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PIK1

Victor ID 5344
Gene Name PIK1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23887770
NCBI Protein GI 799337705
Locus Tag CNAG_04335
Genbank Accession CP003828
Protein Accession XP_012051498
Taxonomy ID 235443
Chromosome No 9
Gene Starting Position 596079
Gene Ending Position 603537
Gene Strand (Orientation) -
Protein pI 6.78
Protein Weight 210128.5
Protein Length 2017
DNA Sequence 
>gi|799350821:596079-603537 Cryptococcus neoformans var. grubii H99 chromosome 9, complete sequence
TATGTGAAATGCGAGTTACATGCATGCAGAACCTTTTTTTCGCGTTATAGTTTTATGGCAATATGACCAT
AACTGCACATGGCAGTTTAAGATGCCGACGACATATACAACAGCGATTATATGTACATTTCTTAAATATC
CATTGCCTAGTATGGAATACCGCTGCACAATGTCAGTGCGAATTACCCGAAAATTCATACATTAACTTAC
TTTTGCATTTTCTGGAACCCATCGTATACGTTGCTTCGCATGTTTTCATGCGCATTTCTGATTACTCCCA
TCATAAATTCTGCCGCTTGCCTTTCCCCCAGCTGTAACTGGAATCGGTTCCGTAGCCTGGTAATAGTGCC
TTCGCCCTTGAATGATGGCAATGCAGTACCAAGCATAAGGTGCACAGCATCAATAAGCTGATCAGCATGG
GGTCTTATAGCGAGGAAGGCCTTGACGGTAAGCTCAGTAAACATTTTGTAGCCTTGAGAATCGCGGCCGC
CCATAAGAGCCACCATTTCATGGTTAAGCTTGAAGCTTGATGGTTCGAACTTCATGCCCTGTGACAAGAC
ATCAGCTTCGTCCAGATAGTCAAGCTGATTTGAAATCTCGACGTACACCCGGGCCAATATCGAACAAGAA
TCCAAAATCTACAGAGGACATCAGCAAATTCACGCCAATAAGGAAAAACCGGACTAACCGATATGCACAA
TATGACCCTCTCCGTCTATCATGATGTTACCGTTGTGCCTATCCTTGATCTGCAAGATGTAGCAAGCTAC
AGAATATGCGGCCATTGACTGGATGAAATTGAGTCGCGCCTTCTGGAATGAAGCAGTATCTACACCGCCA
TATTTGTCAACGAAATAAGAGAACAAGTCGTTTATTTTTGCCCGTCCCATCTCATCCCGTGAAGTAGCAT
TGGGGACGACATCGATAACACCGCACTTCACAGATTTTCAGCATAAATATCAGGACTTAAAATGATGCAC
TCACGCCAGGGGCAGTCGCGGTGACTCGGTAAGGGTACAGATAAAGCGTCAGACCAATGGATGTAAAGAC
ATTCTTGAACATTGCAATGATCTGTAATGCTAGCACATCCTGCCTACAGTCATCTCCCACCTTGAAGATC
GCCGCCTGCCAGACATCGTATTTGGTTTTGACGGTTTTGGCCTCATCTGCATTCTCAATGGACTGATTGG
AGGGTAGGTCGAGCTTCTCTTTTTGGACTTTAAATGTCGCCATGAAAGGTGCTTTTGCGTGACTTTGAAG
AGGCCGACCTGACTTCCTGTCAAGGTCTACGACAACACCGTCGGGATTGCTAGGCAAGTATACTCCCACG
GACAGTTTGATCTTTGCCATCTCTTCATCGATCTTGGCCTAATGTAACTCTATCAGTACCAAATCTGTAA
CCCTTCGGCCGACCATTCTTACCTTCTTCTCCGGCTTCGATTTCTTAATGAATGGCTTGAGTTTACCTGA
TATGGAAGTTACTTCGTCGAAGAAATCAAATTCAAGGTCGTAGAACGCTTTGGCTTTCCCAGATAGACCA
TGAACAATCATGTCTATCATGCGGTCCAAAAGGGGCTTCATCGGGTCCGGCTGGCTCTGTACAATCATGA
GTCATCTGCCCGGAAAGATCATCGTTGCTTTACTTACAGCATCGTCATCCCTATATGTGTTGGCTTTCAT
GTTCCAGATGATCTGATGGCAAAACAGCTGTGAAATCTTAGACGTCTCAAAGATGAATCTCTCCACATAT
CCCAAGCCGTCAGCACGAAGTGCTTGAACGACTTGAGGCACGAAGAAAAAGGTCAATTCAACGGGATGCT
GTTCCAATACTCGCATGGCGTATTGTAAAATAAGAGGATGATTACCATAGCGGGGTTGGAAATACACGAT
AGCTGTGACTGGCGGTACAGCTGCCCATACAGGCAACCACTACAAAGGGAATTAGCAGATTTTCCACGTT
TTAGGATCTCACTTGCTTTAAGAGCTGCCTTTGCATCCTGTTCAAGCTTATCGCCAAGGAGGAAGTGGAG
CGCCTCAGCAACATCTTGAACAGCTTTGGGATCAGATTTCACAAGATGAGTGATTTCCGCCTGTAGAGGA
GCGATCTTAAATCTTTCTCCCATTTGGACTGCCATGGCAGGATTAAGCTTCCAAGCCATTTGCAACAAGC
GAGTCCAATCGGCCTGTGGATCAATCAGAACAGTATATAAGAATAACAGGAAATCACATACTGTAGAAGT
AGACCTTTCAAGCGAACCCACAGCAGGCGCCGAAGTCCTTCCGTGTTCATTCACCGGGTTGCTCCATACG
GCAAGTCGTGAAATTTCGTTTTCAACCAAAAGCTGGAGAAGTCTCACTCGATCTTTGTGCTGGACTAAAT
ATTCTTGAATTGAAGAAGCTCCAGGTATGAGAAAGGCGGGAGTGCGATCGGCCATCGAAGAAGTGTAATG
TTCAGCTCGGATACCATCGTTTGCTACTGCGGAAAGAAAGTCTTGCAAAAGTTTGATTTCCGCCCCGACT
TGAATCCTGTCGCTACCATACGACCACCTATTGTACTGTGTCAGAAAACGATGATTGCGAGGTAGCAACA
AGATACTCACTGAGGCCTGACTGAGAACCAGGAGAAGGCTGCTTTGTAAAGGTTGTCGCGCAGCCTAAGC
TCCAGCAAGGCTTCCATCCGACTACTGGAAAGTATTTGAAACCCCAAAAGCAAGAAAGAAAAACGGACTT
CTCTTGCCAATGGATGAGTACTATTCCAATCGTGAGCCGCCTTGTCCCAGGTGACATGCCATGACTCACC
TCATCTCCCTGTGAGCTTCCAGTGATCGCATCATCAACCTAATCAAGGAGATGGTCATCGCTCTTTCGCG
ATACTTGATGGCATGGAATTGAGAGGACAAGACTTGTACGAGAAGAGTATGGGGGCGAAGAAGTCGGCGT
GCCTTGGCGAGTTCCAGGTCTGTTACCTTCTTGTCACTGGGAGAATACTCTACTGGGCGCTCGAAGGGGT
CTTGGTAGCTTTTATTTCGACATTTAGCATCACTTGTGATAGGGTAGATACTTTCACGTACTTCATAGAA
TTGTTAAAAAATCCTTTCTTCTCAATGATCGTCTGCATCCATCCGGCAGTAATCGCACCAACAATAGCTA
CTTCAGCTTCTGGACGCTGTCGGAGCAACCACGTCCAAGCATCAACACCAGCGGCGATGGCCAAAGGCGT
GAATGCCACCATGGGAAGCTCCACCAAGTAATGGAGTATGTCTCGATCCATCTGGATACCACAACATAGT
CAGCAATTAAGGGGTGCAATCATACAAAGAGGAGGACTTACTCTGCGAGACGCGACAAGGACAGAGACCC
CGCGGAGCAATAATCGTCTGATCTCGGGGACATCAAGGGATTTGCTGTTGATTCGTATGTTTGACACTGC
CTGAGCCATTTGGGATTTAAATGCTACCAGCTCAGCTTGTGAGGATTCGGTAGGAGACCCTTTTTGTAAA
TCACTTAACCCTAGATTTATTTGGTCATTGGCATGCCATCAGATTGAATGAAACCTCATACCATAAGAAA
GAACCAATCGAGCGCCACTAAGCTCTCCAGTGTGGTAATTTTTGGAAGCAAACTGACTTGCAACCAGGTT
TGAACTATCAGAAGGCCATCCACCTATGTTAGGCATGATAGCTAGAAGATATGTTAATCGCTTTCATTTC
ATGCGTTCCCCCCGACTCACTCTCTTGTCTGTCAAGTCTAGATATTGCCTTCGAGAAATGCAGCGCCAAT
CCGGCCCCCATCTCGACGCTGTCGATCAACAGCACATCTCTTGCCTCGTTCAGATAACTCTGGAGGATAG
ATTGTACTTCGATGGGTGCGCGAGATATGGCAAGAGTAAGCCAAGTGCAGGTGACGGTGTGAAGTTGAGT
GATTATCTCATTGCGAACAGCGTAATCGTCAGTGAGGTGAAGGGTGAGATCCATCCTGTCGGAAGAAAAC
TCGTATACGGGGGAGTACTGGGCGTGCATCAGTCATTTGCACAAGCCTAAAACGTCTCTGGCTTACTTCG
TCTGTGTACTGAGTCTCGCAGGCGCGTCTCATGAGCGTCAAGATTTCCAGTAAAGTGAACACCACCTCTT
TATCGCATAACAACGCAGAGAACGTTTCCAAGATCAGACGAGCGTATGCCAACGCCTTTTCACGGACTTT
GCTCATGCGATGCGTGCAAGCTATAAGAATTTTACAAACCTCCTTGCTGATTATGGGAGGGAGCGAATGG
GTGATGGCTTGGTGGTAAAGTTGTCTCAGGAAGCTTTTGGAAACCTGCAAGAGTACGTCAGCTACACAGC
ACAGACTATTAAGACTTGTACCGTACTTTTTGCACAATCGCGTCCAGGCATCCGATCAACGAGCTTGTGT
TCAGACTGACGTTGCAAAAATATTGCAAGACGACAGAAGGTCGGTGCCGGAGCGTCCTCATTTCTTCGAG
GTCATGCACCGCCATGAGGAAAGTGATCTGAGGCGTGCTCAAGTTGCGCGTATCATAGCTTTGGCGCTGT
TGAGGTAAGTATTCGTTCAAAGCTGTAGACTGCCGATGTTGAATCTTTCTATTGCATCAGGATTTGCCCT
AACAGATGTCGCAAGGCGAGGACTTACAGATGCAGCAAAGTCCTTTCTCAATGTCGAATTATACTCCAAC
TCACTCTCCACAAAGTCATTTGAGCTTTCCAATACCAAGACTGGTGTCTTTTCTGCGATGACCCCGAGCG
CTTCCCATTCGTGCTCATTCAAATTATTCTTTCCAACATTCCCGCTAAGCCCGAAGACCACCAAAGTAAA
CCAAAGGTTTCTGAAATGTGTTACCAGCTCGGGACTTGCTGCTTCATCGGGATGATAATGAGGATGGGAT
AAGAGAGTTGAAATGGGGATAAGAAGAGCCGAAAGCCAAGACTTCATTTCCGCAACTCTAGTGTTTCCTT
CCGTACGGAGTTGGGCGAGCTGTTCTCGGTCTTTAGAATCGTATGCGTGAGCAGCCATGGATATCATCTG
GGTTTGAGTACCCTTGTCGGCAAAGAGCGTAAGGAGTTCGACCAGATACCCATCTGCGCAGTCGAGCCTC
TTGTACATGCCTTTCGCTAGCGTGGTCAATGCGGCGAGGATGGCGTTGGACGATCTGCGCGGATCTTCAG
GATGAGAGGAGCGAGCGATTTGGGAAAAGGCGCGGTAGACTTCGACGAGGTCTGCGTTGGAGCTGGCAAG
TGCAAGGGGTACAAGATTGGCAACAATAGTTGCTTCTGTGGTGATGTCGACGCCCCGGAGCCGCTGTAGC
AACATAGCTAAACTGAGATGCAATATCTAGCCACGCATTAGTCTCCATACATAACAAGAAAAGCAGGCTT
ACATCGTCCTTCCCTAGCTCCAACGCCAGTCGACTGACAACCTGAACCGCGGCGGCCGCTACAAGTCTTT
TTTGCTCCTCTGAACCTTTCCCGCCTGTGAGAGTGGTCTTCAAAGTGTACGTATCAGCTTCTCCGCCTTG
ATGATGCAAGGGAAGAGAACGGATGGAGTTGACGCCTGCCGAACCAGAATTTCCTTGCCCATGGCTGAGT
GTATTAAGAAGGGAATAAAGGGTAGACGAGGTAAGGTCATCGTCGGCGGACATCTAATACAGCGTAAAGT
CAGTTAACCTTCGCCTTCCCAACATTGCCGACTCGCCTCAATGCAAACGGACAGACACTTTCCTGCTGCC
ACTACAGCAGGGGGCACATCTCCGCCCAGCCCCGCGATCTCCCCCTCGAACGCTGGCAGAGGGGTCATCA
ATAGACGACGGATATGGTGAGTCATTGGGGTCCCAAGAGAAGGATTGCTGCAGTATAACGTTAAGACGGG
GCCAGAAAAAAATGGCATCACTTACTTCCTGACAAGGATGGTGGTGCAAGTGAAGGCAGCCTCGAGAACT
CTGGCATCCGTGATTGTAGAACTCTCTGAGAGCAACATTTTAAGCCTGGCAAGCTGAGTTTTGTCTCCAT
CTGGCTGACGCAAGACGATCATGTTCATCAGGTGCTGGCGCCACTGTTAGCAGTCACCCGAACGAGAGCA
ACATTGGAGCTTACAAGGACAGCAACAGTCAAATCTACTTCTTCCTCCGGCTCATTTCTCCCATGAGCGA
ACAGATTACCCCTCTTCCCAGGAAGCTCTCTTTCTGTATCAATGTACGCTGATCCCATCAAATCACTCCA
CCATCGCAAACTCATCCTATCCACCTCCGCAAGTACCGCTCGGCCTTCCGATGTCAAAGATAAGCTGTGA
CCTTCCACTGGGAATGACACAAGTTGGCTAATTTGATGTTCCAATACAGGCCTTGAGCCAGGAGGTTCCG
GATTAGGGAGGAACGAGGAATTCATTTGATCAGAGTGTTTCACAAAAGCCTTTTGGACTTCATCAATGTC
AGGCTGGGAAAAGAGGGAGTTACCCAAGAGAGCAGTTATTGCCTCTGTGACAAGCATAACCACCGCAACT
GGAGAACTCGGGTACTGAGCTAAAAATGGGCTATTCTTAGGCAAACGAAAATGAGGGGTTGAGGCAGCTG
ATGACGATTGCCTGACGAGTTTCACAAGGAATTTCGGGGATGAAATGGGGAGGAAAGTGGATACCAATCG
AGCAATGATGGATGTTGGGAACGGAGGAAGGGGACAATGGGTGATCACCGAATGGACCGAGTTGAGAAGA
ACCAAGGGAAAGGCTGTAATGGGCGAATCAGCCCCGCTTTACAGCTGACTCGATTGGACTTACTGGTTTG
CGCATTTGACGCGCACAAATCTGCAATCTGCTGCCCAAGTCTCACCAATGTTTCCCCTACATCAGACCTA
GCATCCTCACTGCTCCAGCCGGCCCAAATCATAGCTTTGATAAGGTCTTGGCAGAGTTGCGCTTGCCCTA
CCGAACCCGCAAGGCCGACGTTCGCTCGGGCACTTGACGATGACGCCGGAGAAGCTGCGGGATCGACTAC
TATTGTTCCTTGTCGAATGAGTCCCCACAGAAGCTTTTTCAATTTCCCAACCGAAGATGCAAGGTTCGCA
GACGTGATGGGGAGCGAGTAGACATAATGGGCATAAGATATCGCATGATTTATCTCCAACTCGGTCTATA
GAACATCAGAGATACGATCATGAGTGTCCTTAATGAAATAGACATACCCATTCATCGTCTTCTTCGTCTG
ATCCCAGAAGGTCTAGGCCAGCCGATGTGGAGAGCGCGGTCTGTGGAAGACCGACCGTGAGTGCGTTTAT
GGGTTGTTCATCGGAGTTTGAAGGGTGTGCAGCGTAGCTGGAAGCAAGGGAAGTGAGGATGTGAAGATGG
AGCGGCTCATCAAGGCTGTGGGGGTCAGCGATGCGGGGGAGAAGGGGCTGCCTGCTTACGAGTCCATCTT
CGCGGTTGGATATGGGGATATGGATAAACACAAGGTACA
Protein Sequence 
>gi|799337705|ref|XP_012051498.1| phosphatidylinositol 4-kinase [Cryptococcus neoformans var. grubii H99]
MDSLDEPLHLHILTSLASSYAAHPSNSDEQPINALTVGLPQTALSTSAGLDLLGSDEEDDEWTELEINHA
ISYAHYVYSLPITSANLASSVGKLKKLLWGLIRQGTIVVDPAASPASSSSARANVGLAGSVGQAQLCQDL
IKAMIWAGWSSEDARSDVGETLVRLGQQIADLCASNAQTTFPLVLLNSVHSVITHCPLPPFPTSIIARLV
STFLPISSPKFLVKLVRQSSSAASTPHFRLPKNSPFLAQYPSSPVAVVMLVTEAITALLGNSLFSQPDID
EVQKAFVKHSDQMNSSFLPNPEPPGSRPVLEHQISQLVSFPVEGHSLSLTSEGRAVLAEVDRMSLRWWSD
LMGSAYIDTERELPGKRGNLFAHGRNEPEEEVDLTVAVLHLMNMIVLRQPDGDKTQLARLKMLLSESSTI
TDARVLEAAFTCTTILVRNNPSLGTPMTHHIRRLLMTPLPAFEGEIAGLGGDVPPAVVAAGKCLSVCIEM
SADDDLTSSTLYSLLNTLSHGQGNSGSAGVNSIRSLPLHHQGGEADTYTLKTTLTGGKGSEEQKRLVAAA
AVQVVSRLALELGKDDILHLSLAMLLQRLRGVDITTEATIVANLVPLALASSNADLVEVYRAFSQIARSS
HPEDPRRSSNAILAALTTLAKGMYKRLDCADGYLVELLTLFADKGTQTQMISMAAHAYDSKDREQLAQLR
TEGNTRVAEMKSWLSALLIPISTLLSHPHYHPDEAASPELVTHFRNLWFTLVVFGLSGNVGKNNLNEHEW
EALGVIAEKTPVLVLESSNDFVESELEYNSTLRKDFAASIQHRQSTALNEYLPQQRQSYDTRNLSTPQIT
FLMAVHDLEEMRTLRHRPSVVLQYFCNVSLNTSSLIGCLDAIVQKVSKSFLRQLYHQAITHSLPPIISKE
VCKILIACTHRMSKVREKALAYARLILETFSALLCDKEVVFTLLEILTLMRRACETQYTDEYSPVYEFSS
DRMDLTLHLTDDYAVRNEIITQLHTVTCTWLTLAISRAPIEVQSILQSYLNEARDVLLIDSVEMGAGLAL
HFSKAISRLDRQETIMPNIGGWPSDSSNLVASQFASKNYHTGELSGARLVLSYGLSDLQKGSPTESSQAE
LVAFKSQMAQAVSNIRINSKSLDVPEIRRLLLRGVSVLVASRRMDRDILHYLVELPMVAFTPLAIAAGVD
AWTWLLRQRPEAEVAIVGAITAGWMQTIIEKKGFFNNSMNYQDPFERPVEYSPSDKKVTDLELAKARRLL
RPHTLLVQVLSSQFHAIKYRERAMTISLIRLMMRSLEAHREMSTHPLAREVRFSFLLLGFQILSSSRMEA
LLELRLRDNLYKAAFSWFSVRPQWSYGSDRIQVGAEIKLLQDFLSAVANDGIRAEHYTSSMADRTPAFLI
PGASSIQEYLVQHKDRVRLLQLLVENEISRLAVWSNPVNEHGRTSAPAVGSLERSTSTADWTRLLQMAWK
LNPAMAVQMGERFKIAPLQAEITHLVKSDPKAVQDVAEALHFLLGDKLEQDAKAALKWLPVWAAVPPVTA
IVYFQPRYGNHPLILQYAMRVLEQHPVELTFFFVPQVVQALRADGLGYVERFIFETSKISQLFCHQIIWN
MKANTYRDDDASQPDPMKPLLDRMIDMIVHGLSGKAKAFYDLEFDFFDEVTSISGKLKPFIKKSKPEKKA
KIDEEMAKIKLSVGVYLPSNPDGVVVDLDRKSGRPLQSHAKAPFMATFKVQKEKLDLPSNQSIENADEAK
TVKTKYDVWQAAIFKVGDDCRQDVLALQIIAMFKNVFTSIGLTLYLYPYRVTATAPGCGVIDVVPNATSR
DEMGRAKINDLFSYFVDKYGGVDTASFQKARLNFIQSMAAYSVACYILQIKDRHNGNIMIDGEGHIVHID
FGFLFDIGPGGMKFEPSSFKLNHEMVALMGGRDSQGYKMFTELTVKAFLAIRPHADQLIDAVHLMLGTAL
PSFKGEGTITRLRNRFQLQLGERQAAEFMMGVIRNAHENMRSNVYDGFQKMQNGIPY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Deletion of each PIK1, RUB1, and ENA1 differentially reduced pulmonary growth and dissemination rates of C. neoformans and extended mice survival (He et al., 2012).
References
He et al., 2012: He X, Lyons DM, Toffaletti DL, Wang F, Qiu Y, Davis MJ, Meister DL, Dayrit JK, Lee A, Osterholzer JJ, Perfect JR, Olszewski MA. Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination. The American journal of pathology. 2012; 181(4); 1356-1366. [PubMed: 22846723 ].