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PLC1

Victor ID 5348
Gene Name PLC1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23888974
NCBI Protein GI 799332333
Locus Tag CNAG_05677
Genbank Accession CP003826
Protein Accession XP_012050330
Taxonomy ID 235443
Chromosome No 7
Gene Starting Position 589054
Gene Ending Position 592716
Gene Strand (Orientation) -
Protein pI 5.26
Protein Weight 90581.67
Protein Length 851
DNA Sequence 
>gi|799350762:589054-592716 Cryptococcus neoformans var. grubii H99 chromosome 7, complete sequence
CATTGAATATGTACATGCATAATAAACCGTAAGCAGACGACTTCCATCACACTGTATACTATCGAGATGT
GTACTACTTGATAGATGTCAGATATTCGCACCATTTTCAGGCGGTGGTTGATTTGCTAAGCCCATCCCAG
TCCTCATTAGATCTAATCGGGTAGAAAATATCTCAGTCAGGAGAAATGCCGCAAAAGAAGAGTCTGTCCA
ATACGAAAGATGCGCAGTCAACATGTCTGCGATGTTTATTAGGGGCGGTATTTCGGTTTTCAGTATCCCT
TGGTCTGGGTGAAATCTCACCTAGATACTCGTTAACTCCAGCCGACGGCAAGAAGAAATCCACGTTGCCA
TGTGGATTTAGAGCAGAAAATCGTCGTTCGCCTCGAGATCCTTGGAGTTTCTCTTCGCCATTAGGACCAG
TCATCTGTAATATCTCCTTAATCTTCAAAGCTTTGATGCCTAAGGGTCAATTGCTCACCTCGATCCCACT
CGGGAGTCGGAAGATACCGGGCCTATTACCGGACCTTATATCATTGCCCCCACCCCCTCCAAGTATGGCG
GGTATATATCTTGAGATAGAACTAATGCTATCTGCGACAGGAGCATAAAAGGGAGCTGTCATGGACATTA
TGGCGAGAGGGGGCCTTTGAGATGCTAATTGGGAGTCGACAGCTGCATTCAGTTGATAGCTACAAAATAA
ACGAGTGCGTTTAGCAATGGAAAGGCGAGACCATGTGAAGTGACCGAAACAGTACATACGCGATAGGGTC
CGTATGGTAGAAGACATTGTAAAGGCTGAGAAGGAGTTAGTATAAAATAAGCAAGAGGTTGACGATGACG
CACGAATCTATAGCCAAGCATCCGAATCTTCCCGCTCGGTCAAGCTACAATACATGGGCCAGAAGTCAAC
AATCATATCAATGTTGCGTGTTGCACTTCTTACCGCTTCATCAGCTGGCGATTCTGGCAAAAATATCAGC
AGGGCCCGACATGAATATAAGTCCGCACTCACGCATAGTCCTTTCCCTCCCCTTTCTCGGCATAAGTTGA
GCTTGCTCAAGGTGCAAGAATATCCCAAGAGGGCTGCCTACAAGAAAAAGATTGCTTGTATTGAAAAGAA
AGCGGTCCATTGTTTCGGAGATGACCTGTTTAGGAAGCTGTGATAATCGTGGCATTTTAGTGGGTTGATT
GGATAAAATATGGGCTACCAGAGCGGATCCAAGCTTTGTAAAGTTTAGCGCCCTACTTTTAGCCCGCGGT
TCCGCAGTTGCATGCCTTTAAGACTCACGGAGTGAGCAATGATATGGACTCTTCCATACTCTTGAAAGTG
TGGGTTTCTAGCAATCCAAAGGCGATAAAGTTTATTAGCCTGCGTACAGACGGCCTCAATCATTTTTTGT
CTATGATGTGACATAAAAAGAGGTATATCCAGTAGTACCTACCCCATGACATGTAGCTGTGAGCTATCCT
CAAGTTCCCTATCACCACTCAACACTCACAGAGTTGGTAAGTTCACGGACATATGGGATTGAGCGATGTA
TCGTGATATCTGTTAATAGATAAGTTAAAGTGTTATTTATTACCATCAATGCTTGACGAATACTTTCCAG
ATATGGTAAAACGGTTGTCTATCCCGTGGAGCAGCTCTTCTTCAGTTTTCCGTTCATCCAGGTTGAGAGA
TGTTCGCCATTGTACTGGAAGTACCTAACGCACTCACGTGTTAACGCAGGAAAGCTAACATGAGAATGTT
GACTTACTTGACATCTTCGATCTCTTATGATTGAAGCAACTGCAGGGTTGGAGGTTTGCTTTCTGGAGAG
AATGTTAGGAGAGAGAGAATGTCATTTCCCACTTACCTAAGCACCTGTCGCAATTGATTGCCAGCATAGC
TGCCAGTTCATCAGTGATTCAGATCGGAAACCATGACTCATGGCGCTCACACGAAGTTATATGCCTCGTT
CTGAGCAGCAAGCTGCTGCCCTGCGAGCAACGATGATATAGGAATTGCAGCTTTTGAAATGAATTTCCTC
ACCTATGCCATGTACTACAAGAATAAGGTCAGTACATGGATTTACGTCTTCGGTGTCGTGAACCTGTCAA
TTTTACATCAGAGTTTTGAAGACGCATCCCTCAGAGGATGTACCAACTAAAGGAGCATTTTGCTCTTCCA
GCGCCCTTCGTTCATCATCATTGCTTCCTGACGCTGGAGCTTGGCGTCGCTCTTCTCGAAGATCGTAATC
TTTGAATCCCTCTTTCATTCCTTCTATGGCCTGTCCTGCGGTCTCCCTCACGTCTTTGAATGCAGTGTCC
AGAGCAGCTAAGGGCTGGTTGTGCTTTTGGTTCTCGGGCAAATTAAGACATCCATCCTGAGTATAGTCCT
TTTCGTAACCTTCGTAAGAATGGCTTTTGGTATTGACGTGACCTTTCCCTTCTGGATCCATGAGAGTAGC
GGTAGTATCTGCTGCCGGCTCTACTTTCGCCGAACGCGCAGCGCTGTAGCCCCGATAGACATATGTGCCA
GCCGACTGGGCTTTTAAAGAAGACCAAAACAAGCGTGTGATATATGTGAGAGTTCCGGACCTATTCAAAC
TTATATTTCAATCTGGAGACAGATTCAAACATGAACTCACGTTACAATGCGGCCTTTTGCACCGTCTTCA
AATATAATGCCCAGACCATCTCCGAATTTCGAAGGAAGCGTATATTTGATTTTTTCCTCCCCTGAGGTTC
CCAGCGATAGTGCCGTAGCGAGTTCGTGACTGTATGATCGCTGGACAATATTTGAGAAAGTAAGCAGAGA
CCCGATCCATCATTCTCCATCCTCTAAACCCACTTGCCACGGTTGAATCTCCCTAAGAAAGAGCGGCCTT
AGCCTCTGACCATCCAAGTTAGATATCTATACTCACAGGTAAGCCTTCTCCAGTTCCTCGGCAAGCTCCC
AGCAGCAAGGCCTCGATTCGTCATTTACAAACCATGTTCCCCGCAACACTGCCACTCGTGGGCCTGTATG
AGCCCAAAATACTGGATGAAGCGACAGAGTGGATAGTGATACCTCAAATAATGAGTCCTTATGGACGTCC
ATCAGACATCATTCGGAGTTATTTCACAGTCAAAAGTCCTGAACACTTACTTGACTGACGGGAACGCCTT
GGACTAAATCCAAGTCATCGTTCTTTCCCCTAGCTTCGAGTAATAATGCATGATACTGCTTGTTGATTTG
TTCTTCAGATGACATATCATCCACGTCCAGATCCAAATGCTCCTCTGCATCTTCTCTCTTCATTTTGGAA
TCAACTGGATGTGCATCTGGCCGATCTATCGCGTCGCATCCTTTACTCTCTTTAGCAGCCTCCTCATTAT
GACCGATCTCCTCTCCTTGTTTTACTATTTCCTCTTGACTTTGAAAAGCCCCCTCGCCGTCATTTCTTCC
CCACGATTTGATTGTTTTGAGCCTATCAGACTCCGATATACTTTGCCACCGTAGTTCTATCCTTGAGGAC
TCGCTTTTTGAGAAAGCTTCAAAGCTGTTTGAAGCAGAAGTGATAGGGGTTGGAAGAAGATTGAGTTGTT
GAGCACCTGCGTGTACCCATCGTACGTCTAAAGCAGGCACTGCAAGAAGAACGGGAGGTTCCTCCAGCCG
GGCATCGGGAGAGGGAACAGACA
Protein Sequence 
>gi|799332333|ref|XP_012050330.1| phospholipase [Cryptococcus neoformans var. grubii H99]
MSVPSPDARLEEPPVLLAVPALDVRWVHAGAQQLNLLPTPITSASNSFEAFSKSESSRIELRWQSISESD
RLKTIKSWGRNDGEGAFQSQEEIVKQGEEIGHNEEAAKESKGCDAIDRPDAHPVDSKMKREDAEEHLDLD
VDDMSSEEQINKQYHALLLEARGKNDDLDLVQGVPVSQDSLFEVSLSTLSLHPVFWAHTGPRVAVLRGTW
FVNDESRPCCWELAEELEKAYLEIQPWQRSYSHELATALSLGTSGEEKIKYTLPSKFGDGLGIIFEDGAK
GRIVTSGTLTYITRLFWSSLKAQSAGTYVYRGYSAARSAKVEPAADTTATLMDPEGKGHVNTKSHSYEGY
EKDYTQDGCLNLPENQKHNQPLAALDTAFKDVRETAGQAIEGMKEGFKDYDLREERRQAPASGSNDDERR
ALEEQNAPLVHDTEDVNPCTDLILVVHGIGQQLAAQNEAYNFVKQTSNPAVASIIRDRRCQVLPVQWRTS
LNLDERKTEEELLHGIDNRFTISGKYSSSIDDITIHRSIPYVRELTNSVLLDIPLFMSHHRQKMIEAVCT
QANKLYRLWIARNPHFQEYGRVHIIAHSLGSALVAHILSNQPTKMPRLSQLPKQVISETMDRFLFNTSNL
FLVGSPLGIFLHLEQAQLMPRKGRERTMQSPADEALDRAGRFGCLAIDSLYNVFYHTDPIAYQLNAAVDS
QLASQRPPLAIMSMTAPFYAPVADSISSISRYIPAILGGGGGNDIRSGNRPGIFRLPSGIEMTGPNGEEK
LQGSRGERRFSALNPHGNVDFFLPSAGVNEYLDMLTAHLSYWTDSSFAAFLLTEIFSTRLDLMRTGMGLA
NQPPPENGANI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Plc1 is a central regulator of cryptococcal virulence, acting through the protein kinase C/MAPK pathway, that it regulates release of Plb1 from the plasma membrane and is a candidate antifungal drug target (Chayakulkeeree et al., 2008).
References
Chayakulkeeree et al., 2008: Chayakulkeeree M, Sorrell TC, Siafakas AR, Wilson CF, Pantarat N, Gerik KJ, Boadle R, Djordjevic JT. Role and mechanism of phosphatidylinositol-specific phospholipase C in survival and virulence of Cryptococcus neoformans. Molecular microbiology. 2008; 69(4); 809-826. [PubMed: 18532984].