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RUB1

Victor ID 5345
Gene Name RUB1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23889180
NCBI Protein GI 799333617
Locus Tag CNAG_05896
Genbank Accession CP003826
Protein Accession XP_012050615
Taxonomy ID 235443
Chromosome No 7
Gene Starting Position 1153778
Gene Ending Position 1156384
Gene Strand (Orientation) -
Protein pI 4.85
Protein Weight 67662.93
Protein Length 662
DNA Sequence 
>gi|799350762:1153778-1156384 Cryptococcus neoformans var. grubii H99 chromosome 7, complete sequence
ATCCGTATATCAACAAATATGCATGTACCACCAATGGTCCACCTGTCCCTTTCGTGCCCTGACTATATGC
CATGAATTGTATGTATTTTATAACCCCCAGTACCCTTTAGAATTGTTGTATCACTTTACAAGATCTCGAA
ATCATCATCATCATCCACCACAGTAGTCACCCTTCTTTTCTTCGCATCATCCCTTCCCACGGCAATTTGT
CCATCATCTTCGGGCGCTGGTCGCTTCACTCCTGCAGTCACATTAGGCATATCCTTCGGCGCAGTATTGG
CGGGGACATGTTCGACAATCTCGGGTTCTTCGGAAGATTCACGAGCGGCATCTTTGGGTTTAGCAGGAGC
GAGCGGGATGGTGAGTTTTTCGTCGGGGAGCGTGTAAGCATTTGACGCTTCGGGGTCACTGTTATAATGA
TGTTAATGATCTATCTTTTTGGCAAACGCGATAATATATATTTGAGACTCACGGTTGGCAGACGCAAAAG
TGTACAGGTCTGTACTTTGTATCTTCATCCCTCACCGTCAGAATCTTACCTCGTCCAACCCCAAGATCCT
CCAAAGTCCTTTCAAAATTATCCTCAAAGTCTGGATCGGCCAAAAGCCTCCCTCCTTCAAACACCGTCCA
TTCCACATCCTTCCCTTCTCCTTGTCCTTCAAACTCTGCTGATCCAAGCCAGCCTTTTACTACATCCTCC
ACAAACTCGCCCAACGTGCATTTCCCGACATCAGCTTTGAACGGGATGTATACGTCTCGACAGACGCTGC
ATGTCGGGTCTGGATGTTGGGGTACAAATGAGCCGAGGGGTTTGGTAGGGTCTGTTCGGAGGAAGACGTT
GCGGACGGGGATATGGCTGGAGTCGGTAGATGGGCCGCCGTTGGAGATGGAGTGCATTCGAGAAAGGATG
TTGAGGGATTGCATCACGATAAGACCGGCGATGATGGCGTTAGTGGTAGCGATAGCGGGAATGATATTAC
CAGCCATTTCTACAGCGGGTATCAGTATTGATTGATTTTTTTTACCCCTGTGCGACAAGCAACTTGCCTT
TCACTTGGAACCGAGTCTTATTGGGGATACCATAAGCGGTAGCTCGAAGGTTAGCGGTCGCAAGTACAAA
GTCAAGAGTATCGTCATCATCCTTATCAAAGGATAGAGGTGTGTCGGGGAAGGCAAGTGCTCGAGCGGAA
AGCCTCTTGCAGCTATTCAATCAGCAATATTCAAATATGTAAGCAACCTACCTGTCCAGGAATAATTCCA
AGTTCTCCTTCAAACTCAACTCTTTCTGGTCCTTCAATAACGCCGCAGGTTTATCCTTGGCCCTTTCAGC
CACCTTGTCGCTGTTCGCCTGCTGATTCGCTGCAGGCACCGTACGGAGTGGTGGGGCGACAAACGTCCCG
TCCAGAATGGCATCGCAATCAAGAGGTACAGGCTTTACACGGCCTTCCTTTTTCCACATATCCTCCATAG
CCAAGAGACGGAAGATATCTTCGTTGAAAATTTTGTGGAATACTCGACGAGGGCCATCTTCTTCACTAAG
CGATTTTCTTACTTGTCTGAAGGCAGCAGCTTCCTTTTTCAGGTTTTCAATCTCCTCCGCTGACAAGTCA
TACTGAGCATGGACATATGGAGTTGTTGAGAGCAACAATTTTGAGCACTTACCATTCTCCCCGCTAGCTT
TGGCCTTGTCCAGCTCTTCAGTGTCCATGTCCTCATCATCTTCACCGAATAACTTTCCAAAAAGATACGT
CTTTCCCCAGACGATACAGTGAATAGGTTCACTAGGTGTTGAACGGATAGTGCAGACTGGGAACGCTTTG
GGAGCAGGCTTGGGCACGCAGTCAAAGCATTCAGTAACGTCCTATGTGGGAGTTATCAGCCTTATAATTA
TTGATCCTCCATCCAAGAAAACGGCAATTTTGGACGAACCTTGATCATGGGAGTAACCTGACCGAGATAA
CCGGCAGTACCAGACTCGACAAGTGGAACACCAGCGGCCTGACAAAGCCTATTCACATGTCGTCGTGCAT
CTTACTCGCGACCATCAGCTCCAATTTGATGTAAACACCCTCTTTGCTTAAAACCTACCCATATTATCCA
ATGCGTTCATGACCAACCCGAACCCTTTGATCCACTCGAGATCATTCACACTATCCTTGACATTCCCATG
CCTAGCGTTGATGTTGATGCCAGAGCTGGGGTTGAAGTGGTGAGCTGTCGCAGCGGCAACAAGGGCTTTG
GATTTGGAGATGTCCGGTTTTCGGAAGAGAAATTGGCGGTTCAAGTTTGAGAGGTCAATGGTGTCAAGGT
CAATCTGAAAACGTGTTAGTTGATAGGCAGAAACGCAGGACAATAATAAGCTACATACAATCTCAATATT
GGCGAACCCAACCAAAACAAGGTTCTTCACTAATTTTTGGTGTTCAGCAAGTCGCGCTCCAAGTCAAACG
AAAGACTTAATGCTGAAAGCTGACCTACGGAGTTCACAGCCAATACCACCAGCACCAACGACGAGAACCT
TTGTCTCTCTAACCTTTTTATACACCTCTTGCCCGAGAAGCGCTTCAGTATATGTTGACCTGGGCATTTT
ATAGTCGTTCGATGATG
Protein Sequence 
>gi|799333617|ref|XP_012050615.1| ubiquitin-like 1-activating enzyme E1 B [Cryptococcus neoformans var. grubii H99]
MPRSTYTEALLGQEVYKKVRETKVLVVGAGGIGCELLKNLVLVGFANIEIIDLDTIDLSNLNRQFLFRKP
DISKSKALVAAATAHHFNPSSGININARHGNVKDSVNDLEWIKGFGLVMNALDNMDARRHVNRLCQAAGV
PLVESGTAGYLGQVTPMIKDVTECFDCVPKPAPKAFPVCTIRSTPSEPIHCIVWGKTYLFGKLFGEDDED
MDTEELDKAKASGENAEEIENLKKEAAAFRQVRKSLSEEDGPRRVFHKIFNEDIFRLLAMEDMWKKEGRV
KPVPLDCDAILDGTFVAPPLRTVPAANQQANSDKVAERAKDKPAALLKDQKELSLKENLELFLDSCKRLS
ARALAFPDTPLSFDKDDDDTLDFVLATANLRATAYGIPNKTRFQVKEMAGNIIPAIATTNAIIAGLIVMQ
SLNILSRMHSISNGGPSTDSSHIPVRNVFLRTDPTKPLGSFVPQHPDPTCSVCRDVYIPFKADVGKCTLG
EFVEDVVKGWLGSAEFEGQGEGKDVEWTVFEGGRLLADPDFEDNFERTLEDLGVGRGKILTVRDEDTKYR
PVHFCVCQPDPEASNAYTLPDEKLTIPLAPAKPKDAARESSEEPEIVEHVPANTAPKDMPNVTAGVKRPA
PEDDGQIAVGRDDAKKRRVTTVVDDDDDFEIL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Deletion of each PIK1, RUB1, and ENA1 differentially reduced pulmonary growth and dissemination rates of C. neoformans and extended mice survival (He et al., 2012).
References
He et al., 2012: He X, Lyons DM, Toffaletti DL, Wang F, Qiu Y, Davis MJ, Meister DL, Dayrit JK, Lee A, Osterholzer JJ, Perfect JR, Olszewski MA. Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination. The American journal of pathology. 2012; 181(4); 1356-1366. [PubMed: 22846723 ].