Victors

PTP
Victor ID	5351
Gene Name	PTP
Sequence Strain (Species/Organism)	Cryptococcus neoformans var. grubii H99
NCBI Gene ID	23888497
NCBI Protein GI	799324873
Locus Tag	CNAG_05155
Genbank Accession	CP003823
Protein Accession	XP_012048746
Taxonomy ID	235443
Chromosome No	4
Gene Starting Position	574909
Gene Ending Position	580271
Gene Strand (Orientation)	-
Protein pI	8.39
Protein Weight	124889.77
Protein Length	1211
DNA Sequence	>gi\|799350666:574909-580271 Cryptococcus neoformans var. grubii H99 chromosome 4, complete sequence ACCCACTCAATGAAACCATTTCTTATGCATGCTTCTGATCTCACTTCCCCAATGTTCAAACATGATAAAA TATAGCTACACTATGCGCCTTTTCGGCCTCGTATCGAAAACCATGGTCTTATAATCTCATGATCTCACAA TCTTCTAGCAAAACAATGTTCGGATGGATATCTCTGCAAAACCGTCTAACCCCAAATGCTGTAATATGTC ATGATTTGTATTAAATCTCTGGAACACCGGAAGGAATATGGTGAAACGTTTCATTCGACTTCGGTCGAAA AAGGAGGTGTTATTATGTCGAACGTCGGGCAAACCATGATGTAATAAAGTGTCCTGTGATAAACGTGTTC GTTATGTAGGGGATGATGACTGTTATGAAAAGCTCGAGACTTGAGTGATTGCTAGGACGGTCAATTCCTT TTCTAGTTCTTTAATTCCTCCGCTACAGCTTCCTCAGCCACAGCCTCCTTCTCCATACCCTTCCACATCG CACTCGATTTCCTCCCCATTCGTCCACTAGTAGTTCCCGGCTTCATTTTCTTGAAACTCGGTCGTTTGGA TAGCTCGGATCCTCCTTCCCCGCCTAGTCTCACATCAGGATGAAGTTCAGTTGGGCTGGCTCGACGTTTT GTATGTGAGTCTTCATCGACACTCCCTTTTGTCAGATCGGCCTGAGAGTTTGTGCTAAGAGAGTCGGTAT AAGATCCGGAACCCGAGTTTGTGGTACCTAATGACCCGAGTGACCCAATCGCCGAACCAGAAACGGATGA GCCCACAGAAAGAACATGCTTCTGTAAAGGAGAGGGATTGGGTCTTTCTTTCACTTGATCGTGGTCGAGC ATATGAAGGTAATGGTATATGATAGCTCGATGCACGAACAAATACTGCCGTAATGTTTGTACAAGGGACA TACGCTGGACTCGCATACTTTCAAGAACACACGACACTGGGTCACGCATCTTAGAAAGTGGAGAAGGTTC GCGCCGACGTCGGTTGGAGAAAGTAACAGGCTCAGGGTCAGCCAAGCAACTGGATATCCTGTTACGGTGT CAGTCTACGACAATCATATGAATAATGAACATTACTCACGATTCTGAAGAAACTCGATCAGACGATGTTT GTACAGACGCCAGACTGGGCCTTCTCGTATCGGTGTCGCTCGACACACTCGTACCCCCAGACATCATCCT GTACTGCATGAATCTATCATCGAGGCCGTTAGCAGCCTTGGGAGGATCGACTTCCATCGTTTCATTACTA CCCTGCTTTTTGGGTGGGAATGAAAAATCGGGAGCGACTTGATGTTCGGGTTGGGTAGGCATCGTACCAG GAGAGGTTGAATGCTGACGGGCAACGGAGCCACTAGGAGCACCCAAGTTAGAGAACTGACTGACGGGTTC AGGCGATGCAACTGCTGAAAGGCTAGTAGCAGGAGGTGCAGAGCTAGAATGCTGTGGCGGTATGACTTTG GGAAGACGTGCAGGCTCATCTACAGACCGAGCTTCAGCGGCACCACGCTGACAAAGGTCTCGGTGAAGGC CATCCAAGATAGCGTCTACCACGATGAAACTTCCTGTCCTTCCAACACCAGCGGAGCCTGAGTAAAATTA GTATCAATCTGAGAAACCAAAATTGTGGTACTTACAATGTACCAAAATCGGCGGCTCGTCAGCTTTCCTG TGACAACCCTCTGGTCTGGCCTCGTGCGCCGCATCGTTGACTTCTTGGATCAACTTGAGCAACGTGTCCG GCGTCTCTGGCACATCAAAGTCAGGCCAACCAACACATTGAAGCTGTACGATTTTTCTTGGCGGCTGATC AGGCTTGCCATCGTGGGAGACGAGGAATACCCGTTTGATGTTGGAGTCACTTCCTTCAGGGAATTTGGAA GACTTGGGGGTCGCTCCTGCTGTCCCAAAATCAAATCCAGAGTTCGCGGCGGGAAGCGCAGTATCTTCCC CTCCAGACTGACTGATCAATTGCAGTTTTATATGCCCATATTGCTCCTCGCCCCAGTAATTGCCGCACTT GATCAATCCGCCTTCGAACTGTTTCGTAATCATGACAATTATCCTAACGTTTTGTTCCCAAACAAGGGTC CAGAAGTCTCGATATGTAGCATCTAATGGACCTTGAGTGGCGATATATCGTCGAGAAGTGCCTCGAGGTT GAATAAAGGATGCGTTGATGTAATCGGAATCCTGATCGGGCGGAGAATCGAGACGAACACGGGAGAAGTC GTATGGCCAGATGTTCTTGTATCTATTTCAAAAATCAATTAGATTACTCGTGTTGTTATGCGGGATAACT TACCTGTTTTTAGTACCTCTCTCAACACCTGCGGTGATAGAGAACGGGAAGTATTCGATATCCTCAATTC CCCTTTCCCAGTTCATCAACCTTTTCAACTCTTTTATATCGCTTTCTCGCTGTATAGCCCATTCCCAACC TTTCTTCTCAGAAGCATTTCTGTGGATTTTCTCGTCACACCCTGCAGTTGGTTGCAGAAGAACTCCAGAA CCTTTGGCATGCCATTCCATGATAGCCTGCAGGCGTTTCTGTTCATGCAGCTCCAATTGGTAAAATTGGT GGGCGAGCTTGTCCATACTGTCCTGCTCTGGCATAGTGACTAGCTCACGCAACCAATCGGGGAATTGGTC AGCTCGTTTCCGTACAAAATCGGGTAAATTGAGCGGTATTCTTTCAGTGATTCCACCGTGGGATAACTCG AGGTTTTGACGAATGTTGTCGAAGAATGGATTTGCAGGCTGAAACTTTGCCTGTGTGGAGTCGGCCATGC CGGTTGTTGTGACCGGGCCCTTGTCGAGTCGATGGAACGCGGCTGGGCGTTCGGTAACAGCAGTAGTCAT AGGGAAGGAAGAACCAAACGGATTGGATTGGAAGTTCAAAGACGGGGTGGGTGGGATAGTGAGACCCTTG GGAGGCGGTTGGCGTCCTGATGACTTGCCTCCGGTGGTCGACTCTGGAATTCATGGTCAGTTTTAACAAA AGCGAATATTGGTGATGACAGCAACTACCTACCATGCGAGAAGGCTAAAGATGCTAATCTACCTGCCATC AAACCTTTCTGAGCACCCGCAGCGGCCGCGCCCTGTTGAGGCTGAGGCCCTTCATCGTCGTCTGACACCA GCGGCAAAGCGCCGCTCAACTTCATCGCAGCGTGACCTCCTTTGACGAACCACAGTCTACCCGAATATCC TTCTCTCCCGAATTTCCCAGCAAGTCCATCCAATACCCCTCCGTCTGGAACGCTACCACTGTCAGCATCA ACCAAGACAATATCACTCTTTTCTTGCCACTTCGATACTTCTTGCATTGAATGTGGTGAAAGCATCTGCG TGAGTTTATCCAACGTGAAAGCTGGACGTCGAAGCAGAGTAGAGGGAATCGGGAGCGAATGAGATGAGGG AATATGCGATGACTGAAATGACGAAGGGGGCCGTACATCAAGAACGAGGGTAGTAGAATTGGGCAAGAGT TTTGCTAGATCAGTAGGTGCAATCATCTGTGGCTTCATGCCGCCCGGGGATTGAGAGCCGCTAACGCTTG ACGCCAGAGGACTGGGGGATTTGGTTGAGTGTGGGGTTGATGCGCCGAGAGTTGCTGAAGGAAGTTTTGT AGGGAGGGAATTCTTTTTTCTAGAAGCAGGTGCCAAAGGATTTGATTCACCGCCGATATCTGGCTTGCCA GCACTTGTTGCTATAGCCTTATACCTCATGAGTGTCTCTGCACTCAATCCTCCTCGGACGGGAGGTGCTG CACTGGTTGGCGCCTGCTTATTACTTGGTGACAAAGACATTGCCGGTGCTGCATGACTAAACTGTCCTTC GAAGGGAGATGTCAATGACTCTCCAAACTGTATTCTCGGACTGTCGTCCCGTAACATGCTGCTGCTATTG CCACCACCGCCGATATTGAGCCTTTCGAATGGAGATCCAAGATGAGGACTATTTCTTCCCATCGGAACTT CCAGTGACGGAGTGGGTGCACCTGATGACGCAGCCAAAGCAGCCCAAGGGGAGCTAAACTCGGTATTCGC GGTTGCTAAAAAATTTGGTTGTTGAAGTGGCAAGGAGAAGCCAGACGATGATCTGCTAGCAGGGGACGGA CGGCTTGGGGAACGAAAAGGTGAGGAGGCGGCAGGCGATCGTGTCGGGGAAGGGGAAAGGGGGTCGACAG GCGGCGGACTGCGAGGTTCAGAGGCAGATGGAAAATCTGATAACGTCGGGGGAGCTTGTCGACCCATAAT GTCTGGCGTGAAGCTGGTGGAATAAAGGACGAGATGATGGTATGAGTGATTGTGCCGATGAAAAAAAGAT GATGCGGGTGTAAAATATAGGTCGGTGATTTTTTTCTATTTTGTCTGTCTGGAAAAGAGTGATCGGATGG CCGGAGGCTGGTAGAATGTATGTACGACGGAGAAATCGTGATTAGCAAGCCGTGGCTGGCGTGTATAGTA TATGGCGATGGGATACCCGGGAACAAGTGGATGGTCGATGGTCGACGGGGGTGTTGACTGGGGATGGCAA ATGAATGCTCGTGCTCGACTGGCCGGCTGATGATGGTATGATGTGTAGTTATAACGTGTATGACGTGTAA TGACGCTAAGGCCCGGTGTTTGCGGAAGGAGTGCCTCTGTTAGGCGGGCCAGCACGAGAATGGAGGGCGG ATGGCAGGAGTAAGAAGCTATTGGGCAGGTATTGCTATGGCTATGGACTATAGGTGTGGTAGAAGTGACA GCCTAACTCTTCTGGCTACCGCTTGTTGCTGCATCAAATCCGCTCGCCGGAATCTCTTTGTACGAGTCTT TTTTGACTTTTCCTCGCCACTTTTTTCCCTCTTCGCCTGTCCCCATCACTGGAAATCTCTGCCCTGAGTA AACACCCTGGTTCCACAGCAGCCCTGATCGCAAAATGATGTCATAACGCTCCTTTTCCATTTCTTTTCTA TTCCAGCCCGCCTTTCGGCCTTCGTCGTCTTCCAGAAGCGGCGTAAGCCACCCAACGCCCAAAAGCAGAA AAAAAGGCACAAAAAGCATGAAACATGAAGACCGCATCGCAGTAGCCATTCCATTTTATAGCAAGTGGCT CAAATCTATACTAACCTTTATGCTACAAAAAGTCCTTTTTGCCGACCTTCGTTTCAGGTCCATCCACACG ACAGTAGCAGGAGCTTGCCATTGGGCAGTTGTTTGGCTGAATCGCGTGGGTTGGACGTTCGTAATCATGA CGTCTGCGATGATTCAGTTTGCGATGCGAGAAAAGGGCGAGCGACGACGAACGACGCGTCTTCAAGTCTA GTTGAAAAGAAAAACAGGCGGCCAGCGGCCAGCGACAATTAAT
Protein Sequence	>gi\|799324873\|ref\|XP_012048746.1\| protein-tyrosine-phosphatase [Cryptococcus neoformans var. grubii H99] MGRQAPPTLSDFPSASEPRSPPPVDPLSPSPTRSPAASSPFRSPSRPSPASRSSSGFSLPLQQPNFLATA NTEFSSPWAALAASSGAPTPSLEVPMGRNSPHLGSPFERLNIGGGGNSSSMLRDDSPRIQFGESLTSPFE GQFSHAAPAMSLSPSNKQAPTSAAPPVRGGLSAETLMRYKAIATSAGKPDIGGESNPLAPASRKKNSLPT KLPSATLGASTPHSTKSPSPLASSVSGSQSPGGMKPQMIAPTDLAKLLPNSTTLVLDVRPPSSFQSSHIP SSHSLPIPSTLLRRPAFTLDKLTQMLSPHSMQEVSKWQEKSDIVLVDADSGSVPDGGVLDGLAGKFGREG YSGRLWFVKGGHAAMKLSGALPLVSDDDEGPQPQQGAAAAGAQKGLMAGRLASLAFSHESTTGGKSSGRQ PPPKGLTIPPTPSLNFQSNPFGSSFPMTTAVTERPAAFHRLDKGPVTTTGMADSTQAKFQPANPFFDNIR QNLELSHGGITERIPLNLPDFVRKRADQFPDWLRELVTMPEQDSMDKLAHQFYQLELHEQKRLQAIMEWH AKGSGVLLQPTAGCDEKIHRNASEKKGWEWAIQRESDIKELKRLMNWERGIEDIEYFPFSITAGVERGTK NRYKNIWPYDFSRVRLDSPPDQDSDYINASFIQPRGTSRRYIATQGPLDATYRDFWTLVWEQNVRIIVMI TKQFEGGLIKCGNYWGEEQYGHIKLQLISQSGGEDTALPAANSGFDFGTAGATPKSSKFPEGSDSNIKRV FLVSHDGKPDQPPRKIVQLQCVGWPDFDVPETPDTLLKLIQEVNDAAHEARPEGCHRKADEPPILVHCSA GVGRTGSFIVVDAILDGLHRDLCQRGAAEARSVDEPARLPKVIPPQHSSSAPPATSLSAVASPEPVSQFS NLGAPSGSVARQHSTSPGTMPTQPEHQVAPDFSFPPKKQGSNETMEVDPPKAANGLDDRFMQYRMMSGGT SVSSDTDTRRPSLASVQTSSDRVSSESISSCLADPEPVTFSNRRRREPSPLSKMRDPVSCVLESMRVQRM SLVQTLRQYLFVHRAIIYHYLHMLDHDQVKERPNPSPLQKHVLSVGSSVSGSAIGSLGSLGTTNSGSGSY TDSLSTNSQADLTKGSVDEDSHTKRRASPTELHPDVRLGGEGGSELSKRPSFKKMKPGTTSGRMGRKSSA MWKGMEKEAVAEEAVAEELKN
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: PTP1 and PTP2 were found to be stress-inducible genes, which were controlled by the MAPK Hog1 and the transcription factor Atf1. Ptp2 suppressed the hyperphosphorylation of Hog1 and was involved in mediating vegetative growth, sexual differentiation, stress responses, antifungal drug resistance, and virulence factor regulation through the negative-feedback loop of the HOG pathway. In contrast, Ptp1 was not essential for Hog1 regulation, despite its Hog1-dependent induction (Lee et al., 2014).
References	*Lee et al., 2014:* Lee KT, Byun HJ, Jung KW, Hong J, Cheong E, Bahn YS. Distinct and redundant roles of protein tyrosine phosphatases Ptp1 and Ptp2 in governing the differentiation and pathogenicity of Cryptococcus neoformans. Eukaryotic cell. 2014; 13(6); 796-812. [PubMed: 24728196].


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PTP