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OVA1

Victor ID 5336
Gene Name OVA1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23890195
NCBI Protein GI 799316317
Locus Tag CNAG_07338
Genbank Accession CP003820
Protein Accession XP_012047040
Taxonomy ID 235443
Chromosome No 1
Gene Starting Position 595351
Gene Ending Position 597286
Gene Strand (Orientation) -
Protein pI 5.32
Protein Weight 56348.93
Protein Length 515
DNA Sequence 
>gi|799350543:595351-597286 Cryptococcus neoformans var. grubii H99 chromosome 1, complete sequence
CTGCCCCGACCATAATGATGCATAACTCTCGTTGGTCTAATTGCCATCTGTGGTGTTTGGGAAAACAAGC
GTCTGACCTATGTCAGTTATGACAAATCTTCCTTTCTCGGCCTCAGTGGTATCCCATTCTCGGCTCACGC
CGTACAATCTGCGACATCTTCCAAAGTCTACTCTTGTTCCTCTCGCCTCGTCTGCGTCACAGAACGTTCC
CCAATGTATCCCCAGTGTTCTCTCGCTTTTAATGATGAGGTGTATGTCAAGTGAATCTGCTGGTGAGCAG
TGGAGGGATGAAGTGAGAATATACTGATCTAAAGACAGCGATAAAACGGTACGAAGGAAAGGAAGTGACG
ATCCAGTTGAAAGAGGAAGGAGAGCCAGATTGAATGGTGCGTAGTAATCGGCAATTTCTTGATAGAATCT
TGGTCAGCGTGGAATGAAAAAGGTAAAATAATGGCAGAACACACGCTGGAAGGCAGGACAAATGGCGTCA
GGGTCGCCTTCGGGAGCACTTGCATAGCGATACCCGGTGTCTCTATGATGTTAAGTTTCATGAGCAAGGA
ATCTGACAGATACCGTGAGCAGTGCCCGAACCTACCCTCCAAAATAGATCTTGAACCCCTTCCAGTCATT
CATTCCCCTTTTCAAAACTTTACCAGCATCGGCTGCTTCAACTGCACCTACACACCAGCTTCCCCACAGC
GTTGTCATGTGGTCAAGTACGCTTCTACCAGAGCGATGTTGAGCAGGTGTGAATGCGACCTTCAAAGTGA
GTGCTGAAGTATTTATCTTGGCGATGTCTTCAACTATACTCTCCTTGTTCTCATAATCGTCAGGAGGATA
ATGAGGATCATAGTCCACATCTGGAGAAGCCTCAAATGATAGAATGGCTTCGCGCCACCAATCCAACTCT
GTCACTCTATGAGATGGTATGCCAGAAGCAGTAAACCATTGTTTGAGCCCTAGTCCCAAAGTCAATAAAT
GCGTGTTAAACAAATGTGACTAACCTATAGGCACAAAAAAGTGGATAGTGGCCTGATGATACTTCCACAG
GTCCATTATAGTGTTGTAGTCCAGATGGTCATCTACCGCTATTAGGCAAAGATCCCTATAACCTTCCAGA
GATACTCACAATGGTCATGGGAGATGCAGCAGATATGTATTTCTGGTAGCATAGAGACGGAACAGGGGGG
ATCCATGTATCTTGCAGGGCCAATGTACTGGGTGGGCGAGCATCTGAAGATGGCATGTCAGGAAGAAAGA
AAGGCAAATGTAAGGTGGCCTACCTATATGAAAATATAGGGTCGAATATTATCCCACATGTAGCCCCACC
TCTATTAATTTGCTCCTGATTCATGTTCCTCCATGGTATCTGCACCAACACACCGGCATGTCCCAGCCAA
GTGACTCTCTCTCCTGTCTTCGAATTGCCGCCCCAATCTGGCTCTACCAGCCCCACGGGTGGGTCCCTCC
AGTCGTCTTTTTCATCTCCCTGTCTGATGTCTGAAAATTCTGGCCGGATATAGATTTTCCTCTTTTTGAT
GGAATCAGATTCTGTCCAGATTGGTTCACTTTCATAGTCATCTTCTTCCTGATCTCTATAAGGCTCGTCC
CCATCAAGAAATCGGTTTCCCTGGAAGAATGAGGGATGAGGAGCAATTGATGCTCCGCGCTGGTAGGCTT
GATAAGCGTCCCACATGGAGGCTGTTCTGTATGAAGGCCATGGGTTGCGAAAGTACTTGGGTTTGGCTAT
CTCCTGGAGATGGGGAGGAGATTTCGCGGGTGTGCCGTGGTGGTCCCTCGGCAGGTCTGGGGTGGGAGGT
ATCTTGGCCACGGTGGGTGTGAGCATGGCGTGGTAGGGAACTAGTAGCACAGTACATAATAGCCAGAGAG
CAATAGTGGCTAGTTGGTGAAGGAAAGACGGCCGGAACCAAATACG
Protein Sequence 
>gi|799316317|ref|XP_012047040.1| N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D [Cryptococcus neoformans var. grubii H99]
MLTPTVAKIPPTPDLPRDHHGTPAKSPPHLQEIAKPKYFRNPWPSYRTASMWDAYQAYQRGASIAPHPSF
FQGNRFLDGDEPYRDQEEDDYESEPIWTESDSIKKRKIYIRPEFSDIRQGDEKDDWRDPPVGLVEPDWGG
NSKTGERVTWLGHAGVLVQIPWRNMNQEQINRGGATCGIIFDPIFSYRCSPTQYIGPARYMDPPCSVSML
PEIHICCISHDHYDHLDYNTIMDLWKYHQATIHFFVPIGLKQWFTASGIPSHRVTELDWWREAILSFEAS
PDVDYDPHYPPDDYENKESIVEDIAKINTSALTLKVAFTPAQHRSGRSVLDHMTTLWGSWCVGAVEAADA
GKVLKRGMNDWKGFKIYFGGDTGYRYASAPEGDPDAICPAFQQIADYYAPFNLALLPLSTGSSLPFLRTV
LSLSLDQYILTSSLHCSPADSLDIHLIIKSERTLGIHWGTFCDADEARGTRVDFGRCRRLYGVSREWDTT
EAEKGRFVITDIGQTLVFPNTTDGN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: OVA1 encodes a putative phosphatidylethanolamine-binding protein that appears to negatively influence capsule production and melanin accumulation (Hu et al., 2007).
References
Hu et al., 2007: Hu G, Steen BR, Lian T, Sham AP, Tam N, Tangen KL, Kronstad JW. Transcriptional regulation by protein kinase A in Cryptococcus neoformans. PLoS pathogens. 2007; 3(3); e42. [PubMed: 17367210 ].