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RDI1

Victor ID 5355
Gene Name RDI1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23886828
NCBI Protein GI 799336188
Locus Tag CNAG_03316
Genbank Accession CP003827
Protein Accession XP_012051176
Taxonomy ID 235443
Chromosome No 8
Gene Starting Position 632495
Gene Ending Position 634530
Gene Strand (Orientation) +
Protein pI 4.69
Protein Weight 20320.51
Protein Length 196
DNA Sequence 
>gi|799350780:632495-634530 Cryptococcus neoformans var. grubii H99 chromosome 8, complete sequence
TCGGAAATCCACTGCGCACCAGGGTCAGCGTTGCCAGCAGGCGTCGTGCGGCGACAAAGGGACGGACCTT
TTCTTGCACATTGTCAAGGGAGTCGGGGGAGTCAATGGCGAAACAGATGAGAATGACATGGGAGTCGGGG
TAAGAAAGAGGTCGGAGTCGGCTGCAGCATAGGTTAGACGCGGATATCGGCTGATTTCACATGGCAACGC
ACTCATAGTCCTCCTGCAAAGGTCAATGCGTCAGCGACCGTTCTTGCCACCGAGCGCCGAGCGCCGACTG
GGCGACAATTACCACGCACCTGTCCAGCAGTATCCCACAATGCCAACTCGACCTTCTTTCCGTCCACTTC
CACATCGGCAACATAGTTTTCAAAGACGGTAGGCACGTACACCTAAAGAGTAACGATAAGCGCGACTGTG
CGATTCGATGCGAAAAGCGGCGATCTCAGTGACGAACCTCGGGGAACATGCCCTTGCTGAACACGATAAG
ACTGTGGGAATGTGAGCAGATGGGCGCGCAAGTGGATGGATGTACTTACAGACATGTTTTACCACAAGCA
CCGTCGCCTGATGGTCGTGAGCGGGCGGTGTTGTGTGAGCCGGGGAGTACTCACCGACAATAACAAGCTT
TCTCCTGATTTCTCCGGACATGGTGTGTGGCTATGGATGAGTGTGCTGGCGTGGATGAGGATTGAGTATA
GGAGCTGTTCTTGGATACAGGGTGTAGAGATGCTGTATACTGCTATGCTCTCCCGCTGTCGCCCCGGCGT
TAGAGAGACAGACTCCCCCAGTGTGGCGGTGTTCCCTAGGCGTGCCATGTCCCCAATGTGTTGTTAGGCA
TGCAGCACGGGCCTGCTTTTACGCGTCGCGTCGCGCCATTGCCATTCCCGCATCCAGCCGGCAGCCCGCA
CTGCCACTCACCCATTTTCTTCCTTCCTGCCACCGCCCACGGCAGCTGCCACTCCACGATCCACACACCA
TGTCCAACCAACAGGTAAGCACACACACAGCACACGCAGCGCTGACATGCAGCCCGAAGACGAACTCGCT
CCCACCCGCACAGAAGGCTACAAGGTAAGCCCTCTCCACGGGGACGACGTTGACCCTCGCAGCTAGGCCA
GTCAAAGACTGTAGCGGAGCTCGCTGCTCTCGACCAGGTGCGCAGATTCATCTCCCAAAGATGCGCTGCG
TCCGCTGATGGCCATGCAGGATGACGAATCTTTGCAACGCTGGAAGCAGTCTCTCGGTATCGGCGCAGGG
GCCTCTGGCGGTGGTGAGAAGCGCGTGCGTTGGTTTCCCGTGTTCCCGTTCCCTACTTTACGATTACTGA
GCCGCCCTTACAGGTTGTTCTCAAATCGCTCTTCCTTTCGTCACCTACGCTCCCCAACCAGATCACCATC
GACCTCACCCAGTCCAAAGATGCGCTTGCAAAGCTCAAAAAGGATCCAGGTGGGTGATTGCTTTCAGAGG
ATATAGCTGATTTACAGTGACCATCAAGGAGGGCGTCGAGTACTCTGTCGGCATCACCTTTATGCAAGTC
GAGCGATACCCCCGCTGTCCGTCAAATGCCAGCTGACTTTTTAGCACAGGATTGAAAACGAAATTATCTC
TGGTCTCAAATACCTCCAGGTCGTTAAACGCAGTGGAATCACTGTTGACAAGACTGAGGCCATGCTTGGA
TCTTATGGTCCCCAGCAGGAACCTTACACAAAAGTGTTTGCCTCTGAAGAGTCTCCCTCTGGGATGTTGG
CTCGCTCAGGTACCTATGTCGTCAGGAGCCGAGTCATTGACGATGACAACACCATCTGGCTTGATTTCGA
ATGGGGTGGGTATCTGGTAATTTACCACCAGAGCATTTGCTGACGGTATGGCAGGCTTCAAGCTCGGCAA
GGAATGGTAAACAGGCCGGAGAAGGATTGGTGAATAGTCGCAGCGAATGGTGAAAAGTAAAGCATGGAAC
GTTTTGTAGCCTTTGTGTATATCATCATGCAGTTTGTCATCTTGTTCAACTTCCAAGTGTCGGTGTGCAT
GGAGTG
Protein Sequence 
>gi|799336188|ref|XP_012051176.1| rho GDP-dissociation inhibitor [Cryptococcus neoformans var. grubii H99]
MSNQQPEDELAPTRTEGYKLGQSKTVAELAALDQDDESLQRWKQSLGIGAGASGGGEKRVVLKSLFLSSP
TLPNQITIDLTQSKDALAKLKKDPVTIKEGVEYSVGITFMIENEIISGLKYLQVVKRSGITVDKTEAMLG
SYGPQQEPYTKVFASEESPSGMLARSGTYVVRSRVIDDDNTIWLDFEWGFKLGKEW
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: RDI1-overexpressing strains exhibited altered morphology compared to that of the wild type, with apparent defects in maintaining proper cell polarity and cytokinesis. RDI1 deletion resulted in increased vacuole size in tissue culture medium and aberrant cell morphology at neutral pH (Price et al., 2008).
References
Price et al., 2008: Price MS, Nichols CB, Alspaugh JA. The Cryptococcus neoformans Rho-GDP dissociation inhibitor mediates intracellular survival and virulence. Infection and immunity. 2008; 76(12); 5729-5737. [PubMed: 18779335 ].