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PMT4

Victor ID 5349
Gene Name PMT4
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23884742
NCBI Protein GI 799327247
Locus Tag CNAG_00996
Genbank Accession CP003824
Protein Accession XP_012049244
Taxonomy ID 235443
Chromosome No 5
Gene Starting Position 1479600
Gene Ending Position 1482716
Gene Strand (Orientation) -
Protein pI 9.24
Protein Weight 82213.22
Protein Length 767
DNA Sequence 
>gi|799350697:1479600-1482716 Cryptococcus neoformans var. grubii H99 chromosome 5, complete sequence
ACGAGGGTCACCACTAGGCGTGCATACGTATGGGATGTATAGGGATATGATAATGCCTCAGATGTGGGAA
AACTATTAAAAATCAAGTCGGAAGTGGAACAGCATTTCTGCGGCTCAGAAAATTATTTTGACTTCAGACA
GATCACATCTGAATCTATGGCAGTAACTATCCTTTGACATATCATCACTCATCCATCGAATGCGTCTTCT
TGGCCTCAAAGTGTAATGACCAAGTGCTTAACAATTTTCTTCGATTCACCTCTTCTCCGGTCATCCTACG
AACCCATGTCAGCTCAAATGTCATGTCATCGTGCAACAAATCGGCTATTGGGGGACTTACGATTGGCCAT
ACGTCAATGGACTCAAGAAGAGATACACGCCGATCACAACGACAAGCAAACCAGCAATCACCATTTTGGC
CGGCCTGTTCAGTTTGGCACGCACTGCTGGCCGTAGTCTTGTGGTCGGACCGGCAACACTGATGGGATAG
TTGACAGCCTCAATGAGGATAAAGTTCATCACCGAGCCGGCAACGAGGACGGAGGCAAGATGAGCGGGAA
GGTAGTGGTGCAAGAAACGTTGCCGACCCATGAGATAAAATGGGAAGTAATGGAACGCCCAGGCGCCGAG
GAAGAATCCAGTATTGCGGTACAAACGGTTTCGTACACCTGCACAAGTGTTATCAGCACAACTAAGCATA
ATAAGAGAAAGACGGCGCTTACCATCCTCGATAGGATGTATTCCTCGCCTCCTCGCAAGCATATCCGCAG
CAACAACTCCGACGTAGACAGACACAGAGACAGCACAGATCCACCAAGCAAGAAGGTTTCCGATCATATA
GATTTGTTGCTGACCCTCATTACGTGTCCAGAAACTGATACCACTCAAGCAGAACGGCCACTCGATGGGT
GTAGACTGATAAGGATGAGTGGAAGTAAGACCCGCATTGTGCTGAAGCATAAGAACTTGGAGCTCAAACC
ACTTTTTGATGAATGCACGCTTCTTGACGGCTTTGGGCTCGACATGAACCGTACGGTTCTTAAAGTCGAT
ACCCTGTCCATCTTCCACGATATCATTAACAAACCAGAGGGTCGATCGTTCGGCCGCATTCTTGTTTCCG
TTCACCTCCTGCTGACCGAATGCCCAATCAGGAAGCGCTTTAGGGTGTGTCCAAAGAGCGACCTTTGTAG
GTACATGGATAAGCCTAAAGTGCCCGGACAAGGTCTTCCACGCTTCGCCATCATGAGCGTCGTTGAGCAC
CATCTTGAACAAGGTATCGTTTCTTCTATCTTCCTTGTCGGGAGAAACAGTCGTGAACTCTTGGTTGGTC
GGCATAAGAGGTGAAGCTACATCGTGCGTAAGCAACAGTGTCTGGGTGTTGATATGCTTCAGTTGAATGA
CGTCGTTGTGTCGCACGATCCTGCCGCGACCAGACTCGGGAATTTCCTTGGTAGGAATGACTTGCCAGTG
GTTGTTTGTGTCATTGTGGGGATAGCAAGTTACTTGCTGGCCTTGAGAACTGATACGGCCGTCATCATAC
CTCAAGGGGTATCGTTCTTCGTGAGAGTGGAGGTATTGTTTCGTGTCCTTGTGGCGTAAGGTGATAGTGT
CATAGTATCGGATTTCTTTGTAATGTCAAGTCCGTTAGAAAACACTTGGAGCTAGCTAGCAAGAACACTC
ACCTTGAGCGTTCAACAGCAACTCATTACCTTGCAGAGTTTCCTGGAAAGCAGGGCTCATGAAAGAATCA
CCGGGACCGGAAAACTTGAGAATCTTGAAGTGCGCCCAGAAGAAAGACAGGTAAACGAAGAATGGTACGA
TTACCAGTCCGATGGCACGGTAACAGAAATGCCTGGTCCAGTAGGACTAGGGGATCATAAGCTACTGCAA
CTATCACTAATTGATATATATCCAACATACCATAGAATGGCCCCTTTTGATGTCCAAAATCTCCCACAAG
TCCCAAAGAACAGCAGCGCCGACTGTCGCAAAGGTGAACAGCCCCACCATCTTGCATCCCAAGGTACAAG
CCAGCCAGAATCCAGTGGCGAGCAACCATCCCCACCAAGCCCGGGAAAATTCTTGGTATCTGTACTGGTG
GAATTTAACGTAGCAGAAAAGGGAAAGGGCCATGAAGAGAACGAGAGCAGCGTCAAGGAGAATGAGTCGA
GTCTGGGTAATGTGACCGTTGTCAAATAGGATTAAAGCCGCAGAAAAAGCAGCAATGCCGACCGGGTAGC
CAGATTCTCGCATGATGGCGTAGACAACAGGGATCGTGAGAGTGCCGAGGATCGCACAGAAGCTTCTCAT
CCCGACGTAGGGAACCTTCCATTTTGTTAGCGCTCTTTCTGAATGTCCTTCATGGGGGAAGTTGAATTTA
CTTACACCAGCGTCTGTATAGCTGTCACCAATTTGATCAAACCCAAAGTTTCCATCAAACCCAACAAACC
AGGCGGCCAAACCATTCAACATCTTTGCCAAAGGTGGATGAACATCGAAATAATACTCCCTCTTGATGTA
CTGAGCTGCAAAGGACCCAAAGTGGACTTCATCGAAGACGACTTGGTCCGGGTGGGCAATGCGCCAGAAT
CGGACGATGCAGGCAACGACGGTCAAGGCTGTTGCTGTTGACCACGATATGATGTACTCATTGCGAAGAG
AGGGGGCTGAAAGGTGTGGTTTGGGGGTACGTTGCTGTTTTGCCCGAAGGCATATACTTGATCAGTCTAT
AATTCTAATTTGGGACAAATTGCAAATTCACCTTGTCGTCGTCGCTGTAAGACCTGACGGGCAAAGATGG
GGTCTCATTCCTGTCCGTGCGCCTCTTGCGAGGAGCGAGAGACATATCTGGAAGATGGAGTTGGGATGAT
AGGTGGAATAACAAAGGGCTCTGATATATATCTATCGGGAGAGCACGAACAAAGAAAGATGGCCGGAACG
AAGCGGTGAGCGCGGCTGCAACGCAAGTTGCGGCGACAGCGCGACTAGTTCTTTAACGCGACCGACTTCG
TTGTGATGTGGCACGTTTGATTGACGCGACGTTGAAATGGATGTCTTGTAATTATTTGACAACTTGTACT
CCATTCTGCTGCCGATGTTTAGGCTTTGTCAATGGAA
Protein Sequence 
>gi|799327247|ref|XP_012049244.1| dolichyl-phosphate-mannose-protein mannosyltransferase [Cryptococcus neoformans var. grubii H99]
MSLAPRKRRTDRNETPSLPVRSYSDDDKQRTPKPHLSAPSLRNEYIISWSTATALTVVACIVRFWRIAHP
DQVVFDEVHFGSFAAQYIKREYYFDVHPPLAKMLNGLAAWFVGFDGNFGFDQIGDSYTDAGVPYVGMRSF
CAILGTLTIPVVYAIMRESGYPVGIAAFSAALILFDNGHITQTRLILLDAALVLFMALSLFCYVKFHQYR
YQEFSRAWWGWLLATGFWLACTLGCKMVGLFTFATVGAAVLWDLWEILDIKRGHSMSYWTRHFCYRAIGL
VIVPFFVYLSFFWAHFKILKFSGPGDSFMSPAFQETLQGNELLLNAQEIRYYDTITLRHKDTKQYLHSHE
ERYPLRYDDGRISSQGQQVTCYPHNDTNNHWQVIPTKEIPESGRGRIVRHNDVIQLKHINTQTLLLTHDV
ASPLMPTNQEFTTVSPDKEDRRNDTLFKMVLNDAHDGEAWKTLSGHFRLIHVPTKVALWTHPKALPDWAF
GQQEVNGNKNAAERSTLWFVNDIVEDGQGIDFKNRTVHVEPKAVKKRAFIKKWFELQVLMLQHNAGLTST
HPYQSTPIEWPFCLSGISFWTRNEGQQQIYMIGNLLAWWICAVSVSVYVGVVAADMLARRRGIHPIEDGV
RNRLYRNTGFFLGAWAFHYFPFYLMGRQRFLHHYLPAHLASVLVAGSVMNFILIEAVNYPISVAGPTTRL
RPAVRAKLNRPAKMVIAGLLVVVIGVYLFLSPLTYGQSMTGEEVNRRKLLSTWSLHFEAKKTHSMDE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Disruption of the C. neoformans PMT4 gene resulted in abnormal growth morphology and defective cell separation and attenuated virulence (Olson et al., 2007).
References
Olson et al., 2007: Olson GM, Fox DS, Wang P, Alspaugh JA, Buchanan KL. Role of protein O-mannosyltransferase Pmt4 in the morphogenesis and virulence of Cryptococcus neoformans. Eukaryotic cell. 2007; 6(2); 222-234. [PubMed: 17142566 ].