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MPR1

Victor ID 5335
Gene Name MPR1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23884111
NCBI Protein GI 799314471
Locus Tag CNAG_00289
Genbank Accession CP003820
Protein Accession XP_012046632
Taxonomy ID 235443
Chromosome No 1
Gene Starting Position 746859
Gene Ending Position 748134
Gene Strand (Orientation) -
Protein pI 6.51
Protein Weight 23022.35
Protein Length 222
DNA Sequence 
>gi|799350543:746859-748134 Cryptococcus neoformans var. grubii H99 chromosome 1, complete sequence
CCTTTGGTCGTCCATCCACGTCACAACAGGAAAATATTGGCCATAAAACGGCATTATGATTCTGAAGGAT
ATGTAATTGAATTGCACATTTATCATGCATTGATTGATTGTAAGGATATAAAACCCTTCATTACACAAGG
CTCTTGTATATTATGACAGCGTCAACGTATTCTTCGCTGCCGTTGGGACCTGTCTTCAGACGACCCGCTT
TTGGGATGACTCCAACGCGCTGAAAACCAAGCTGATCCCAGATGGAGAGGGAGGGTATGTTATCTAATAT
GAATATCATATTCAGTATCGCAAATGGATGGAGTTGCTCAGCTTTTGAAAAGGGTCACTCACTCTTGTAC
ACCAGATTAAACACACTTCCTCTGTATCCTAACCGAGGCGCGTACTCCAAGTAGCTCTTTCCGAGTGCGA
TGCCCAACTTTTTCCCTCGGTGGTTGGTGGGCACAATAAATCCAGCGTTCTGTTTTTATAAATAGATTAG
TTCGGGATGTTGTATGGTTGTTGAAAATCCATGCATCGCTCACGCAGTTCTAGAGTTATAAGTCTTCTGG
TCAGCGATATCATCCTAGACTCTAGACCTAAGACGTACATGGCTGCTTCTTCCGGGATAATTGGGTTTGC
TACAAATTTATCACTCTAAGCTTTTCACTTTTGGAATGCCAGCCATAAGCTAGCCAAGAAACCTTACATA
TAGTAACAACCCCCTATACATTCTTCCCATGTCCTTTCGGCTCTTGCAGTCTCAAGATCACCAGGGATAT
CAATCTTGCCATTAGTTCCAACCGGCTGGATAATTCCAATGATAGTAGTAGCGGCGAAGAAGTATGACAG
AAATTCTTCGTATGTCACGGGGCCTTCCTGTGGATATGTACAACCACCTGCAGTCAATGGTCAGGGTGAG
AGCCCATAAGGCGGCAAAAAAGCTGCTTACTTTCTAATTCATTGGAGAAGACGATATAGAAATAACGAAG
TAATTCTTCGGGGGCATCAGCACCAGTTACCGGGTATGTGACTAAAGCGAAACCAGCAGAAGGCAAGGGG
AAGGAAAGGATCGGCAGGGAGCTGGTTGGTTGGGGAGTAGCTATGGTGCCGTACGCCGACATGGGGGAGA
TTCTCGATGCTTGAGGTGGATTTGCAGGAATACAATGAAGTGAGATGACGCTTTTTATGAAACAAGGGAA
TAGAAAAGAATCGACAGTTTACTTTCTTTGATACTGCTCTACTTGCATTATAAACGGACCACTGCTGGCA
TTGACCAGCGACTATC
Protein Sequence 
>gi|799314471|ref|XP_012046632.1| hypothetical protein CNAG_00289 [Cryptococcus neoformans var. grubii H99]
MSAYGTIATPQPTSSLPILSFPLPSAGFALVTYPVTGADAPEELLRYFYIVFSNELESGCTYPQEGPVTY
EEFLSYFFAATTIIGIIQPVGTNGKIDIPGDLETARAERTWEECIGGCYYIKPNYPGRSSHNCNAGFIVP
TNHRGKKLGIALGKSYLEYAPRLGYRGSVFNLVYKNNIPSLSIWDQLGFQRVGVIPKAGRLKTGPNGSEE
YVDAVIIYKSLV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Mpr1 (mpr1Ãâ) failed to breach the endothelium in an in vitro model of the human blood-brain barrier (BBB) (Vu et al., 2014).
References
Vu et al., 2014: Vu K, Tham R, Uhrig JP, Thompson GR 3rd, Na Pombejra S, Jamklang M, Bautos JM, Gelli A. Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease. mBio. 2014; 5(3); e01101-01114. [PubMed: 24895304 ].