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ICL1

Victor ID 5320
Gene Name ICL1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23888629
NCBI Protein GI 799325265
Locus Tag CNAG_05303
Genbank Accession CP003823
Protein Accession XP_012048837
Taxonomy ID 235443
Chromosome No 4
Gene Starting Position 988896
Gene Ending Position 991401
Gene Strand (Orientation) -
Protein pI 7.37
Protein Weight 57417.92
Protein Length 549
DNA Sequence 
>gi|799350666:988896-991401 Cryptococcus neoformans var. grubii H99 chromosome 4, complete sequence
GCGCCTTTGACCCAGTACAATGCATGCCAAGTATCCAAAAAAAAAACATAATCCTAATATTCTTTTTTTT
TACTAATAATCGATGACTTCTCATATCTCAAGACTTTGGGGATTAGAGCTTGTGCAAAGCGTCCTTGGTC
TTATCATCTACAAATTGGTTTTCCGTCACGCCTTTACCCATAGCAGCGGTGGATGAGACACCGCCGGTGA
CCGTCATCAACATTGCGTCCGCATAGTCTGCGCCTGACCACTGTTTCAATTGGGGGGGAAGGATGGTTAG
CTTGAGTTCCTCTGTGCTTTGAACGGAAGAGGGGAAAGGAGGGACGAACCTTTTGATGAGTCAAGACATC
ACATCCAATCTCCCGTTCTCGGCTTTGAATCAATTCGACATAGGCCTTCATGCCTTCCTTTGAGAAGGCG
TTGGCGAAGAGATCGTTGATATAGGCGTTGGAATGGAGGCCGGCGAGCTGTTGAGTTACGTTCTGTCAGC
GAGGAGACGTTTGAGGACACAGGGGAAGAAAAAGGGACTTACAGTAATGAATTGGAAGACGAAACCAAGT
TTTCCCAACTCCCACACATACTCCTTCATCTCCTTCTTCCCCAATCCTGCCTTTTCCCAATTGAAACTCG
GGCTCAAGTTGTACGCCAACCACTGACCGGGATGGACTTTATGTACGCCTTCGGCAAACTCTTTAGCCTG
CGCGTAGATGGGAGACTTGGTCTCCATCCAGAGGAGGTCGGCATAAGGTGCAAAGGCGATGGCGCGGTTG
ATAGCGCATTGGGTGCCGCCTTGGTAGCGGTAGTAACCCTCGCGGGAACGGGGAGTGTCCCATGACCAGT
AAGGGGTGGCGGAGGCTGGCAGACCGAACGATTGGGCGAGCTGGAGAGTGGAAGCGTGCGAGGTGCCGAT
CGACTGTTCTCTAAACTCGATGATTTTTTTGGAAGAGACGCCGTGCTTCGAGAGAGCGTCGGCGAGTACG
TCGGGCCATAGTTTCAATCCCGCCTGTTTCGTCCATGCATCCTCTATTTTCTGGAGTTCCTGTCCGTACT
TGCCCTCCATTTCGGCGGCGATCATGAGATCGTTAAGAGGGGGTAAGGAAGGGTTAGTAGAACCCAAGAT
GAAGGAGTGGTCCCGAGGGTCAATGTTAGTGGAGAGGAGGGTAGCGGCTTCAGAGTCGGTACGACAGACG
ACGAGGTTGGTGGTGCCCATGATGTCGCACTGGAGACGCATGGCCACGAGGCGGTTGATATGTTCAGAGA
TGGGGACGAGGACCTGGGTGAGGGGGAGAGCGACCGTCAGCCAGCGAACGAAACGAGAGGGCGAAAGGCA
CGGGAGGGAAAGGAAAGGACAGAAGAGATGACCGACCTTGCCTGCCATATGACCACATTTCTTCGTACCA
GGCGCTTGATCCTCGATATGGATTCCCGCTGCTCCACTCTCGACCATCATCTTTGTCAATCTCATCACTG
CTGTCAAACCTATTGGGGGGAACGGTAGGGTACAACATTAGTATCTCCTCTTTTAGTGAAAAGGTGAGCG
GACTCACCACCATGCCCAGTATCCGCATCAGCCACGATAGGTCTGAGATAATCAATCCTCTCTCCTGGGT
CTTGGCCTTTGGCCAAAGCGGCAGAGCGGGTGTATCGCTGTTTGCGGTCGTGGTAGAGTTGGGCTGTGAA
GAGTTGGGCGACTTTGTTGGGGACAGTGTTGGATGGGTAGTCTGTTTGAGTTGGTGGGTGAGTAATTAAG
CGGAACAATGATGAGGTGATAAGGGGGGTTGGGATGGGAACTTACCGGCAAGGTCGGGTCCGGGTTCGAG
GGAAGATGATGCAGTGGAAGAACATTGCCAGCCAGAGACGTATACGGTCTCGAGGTATTTCGCCATTTGG
GTCAACTGCACGGGATCGAGCCTGTCTCGGGTATAGTCGATCTTTTTGTCAGTACTCCTAAATTTTTACT
CAAGGAACAGAAGAGCAGGTCGATGGATAAAGAGATGAAACTCACGCGCCATAGGTAGCCGTACATCCCC
CGCCCTCACCACGAGCTTTTGACTCCAAGATCTTCCACAGCTTTTTCGCCTGGACGTCGGAAGGGTAAGA
GATGGGAAGAGTACCACGTTTGGAGACAACGTCGGCAGGGGTGTATGGGCGGGTTGTTCGTGCGAACCGT
GGGGACTGTTTTTTTGCGTAAGGAGCAGGAGAGGAGGATAGGTTAGCTTGGGTAAATTGGGGTAAAGGAG
AGGGGACAAGGTCGTACCTTGGCGAAGGCCTCAAAGGCTTTGACTTCGGCGTCAAACTCTGCTTTCTCGG
ACGACATGATCGTTGATCGTTGTTTCGATTGTAGGATTGTTCAGTTACTCAGTAGAAGTTGACGATGTAA
GGACGTAATGAGTGAAAAGCAAAAAAAGCTCTGTGGGGATCTCAACATAGCCTCGCAGATTGGCTCGTTA
TAAATCATCTCGTGGACTGGAAGAGCATAGGAGATGACGGGTGTAGTGCGAAGAAG
Protein Sequence 
>gi|799325265|ref|XP_012048837.1| isocitrate lyase [Cryptococcus neoformans var. grubii H99]
MSSEKAEFDAEVKAFEAFAKSPRFARTTRPYTPADVVSKRGTLPISYPSDVQAKKLWKILESKARGEGGG
CTATYGALDPVQLTQMAKYLETVYVSGWQCSSTASSSLEPGPDLADYPSNTVPNKVAQLFTAQLYHDRKQ
RYTRSAALAKGQDPGERIDYLRPIVADADTGHGGLTAVMRLTKMMVESGAAGIHIEDQAPGTKKCGHMAG
KVLVPISEHINRLVAMRLQCDIMGTTNLVVCRTDSEAATLLSTNIDPRDHSFILGSTNPSLPPLNDLMIA
AEMEGKYGQELQKIEDAWTKQAGLKLWPDVLADALSKHGVSSKKIIEFREQSIGTSHASTLQLAQSFGLP
ASATPYWSWDTPRSREGYYRYQGGTQCAINRAIAFAPYADLLWMETKSPIYAQAKEFAEGVHKVHPGQWL
AYNLSPSFNWEKAGLGKKEMKEYVWELGKLGFVFQFITLAGLHSNAYINDLFANAFSKEGMKAYVELIQS
REREIGCDVLTHQKWSGADYADAMLMTVTGGVSSTAAMGKGVTENQFVDDKTKDALHKL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Targeted deletion of ICL1 resulted in a dramatic decline in viability of C. neoformans cells under nitrogen deprivation (Xu et al., 2016).
References
Xu et al., 2016: Xu Z, Zhi Y, Dong J, Lin B, Ye D, Liu X. Requirement of the isocitrate lyase gene ICL1 for VPS41-mediated starvation response in Cryptococcus neoformans. Journal of microbiology (Seoul, Korea). 2016; 54(7); 487-491. [PubMed: 27350614].