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HXS1

Victor ID 5318
Gene Name HXS1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Gene ID 23887240
NCBI Protein GI 799317528
Locus Tag CNAG_03772
Genbank Accession CP003821
Protein Accession XP_012047216
Taxonomy ID 235443
Chromosome No 2
Gene Starting Position 772401
Gene Ending Position 775010
Gene Strand (Orientation) -
Protein pI 7.41
Protein Weight 56085.55
Protein Length 551
DNA Sequence 
>gi|799350600:772401-775010 Cryptococcus neoformans var. grubii H99 chromosome 2, complete sequence
TCCATTCAAACAGGACTTCGTGAACCGCAATTCCTTGACGAGGAACGATTCGGATGCGTTGCTGATAATG
ACCGGTTTTAATGAAGCTGAAACTATCTATCAATAGTGATCTCGACGACTGAGGCTGTGAACACCGCTCA
AACTTTGTCACAAAAGCGCTTCAAATCAATGGAACGTACTTTTGCCTATGAACACTCCTCTCAATAATCA
TGCAGAGAACGTTTTGGAAAAATGATAGAGCATATCATATATCTTACAGGTGTTCTGGCCTTATGGGTTG
AGAATTTCTAGTAGAGGTATTTCTAACTCACGGCGAATTCTGAGGGCTTCCTCAAATCAAAGATCATCCA
TAGGATGTAAAACCAATCATAGTGTCCCTTCAAATCGTATACATGTGACAAAATAGGAAAACCGGTATCG
ATTACTTAAACTTGCTCCACCAACTCTGACTGTGACACAGGTCCAGCTTTCGCTTTCTCATTCTGGTCAA
TCGCAAGTGTACCCTGAGCAGCCTCCGCTGCAAACGTGGTATGGGGTTTCCAGCCCGCCGAGCGTCTGGG
GCTCCCGCATTCTTCCATCATCCTATCAACCTGTTCCAATGTGAGGCCCTTGGTCTCCCATACAAAGAGA
TAGGCGTAGATAAAGCAGAGAATACAGGTTGAACCCCAAAGGAAAAAGACTTTTGAACCGAGGTTCTAAG
AAAATGTCAGCTTCAAGTGAAATCGTCTTGCCGAAAACACTCACCGCCTGGTCAGTTCCCACAAGATAAG
GGGTAATTACGGCGATAATACAGTTCCATAGCCAGTTAGAGGCAGTGGAGAGACCAACTCCTCGAGCCCT
AATAGGCAATGGGAAAATTTCACCGATAGAAACCCAAGCACCTGGACCCCAAGTTGACGCGAAGAAGAAG
ACGTAAACGCAAATGAAGGAAATCTGCGCCTTAACGACTGTAGTGTCTCCAGGCTTGGCGACACCAATGA
TACCGACAATGAACTCGCAGATGAGCATACCGAGGGCACCATAGATAAGAAGGGGTCGTCGTCCAAATCG
TTCGATAGTCCAGAAAGACACAGGTGTGGAGCAGACGTTAACTAAAGTGGTGATGAGAGAAATCAAGAAG
GGGTTCGAGATAGTCCCAAGATCATTGAAGAAGGTGGTTCCAAAGTAGAAAATGAAGCTGGACATCACAG
TCAGTAGATTATAAAGGACACAACGAAGGGCAAACTCACTTGACACCAGTCCATTGCTGCATCATTTGCA
TGGTAATACCGAGAAGGGTTCGACGAAGGTTAGACCCAGGGTTGCGAATACCACCAGTGAAACAGGCAGC
CCAAGAGGAGAAGTAAGTCACATTGGGAGTAAGCTCCGTCTCGTACTCGTGGTTGGCTACAATTTCGGCG
ATTTCATCCTTGATGTAATCAGAGTCCATTGGTTGACCTCGGACTCGAGACAATGCCTTTCTGGCCTGTT
CTACCTTGCCGGCTTTCACATACCAACGAGGTGACTCTGGAAGCAAAAAGAGACCACCACCGAGGATAAG
GCTAAGTTGAAATCAGTATTGTTTTGGACGGAATGGAAAGGCACTTACGCCCAAGCAAACTGAATGGCGA
TAGGGATACGGTATGACCCGCTATCGGTACGGTTCTGAGTTGCGTAACATACACAAGAAGCAAGAAGAAG
GCCAATAGTGATGCAGAACTGATAGCCCGAGACAATTGCACCTCGAACCTAAATTTCTTTTAGTCGGGTG
TAATAAATTAAGTTTAATAATGAGCGTACCTTTCGAGGAGCGATCTCCGACATGTAGAGAATGATGATAG
CTGAAATGAAACCGACACCAAACCCAGAGATGAGACGACCGGCCACCAGCTGCGGAATTGGTCAGGACCT
CGAATACCAAGTACCTTACGAATTAACTCACCAAGCCAAGGCTGGTTGAAGCAGTTTGCAGACAGCAACC
AACAATAAATACAATACAACCAGAAATGATAGTAATCCTTCGGCCGAAGTAATCGGCAAGGTCACCAGCG
ATGATCGCACCAAAGAAAGTTCCAGCAGAAAGGATGGAAGTGATCAAAGACTTCTCCCAAGCTGGCAGAG
TGAAGGCATCTTTGGTGGCTTGATCCGCATCGGGGCCAGGAATAGGAAGACCTGTCATCATGTTGATGAA
GTAATTCATACCCAACACGCCGTTCATGTAACCGGAATCAAAACTATGGGCAAGGAGTCAGTTTCCGAGG
TGAAAGAAATCAGATCATGACTTACCCGAAAAAGATACCACCGAAAGAGGCAAAGACACAGAGGAGATAA
GCCTTGACAGTCACAGGAGCCTCCACCCGCTCGGGGCTGAGAGGCGCCGAGAGGACGCCAGCACCACCAG
GCACTGATATCAGAGTTAGAGAGACTGTAGCAATGAATATAAGGGAAGCACCTACTGATGTTTGAGTGTT
TAGTAGTAGTACGTGAATTAAAAGAAGGAAAATATGTTCTCCACTGAAGTACTTTTCACGGTATAGGAGA
TGAAAGTTGAGAAGGGTGGCAGTCGCAGATTAAATATGAGATAGTTGCTGAGGTGGGGATGGAATTACAG
TGCATTGTTGGCCCCTTTTT
Protein Sequence 
>gi|799317528|ref|XP_012047216.1| glucose transporter [Cryptococcus neoformans var. grubii H99]
MPGGAGVLSAPLSPERVEAPVTVKAYLLCVFASFGGIFFGFDSGYMNGVLGMNYFINMMTGLPIPGPDAD
QATKDAFTLPAWEKSLITSILSAGTFFGAIIAGDLADYFGRRITIISGCIVFIVGCCLQTASTSLGLLVA
GRLISGFGVGFISAIIILYMSEIAPRKVRGAIVSGYQFCITIGLLLASCVCYATQNRTDSGSYRIPIAIQ
FAWALILGGGLFLLPESPRWYVKAGKVEQARKALSRVRGQPMDSDYIKDEIAEIVANHEYETELTPNVTY
FSSWAACFTGGIRNPGSNLRRTLLGITMQMMQQWTGVNFIFYFGTTFFNDLGTISNPFLISLITTLVNVC
STPVSFWTIERFGRRPLLIYGALGMLICEFIVGIIGVAKPGDTTVVKAQISFICVYVFFFASTWGPGAWV
SIGEIFPLPIRARGVGLSTASNWLWNCIIAVITPYLVGTDQANLGSKVFFLWGSTCILCFIYAYLFVWET
KGLTLEQVDRMMEECGSPRRSAGWKPHTTFAAEAAQGTLAIDQNEKAKAGPVSQSELVEQV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Hxs1 is required for glucose uptake. hxs1Ãâ mutant exhibited a significant reduction in glucose uptake activity (Liu et al., 2013).
References
Liu et al., 2013: Liu TB, Wang Y, Baker GM, Fahmy H, Jiang L, Xue C. The glucose sensor-like protein Hxs1 is a high-affinity glucose transporter and required for virulence in Cryptococcus neoformans. PloS one. 2013; 8(5); e64239. [PubMed: 23691177].