Victors

PYK1
Victor ID	5352
Gene Name	PYK1
Sequence Strain (Species/Organism)	Cryptococcus neoformans var. grubii H99
NCBI Gene ID	23885494
NCBI Protein GI	799342196
Locus Tag	CNAG_01820
Genbank Accession	CP003830
Protein Accession	XP_012052462
Taxonomy ID	235443
Chromosome No	11
Gene Starting Position	999758
Gene Ending Position	1002751
Gene Strand (Orientation)	+
Protein pI	6.53
Protein Weight	57227.9
Protein Length	572
DNA Sequence	>gi\|799350881:999758-1002751 Cryptococcus neoformans var. grubii H99 chromosome 11, complete sequence GTTCATTAAGGGATGGAAGCCACGCGGCTGAGATTGCGGCAGTGGTTGGGGATGGTTGAGGGACAGGCAG GGTAAGAGAGGAACAGGAAGGCACGGGCACAGGGAAGGCCAAGAGGAACAACTCGGGGTCCGGCCTATTA TGTATATGCTTGGTGATTTGAAGATGATTGGTGGGGACTCGGTGAAATTATGGGAGGATATGGGAAATGA CTGATCAGTAATGAGTAAAAGAAATCTGATCGCAGCAGGAAAGGGGAAACAATCCATCTTCATTTCCTAC TACTCGCCTCTTTTTCTTATATCTGTCTACCTATATATCCCCCTCTTGCTCTGCGGGTACTTCTCCTTTC ATACCTTCCTCAGCACTTCCTCCCCAAAAAAGACAACCAACTTGGTACGTAACACCTCTTTTCATCTTTA CGCACGTCATATAATAGTTCCCTCCTTTACTCCAGCCCCACAACAAATATTATGATTCCGTTCTAATAGT TTCGCTAACAACTTTGTTTCTTTTTCTTCCATCTACATCTATACATCATACAAATGGTTCTTGGACATTA TCCTCCCCAAACAAACACCTCTGTCCCCCCTCCTCCCCATCCCTCTGCCTTTGTGCCCCTGTTTCAAACA AATACTTCCGTCGTTTCTGGTAAACCCAACGCCTATAGCACCATGGCCGGTACCCCTTCTTCCCAGCTCG CTTGGCTCTCTGGTCTCAGCACCAACTTCAATGAGATGTCCGCTGATCAGAAGTTCCTCCGCAAGGTATG TATCGTCTTTCCATTTCATATACATTTTCGTACCAGTTGTCGTAGTGTAAGATGAAGAAGACGACGTAAT GTGAAATGAGAAGACGACGATGGGAGCGGAGGTAACATTTGACCTCACAGACTTCCATCATTGCTACCAT TGGCCCCAAAACCAACAATGTCGACACTCTCGTGCAGCTCGCTGATGCGGGCATGAACATCGGTAAGCAT GTCTATTTTGTATGCATTCATTAGCTGATAATTGCCAGTTCGAATGAACTTTTCTCATGGCTCCTATGAA TACCACCAGTCTGTCATTGACAATGCTCGCGCTGCTGCTGCCAAGAGCCCTTCCGGTCGACCCATTGCCA TCGCTCTCGACACCAAGGGTCCGGAGATTAGGACTGGTTTGATGAAGGATGACACCGATGTCAGTTGTTC CATCTGCAATTATTCTGGTTTCTAACTCCTCTTTAGGTTCCTATTTCTGCTGGACACGAATTCTGGGTTA CTACCGACAAGGCTTATGCAGAGGCTGGTACTGCCGAGCAGATCTATATTGACTATGTAAGTGATGTTAC CTATATGAAAAATTTCATTATTCAAGCTCACACACTTGCAGACCAACATCGTCAAGGTTACTGCCCCGGG CAAGCTCATCTACGTTGACGATGGTATTCTTTCTCTCCAAGTCATCTCTATTCAAGGTGAAAAGATCCGT GTCAAGTCTCTCAACTCCGGCGTTCTCTCCTCTCGCAAGGGTGTCAACCTGCCCAAGACCGCTGTGGATC TCCCCGCTCTTTCTGAAAAGGACAAGTCTGATCTTGCCTTTGGTGTCAAGAACAGTGTTGACATGATCTT CGCTTCTTTCATCCGTTCTGCCAACGATGTCAAGGAGATCCGTAAGGTCCTCGGCCCTGAAGGCGCCGAC ATCAAGATCATTGTCAAGATTGAGAATGAGCAGGGAGTGATGAACTTCGATGAGATTCTTAGGGAAACTG ACGGTGTCATGGTTGCCCGAGGTGATTTGGGTATTGAGATCCCCGCAAGTCAGGTATTCATGGCCCAAAA GATGATGATTGCCAAGTGCAACGTCGCTGGCAAGCCTGTCATCTGTGCTACTCAGATGCTTGAGTCCATG ACTTACAACCCTCGACCCACTCGTGCGGAAGTTTCCGATGTTGCCAACGCGGTCATCGACGGTGCTGACT GTGTCATGCTTTCCGGCGAGACTGCCAAGGGCAAGTATCCCATTGAAGCTGGTAAGTTTACTTAAGATTC AGTCTTGTCCAAGAACGCTATTGATACTTTGATGTTCAGTCAAGATGATGGCTGAGACTGCTTTCCTTGC TGAGTCTTCTATCGCCTACCCTCCTCTTTTCGACCAGCTCCGAGCTCTTACACCTCGACCTACCGAGACT GCCGAGACCCTTGCTCTTTCTGCTGTTGCCGCTGCTATCGAGCAGGATGCCGGCGCTATCATTGTGCTTT CAACTTCCGGTGTTTCTGCCAGATTGATTTCCAAGTACAGGCCTGCTTGTCCCATCATCTGTGGTAAGTA AAAATTATCCTGTTGTTATGCGATGATGCTGAGCAATGACAGTGACCCGAAACGAACAAACCGCTCGACA ACTCCACCTCTCGCGAGGTGTTTACCCTGTCTGGTTCCCTGAGCCCCGCGGTATTCCTGCTGAGAAGTGG CAGATTGATGTTGACAACAGGATTCGGTACGTATCTTGGCAACAAATAAAGCATAATTTACTAATATTTG TGTAGATATGGTCTCAGGATGGCTCTCGGTTTGGGCATCATTAAGCCTGAGGCTACCGTCATGGCTGTCC AAGGATGGAAGGGCGGTCTTGGCCACGTGAGTAACCGCCGTCCTATCGTAAAGCTCAGTACACTGACAAC CATTGATCTAGACTAACACTCTTCGTATCCTCTCGTACGCGGTCGTCTCAGTCGTGTATTTTGATGTAGT ATGCTAACCAAAGACTCTAGCGTTCCTTCTGACCCTGCTGACCTCGACCTTCACTCTATCGAGCGCGACT AAGGCCACCATCCTTTTCGCCTGTCTCGCTTCTGCTCGTCCCAAAAGTGAAGGGATTTAGACAATGGGGA GGGTCTCGAAAAATCCAAAAGTTATATAGACGAGCTGGTGTATATGATGATCTTGGTACAGAAGCTTTGC GCTCAGTCTTGAAAATGAATGAAGAAGATGCATATGTTGGTCATTTGTGCGACA
Protein Sequence	>gi\|799342196\|ref\|XP_012052462.1\| pyruvate kinase [Cryptococcus neoformans var. grubii H99] MVLGHYPPQTNTSVPPPPHPSAFVPLFQTNTSVVSGKPNAYSTMAGTPSSQLAWLSGLSTNFNEMSADQK FLRKTSIIATIGPKTNNVDTLVQLADAGMNIVRMNFSHGSYEYHQSVIDNARAAAAKSPSGRPIAIALDT KGPEIRTGLMKDDTDVPISAGHEFWVTTDKAYAEAGTAEQIYIDYTNIVKVTAPGKLIYVDDGILSLQVI SIQGEKIRVKSLNSGVLSSRKGVNLPKTAVDLPALSEKDKSDLAFGVKNSVDMIFASFIRSANDVKEIRK VLGPEGADIKIIVKIENEQGVMNFDEILRETDGVMVARGDLGIEIPASQVFMAQKMMIAKCNVAGKPVIC ATQMLESMTYNPRPTRAEVSDVANAVIDGADCVMLSGETAKGKYPIEAVKMMAETAFLAESSIAYPPLFD QLRALTPRPTETAETLALSAVAAAIEQDAGAIIVLSTSGVSARLISKYRPACPIICVTRNEQTARQLHLS RGVYPVWFPEPRGIPAEKWQIDVDNRIRYGLRMALGLGIIKPEATVMAVQGWKGGLGHTNTLRILSVPSD PADLDLHSIERD
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: Deletion of PYK1 blocked for entry of 2- and 3-carbon substrates into gluconeogenesis and attenuated for virulence in a murine inhalation model (Price et al., 2011).
References	*Price et al., 2011:* Price MS, Betancourt-Quiroz M, Price JL, Toffaletti DL, Vora H, Hu G, Kronstad JW, Perfect JR. Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host. mBio. 2011; 2(3); e00103-00111. [PubMed: 21652778 ].


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PYK1