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PKH2-02

Victor ID 5347
Gene Name PKH2-02
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23886463
NCBI Protein GI 799320505
Locus Tag CNAG_02915
Genbank Accession CP003822
Protein Accession XP_012047847
Taxonomy ID 235443
Chromosome No 3
Gene Starting Position 455883
Gene Ending Position 460437
Gene Strand (Orientation) -
Protein pI 9.68
Protein Weight 124017.02
Protein Length 1230
DNA Sequence 
>gi|799350639:455883-460437 Cryptococcus neoformans var. grubii H99 chromosome 3, complete sequence
GTCAACCGCTGAAACTCGATACATGTGAAAAGAAAACGCAACGGTGCTACAAATAAATACAGATGGCCCA
GTGACGACCTTTTTTTCCCTTTTTCCGTCTCCATCAACTATTTTCTTTTTTCTTCGCTCTCAGGATTACT
TGACCAGTGTTGAATTTCGTGTTTTGCGTTTTCGTGCTCTTCGTGCTTTTCGTGCTCTTTGCCGTGAATT
GTTACATTTTGCATTGTCCTGAGGGGTGGGGGGGCCGGACGTCGAAAGCGAAGAAGAAAAAAAAGCCGGT
TTACAACCCGACCCGGTGAATTGCCGCCATCCACTTTGCTCTCAACTCTACGCTATCCACATGGCAATAG
TAAACCATCCCGGGCTATCGGTATCACATTTTCATCAGTAAAACCCCCCCTCCCCGACTTGACCCCGTTG
ACTGGGATCGCAAAAAGGCAGAAAAAGACCCCTTGACTCACAGTCTGGACAGTAAACCCTTTACTCCCCT
TTTCCTGCACATCCATCACCGCGTTCGGTACGGCAGAGTAACCACCACCTTTTGTTGTGGAAGATCCGGT
GGCAGTCGACGGCCGGGGAACAAACACGGCTTCTCCCTTGATCCTCAACGATCCATGCCCGCCACCACGG
CCACCACCACCAACACCACCACCACCAGACTCGACATGTGACGACGACGACAACCCGGCGCCAGAATCGG
ACCCTGCTGGATCCCCATCCGCTTCGTTATCGTCCTTGATCATCAACAACCTCGGGAAATCGGTCAGGAC
TAATTGTCTCTTCTTGGGGGCTGGTAACAAGAATGCGGGGAGGTGTAGCTGAAGAGCGGGGGAGGAGGTA
CGGAGGGTAATGGGGGAGGTGAAAATGATGGATTCATTGGCAAGAAGAAGGGGAGTCCTAAACCATACAT
TGTTTTAGTTGCCATTTCCCTCTTTTCTTTCGTCACAGAATGCAATCAAAACACGTACCATTTGTCAAAC
TCTGAGGCTTTTGACATGTTCATCCGCAGTCCACCAAGAGACATTGACAAATCTCTCGCCTCATCGCTCC
TCATACTCGCCCCACTTCCCCTGTTGGACCTCGAACCACTGCCAGGTCCAAGTCCAAACGACGGGATGCC
AGCACGCGAACCAGGCCTCGAGCCAGGCCCCGTACCCGTACCCGTACCAGGCGTTCGAACCGTGTCACTC
GCCGCCACGCTTGTCGCACTTCCACTCATCCCGCCTCCCCCTGCCCCACCAAACTTGATCGCCTCCAACC
ACCCCGCCAACGCCGAGCGGTTCCCACCCGAACTCTCACTCCCGTGACTCAATCCCCGCGCTTTTTCCCC
CTTCTTCTTCTCCACTTCCTTCTCCCTTTTTCCGCGTCCCCCTGTGCCAGCACCGGCATACGCAGGTCGA
GGAGGGTCGAGGTCTTCGCCAAGGTTGATATATTGGTTTCGTAATCGACTAAATTTCGGATGATCGACAT
TATGCACTGCGCTAGCCGCGGCGCGCCGGTCAAACAGAGGTTCCATCATCCCCTCCCCAACCGCACCGCC
CTCTGGCCGGGGCGATACAGTATCAGCATCATATTCAAACCCATCCTCATCCTCCTCACCCACATCGCTC
CCTTCAAACACACCCCAAATATCCGACGCTTCAAGCTGGGCCAACGTCGTCGACTTGCTTGGTTCTCGCA
GACCACTGGATATGGGAGGAGCAGGGATGGTCCAGAGTGTGGAAAAGTCGATAGACTGGAAGAATGGATG
GGTTTTGATGAATGTAATGCTAGGTCGAAGATTGGGTTCGAGGTCCTAAAATTAAAAAGAAAAAGAAGAT
AAAATAAAAAAAAGTGAGGATTTTTCTCTCTCGAGGTATTTCGTGACTTACAAGAATGGTGTCAATGAGA
GATTTTGCATCTTCATCAATACCTTTTGGGAACTCCACTTCTCGTTTCAAGATCTTTTGAAAGGTCAAGT
AATCTGTCGCACCTCGGAAAGGGGGTTTTCCACAGATAAACTGGTAGAGAACGCACCCAAAGGCCCAAAT
GTCGGATCTGTGTTACATCAAAGGGCAAATTCCAAGGTCAGCAATTAATTAAAAAAAGGGAAAAGGAAAA
CCATTGTAAACATACGCAGTGGTTGCAACTTCGTTTCGCAAGACTTCAGGACTGACAAAGTCCGCGCTCC
CAACAAACGATCGGCTTCTTGAACTGTCATCTACGATCGGCTCGTCCTTGGCAATGATCTTGGCACTTCC
GAAATCTGTAATCTTGATACGCATATCCTCATCAAGAAGAATGCTTAAGATACATGAATCAGCATGCAAG
CCAAAAAAAAAAAAAACAAAAAAACAAAAAAAAAAAAACAAAAAAACCACGAAGAAACTTACTTTTCCGG
CTTGAGGTCACGGTGGATGACACCTCGGGAATGCACGAATTCAAGAGTATCGATCAACTGAGCGGCATAG
TACCTTGCAGAAGTGATATCGAGCGAGCCATGTTTGCGAATGATGGATGCCAACTCGCCATTACTCGCAA
GGCTCAGTACAAAGTCTAGCATTTTTTCCCGTTAGCTCCCCGTCGCTCCCTCTCTATATAAGATGAAAAA
TGAATCCGCTTACAGAGTGAAGAAGAATCATTAAAAGTCGAATACAATCTGACAACACCCGGGTGCGCAG
CAGCAGACATTTTGCCTGTAGTACTTGCACTCTTCACAGATCTCTCACTCGGGGCCAACGACTGACGCCG
GCGTTTAGGTGTCAGGTGAGGTCGATCTCGGGGGGTTTCTCTGCTCGTACGATGTCCGTCGGTTGACAAA
AGGGGCGAACCGCGTGGTTCGGGAGTAGAGGGTATCTGAGGTGGAGGAAGCGTAAGGTGGATGGCTGCTC
CGAGCTCTACAGGTTCTGCACCTGACCGCTCCTCTTCGTCCTTTTCCTTTTCTCCGCCCTCAGCTGACTC
TTCCCTTACAGGTGAGGGAGGACGAGACCTTGTCATATTATCCCAATCTCTATCCCTATCCCATTCTCGT
GACGGTGTCTCCTGTCCATCTTGCCCATCTTTTCCATCTTCTCCACCACGAATAAGCATCTCAGTCTGTT
CCTGCACCGGTGTCGGAGGTTCAGCTGAGCGGCTAGGTCGCCTACCCTTGATATTGCCACCACCTCCACT
TACTGCAGTCGGAGAGAGCTGAGTGCTACCACTCGAAGCGGTAAGGACGGGGCTGGAAGCGGCACTCGAG
GTGGTTACGATTGAAAGGCGATCGCGCGTGTCTTTTTTGCTGTTGCTGACCGTCCCGCCAGAGACTGAAG
CCATACTGGACTGGCCACCTATGCTAGCGGTGGATCTGCGTTTCCCAGCGCTTCCCGTCTGGGCATACCC
ACTACTCGAAGAGCTCGATACACCTCGCTTATGGCCCTTGGAAGGTCGAGGATCAGATAATCGAATAAGA
GCGTCCCGCTCTACCATTGCGTACTTGACCTTTTTCTCTTGAATAAGATGCGCCTGGTTGATAACCTTGA
GGGCATACTTTCTCGCCGGTTGAGGAGAAGTAGGAGAGTGTGTGTTGGCAGAAGGGGTGACACAGTAGAC
TGTAGAGTAGGATCCGACACCGAGCTCCTCACCAAGAACCCAGTCGTCCAAGCTGTGTTTCTTGAGAGCT
CCAGAGCTCGCGCTTGAAACCTGGCTCTGACGACGCTCTCGATCATCTCCATCTCTCGCTCGACTCCGAT
GACTGCCTCCCCAGTTTTGTCCAGCGTCCACACTAAGTGTCCTTGGCTTCCCCCCAAGCGCCCTATACGA
GTTTGTAGGTGATGAAGGCGTGCTCAAATGGCCATGTCGGCCGCGTACGGGCGAGTTACCGCTTGAGCGT
GGCCGTTCGGCAGAGTGGGATTCGCGGTCATGAGAAAGCCGATCATTTGGGTCAACAGAGATGGTTACGC
GGAGAGGAATCGTGCTGCTATTTGGCGAGAGGTCTTGCTGGGCTAAAAAGGACTTGCCGAGAGGTGTGCT
TGGCGAAGTACCCGACACAGTCTCAGTGTTTGACTGTCTTTTGGAGGCCATGTTGAGGATTGGAGACGGT
GACGGTGACAAGGCGACGATGGAAGGTGGCACATGCCTCGCCTGTGGACTTGTCCCAAGTCTGTTTGATC
TTGGGCCATTCCTGGCTAATCCGCCTCGTCCTCCGACACTCAATCCGGGACTGGTGTAACTCGTATCGTG
CTCTGCCTCGTTCTCACTGTGCCGATTGGACGGAAGCTGTGACCTGCTTGTGGCTGCTGTAGAGGTCTCT
ATGGGTGGTGGGCGCATGGGGACTGCCTGTACGGAGGAGGTGGAGGAGCATGTTGTGGTGGAGCGGGAAG
AGGAGGAGGAGGAATTCCTGGTGATAGTGGGTGCGATGAGGCGGGCGTAGGCGGAAGAAGGAGGCGGAGT
GGAGGAGGCGGGGGAGGCGGGGCCGAAATGCGAGGAGGCCATGGTGGCAGCCTCGGGTTTTTTTGGAGAC
AAGCATGCAATAATGAAAGGAAAAGAGACTGAATGTTAATGAAAGAAGACAACGAAAGAACAGCAACGGG
ACCAA
Protein Sequence 
>gi|799320505|ref|XP_012047847.1| AGC/PDK1 protein kinase [Cryptococcus neoformans var. grubii H99]
MASSHFGPASPASSTPPPSSAYARLIAPTITRNSSSSSSRSTTTCSSTSSVQAVPMRPPPIETSTAATSR
SQLPSNRHSENEAEHDTSYTSPGLSVGGRGGLARNGPRSNRLGTSPQARHVPPSIVALSPSPSPILNMAS
KRQSNTETVSGTSPSTPLGKSFLAQQDLSPNSSTIPLRVTISVDPNDRLSHDRESHSAERPRSSGNSPVR
GRHGHLSTPSSPTNSYRALGGKPRTLSVDAGQNWGGSHRSRARDGDDRERRQSQVSSASSGALKKHSLDD
WVLGEELGVGSYSTVYCVTPSANTHSPTSPQPARKYALKVINQAHLIQEKKVKYAMVERDALIRLSDPRP
SKGHKRGVSSSSSSGYAQTGSAGKRRSTASIGGQSSMASVSGGTVSNSKKDTRDRLSIVTTSSAASSPVL
TASSGSTQLSPTAVSGGGGNIKGRRPSRSAEPPTPVQEQTEMLIRGGEDGKDGQDGQETPSREWDRDRDW
DNMTRSRPPSPVREESAEGGEKEKDEEERSGAEPVELGAAIHLTLPPPQIPSTPEPRGSPLLSTDGHRTS
RETPRDRPHLTPKRRRQSLAPSERSVKSASTTGKMSAAAHPGVVRLYSTFNDSSSLYFVLSLASNGELAS
IIRKHGSLDITSARYYAAQLIDTLEFVHSRGVIHRDLKPENILLDEDMRIKITDFGSAKIIAKDEPIVDD
SSRSRSFVGSADFVSPEVLRNEVATTASDIWAFGCVLYQFICGKPPFRGATDYLTFQKILKREVEFPKGI
DEDAKSLIDTILDLEPNLRPSITFIKTHPFFQSIDFSTLWTIPAPPISSGLREPSKSTTLAQLEASDIWG
VFEGSDVGEEDEDGFEYDADTVSPRPEGGAVGEGMMEPLFDRRAAASAVHNVDHPKFSRLRNQYINLGED
LDPPRPAYAGAGTGGRGKREKEVEKKKGEKARGLSHGSESSGGNRSALAGWLEAIKFGGAGGGGMSGSAT
SVAASDTVRTPGTGTGTGPGSRPGSRAGIPSFGLGPGSGSRSNRGSGASMRSDEARDLSMSLGGLRMNMS
KASEFDKWTPLLLANESIIFTSPITLRTSSPALQLHLPAFLLPAPKKRQLVLTDFPRLLMIKDDNEADGD
PAGSDSGAGLSSSSHVESGGGGVGGGGRGGGHGSLRIKGEAVFVPRPSTATGSSTTKGGGYSAVPNAVMD
VQEKGSKGFTVQTPGMVYYCHVDSVELRAKWMAAIHRVGL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Pkh2-02-mediated signaling in C. neoformans is crucial for stress tolerance, host-pathogen interactions, and both temperature-dependent and -independent virulence (Chabrier-Roselló et al., 2013).
References
Chabrier-Roselló et al., 2013: Chabrier-Roselló Y, Gerik KJ, Koselny K, DiDone L, Lodge JK, Krysan DJ. Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes. Eukaryotic cell. 2013; 12(1); 12-22. [PubMed: 23087368 ].