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HEM15(Cryptococcus neoformans var. neoformans JEC 21)

Victor ID 5316
Gene Name HEM15(Cryptococcus neoformans var. neoformans JEC 21)
Sequence Strain (Species/Organism) Cryptococcus neoformans var. neoformans JEC 21
NCBI Gene ID 3258191
NCBI Protein GI 58268754
Locus Tag CNF01700
Genbank Accession AE017346
Protein Accession XP_571533
Taxonomy ID 214684
Chromosome No 6
Gene Starting Position 498105
Gene Ending Position 499822
Gene Strand (Orientation) -
Protein pI 9.35
Protein Weight 42626.45
Protein Length 413
DNA Sequence 
>gi|58272423:498105-499822 Cryptococcus neoformans var. neoformans JEC21 chromosome 6, complete sequence
TGGGATGATGAGATGGGGTATACATCTTTTTAGATCGTACATCTTACAAACAGTGCCGAAACAGCATGAC
ATGTACTCTAAATGCAAACAGTCAAATGTTGTTGTTTTTCAGTCACATTATATCACCTTTTTTTCCACTG
CCTAAGCGGCCATTTTCGTACCTCCACTAGCTAACCAGCGCCTAGTCTCTTGCGACCTAGGGCTCACATG
TCGAGGATCAGCGGACAAGAGTTGCTTGCTCGCGGGACCTATCAAACCGGCATCATAGTCTTTGAGGTGG
TTGGAGACAATGTCGGCAAGGGCGCGGATGAATATGGGAGAGTCGTTGAGAGAAGAGGCTCGTGTCAAGT
GAACACCGAGCTATTGACGGTCAGTCAGTATAACTTCGCTCATCGATCATATTGAACGGTTCACCTTTTC
AGCCTCTTCTTTGACCTCAATATCAAGCTCATAGAGGGTTTCGATGTGATCACTGGTGAAGGCGACGGGA
ACGAGACAAATGTCCTTGGTGCCCGCCTTGGCGTAACCCTCAATGGCCGCGGCGGTCTGAGGTCCTTGCC
AGGCTTTGGGACCGACCTTGGATTGCCATGTAAGACGCCAAGGGTTGGAGAAGTTGAGCTTGGACATGAC
GGCCCATACTGTAGCGGCAACTTCGGCAGTGTATGGGTCACCGCGGCTATGACAAATGTAAGCGCTACTC
TTGGTCATGACTGGGTTTAACATACTTGACAATGTCAAGAGGGAGAGAGTGAGCAGAGAAGAGAATGGTG
ACATCACCTCGTCGGTCTTCCGGGTAAGTCTGTAGGGCAGCTTTGATGTTGTGTGCAAAAGCCTGTCTGG
ATGTAAGTCTTTTCCCATGTCAAAGCAATTCACAGACTCACCTCTACCAGTCCAGGGTGAGTGGGCCATC
GGTCAATAACGCTCCACTTGACTTCGCCGTTTCCGCCCCAGCCTAGCTGTTTCACCTGTTTGTAAAGTTC
ATTCAAACTACTGCCAGTAGTAGAGCTACTGTATTGAGGATATTGGCTGAAAGCAACGGCCCTCTGTACG
CCATCCTGCTTCATCTCTGCCAGGGCATCTTCGGTGAGGGTCTTGGCATATCGGAAAGCAACATAAGGTT
TGTGTGGCGCCGATTTGGGGTTAAGCTCATCCAATAGAGAGCACATGGCAGCGCCTTGAACCTGAGTCCA
TTTGAGGATAGGAGAACCGCCGCCAATGGCGGAATATTGCTCTTCGATGGAAGGGGTTCGACGCTTGGCG
ATGAGGGGGGCAAGGAGGGGCTGGAAGGGCAGAGGAATAAGGTCGTTATCATGGAATAAACGCGAAAGAA
AGTCGTGAACTTCGGGAACCTGCCGCAATGGAGTTAGTCTCTGCCCTGTATTCACTCGGGACTAAGGGCT
TCAACGCTTACAGTTGAAGGTCCACCCATGTTCATCATAAGAACAGCTATAGTATGTTAGATTTGGCCAA
AAGTCGACACCATTAGTACTGACCTGTTGGTCTATATAAACAGTCAGTACATATATACACACATTTATGT
TTTAGTTGGACATTTAGGACTCACGGTTTTGAGCCAACTGCAGGTCCATCTCTCACGGTGGCCAGGAATC
TTTGGCGAGCGATGGCAGGGGGGGCGAGACGGAGCCTGGAAGAAGAAGGGAGCAATGGGCGAGCAAAGAC
AGAGATGGGACGTTGGATTGCAGTCATGGCTGTAGCGT
Protein Sequence 
>gi|58268754|ref|XP_571533.1| ferrochelatase [Cryptococcus neoformans var. neoformans JEC21]
MTAIQRPISVFARPLLPSSSRLRLAPPAIARQRFLATVRDGPAVGSKPPTAVLMMNMGGPSTVPEVHDFL
SRLFHDNDLIPLPFQPLLAPLIAKRRTPSIEEQYSAIGGGSPILKWTQVQGAAMCSLLDELNPKSAPHKP
YVAFRYAKTLTEDALAEMKQDGVQRAVAFSQYPQYSSSTTGSSLNELYKQVKQLGWGGNGEVKWSVIDRW
PTHPGLVEAFAHNIKAALQTYPEDRRGDVTILFSAHSLPLDIVNRGDPYTAEVAATVWAVMSKLNFSNPW
RLTWQSKVGPKAWQGPQTAAAIEGYAKAGTKDICLVPVAFTSDHIETLYELDIEVKEEAEKLGVHLTRAS
SLNDSPIFIRALADIVSNHLKDYDAGLIGPASKQLLSADPRHVSPRSQETRRWLASGGTKMAA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: This gene, HEM15, is predicted to encode a ferrochelatase that catalyses the final step in haem biosynthesis from highly photoreactive porphyrins. HEM15 is regulated by light and the mutants are photosensitive and exhibit reduced virulence (Idnurm and Heitman, 2010).
References
Idnurm and Heitman, 2010: Idnurm A, Heitman J. Ferrochelatase is a conserved downstream target of the blue light-sensing White collar complex in fungi. Microbiology (Reading, England). 2010; 156(Pt 8); 2393-2407. [PubMed: 20488877 ].