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PCK1

Victor ID 5338
Gene Name PCK1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23887655
NCBI Protein GI 799338421
Locus Tag CNAG_04217
Genbank Accession CP003828
Protein Accession XP_012051670
Taxonomy ID 235443
Chromosome No 9
Gene Starting Position 319580
Gene Ending Position 322757
Gene Strand (Orientation) +
Protein pI 5.94
Protein Weight 58692.9
Protein Length 551
DNA Sequence 
>gi|799350821:319580-322757 Cryptococcus neoformans var. grubii H99 chromosome 9, complete sequence
CTTGGGACTTCTTGGGACTGCCGTCATATAGATATGTGCGCAATGCATATATAATCATTGCGTGTTTTGG
AGTGCTAAGCCTTCTTCCCACACTGACTTTGCACTTTCTGCATACAGACCAACATATCTTTACCTCTCAA
CAACTATTTTTGTGAGTATCCTCTTTTGTCTTTGAGCGGTGGAGGTTGCGGGGCACCCAGTGATCGTCGG
CGCGGGTGATTACCGGCTGGTCCACTTGCGTCCATTTGTCCACCACCGATTCCTATATATAACTTCTGCA
CACGATCATTGCTGACAATGCCCACAACAGTCATCTCCCCACCCAATTTACCACATTTTCAATATGGCTC
CCAGACAACACCATCACGACGAATTTGAGAGCAATCAGTTCCTAGGTAAGGAACTCAAGTACTTCTCCCA
GGCTGGTTTCGACTTGGACCGAATCCACATTAAGGTGTGTTCATGTGCTCATCTGAGTCGCAACGTCAGC
TGACTCCATCCGCAGAGAAATGCTCCTGTCGCTTCCCTCTATGAAGATGCCATTCTCAACGAAGGTGCTG
TCATCTCTTCAAATGGTGCTCTTATCAACTTCTCCGGCAAGAAGACAGGTCGAAGTCCCAAGGACAAGCG
AATTGTCTTCGAAGAAACTAGTAAGGATGACGTCTGGTGGGGTCCCGTGAATATCAAGATGGAGTAAGTC
GTCAGCCTTATGTATCTTGTAATCTTAGCTGACTAGGATCTAGCGAGCACACTTTCGAGATTAACCGAGA
ACGAGCTATCGACTACCTCAACACCCGAGAAAATGTCTATGTCTTTGACGGTTTCGCCGGTTGGGATCCC
AAATACAGGATCAAGGTCCGAGTTATTGCTTCCCGAGCCTACCACGCCCTCTTCATGGTAAGTCAATTGC
CTTGTCCATTGCCCAAGCCGTTTTCTAACTCGATACCCAGCACAACATGCTCATTCGACCAACTCCTGAG
GAACTCGAAAACTTCGGCGAGCCTGATTTCATCATCTACAACGCTGGTCAGTTCCCTGCCAACCGATTCA
CAACTGGCATGACTTCCACCACTTCCGTCGGAGTCAACTTCAAGCGAATGGAAATGGTCATCCTCGGTAC
TGAGTACGCCGGTGAGATGAAGAAGGGTATCTTCTCCGTCATGCACTACCTCCAACCCGTCAAGTTCGGC
CAGCTCTCCCTCCACTCTTCAGCCAACCAAGGCATCGGAGAGAATGACGATGTCACCCTCTTCTTCGGTC
TTAGTGGTACTGGCAAGACAACTCTTTCCGCCGACGCTAACAGATTATTAATTGGTGACGATGAGCACGT
CTGGAGTGACACTGGTGTCTTTAACATCGAGGGTGGCTGTTACGCCAAGTGCATCAACCTCTCTGCCGAA
AAAGTGAGTTATTACCAATATCACCTTTTGCATTAGTACATCCGCTGACTTGGAGACCTTGTAGGAACCC
GAGATCTTCAATGCCATCAAGTTTGGCTCCATCCTCGAAAATGTTGTTTACAATCCTGCCGATCGTAAAC
CCGACTACGACGACGTTTCCATTACCGAGAACACTCGATGTGCCTACCCCATCGAGTACATTCCTAATGC
CAAGATCCCCTGTATCGCAGACCGTCAACCCTCCAACATCATTATGCTCTGTTGCGACGCCTTTGGTGTC
CTTCCCCCCGTCTCCCGACTTACTCCCGAGCAGGCTCAGTACCACTTCGTCGCTGGTTACACCTCCAAGA
CCCCCGGTACTGAAGATGGTATCGTCGAGCCCTCACCCACCTTCTCTACATGTTACGGTCAACCTTTCAT
TATCCTCCACCCCGGCAGGTATGCCAAGATGCTCGCTGAGAGGATGGAGAAGAACAGAGTCAATTGTTGG
TTGATCAACACTGGTTGGACTGGAGGCAAGTTTGGTACCGGCAAACGTTGCCCGCTCAAGTATACGCGAG
CTATCGTCGACGCCATCCACAACGGCTCTCTCGCCGAGGCCGAATACGAAAACTTCCCCATCTTCAACCT
CGCCATTCCCAAGGCTGTTGAAGGTGTGCCCAGTGAGATCTTGAACCCTGAGAAGGTCTGGCCGAGCAAG
GAAGCTTTCAAGGCGGAGTTGGACAAGTTGGGCGGCATGTTTCAGAAGGCTTTTGCCAAGTACGAAGCAG
ATATTGATGAGAAGGTCAAGCTGTCGGGTCCCGTGTTCGCGTAAGAAGGTTTCTGTCGGCATTCTCATTT
AATGTTTGTACATCATATGGACATTTGTACTCATACTCTCCGGGCTCCTTGAGCTATGCTTTATGTATTA
CAATACCATTCGTCATTACTTCCTAGGCGAAGAAAAAAGAAAAATATATACTCACTTCAACACATCTTGA
GACCTAACGGTCAAACAGGTCATAATGATTATCAAGATCTTCTTTCTTTGATGTTCCCATCACTATTCTT
TTGCACTATTCTAAATTATTCTACACTAAAGTTCGCTCTCTCGACAACCTCAACCCAAGCCTCCATAATG
TATAATGTCGCTCTCCAATTTGGGCCTTCACCTCTATCGACTGTTTCACAGGATGTTTCAAAACTTCCTG
ATCAATCAGCATGTCCACCCTTTGTCTGGTCATTCTCAAACCTGACCTCTTTGTATCTCTCTCAATAGAG
ACTGCTGCTGACTCCAAAGTCTGGCTCGTCGTTTGTTCGCTCTCAGTCCTCGCTCTTTTCATATTCTCCT
TACAATCGCCCAGTTACGTTAGAGCACAAACAGTAGCGGCGGCTCATTCTCTGTCTCACTGACTTCTATA
CCTCCCAGCTGCCCATTCATTAGGCTTCCTGATACCGTCTGGCGGCTCTTGGTTGGTCCTGGTAATTTAG
CTTGCGGAAGACAGCAATAATTAAATCACACGGGATTTTGTAATCACTCATTTGCCTTGCCGTTGGTTGC
CGCTCAACAAGTTGGTGCCAAAAAGCTCAAGCCATTGATGTTTGGGAGGATAGTCTCTTTCACATGCACT
TTCGCTTTCAAAGTAGCAATGGTGTCAGATAGCTTCGCCATGTAGGTATGTGGTTTGTATGCCTTTGGGG
CTACAAAGGTCACAAAATATCAGTCATACTCTACGTAATGGGGTCGAGATATCTGCTAAAAATGACTTAC
CTTCTAACTTGAATTATGTATTCCTTTC
Protein Sequence 
>gi|799338421|ref|XP_012051670.1| phosphoenolpyruvate carboxykinase (ATP) [Cryptococcus neoformans var. grubii H99]
MAPRQHHHDEFESNQFLGKELKYFSQAGFDLDRIHIKRNAPVASLYEDAILNEGAVISSNGALINFSGKK
TGRSPKDKRIVFEETSKDDVWWGPVNIKMDEHTFEINRERAIDYLNTRENVYVFDGFAGWDPKYRIKVRV
IASRAYHALFMHNMLIRPTPEELENFGEPDFIIYNAGQFPANRFTTGMTSTTSVGVNFKRMEMVILGTEY
AGEMKKGIFSVMHYLQPVKFGQLSLHSSANQGIGENDDVTLFFGLSGTGKTTLSADANRLLIGDDEHVWS
DTGVFNIEGGCYAKCINLSAEKEPEIFNAIKFGSILENVVYNPADRKPDYDDVSITENTRCAYPIEYIPN
AKIPCIADRQPSNIIMLCCDAFGVLPPVSRLTPEQAQYHFVAGYTSKTPGTEDGIVEPSPTFSTCYGQPF
IILHPGRYAKMLAERMEKNRVNCWLINTGWTGGKFGTGKRCPLKYTRAIVDAIHNGSLAEAEYENFPIFN
LAIPKAVEGVPSEILNPEKVWPSKEAFKAELDKLGGMFQKAFAKYEADIDEKVKLSGPVFA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Deletion of PCK1 results in defective growth on lactic acid, normal growth on glucose, and attenuated virulence (Panepinto et al., 2005).
References
Panepinto et al., 2005: Panepinto J, Liu L, Ramos J, Zhu X, Valyi-Nagy T, Eksi S, Fu J, Jaffe HA, Wickes B, Williamson PR. The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformans. The Journal of clinical investigation. 2005; 115(3); 632-641. [PubMed: 15765146].