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ITR3C

Victor ID 5323
Gene Name ITR3C
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23888700
NCBI Protein GI 799348169
Locus Tag CNAG_05381
Genbank Accession CP003833
Protein Accession XP_012053726
Taxonomy ID 235443
Chromosome No 14
Gene Starting Position 149492
Gene Ending Position 151997
Gene Strand (Orientation) -
Protein pI 7.56
Protein Weight 58935.34
Protein Length 590
DNA Sequence 
>gi|799350995:149492-151997 Cryptococcus neoformans var. grubii H99 chromosome 14, complete sequence
ATCATGGGATACAGTGTGCAATGCATGATATGGTAAGTATTATACTAACGAACAACAGGTATGCACGTAA
TGCAAAATTTATCTTGAGATCGGAAACCTCTTGGCACCATTCTTCAACTCCTCCATGAAGTTGTCCAACT
CTGATCGAGTAACAGCGCTATCTTTTTGCTTCTGTGCTTGAACATGAGCGGTAGCAACTTCTGTCATCTC
GGAATCTGCCAAACGACGTTGGGTCTCCCGACGTTCTCGTCGCATCTCCCTGGAACGCTTGACTCCCCAA
TCCTCCTCGAAGAGTAAAGATGTTTCATCAATAGAAAGTTGTTCTATTGGCTATTGTCAGCATTGTGACG
CAGGAAATTTTTTATGAGGGGAAACTTACTTGTTTCGGGGTAACAGAAGACGGCAAATATGAAGAATACG
ACACTAAACCCAAGATAGAGACCGTAGGTACCGGAAGGTGTAAGCGTTTCGAGTTCGGTGAGATATGATA
CAGATACGACGAGATTTGCAACCCAGTTGGCAGTGGTCGCAATGCCGGAGCCGACGGATCGAACTTCAAG
CGCCAAGAATTCAGATTGGTACCAGGCCAAATGACTGTAGGTAAGACCGAAGCCGGTGGTAAAGAAGACG
ATACCGCCAATGACGATACCGACGAGCTTTGTGTCGTACTTGTAGGATGTGTCGAGAAGACCGCCGGTGG
GGATACACAGATCTTCCAAAATGATCAGCTTAGAGGGCGATTTCAATTACAGGGCTTGCTTACAGTGGAA
TGCAACAATATTCCAAACCAAACCTGCAAGCTGCAATAGCAGATAGGGTCAGTCACAATACTGCAACCTA
TCAGATGTGACTCACCATAATTGGAACACCAAACATCAACAAGCCTCGACGACCAACCTTGTCAACCAAA
GTCATACCAACGAGAACGAAGAACGCATTTGTTCCAGCAGGAATGAGACCTCCAAGAGCAGGGTTGGTCA
AACCGAGAAGGCTGAATAGAGTACCAGCGTAGTAAAGGAGAGTGTTGAAACCGGAAAGCTGACCAGCCAT
CTGAATGAGACTAACAGTAACGATGGAACGACGGTAAGATCCCTTGGTAAAAAGTGTTTTTGTTCGCTGC
CAGTAAGTTGTACCAGATTGGAGGACAGTGGTAGCCGTAACATATTCCTGAGCGACGCGGAACTTATAAT
CGATCATCTCGGGAGTGGCGTTGGGGTATATCCTGCTGAAAACATGTCGAGCACGGTCTGTTTGGCCACG
GAGGATAAGGATTCGGGGAGACTCGGGAAGGTAATGGAAGAGAATGAGCTGAAATAGGGATGGAACAGCA
CCAAGAGCGACTAAAAAGGAGTCAACTTAGTCTTCTAAGAAGGGAATACGTACAGAGAAGACGCCAGCCA
TTCTTCATGTCTTGAACGCCAGCACCGATAGCTTCTGAAATCACCTGACCAAAGGGGATGAAGAAGGCGC
TATTCAAAGATTTAGCTGAGTGGCACAAAGTAGACATAAAGATAACACACTTAACACCGATACATCGACC
TCGGACTGCTGTGGGGGCGGTTTCTGTGATAAACAGAGGAGCAATGGCAGCTGCACCGCCAACACCGACA
CCAAGGACGATCCGACCGACAATCATTTGGGGGACCGAGTAACTTGCAGCAATGAGTACAGCACCAACAG
TGAAGCTGAGATAGAGAAGTTAATCAAACATATTCAAAAACGAGGTTAGTCGTATAACTTACAAAACGTC
AGCGATTAAGATGGCAACCTTTCGTCCCAAACGATCACCCCAGCCACCAAGAATAGCCGAACCAAAGATA
GCACCTATTGTTGTGCCTGCGGTAATGATCTCCTGCTGTGATGAAGAAAGTACAGATCCTCCTAAGTCGG
TACCAACAAGAGGCAATGCGACACCAACAACACCTGTATCATAACCAAAGAGGAAACCGGCAATGGCAGA
CTGCACATTGATTAGCTTCGTTTTCGCCTTTTTCACCTAAGAAAAACTCACAGCAGAGATCAAAAAGCAC
AGATACGGTGTCACTTTGTCTTCTCCTTCGACCTTTACCAGATTTTCATCCTTAAGTTCTGTTAGCTCTG
AGGTTGCGAACTAATGTCTAGATATCACTCACTATCAAATGACCTCCGAACCCAGAGGGCTTGTCAGACG
GAACTCGAGTATGTTCGATGATCTCAATTTCATTCATATTCTCGACAAATTCTGATGAACCTTTATCTTT
GTCAAGACTGGACGGTGTTCTGCTCATAGCGAAAATGCGATGTTGTTGAGGGGAGGGCACTGAGTATGTT
TACTGAAGGTAGGGGAGCTGGACAAGGCGGGCCAAGAAGATACTATAACGTTGTTGGCTGCTAAAAGAGA
ACATCTCCCAAGTTATATAATCAACCATATGAAGAGACACCGGCAGGACCATCCGAGCTGGGACAATCTC
TCTTGTTGGAGGGCATGACGATGATACTTCTTTTTTGCGAACGACAAGCGAACGAA
Protein Sequence 
>gi|799348169|ref|XP_012053726.1| MFS transporter, SP family, solute carrier family 2 (myo-inositol transporter), member 13 [Cryptococcus neoformans var. grubii H99]
MSRTPSSLDKDKGSSEFVENMNEIEIIEHTRVPSDKPSGFGGHLIDENLVKVEGEDKVTPYLCFLISASA
IAGFLFGYDTGVVGVALPLVGTDLGGSVLSSSQQEIITAGTTIGAIFGSAILGGWGDRLGRKVAILIADV
FFTVGAVLIAASYSVPQMIVGRIVLGVGVGGAAAIAPLFITETAPTAVRGRCIGVNAFFIPFGQVISEAI
GAGVQDMKNGWRLLFALGAVPSLFQLILFHYLPESPRILILRGQTDRARHVFSRIYPNATPEMIDYKFRV
AQEYVTATTVLQSGTTYWQRTKTLFTKGSYRRSIVTVSLIQMAGQLSGFNTLLYYAGTLFSLLGLTNPAL
GGLIPAGTNAFFVLVGMTLVDKVGRRGLLMFGVPIMLAGLVWNIVAFHYLCIPTGGLLDTSYKYDTKLVG
IVIGGIVFFTTGFGLTYSHLAWYQSEFLALEVRSVGSGIATTANWVANLVVSVSYLTELETLTPSGTYGL
YLGFSVVFFIFAVFCYPETKQLSIDETSLLFEEDWGVKRSREMRRERRETQRRLADSEMTEVATAHVQAQ
KQKDSAVTRSELDNFMEELKNGAKRFPISR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: itr1a itr3c double mutants showed significant virulence attenuation in murine infection models (Wang et al., 2011).
References
Wang et al., 2011: Wang Y, Liu TB, Delmas G, Park S, Perlin D, Xue C. Two major inositol transporters and their role in cryptococcal virulence. Eukaryotic cell. 2011; 10(5); 618-628. [PubMed: 21398509].