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PDE1

Victor ID 5339
Gene Name PDE1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23888431
NCBI Protein GI 799323689
Locus Tag CNAG_05081
Genbank Accession CP003823
Protein Accession XP_012048491
Taxonomy ID 235443
Chromosome No 4
Gene Starting Position 391624
Gene Ending Position 393845
Gene Strand (Orientation) -
Protein pI 8.22
Protein Weight 49573.6
Protein Length 480
DNA Sequence 
>NC_026748.1:391624-393845 Cryptococcus neoformans var. grubii H99 chromosome 4, complete sequence
GGCGGAAAGTCATTAGTAAATTTGCTGACACAGCTGCTGATGCCATCAGGAAGGGCTTGTAATGTTGAAA
TAAAACTTGAGACGATAGTCCGTTTTCCTTATCATGCGAAAACTACAAAAATGCAAACTGCAAGTAGCAT
ATGGAGATAATATTACAGGCCCTCCCAGCTAACTTCCCATTCTACAACTTCGGATGTACGAATACAACCT
AGAGAACTAATCATCAGCGTCAGCATCGGTCTGGTTGTAATCTGCTTGGCGTCAGCTGAACACACCTATG
CGATCGCCTTTTACTGGGCGAATGAAAGCGACACCTAATTTCCCATCTTTTTCCAGCTCTTGCAATTGGG
CCATTATAATCTCATGTTGAGTTTTACCTTCGGGATGGGGAACGAGGCTTTCCTTAATATGTGTTATGAA
TATTTTAAGACCATCAAGTGGCCTTCTGTCTCGGTTGAATTGATAAGCCAAGAATTGCAATAAGAAAGAT
GGGTCAACTCACGTTTTTGTTTGGCTAACATGACCAGCAAGTACCTTCAACTCATGATAGACAGCGGGGG
GAGAAAGGTGGCCGTACATGTGCTGTCCTAGTCGACTTGAATCATACGAGCATTCAATCTTTAAGAACGT
CAGCGATAAGTCTAGTAGCATGGAAAAGACTTACAAATATACCACATAACCGTCCTTCAATCCATGACCT
GGCTGCTTCTTCCCATATCACGGAGTTAAACCGACCAGCTTTGGCTCTTAGTTCCGGGTGCGCGCCATTT
TCTCCTGATTTCCTATAGGCCGATTCCATATCTCCCAAAAAAAGAAATTCTTTGCCTTCCTTTGGCTTTC
GTCTTGAGCGAACGCTGGTCACTGGTTTGGGGGAAAGATATGGTAATGGCATATGTCGGATAAATGCACC
AGAAGACTCGTAAGTTTCTTTGGATGTACTTCCATGAACTAGAGGGTATAGCCTGACCCCTAAAGACGGA
GCACCAATTAGTGATTGAGGGGCGCTGTTCGTCTGTAGCCTAACAGCGTAAAAATTGAGAGCATTTTCAG
CAAGTGGTCCCAAAAAAGAACTTACGGTGATAGTACTAATGAAGCATTTGGATGCTCGTTATATGTAAGT
CGCGTATCAGACTCAGGAGATTTAGATTTTTTACGCTTGTCTGCTTGATTCACTTTCCTTCGCTTCTTTG
GCGCTTCTGTTTTGCGATCCTCATTGTGTCCTGGAACCCAAGCCACCAGTTCAGGCCATATCTGACCAGT
GTATGCTGTTGATAGCTTTTCTAATGTTCCTGTCGTTCCGTATACAATGGGACACAGAGGAGGCACGGGC
TGCGAAACAGGGGCGTAGTTGGAGGCTGCGAGATTTGGCCGGGGAGGTGCTGAACCCGTGAGCATGATCA
AAGACTGGACATGGTCAAGATGAGCATGCGTGATTAGATATCCTCTGGTACCATTCATTCAGCCTCGATA
CTGTATTCCCTTAAGTAACTAGTGACTGAACTTACGATACAAAGGAAAAGACATAAGAAGCCTGGAGTAA
AGGAGTGCTGTAATCCGTAGGAAAAGTGATACCAGGAAACATCGTATCTGGGGATTGCGAAGAAAATAAG
GCTGAAAGAGCACCCAGGCCTGAACCTGTGAGAAACACCCTGAGTATCTTATTTCCTCCAGCTGAAAGTA
TCAGCAGCACTGACCTCCTTCTAGCCCTAGGATACCATCCTCCCAACGTTGGTCAATAGCTTTCACCAGA
TAGCTATGGAACAGGCGCTTATGAATGAGCTTCGGTTGCTTGCCTCTATGATGGAGTACACTTACCCGGC
GCAATCTGTCTCCAAGGGTCCACCACCGCTTCCCAAGACTACGATCTCGAAAGCCGGCTCTGATGTTTGG
TCGATGACGTCTTGAAGTACTTTCATTGAATTGTGTTCACTTGCCCGAGCGGCGGTCGACTTCCCTGCGA
CAGAAATATCTATCCGGGATCGAAACTGAGTTCCGTTTCCCATCCAAACGGGGGGTATTGTATTTTGTTC
AAGTTGACGTGGGAGCATAAAAGAAATGGGATCTGCGGCTAGTGGCTCTTTATTTATTTTAGGCGTTAAC
TGGTATAATGCTCGACAAGTCGAATTTGGTTTTCAGGAACATGTCTCACACAAGGTTACACTGACGCGAT
GCTGCGATAGTAGGACAGATGAAAAGAGATTATGAAGCTTAAAGAAATCCGA
Protein Sequence 
>XP_012048491.1 phosphodiesterase [Cryptococcus neoformans var. grubii H99]
MGNGTQFRSRIDISVAGKSTAARASEHNSMKVLQDVIDQTSEPAFEIVVLGSGGGPLETDCAGYLVKAID
QRWEDGILGLEGGSGLGALSALFSSQSPDTMFPGITFPTDYSTPLLQASYVFSFVSGYLITHAHLDHVQS
LIMLTGSAPPRPNLAASNYAPVSQPVPPLCPIVYGTTGTLEKLSTAYTGQIWPELVAWVPGHNEDRKTEA
PKKRRKVNQADKRKKSKSPESDTRLTYNEHPNASLVLSPLQTNSAPQSLIGAPSLGVRLYPLVHGSTSKE
TYESSGAFIRHMPLPYLSPKPVTSVRSRRKPKEGKEFLFLGDMESAYRKSGENGAHPELRAKAGRFNSVI
WEEAARSWIEGRLCGIFIECSYDSSRLGQHMYGHLSPPAVYHELKVLAGHVSQTKTRPLDGLKIFITHIK
ESLVPHPEGKTQHEIIMAQLQELEKDGKLGVAFIRPVKGDRIGCIRTSEVVEWEVSWEGL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The resulting mutants exhibited moderately elevated levels of melanin and capsule production relative to the wild type (Hicks et al., 2005).
References
Hicks et al., 2005: Hicks JK, Bahn YS, Heitman J. Pde1 phosphodiesterase modulates cyclic AMP levels through a protein kinase A-mediated negative feedback loop in Cryptococcus neoformans. Eukaryotic cell. 2005; 4(12); 1971-1981. [PubMed: 16339715 ].