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KRE5

Victor ID 5327
Gene Name KRE5
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23887124
NCBI Protein GI 799317274
Locus Tag CNAG_03648
Genbank Accession CP003821
Protein Accession XP_012047161
Taxonomy ID 235443
Chromosome No 2
Gene Starting Position 433178
Gene Ending Position 439266
Gene Strand (Orientation) +
Protein pI 4.81
Protein Weight 166897.95
Protein Length 1582
DNA Sequence 
>gi|799350600:433178-439266 Cryptococcus neoformans var. grubii H99 chromosome 2, complete sequence
TAGTAGACTTTCTTGCGCATTATGTCATGCTGGTTTGCGTGGAGGCCAGCTACAGTTGGCCTGTTCGTTT
TCCCGACGGACTTTGACTAATGTGCATATCCATTTCAACTTTACAGAACCAGGTATACGCATACTAAATC
AGGCCTGCACAATAGAACGGGCATTATGAGAGCAAGCACAGTAGCTCTAGCCCTCGCAGCTTCAGCCCTA
GCGGCGTCCGCGTCTCCACCAGTACGCGTAAGTCTCGAGACAGGCTGGGCAGCTCCCCCCTTGGTCCTCG
AGATCCTGTAAGTCGTCCTTTATAGTTGGAACTAGCTGCTTACATGTCTATAGCGAAACTGTGTATGATG
AATACCCTTCGTCCTACTTCCAGCTCCTTCATCTTTTATCCTCTCTTCCTCCAGATTCTACAGACGAATC
CATATTATCCTCAACGCTGGACCTCATTCAAGCCTACTCACTACTTCCTTCGCCGTCATCACTATCTACT
TTTCACCTTGCCTTATCCCTACACTCAACAGCACCTAGAATAGAAGCCCAATACAACTGGTACAATAGTG
CCGTGAAGGGACAGGAAAATAAGTTGGGAGTGGAAGGTTGTGAAGGTTGGGTTGAATGGCGAGGGAAAGG
GTTCTGTGATGTTGATGGGCTAAAGCGGGACATGGAGATGAGTATTGAGGAAGGAATACATAAAATGTAA
GCTGCCTCATGATGGAAGGCGTGTTCGATGTCTGATCTAGGCCAATAGTAACCAGGAACCTCATTCACTT
CCATTCGATCGCACTTTTTCGTCGGCCTCTTCTACCTCATTCTCGCCTCGGGCCATATTCTATTACGCTC
CATTCGCTTCTACTTCCAATGAACTTCTTGGATACCTGGATCACCATGCGTCTCACTACCCAGAGTTCAC
TTATACCGTCCGTTACCAGTCCCCTTTGTCGGACGCCGCCAAAAAACCTTCGTCTCTCTCAGGATGGGGC
GCGGAGATGGCCCTTAAGAAGATGGATTATCTCGTTGTTGACGACCGCGCTACTGGGAAGATCACCTTCC
AGAATGAAGGTGATGAGGTGGCTCGGAATGAGAGTAACATATTTGCTCACGTATTTGGGAATGACCCATG
GAGTGATCAAGCAACGCCTTTGACAGCGACAGAGATCAGAGGTTGGTTGTCTCATTTTCCATGAGTCCGT
ACTTGGCTGACAATAACTGGAAAGACATTGGTCTCAAGGCTGCTACTCTTATCATGTCTTCGGATGACCC
TATTTCTGCCCTAACTCACCTTTCGCAAGATTTTCCCAAGTATTCGGCTGCCCTCGCTCATCAAGTTGAG
GTACCAGAGGATATTCAATCAAAGGGCAGGACTATTGCTGTCAGAGGAAAGGCGAAAGAAGCTATATATA
TTAATGGCAAGCCGTTTGACAGGGATTTGAATCCGTATACGTAAGTAAATGTTTTCGTTTCGACCCATAC
TGATCATGGCATATAGTCTTCTGAAAGCCCTTCGTGATGAGCGCCAACTCACAATTTCCCTCACTTCCTT
GGGTCTTACCCCAAAGCAATCCATTGACATATTGGCGGATCCCGTTGTTGGCCAAGGCCAGATTGAAGAT
GACATGGGAGAAGGCTTGGTAGATGCAAGTGATAGAATCGAGGGTGGCGACGTTATTACTTATTGGAATG
ACATTGAGAAAGACAAAAGGTATCACAATTGGCCTATCCATCCTCAAGGGGTAAGCAATTCCTTTTTATT
GCGGTACATGCTGAAGCGCTATGTAGTACATGCGCCCTGTATACCCTGGTCAGTTCCATAACGTCAGGCG
GAATACATTCAATCTCATTTTCGCCCTGGACCTCTCCCGAATCTCGTCCCTTGAGCTTATTGTCCACTCC
ATTTCTACCATGATTCAGAGAGGTTTGCCTATAAGATTTGGTATAGTACCTGTATTTGAGCCTGAACAGC
AAGACGACATCTGTAAGTGCCGGCCCTGACTTACATTTATGATTGCTCAAAGAAAATTAGCTCTTCAGAT
GGCCAAAGTCTTCTGGTACTCGGTCAAGACCTTTGGAAGAAGCTCAACCCGGGACTTTTTCGCTGCTGTA
AGCCCGGTAGTTGTGTACGCTATTAATTTGTGCTAAAACCTTTCAATCAGATCATCGATGCAATTCCGCG
CCAGCTCAACAATCCTGCTCCTCAAGTAAATGATGATGTTCTCCGTAAAGGGTATGATGCCCTTTCCGCG
ACTTCTAAAAAGGCTTCTTTAGCCTTTGATGATGTTTTGACCTCTGACGATTGGGATCACCATATCGAGA
AGGCTGGGAATTATTTGAAGAGGTTGTTAATCACCAAAAAAGATACAGAGAATGGCGGTATGTTCATGAA
CGGGAGGTTCACGCCTAATGCGCCTACCTGGCCCAACATTGTTACACAAGAGATGCAGTCACAGCTCGCC
TTCATCCAAGAACAGGCAAGTAAGGTATTTCGTATCCATCGCAATTATTGACTTGGGCGCAGGTCATGTT
GGACGCAATCCCCGAAGACATTTCAACTATGTTCTATGATTTGCCAGCCACCTCTAAAAGGAGGAGCAGC
CTCGTTATTCCAGTTGGCGACAACAAGCTCAAAGTTTTCAATTTGGTCGATCTCTTTAAAAATGAGGGGA
TTGAAGGCAAATTGAGCGGAGAGTTCGTCTATCCAGGTCAGCCATAACATCTAGGAACTGTGGTTTCCCC
TGCTGATTTAAGAATGTAGATGGAGAAAGAGGAACACCGATCAGTATGTGGATTATAGGAGACCTTGATT
CTCCTGAAGGTCTGGAGATTGTCAAGAACGGCCTACAGCACCTCCAGACTCCGCAATGCGCTTCCAGGCT
CGGCTTCATTCATGTACCCCCTGCATCTCGCCATTCTTCTTGTCCCGCAGGGCAGTATTGCTTCTCAACT
GTGCTTTACCAGATTCTTTCCCAAAACGCACTCTCTTTGACCAAACCTTCTGATCTACTGGAGCTCATAT
CAGAAGTCCAGCACTCTGTTAAAACAAATTTGGAAAAAGCTGGCGAAATTAACGTTGGGAACCAAGAAGT
GGATGACTTTGGAATAACATTCACACTGTCTCCCGAGGACCAACAGAAGTATTTCGAGGCTAAACCTTTG
CACAGTATGACGTTTGGCGGGTGGGTTGCTGGAGATACAGCTGCGGCTAGCGAGTTCTGGAAGGCCGGGA
CCCAAATCGCAGGAAAGCTTGCCATCACGGACGGTGTGCACATACTTGTTAATGGTCGAGTAAGTAACAA
TATTATTCGTGAGTAATTGCGTTTCTTATGCTAATACTTGGTTAGCTTGTCGGTCCCATCACTCCAGTGA
CATTCCCGCTTGATGACTTCGAAGCTTTGGAGGCGTACGAGCACAGGAAGCGCGTTAAGCCTATCATCGA
TGTTCTTAAGACGATGTACGATGATATTACTGCCTTTGACAGGTAAGGTTTTTCATAAACCATTGGAAAT
GGGATCACCGACTCTTTCGTAGACCAACATTGGCCAACCTTATCTCCAAAGCCTCCTCTGTAGTCACCGC
GGCTTATAAGCCTCTTGATGGTGAAGGAATCTTCGCACCTGCCCAATCGACTAGGACGAGGTATTATGAA
AGACTTGACGATGGATCCACGTGAGTCATGATACGCCAATCTTCAAGTTTAAGGCGTTGACATGTCAGGG
CAGGTCATTCAAGCTCGGGGATGAGGACATGTCCCTGTTGAAGGTGGCAGTTGTTGTAAACCCATTATCT
GAGCAAGCCCAAAAGTGGTCGCCTCTCATCCAGGTAGGTAATTCACTGGGGCGTAGATGTCGTGAAGCTA
AATCGACCGTAGACTTTGTCTGAAATGGACCACGTCTTTGTGTCTGTATATCTAGAGCCAGAGGCGCTAA
TGGAGGAGGTCAAGTTGAAGAGGTTCTATCGTACTTCTGTACCTTCCAGGTTGACCTTTGATGTCGATGG
GTGCGTCTGCAACGACCTTAATGGCTCTAACATGAAGCCTTGGCTAATGCTCGACTGTAGTGCTGCCATT
GCCCCTGGTCTGACATTCAACGACCTTCCCTCCAACCCTATCTATACTCTTGGTCTCGACACTCCGCCGT
CCTGGATTGTCTCGCCCAGGACTTCACCATACGATCTGGACAATCTTCTCCTGTCCTCCACCTCGTCACC
TGTCGCTGTCACCTTCCAGCTCAAGCAACTTTTGATTGAGGGCCACGCTCGAGAATCAGGCAACATTCCT
CCTCGTGGTCTTCAACTACAGCTCAAAACCCTTGATGGAGATATTGCTGCCGATACACAAGTGATGGCTA
ACCTCGGTTACTTGCAATTCCGCGCCACGCCTGGTTACTATACATTGTCCATCAGACCGGGTAGGGGTGA
AGAAGTCTTCAACCTTGAGAGCATTGGTGCCGAGGGTTGGGATAGCCCGTCGGTAGGGGAAGTCGGAGAC
GGTGTCAGTCTGTCAAGCTTTGATGGAGAGACGATATACCCAAGATTCGCAAGGAAAGAGGGTATGGAGA
AAGCCGACGTCCTTCAAGAATCGGTTGCTGCTCCGGAAGGATTGGCGAAACAGGTCTATTCAAGGTAAGC
TCGGTTACTTATAGTACGAGACTGATCATCGCTGATGATGACTTAGGATGAAGTCTATCGTTGGACTGTC
AACAAAGGTTACGCCCGCTAAGTCTGAGCATGCCGATATTAACATTTTCACTGTTGCTTCTGGTCTTTTG
TACGAGCGTTTTGCATCAATCATGATTCTTAGTGTCATGAAGCACACCAATAGCTCTGTCAAATTTTGGT
TTATCGTAAGCTATTCATCCTGATATGACATAATCGGCTTATTGACCTTCGTTTGTACAGGAAAACTTCC
TTTCCCCAACTTTCATTGTGAACCATTTCCCTCTTTCCGCCGGTTGAATAACACTAACAGGTATTCAGAC
GTTTATCCCTAAACTTGCCGAGGAATACGGCTTTCAATACGAGTTCGTAACTTACAAGTGGCCGCACTGG
CTGCGAGCTCAGACAGAGAAGCAACGAATCATTTGGGCGTAAGTTTTTTTGCAATTTCCTTCACGCAAGA
TCTCACACTATCTCTCAGATACAAGATCCTTTTCCTCGATGTCCTTTTCCCCATGTCTCTTGACAAAGTC
ATCTTTGTCGATGCCGACCAGATTGTTCGTACTGACATGAAGGAGCTAGTGGATGTCGATTTGCATGGAA
GGGTCTACGGCTATGCGCCTATGGGTAACAGCCGAAAAGAGATGGAAGGCTTTAGATTCTGGAAGAGCGG
ATATTGGAAGGAAGCGCTGAGAGGAAGACCGTACCATATTAGGTATTGACATCTCGAATTCTGTTCTTCA
AATACATACTGATTATTGGACAGTGCTCTGTACGTTGTTGATCTCAAAAAGTTCAGGCAGCTCGCTACGG
GAGTAAGTAAAATCTACTTCACTCTGCCAGGCCCAGCTGACCGGTTTTAGGATCGACTTCGAGGGCAATA
CCATGCACTTTCAGCCGATCCTAATTCACTTGCCAACCTGGATCAAGACCTTCCCAACTCAATGCAGGAT
CAAATCCCTATATGGACACTGGATCAAGACTGGTTGTGGTGTCAAACTTGGTGCAGCGATGAAAGCTTGG
CCACGGCGAAGACTAGTATGTCATTATGTAATCTCTTAAGTGTTGGTACTGATCATATCTGATAGTCGAC
CTTTGTCAAAACCCTCTTACTGTAAGTGCTCTACTCATAAATATTTCCGAAAAATGGGTTAACCCCTTAA
CAGAAGGAGCCCAAGCTTGTCCGTGCTCGACAGATTCCAGAGTGGGACGCGTACGACCAAGAAATTGCCG
CGTTCGCTGCTCGGGTGTCAGAGGAGGGTGAAGAAAGCGGGGCTTTGGCTATCAGCGTGGACTATTTGGC
GTCAGAACGCCACGTTTCTGGGGTCGAAGGGAAAGAGGGGGAGACAGAGCGTGAAGCTGAAGGACGTATC
GGGGATGAGCTGTGATTTATTATGACTAGTAAACAACACAGAATGAAATGCATTATTTGTTTCTCAGGC
Protein Sequence 
>gi|799317274|ref|XP_012047161.1| UDP-glucose:glycoprotein glucosyltransferase [Cryptococcus neoformans var. grubii H99]
MRASTVALALAASALAASASPPVRVSLETGWAAPPLVLEILETVYDEYPSSYFQLLHLLSSLPPDSTDES
ILSSTLDLIQAYSLLPSPSSLSTFHLALSLHSTAPRIEAQYNWYNSAVKGQENKLGVEGCEGWVEWRGKG
FCDVDGLKRDMEMSIEEGIHKINQEPHSLPFDRTFSSASSTSFSPRAIFYYAPFASTSNELLGYLDHHAS
HYPEFTYTVRYQSPLSDAAKKPSSLSGWGAEMALKKMDYLVVDDRATGKITFQNEGDEVARNESNIFAHV
FGNDPWSDQATPLTATEIRDIGLKAATLIMSSDDPISALTHLSQDFPKYSAALAHQVEVPEDIQSKGRTI
AVRGKAKEAIYINGKPFDRDLNPYTLLKALRDERQLTISLTSLGLTPKQSIDILADPVVGQGQIEDDMGE
GLVDASDRIEGGDVITYWNDIEKDKRYHNWPIHPQGYMRPVYPGQFHNVRRNTFNLIFALDLSRISSLEL
IVHSISTMIQRGLPIRFGIVPVFEPEQQDDISLQMAKVFWYSVKTFGRSSTRDFFAAIIDAIPRQLNNPA
PQVNDDVLRKGYDALSATSKKASLAFDDVLTSDDWDHHIEKAGNYLKRLLITKKDTENGGMFMNGRFTPN
APTWPNIVTQEMQSQLAFIQEQVMLDAIPEDISTMFYDLPATSKRRSSLVIPVGDNKLKVFNLVDLFKNE
GIEGKLSGEFVYPDGERGTPISMWIIGDLDSPEGLEIVKNGLQHLQTPQCASRLGFIHVPPASRHSSCPA
GQYCFSTVLYQILSQNALSLTKPSDLLELISEVQHSVKTNLEKAGEINVGNQEVDDFGITFTLSPEDQQK
YFEAKPLHSMTFGGWVAGDTAAASEFWKAGTQIAGKLAITDGVHILVNGRLVGPITPVTFPLDDFEALEA
YEHRKRVKPIIDVLKTMYDDITAFDRPTLANLISKASSVVTAAYKPLDGEGIFAPAQSTRTRYYERLDDG
STSFKLGDEDMSLLKVAVVVNPLSEQAQKWSPLIQTLSEMDHVFVSVYLEPEALMEEVKLKRFYRTSVPS
RLTFDVDGAAIAPGLTFNDLPSNPIYTLGLDTPPSWIVSPRTSPYDLDNLLLSSTSSPVAVTFQLKQLLI
EGHARESGNIPPRGLQLQLKTLDGDIAADTQVMANLGYLQFRATPGYYTLSIRPGRGEEVFNLESIGAEG
WDSPSVGEVGDGVSLSSFDGETIYPRFARKEGMEKADVLQESVAAPEGLAKQVYSRMKSIVGLSTKVTPA
KSEHADINIFTVASGLLYERFASIMILSVMKHTNSSVKFWFIENFLSPTFITFIPKLAEEYGFQYEFVTY
KWPHWLRAQTEKQRIIWAYKILFLDVLFPMSLDKVIFVDADQIVRTDMKELVDVDLHGRVYGYAPMGNSR
KEMEGFRFWKSGYWKEALRGRPYHISALYVVDLKKFRQLATGDRLRGQYHALSADPNSLANLDQDLPNSM
QDQIPIWTLDQDWLWCQTWCSDESLATAKTIDLCQNPLTKEPKLVRARQIPEWDAYDQEIAAFAARVSEE
GEESGALAISVDYLASERHVSGVEGKEGETEREAEGRIGDEL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: KREgenes are required for b-1,6-glucan synthesis,maintenance of capsule architecture and cell wall proteinanchoring in Cryptococcus neoformans (Gilbert et al., 2010).
References
Gilbert et al., 2010: Gilbert NM, Donlin MJ, Gerik KJ, Specht CA, Djordjevic JT, Wilson CF, Sorrell TC, Lodge JK. KRE genes are required for beta-1,6-glucan synthesis, maintenance of capsule architecture and cell wall protein anchoring in Cryptococcus neoformans. Molecular microbiology. 2010; 76(2); 517-534. [PubMed: 20384682].