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MPD1

Victor ID 5334
Gene Name MPD1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. neoformans B-3501A
NCBI Gene ID 4934847
NCBI Protein GI 134109153
Locus Tag CNBC1820
Genbank Accession AAEY01000013
Protein Accession XP_776691
Taxonomy ID 283643
Chromosome No 3
Gene Starting Position 508707
Gene Ending Position 510061
Gene Strand (Orientation) +
Protein pI 5.35
Protein Weight 39501.29
Protein Length 388
DNA Sequence 
>gi|134110246:508707-510061 Cryptococcus neoformans var. neoformans B-3501A chromosome 3, whole genome shotgun sequence
TATGAAGATTGCCTGGTCTGCAGTAATAACAGCTGCGCTGTTGCCGTTCTCTGCCTATGCAGGCATGTAT
GGCCAGCCTGTTCTCCATCTCGACTCCAAGACATTCAAGTCCGTCATGGCCAATGAACATGCGGCGGTGC
GTCTTTGTAAGCATTAAACATATGTCGCTAATCATTGAACAGATGGTCGCCTTTGTGGCACCGTGGTGTG
GGCACTGTAAAAATCTCGGACCCGAATACACTGCTGCTGCCCAATCACTTTCGCCTCTGATCCCATTCTA
TGCTGTTGACTGTGACGATGCGTCCAATCGTGGGCTTTGCGCTGAATATGGTGTTCAAGGATATCCAACT
ATAAAAGGTTTCCCCAAGGCGGGGAAGGGAGCTGCTAAGGAATACAATGGTGAAAGGAAGAGGGGTGCGC
TAGTGGAATACGCGAAGGGGTTGGTGCCCGAGAGGGTCAAGAAGTTAAGAGTTCAGGGAGACATTCAGTC
TGATGTGCAAGGTTTTTTGGGGGAGGTAGGTATTGACAAATCAGGTATACTCGCCGAAAGCTTACGGCGA
GAGCAGAAATCTGAGCTTCCGCATGTCCTTCTTGTCCACCCCTCGTCGCCTTCTATTCCTTTCCTATGGA
AAGTTCTCGCTCACCGTTTCTCCAACAAGGTAAGCTCTGACGTTGCATTTGGTAGGTTCTGACTACCATT
TAGCTCCACCTCGGATACGTACGAGATACTACATCACATGAAGTTCTTTCATCGCTCGGCATTTACGACT
CCACAGACACTACTCGTGACGGTACACGAGTCGTCGCTTGGTCTCCCGGCTCTCAAAGCGGGGAGTTTGT
AGAATATGATGGTGAGGCCGATTATTAATTCGCTGTGATTATACCTAACGAAAAAAAGGTATCCTTAAAT
TCAATGCCCTTCTGGAATGGCTCCAAACCACTTTCCCTTCAGCCGCTCCTTCCAACGCCAAACAAAGACC
TGTCAAAGCTCCTCAACCGACCGTCAAATCGACCAACAAGAGGCAGGAGCAGATTCCTACCCAATCCCAA
AATGATGCCGCTGCCAGGAGAGCCAAGTTGGAAGAAATGGAAAGGAGGGACAAGGCGAGAAGAGAGAAGG
CCGCTGAAGCTGCAAGGGCTCAAACGATGGCCACTGAGGCAGAACCCGAGATAGAAAAGGAGGCTACTCC
TGTGGAGGACGCGGCGAATGCGGCCCCTGCTCAAATGGTAGAAGATACCTCTTTACCAGCGGAAGAAATG
GAATCAAGACCTGTGCCCGAGGAAGCGCCTGAGGATGAAGGGTCAGCGGGCGATGTGGAGGTTGAGAAAA
CTGAAGTGGTTCATGAGGAACTATA
Protein Sequence 
>gi|134109153|ref|XP_776691.1| hypothetical protein CNBC1820 [Cryptococcus neoformans var. neoformans B-3501A]
MKIAWSAVITAALLPFSAYAGMYGQPVLHLDSKTFKSVMANEHAAMVAFVAPWCGHCKNLGPEYTAAAQS
LSPLIPFYAVDCDDASNRGLCAEYGVQGYPTIKGFPKAGKGAAKEYNGERKRGALVEYAKGLVPERVKKL
RVQGDIQSDVQGFLGEKSELPHVLLVHPSSPSIPFLWKVLAHRFSNKLHLGYVRDTTSHEVLSSLGIYDS
TDTTRDGTRVVAWSPGSQSGEFVEYDGILKFNALLEWLQTTFPSAAPSNAKQRPVKAPQPTVKSTNKRQE
QIPTQSQNDAAARRAKLEEMERRDKARREKAAEAARAQTMATEAEPEIEKEATPVEDAANAAPAQMVEDT
SLPAEEMESRPVPEEAPEDEGSAGDVEVEKTEVVHEEL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: MPD is required for mannitol biosynthesis and the ability to synthesize mannitol is essential for wild-type stress tolerance and virulence (Suvarna et al., 2000).
References
Suvarna et al., 2000: Suvarna K, Bartiss A, Wong B. Mannitol-1-phosphate dehydrogenase from Cryptococcus neoformans is a zinc-containing long-chain alcohol/polyol dehydrogenase. Microbiology (Reading, England). 2000; 146 ( Pt 10); 2705-2713. [PubMed: 11021946 ].