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ITR1a

Victor ID 5324
Gene Name ITR1a
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23887954
NCBI Protein GI 799340296
Locus Tag CNAG_04552
Genbank Accession CP003829
Protein Accession XP_012052055
Taxonomy ID 235443
Chromosome No 10
Gene Starting Position 1048568
Gene Ending Position 1051138
Gene Strand (Orientation) +
Protein pI 7.82
Protein Weight 56725.13
Protein Length 566
DNA Sequence 
>gi|799350850:1048568-1051138 Cryptococcus neoformans var. grubii H99 chromosome 10, complete sequence
GGCCTAGCACGGTCCACCACCACAAAGGGGAAAAACGCGCATGAGGGGAATGTATTTGTGAGACACTCCT
AGCCACCGGGACGAATGGACACATAAGATGTCATGGCTGATCGAATCTGGGGCAACATCTTTTCCCCAAC
TTGTCCCTAACGCAGTCGATTGCAATTGCAAAGTGGCTTTCGCTAGCACAGCAACAGTAGCTGCTTGTCA
TCACCTTGGAAACTCGAAACGAACCTATCTCGAACCACTGCACATCTAGCCCATATCGCATCATGTCGGA
CGAGAAGAACTATGGCATCTCGCTGGCAGCCCCGGCCCGTCCTGACCTGGGCTCTCGGACCGCAAGTCAG
CTCGAGAAGGCTACTGCGTCTCACGTCGAGTTCGCCACACCCAAGGACCCCGGCGCTCTTCACGACGCCA
CCTTGATGGCCGGTGAACGAACAGAGAAGGTTGGTTGAAGCTCGTTGGAATTTTCAACAATTTCGCTCGC
CACTGACCTGCTTTTCATGCTTCTAGTTGACCAAATTCGTCGTTGGTCTGGCGTTGTTCGCCTCTGTCTC
AGGTTTCTGCTTTGGTTTCGATACGGGAGTTATCTCCGCTGCTCTTGTATCTATCAAGGACGACTTCGGT
CATATTTTGGATGATACCGAAAAGGAATGGATTTCCGCCGCCACTTCATGTGGTGCTTTGGTCGGGTAGG
TTGAATGGGCCTTTGAATCCGCGCTTGGAGCGCCCGCTGATAGCAATGTGGTTCTAGTGCTCTCTCCTCC
GGTGCATTGGCGGACAGGGTCGGTCGAAAGTGGACTTTGGCAGTCGGCGATGTCTGGTTCACTCTCGGAG
CGATCATCATTTGCTCTTCTTTCTCGGTTGTCCAGATGATCGTCGGCCGAGCCGTCCTGGGTCTTGGTGT
CGGAACCGCTGCTGCCATCGCTCCTCTTTATATCGCTGAAGTAGCGCCAACTCGATTCCGAGGAGCTCTC
GTCACGGTCCAGTCTATCGCTATCACTGGTGGTCAATTCTTCTCGTACTGTATCGGCATTCCTCTCACCG
GTCATAACGGTTGGAGAATTCAATTTGCCATCGGTATCGTGCCAGCGGTGGTCCAGGCGGCAGTCGTGTA
AGTCATCGACCTTCTTTTATCATACAACAAAGTACTAATTCGGCGGTTTCGCACCGTAGCCACTTCCTTC
CCGAGTCTCCGCGATACGATCTGCTCAGGGGACAACGGGAGGCTGCGTTAGCGACAATCCACCGAAGCTA
CAAGGGGATGTCGGAAGACTATATTGCGGTCAAGTTTGCGGCTCTCGAGGAAGTGGTCGGTATCTCCGCT
GACTTCAACCGAGGTCATACTCTCGGCCAGAAGATGAGACTTGTATTGACCGAAGGCAAATACCGAAAGC
CCGCCATCACCGCCCTTGGTATCGGAATCTTCCAGCAGCTTTGTGGTTTCAACTCTCTCATGTACTACGC
TGCGACTATCTTCTCTTATGCAGGCTTTGACAACCGTGAGTTGCCACAGGATGCGATCCAGCAGGAGTAG
CTGGGCTGACCCTTCTTGTTCCGATGATAGCTACCTCTGTCGGACTGATCGTCTCCGGTACCAACTGGTT
CTTCACCTTTGTCGCTATGATGATTCTCGACCGAGTCGGTAAACGACGAATTTTGCTTTCCACTTACCCC
GGTATGATTGCTGGTCTCGCCTTGGCCTCCGTCGCCTTTTGGAAGATGACTGGTAGCACCGGTCACCGAT
TGGTCGAAGGCACAGAGTACCCTCAACAGTGGTCCAACATGATGTTGGGTATGATGGTCGTCTTCATCGC
CTTCTACGCCACCGGTTCAGGTAACATCACCTGGACTGTCGGCGAAATGTTCCCTCTTGAGATGCGAGGT
ATTGGTGCTTCGATTCTTGCGGGAGGTGTTTGGGCCGCCAACATTGTCATCTCCGCGACCTTCCTTACCT
TGATGAACGCCATTGGTCCTACCCCTACTTTCGCTCTATACGCTGGTATCTGTCTCGTGAGTGGCCCATC
TACAACAGCTACTTCTATCATTACGCTGACCACACGTTGTGTCACTCTGTTCAGGCTGGTCTGATCTTCA
TCTACTTCTGCTATCCCGAGCCATCCGGCTTGTCTCTCGAAGAGATCCAAATCATCTACAACTACGGTTT
CGGTGTCCAGAAATCTCGAGAGATCCGAGCGGAGCACAAGCTCAAGGCACAAGAGATGCGAGACCGTGCC
AACTCTCACATCGGAGGCTCGGCTACCGCCTCTGATGACCAGCTCAACAAAGTTTAGGTTCGTCATTCAG
ATGAGAGGTGATCACAAACGATGACACGAAGTCGACGAGTAAGCTAGTCGCAACGAGTCGATACATCAAC
GCATGAAGGGGATAACAAGGGAACCAGGAAGAAGTTTGAAAAGAAAAAAAAAAGGATAAAATAGTCTGTC
CCATAGCTAGTCTTTGTCTGTCTGTAACATCATATGATCGATTAGGATTTGTATCTTTGTACTATGACTT
AACATGAATCAGGATGCCTTTTCATATTGCATGTAATCTATGATCTTCCTG
Protein Sequence 
>gi|799340296|ref|XP_012052055.1| hypothetical protein CNAG_04552 [Cryptococcus neoformans var. grubii H99]
MSDEKNYGISLAAPARPDLGSRTASQLEKATASHVEFATPKDPGALHDATLMAGERTEKLTKFVVGLALF
ASVSGFCFGFDTGVISAALVSIKDDFGHILDDTEKEWISAATSCGALVGALSSGALADRVGRKWTLAVGD
VWFTLGAIIICSSFSVVQMIVGRAVLGLGVGTAAAIAPLYIAEVAPTRFRGALVTVQSIAITGGQFFSYC
IGIPLTGHNGWRIQFAIGIVPAVVQAAVVHFLPESPRYDLLRGQREAALATIHRSYKGMSEDYIAVKFAA
LEEVVGISADFNRGHTLGQKMRLVLTEGKYRKPAITALGIGIFQQLCGFNSLMYYAATIFSYAGFDNPTS
VGLIVSGTNWFFTFVAMMILDRVGKRRILLSTYPGMIAGLALASVAFWKMTGSTGHRLVEGTEYPQQWSN
MMLGMMVVFIAFYATGSGNITWTVGEMFPLEMRGIGASILAGGVWAANIVISATFLTLMNAIGPTPTFAL
YAGICLAGLIFIYFCYPEPSGLSLEEIQIIYNYGFGVQKSREIRAEHKLKAQEMRDRANSHIGGSATASD
DQLNKV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: itr1a itr3c double mutants showed significant virulence attenuation in murine infection models (Wang et al., 2011).
References
Wang et al., 2011: Wang Y, Liu TB, Delmas G, Park S, Perlin D, Xue C. Two major inositol transporters and their role in cryptococcal virulence. Eukaryotic cell. 2011; 10(5); 618-628. [PubMed: 21398509].