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PKA2(Cryptococcus neoformans var. neoformans JEC 21,serotype D)

Victor ID 5346
Gene Name PKA2(Cryptococcus neoformans var. neoformans JEC 21,serotype D)
Sequence Strain (Species/Organism) Cryptococcus neoformans var. neoformans JEC 21
NCBI Gene ID 3253199
NCBI Protein GI 58258927
Locus Tag CNA05510
Genbank Accession AE017341
Protein Accession XP_566876
Taxonomy ID 214684
Chromosome No 1
Gene Starting Position 1478933
Gene Ending Position 1480764
Gene Strand (Orientation) -
Protein pI 4.82
Protein Weight 50154.92
Protein Length 482
DNA Sequence 
>gi|58271746:1478933-1480764 Cryptococcus neoformans var. neoformans JEC21 chromosome 1, complete sequence
GTTGAAATAAAAACAATGCATCACTTGGTACAAACTTTCTTAAAGGCGACAATTTACGTTTCTACTTTGC
TGTAAAGGAACGGACTTCACATGGAGCCCCTCCCTGTCGAAAATCCATAACGCTCACTGACAGATCTTGC
CATGATGTCCTTGACAGGTCCAAGTAGCCTAGTAAAGGCTTGCTCACCAAGAGCGGCGACCCGCAACTTG
TCGGGCCCTTCAGCGCGTATAGTAGCTGCTCGCGTCCTACGATTGAGGAGGGCAAGTTCTGCGCAATGTG
TCAACTGACTATGATACGGTGACGCCTGAGGCTCCGCGTGTGATGACAGGCCGACTTACCACCAAAGTAC
TCTCCCTGACCCAAGTGCTTCACGACGGACTGATTTCCATCCTCGTCGGTCTTAATGGCCATTGCGTTAC
CACTCTCGATGAGGAAAAACTCGTCGCCTGCATCGCCCTGACGAATGACGTCTTCTCCTTCATTGTATGT
ACGAGATTCGAGAACATCCGCAATTTTGGCGCGTTCTTGGGGTTGAAGGGAGGCCAGAATGGGGACTTCG
GAAAGAAAAGATTCGTATAGTCGGCGCTTACGAGATGTGTGCTGATCATTCATCAGCGTGCTATTTCGGA
TTACATTTTGTGAATATCTCTTACGTCGAGGAGAATTGTACGGAAAGAGACTCGATCCAGAGCCCATAGA
GTACAAGGGGTGAGAGAAATTATGGAGGCAGCTCGAGGAGCACTGCTCTGCTGGTTAGAAAGATGAATGC
TTAAAAAAGTGGAAGTGTACTAACTTGTGCATCAACGCTAACTCCCCAAACGAGCTCCCCTCGGAACACT
CTGCAACCTTCTTTCCCAACCCCTGTCTATCTCCCTTTTCCAGATCAAGCACCTGCCCTTCCTTGTTGAC
AAACACATCCAACCTTCCATTCTCAACGATGTAAAAGAAGTCACCGGCAGCACCTTGCTCGATGACCACT
TCACCGGCGTCCATCTTCACCTCCTTCATAGCTGCGAGAACATCGGCCTCCTGTTCATCATCAAGATTGC
GGAAAAGAAAGTTGGGCTTGATAGCTTGACGAATGCGGGCAAGTTGCTCTTCAGATTTAGGAAATACAGG
AGTGCCCGAGCTAAGGTTATGCGTATTTTCGTCCTCTTCCATGGTGGTCTCCAAGCCGCTTGTAGGTCCG
TAAGCTCTCTGGCTGGTCGGAACGAGAGACTCAGCAGAGACAGACGTCCTCCGGCCGAGAGCGTATGAAG
GCACGGGCGGATCATCCTGAGCCCCGTGCGATTGAGACTTCTCGCCGAACGGGGAATTGCCAAATGGCAT
ACCACCTCCTTCACTAAAGGGACTGCGGTCATCAGTACGAAGTACGCCAGAAGAGGCGCTGAAAGGCGTG
GAGAACAGTGGCTGGACTGAGAGATTAGATTCTGTCGGAACTGTGGCTCTGCGAGCTGTGGGGCCGAAAG
GCGAGTCGGAGGGACCCATCTCGGAGAAGGGAGAGAGAGTGTGTGGCGGAAGACTACCAAAGTTGGTAGC
GTTGAAGGCCAGAGTGCCGGGATGGGCTTGCCTTGTGGATGCGTTGGAATTTTGTCGCTACCGGATGGAA
GTCAGTTAAATAGAGCAACATATGTAGGCGTACGAACCTCTTGACGGAGCTTGTGCTGGAACCAATCTGC
GCCCCACTGAAGGACATCTGTAGGATTGTCGAGGGCGATGTCCCTGTTCAGGTCATTGAGTATATCGGTC
CAGGAGGACATGATGTATGGTCTCCTTTGTTGAGCATATATATGTATAAAGGTGGAGTAGAGCCGTGGAG
GAATGAGGCAGG
Protein Sequence 
>gi|58258927|ref|XP_566876.1| cAMP-dependent protein kinase inhibitor [Cryptococcus neoformans var. neoformans JEC21]
MSSWTDILNDLNRDIALDNPTDVLQWGADWFQHKLRQERQNSNASTRQAHPGTLAFNATNFGSLPPHTLS
PFSEMGPSDSPFGPTARRATVPTESNLSVQPLFSTPFSASSGVLRTDDRSPFSEGGGMPFGNSPFGEKSQ
SHGAQDDPPVPSYALGRRTSVSAESLVPTSQRAYGPTSGLETTMEEDENTHNLSSGTPVFPKSEEQLARI
RQAIKPNFLFRNLDDEQEADVLAAMKEVKMDAGEVVIEQGAAGDFFYIVENGRLDVFVNKEGQVLDLEKG
DRQGLGKKVAECSEGSSFGELALMHNAPRAASIISLTPCTLWALDRVSFRTILLDHTSRKRRLYESFLSE
VPILASLQPQERAKIADVLESRTYNEGEDVIRQGDAGDEFFLIESGNAMAIKTDEDGNQSVVKHLGQGEY
FGELALLNRRTRAATIRAEGPDKLRVAALGEQAFTRLLGPVKDIMARSVSERYGFSTGRGSM
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The divergent Pka2 catalytic subunit was found to regulate mating, haploid fruiting, and virulence factor production in serotype D strains (Hicks et al., 2004).
References
Hicks et al., 2004: Hicks JK, D'Souza CA, Cox GM, Heitman J. Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. Eukaryotic cell. 2004; 3(1); 14-26. [PubMed: 14871933].