGCCACCCTCTTGAAAGCTGCTCGTCAAGCTCCCAACGTCCCTCCCGCGCCGGATAACAAGTACGCTTT
CCTTTGTCAGGGCTGTTGCCGATCATCATCGTTGACTTTGGTATGTAGGGTGTATCAGTCCACGACCGAC
TATGTCAATGAGTTTTCCAATACTACTATGGATGTTTCCGATAGTATGCGAACGTGAGTCTTGGCGCATC
TGCCCGTCAGTTCGGGTAAGAGGCCGATAATAGCTTACCCGCCATTAGTGCATTATCGGCTAGGCATGGC
TTCTTAAACAAGTTTGAAATTGCTCAGATCATGTCTTTAAGGCCAGAAAGGGTAGAAGTGGCTGTTGCTC
TCATACCTAGGTTCGTTTTTACTTTTGTGTTGCGTTTAACAAGGGCTCCTATCCTCGAAAAGCGACTAAC
TCATGTCTCTAGTCTGGAGAGGTACGCGCAAGGTGACGAAAACGAGGCGCAACTCCAGAGTCTGCTAGAT
GATGTTCGTGCAATGGTTCGTTACGGTGTTCAGCCCTAGATTCTAGTCAAAGGAAAGAGAGGTACCTTCT
GGCCAGAGGAGGGACTTTCCTGGCAATAATAGATAAACTACAAGCAAATGTTGTAAAACTATAATGCATT
TGGGTATATTTTAT
Protein Sequence 
>gi|799325943|ref|XP_012048930.1| DNA-directed RNA polymerase II subunit RPB4 [Cryptococcus neoformans var. grubii H99]
MAALPAHHRRQQIQEEDATKLQFGDFAEGEALTLTEVATLLKAARQAPNVPPAPDNKVYQSTTDYVNEFS
NTTMDVSDSMRTALSARHGFLNKFEIAQIMSLRPERVEVAVALIPSLERYAQGDENEAQLQSLLDDVRAM
VRYGVQP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Deletion of Rpb4, growth at host temperature was impaired and virulence was attenuated (Bloom et al., 2013).
References
Bloom et al., 2013: Bloom AL, Solomons JT, Havel VE, Panepinto JC. Uncoupling of mRNA synthesis and degradation impairs adaptation to host temperature in Cryptococcus neoformans. Molecular microbiology. 2013; 89(1); 65-83. [PubMed: 23659661 ].