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MET6

Victor ID 5331
Gene Name MET6
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23884226
NCBI Protein GI 799314770
Locus Tag CNAG_00418
Genbank Accession CP003820
Protein Accession XP_012046704
Taxonomy ID 235443
Chromosome No 1
Gene Starting Position 1096620
Gene Ending Position 1098763
Gene Strand (Orientation) -
Protein pI 5.67
Protein Weight 40560.04
Protein Length 397
DNA Sequence 
>gi|799350543:1096620-1098763 Cryptococcus neoformans var. grubii H99 chromosome 1, complete sequence
TGGTTTGTGGCGGTTGAGCGCATTGCATAAAGTACCGGAAACCGACAGCCCTACACATGATCTAATGTCT
TTTTATCTATAATCTCACCAAATCAACAGAACTAGAACCAGTAGTAGAGAAGCGGGTAGGGATATACAAC
CTCGCCTCGCCTTCCAGAAAACCCAAAAGACAAGGTCGAAAAGAAATGAGCGAAAGATACGAAAAAAGGG
TATATGCGTTGTGATATAATAAATGCGTTTTACTGTTGGAGAGATTGTCATGGGAAATCGTGCTGCTTGT
AAGACAAGAATGCGAATGATATTGAACGGAGCGAGGAGGAACTCGCATGGGTCCTTAGTAGGTATCCCAT
ATTAAAGATTAAGAGGAAGGAAGAGAGACCCAAGCATGAGAGACTAGCAGCTTAGAAGTTGAGCTGCTTG
GGCTGCTCCCAAGAGTAGGCAGGGTTACCGAAGTGACCGTAAGCGGCAGTCTTAAGGTACTGGGGCTGCT
GGAGGTTGAGAGCTTGGACTGTGGGTGACATTAGCAACTACCGCAAGATGTTTCTTTCTCGAAAAAACGT
ACCGATAAGTCCGGGTCGGAGGTCGAAGTTCTGCCTGATAACGTCGACAAGCTCGGCGTCGCTCTTCTTG
CCGGTACCGTAAGTGTCGACGAAGATGGAAAGGGGTTCAGCGACACCAATGGCGTAAGAGAGCTGGACCA
ATGCTCGTCGGGCGAGACCAGCAGCGACGAGGGACTTGGCGATCCATCGAGCAGTGTAGGCGGCAGATCG
GTCAACCTTGGACCAGTCCTTACCGGAGAAGGCACCACCACCGTGAGCACCCCAACCACCGTAGGTGTCG
ACAATGATCTTTCGGCCAGTGAGACCGGCATCACCCTGAGGACCGCCAATGACAAATCGGCCGGAAGGCT
GGATGTGGTAGATAACTCGGTCGTCAAGAAGGTTCTTGGGGATAACCTTCTTGATGATCTTCTCAAGGAT
CTCCTCTCGGAGCTGCTCGGTAGAGATCTCCTCAGCGTGCTGAGTAGAGATGACGACAGTGTCGACACGG
AGGGGGATCATAGCACCATCCTCACCCTTCTTGTACTCAACGGTGACCTGGGTCTTAGAGTCGGGTCGGA
GCCAGCCCATAGAGCCGTCACGACGGGCAGTGGCCATAGCGGCGTTAAGCTTGTGGGCGAGCATGATGGT
AAGAGGCATCATCTCGGGGGTCTCGTCGGTAGCGTAACCGAACCTGATAAAGTCGTCAGCTCTCGCCTGC
ATGACGGACTCATGCGATAAACCCACATGATACCCTGATCACCAGCACCAATCTTCTCGAGGGCACCGTG
GTCGAGACCTTGAGCAATGTCGGGAGATTGCTGCTCAATGGCAACCAAGACGTTACAGGTCTTGTAGTCG
AAACCCTTCTCGGAAGAGTCGTAACCGATCTTCTTGATGGTGTCTCGGATGACCTTCTGGTAGTCGATCT
GCGCCCTGGTGGTGATCTCACCGAAGACCATGATCATACCGGTCTTGGCGGCGGTCTCACAGGCGACCTA
CGGAACACAATGTCAGTCGAGGGACCAAAGATGAAACATGGTGTATGGATGCATACCTTGGAGAAAGGGT
CCTCAGCGAGACAAGCGTCGAGGATGGCATCAGAGACCTGATCACAGATCTTGTCGGGGTGGCCCTCACC
AACGGACTCGGAAGTGAAAAGGAAGCTGTATCGAGGCAAGGGCAGCAGTGGCAATTATACAGGGCAAAAC
AGGGGGCGGTGGGAAGGATAGGCAAAGATGGGCAAAAACCAAAAACCAGCCGTCAGCAGCCAATTCTCTC
CAATAAGCCCGTCGAGTCGCAGAAAACGTGCGATGCTGTTCTACCGCGAAGAGAAAAAACACTCACTGCC
CGGGAGCCAAGTCAGTAGCGGGACCATTACCGTTAACGTTGACAGCAGTCATTTTGTATATAAGTAGGTG
GGTGGGGGGGGTGGGGGTGTTTCAGACAAGAAAGGTAATTGGAAAAGAGATAAAAGAGAGGATGAAGATT
TATACGGTGACGAGGAAAACAAGGGCAAAAAAAATGGAACCATAGTTGCCCTGTCCCTGCGCCGACGCCC
GACCCGCCGACCAGACGATGGCGTGCGAGCCAGGAACAGGAAAA
Protein Sequence 
>gi|799314770|ref|XP_012046704.1| S-adenosylmethionine synthase [Cryptococcus neoformans var. grubii H99]
MTAVNVNGNGPATDLAPGHFLFTSESVGEGHPDKICDQVSDAILDACLAEDPFSKVACETAAKTGMIMVF
GEITTRAQIDYQKVIRDTIKKIGYDSSEKGFDYKTCNVLVAIEQQSPDIAQGLDHGALEKIGAGDQGIMF
GYATDETPEMMPLTIMLAHKLNAAMATARRDGSMGWLRPDSKTQVTVEYKKGEDGAMIPLRVDTVVISTQ
HAEEISTEQLREEILEKIIKKVIPKNLLDDRVIYHIQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHG
GGAFSGKDWSKVDRSAAYTARWIAKSLVAAGLARRALVQLSYAIGVAEPLSIFVDTYGTGKKSDAELVDV
IRQNFDLRPGLIVQALNLQQPQYLKTAAYGHFGNPAYSWEQPKQLNF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The MET6 gene showed a substantial induction in response to methionine and a dramatic transcriptional induction in response to homocysteine (Pascon et al., 2004).
References
Pascon et al., 2004: Pascon RC, Ganous TM, Kingsbury JM, Cox GM, McCusker JH. Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence. Microbiology (Reading, England). 2004; 150(Pt 9); 3013-3023. [PubMed: 15347759].