Victors

PEX1
Victor ID	5341
Gene Name	PEX1
Sequence Strain (Species/Organism)	Cryptococcus neoformans var. grubii H99
NCBI Gene ID	23890250
NCBI Protein GI	799325851
Locus Tag	CNAG_07403
Genbank Accession	CP003824
Protein Accession	XP_012048907
Taxonomy ID	235443
Chromosome No	5
Gene Starting Position	98671
Gene Ending Position	102783
Gene Strand (Orientation)	+
Protein pI	6.76
Protein Weight	104104.66
Protein Length	1009
DNA Sequence	>gi\|799350697:98671-102783 Cryptococcus neoformans var. grubii H99 chromosome 5, complete sequence GGATTATTCCACTGCTGTTATCGATAGTTTCCAACAAATCCCCGGCACTTCGTACAGAGGTAATTAAAAC TGCCATGGTCAGGAAAGCAGCTGTCAAGTACCGCTCTCTAAGGTCAAATCTAGTCAACCTTCCCCTATCC CTCTACGCCCAGCTCGTACAACAGCAAGCAGTTAGTATCTTTTTTCTGCTCGCAAGCCAATAGCTCACAC CGGATGGTATGAAGAGACCCCAGTCCCTCATCCTCCACTTATCACCATTATTATCTCCATCATTCCCCTC CTCCTCAAGACAACCGAAAACAGCGTACTTGGGATGGTCAGGACTGAATGCAGCGGCCAATGTCTCCCAG GTTGGTGATGGGGTTGAGAGTGTCGAAGTAGATCCCGAAGTCGCCATGTCTTTAGGATGGAACGAAGGCA TTTTGGTGAGCTTCCAGTATCGCTTGCGATTTATCATATTAATTGCTGTCGCATTTTCAGGTCGAGATCG CTGTGGTACATAATCCCACGGTTGCCATGTCAGTATCTGTGACACCGATGAGTCCCGATGACTGGGAGAT CCTGGTGAGCTATTTCATACCATGGCGACCTCAGCGGATGCTGAGACCCAACATAATTATAGGAACAACA TGCATCTTTCTTGGAGAATAATCTCCTATCCCAACTCCGAGCAGCGCAAAAGGGACAAGAGATTGACGTA TGGGTGATGGGTCGAACGAAAATCAGAATACGGGTTGGTGAGTAATTGATCAGTTGTATTCCCATATGTC ATGGCTCTCTAATTTCCTTTTAGATGAGACCAATCCCTCAAGCAACTCCCAGTCTGCGGTTATCATTAAA CCCGACACCGAAATCTACGTCGCCCCTCGACCTCGCTTATCCAAATCCACTTCGTCCATTCCATCTTCCC AATACTTCCCTCAAATAGTCAAGAGCGGCTTTCCCAACGGAAGAAATAAGTTCAGCCAGGTCAAATTACG TCTGATTCCCCCCAAAGTCACATCCACATGGGGCATTTTTGTACCCCCATCCAATGCCCTTTCGAAAACA GAAGATGAGAGAATAGCAGTGTGCTCTCCGACAAGCCTTGAGAAAATCAAAAGAAGACTCGGAACCAGTG ATGGTGAGATGTTCTTTGTTAAAATTGCTCTCGACCAGCCCCTAGAGGAAGAATCCCCCCCTCCAGGTCC CGTTGTCATTGCGCAAGAAAAAGAACCCATGGGCGAAGCAGAGATGCTTCTTGTCTCTTGGGAGGAAATG CCGAATGGATGTCTATCAGTTGCTGGGAAAACGGAAGATTGGATGAATGTATGGGCGAGGGTCAAAATTT TGGAAAGCACGGGTAAGAGGGAGAAGACAAAATCTGGAAAGGGAAGACCCGTCCCTGATTTATCATTGTA AGACCTGTCTCTCTACTTTACCTTCTTGGTCAGTATCACAACTGACCCACTTTTCGTTTTTCCTTTTTCA GTTCTGCCTATCCGAAGCAGACCTCATCACCTCTCCCAGGACTCGATAAGATTTGCCAAGAAGCTATCGA TTATCTTCGGCTTTCAGCGTTTTCTCAAAGATCGAAACCCCTGCTGCTATTGGGTGCGAAAGGTTCTGGG AAGACTAGTCTAGCAAAGATAGTCGGCAATGCCTTGGAGGAAAATAGATTTATTCTGGCTGGTAAGGAAT CCATCTTTCTAGCATCTAAAAATACAATAAATATAATGGGCTGATTGATTGGCGATAGAAACTATCTATG AGGATGTAGGGAAACTAGACCCAGAATCTAGAATCGCGACGATAAAGCAAAACATGGATAAATGGATCGA GGATGCAAAAATGAAAGCGCCTTGCTGCTTGATTCTCGATGATTTGGATAATCTCTTATCGCCCGAGACT GAGGTAAGCGTAGATCGACGTCTCCCAATCTCTTCCATCCCCTCCGAACTCCCAACAGTCTTGAGCTTAT TATTTCTTCTCTCTCTCCACTATTAGTTGAAAACATCAACAAACCCTTCCATCCTCGCTGAATATTTCAC TTCCCTCATTTCATCCCATCACTCCCTCCCGCCGGGCACTCTCATGATCGCCACAGCACAAGACACCTCC ACCCTCCATCCTTTGCTTAACACCCGGCACGTATTCGGCGAGACACTCAAGATTCCTCCGCTTTCTAAAG AGGTCAGGCAGGATATTTTGAAGGAGTTCGTTGCCGCCAAGGGGAAAAGGGGAAAGGAGGGATGGGAGAG GGGAGAGGACGTTGGCCATGGTCTGGATTATGTATTGTTGGGGAGTATGACGGAGGGTTACTCTGTCTCT GATCTGAGTGATCTAGTACAAGGTGCGACGCAGCAGGCTATTATACGGTGTACCAAAAGTGAAGAAATAG ACGTGCGTCCTTTTCCCTTTGCTATTTCCTTCCGTAATAGTCGTTGGAACTGATCAAAGTTCCTTGATTG TAGATCCGTTTGACGTTTCATGATTTCATGATTGCCCATGAAGAGTTTACACCTCTCAGTCTCCGAGGGA TTAGTCTTCAAATCTCAGATGTGAAGTGGAGCGATATCGGAGGTAAGTTGATGTAATCTTCTCACCCTTC ACCATTTCTCCATCCGTTCTCTACATCGGGCAGCACATTTACAAGGTTTGTTTCAATACCACAGGCTTGA AAGGACCTCGACAAATTCTCCGCGAGACACTCGAATGGCCGACTAAGTATGCTCAGATCTTTGCCAACTG TCCTTTACGTCTTCGATCGGGGTATGTCTTATAACACCCTTTATATTATCCAACTCTCTTGAGCAAGGAA ACAAAGGAGCTGACTTTTCGTTCTCACCTCATCCCATCTCCAGTCTCCTTCTATATGGTTACCCAGGATG CGGCAAGACCCTTCTCGCGTCTGCAGTCGCTAAAGAATGTGGACTCAATTTCATATCTGTCAAAGGGCCT GAGATCCTCAACAAGTATATCGGTGCAAGTGAGAAGAGCGTGAGAGATTTGTTTGAGAGGGCAAGTGGTG CGAAGCCTTGTGTCTTGTTTTTCGACGAATTCGATTCTATCGCTCCCAAAAGGCAAGTTAATACATTCTG CACAGGACTATCAAATAAAGTAAATTGCTAATGAAATCGGAAAAACCTGGCAACAGAGGACATGATAGTA CAGGCGTTACAGACCGAGTAGTCAATCAACTCCTCACAGAGATGGACGGCGCTCAAGGTCTATCCGGAGT TTACGTCCTAGCAGCTACAAGCCGTCCAGACCTTATTGACCCCGCACTTCTCCGTCCAGGCCGGCTCGAT AAATCCATCATCTGCGATATGCCCTCGACCTCTGATAGACTCGAAATCATGAAAGCAGTGGTGAAGAAGG GGAAACTGGAGTTGGGAGAGGATGTGGATCTGGAAGTGGTGGCGAGGGAGAGTGAAGGTTTCTCGGGGGC CGATCTACAGGCGCTGGTGTATAATGCGCATTTGGAAGTAGTACATGCTGCTTTCGAAGATGAAGAAAGG AGGAAAGAAGAGGAAGAGGGAGGAAAGAAAGTGGCTGTTAATGGATTAGGAGGAAGGGAAGGGTATAGAC TGATTTCCCAGACTAATGGGGCAAATCTTTCGGCGGCAGCTCGTGCGGAGCTGGGTCAGAGAGTAGGTTT CCTATATCCATTTCTTTCTATGAGGACTTACAGTTTACTGACCTGATAACAGATTGATACAATCGTCAGT AACAGCCAATCGCGCTTCCTGCCGGTCGAAAAGGGGGGAAGGACTGCAAAGGATTTTGTCAAGGTGCGTA AACCATTTCCCTTTTGAGCATACTCGATGATATCTTACTGTATGACATAGCCTACTATACAGCAACGGCA TTTGATGAACGCGCTGCTTGAAACACGGCCATCTGTATCACAAGCTGATCGTCGACGACTTGACCTCATG TAAGCTTTACTTTTAAGATCATCAAGCAATAAGCTCTTGCTCACCATTTGTTGTACAATCTCTAGCTATC GATCATTTGTCAATGATAGAGATGGCAAGATGGGTAATGGAGATTTGGGTAGAGAGACGGGTACGAGAGT GTCTCTTATGTGATTTGTGATTAAAGTTGCAAAGAATGCATTGCATGGCCCAT
Protein Sequence	>gi\|799325851\|ref\|XP_012048907.1\| peroxin-1 [Cryptococcus neoformans var. grubii H99] MVRKAAVKYRSLRSNLVNLPLSLYAQLVQQQARPQSLILHLSPLLSPSFPSSSRQPKTAYLGWSGLNAAA NVSQVGDGVESVEVDPEVAMSLGWNEGILVEIAVVHNPTVAMSVSVTPMSPDDWEILEQHASFLENNLLS QLRAAQKGQEIDVWVMGRTKIRIRVDETNPSSNSQSAVIIKPDTEIYVAPRPRLSKSTSSIPSSQYFPQI VKSGFPNGRNKFSQVKLRLIPPKVTSTWGIFVPPSNALSKTEDERIAVCSPTSLEKIKRRLGTSDGEMFF VKIALDQPLEEESPPPGPVVIAQEKEPMGEAEMLLVSWEEMPNGCLSVAGKTEDWMNVWARVKILESTGK REKTKSGKGRPVPDLSFSAYPKQTSSPLPGLDKICQEAIDYLRLSAFSQRSKPLLLLGAKGSGKTSLAKI VGNALEENRFILAETIYEDVGKLDPESRIATIKQNMDKWIEDAKMKAPCCLILDDLDNLLSPETELKTST NPSILAEYFTSLISSHHSLPPGTLMIATAQDTSTLHPLLNTRHVFGETLKIPPLSKEVRQDILKEFVAAK GKRGKEGWERGEDVGHGLDYVLLGSMTEGYSVSDLSDLVQGATQQAIIRCTKSEEIDIRLTFHDFMIAHE EFTPLSLRGISLQISDVKWSDIGGLKGPRQILRETLEWPTKYAQIFANCPLRLRSGLLLYGYPGCGKTLL ASAVAKECGLNFISVKGPEILNKYIGASEKSVRDLFERASGAKPCVLFFDEFDSIAPKRGHDSTGVTDRV VNQLLTEMDGAQGLSGVYVLAATSRPDLIDPALLRPGRLDKSIICDMPSTSDRLEIMKAVVKKGKLELGE DVDLEVVARESEGFSGADLQALVYNAHLEVVHAAFEDEERRKEEEEGGKKVAVNGLGGREGYRLISQTNG ANLSAAARAELGQRIDTIVSNSQSRFLPVEKGGRTAKDFVKPTIQQRHLMNALLETRPSVSQADRRRLDL IYRSFVNDRDGKMGNGDLGRETGTRVSLM
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: The pex1 and pex6 deletion mutants were unable to localize the fluorescent DsRED-SKL protein to peroxisomal punctate structures, in contrast to wild-type cells. The pex1 mutant exhibits wild-type virulence in a murine inhalation model and in an insect host, demonstrating that peroxisomes are not required for virulence under these conditions (Idnurm et al., 2007).
References	*Idnurm et al., 2007:* Idnurm A, Giles SS, Perfect JR, Heitman J. Peroxisome function regulates growth on glucose in the basidiomycete fungus Cryptococcus neoformans. Eukaryotic cell. 2007; 6(1); 60-72. [PubMed: 17041184 ].


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PEX1