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GSK3(Cryptococcus neoformans var. neoformans B-3501A)

Victor ID 5315
Gene Name GSK3(Cryptococcus neoformans var. neoformans B-3501A)
Sequence Strain (Species/Organism) Cryptococcus neoformans var. neoformans B-3501A
NCBI Gene ID 4934593
NCBI Protein GI 134108634
Locus Tag CNBB4980
Genbank Accession AAEY01000011
Protein Accession XP_776970
Taxonomy ID 283643
Chromosome No 2
Gene Starting Position 2069900
Gene Ending Position 2071312
Gene Strand (Orientation) -
Protein pI 7.63
Protein Weight 41941.96
Protein Length 398
DNA Sequence 
>gi|134108779:2069900-2071312 Cryptococcus neoformans var. neoformans B-3501A chromosome 2, whole genome shotgun sequence
ATCACTGCAATGCATGTCAGCGCTCGTACCGACTACTCGTCCGGTCTGAATTGACTCACGTCCAAAGTGA
CACGCAGCTGTTCAGGAGGAATGGGCTTGAAGTCGTTGACATCGATACCCCTTGAACGAAGCTCCTCCTC
AGCATGCGTAGGCACAAGTTGACGGATAAGGTCGGGACGAGATGACAGTTCTAAAACACCCGTCAGCTCT
GTACTATACTGACCAAAACCAGAAAAACATACCCTCGTGGGTAAAGTTGAACAATTCGGGCATGTCCTTT
CCATTTGGCAACCTCGCACCTTCCACCCTCAACTCGTCAAAGAAGGGATGCACCAATGCTTCAGGAGCAG
TGTACCTCGCGGAAGGAGTGTATTCGAGCAAAGTGCTGATAAGGGAGATGGCGTCAGCAGGGGTTCGCGG
CCGGAAGACTTTGGTGAAGGGGTGAGGCTTGATTTGAGGGAACTTGTGCTCCATGTAGTTGGGGTTCATA
GTCTTGATTTGTTCCCTGGTAGGGGTACCCAAAACCTTGATGATCTCCACTAACTGATCAATGCCTGATT
CTCCGGGGAATAAAGGTTGTCCCAACATCAACTCGGCCATGACACAACCAGTTGACCAAATGTCAATGTT
TGTGGTGTAGTTTGTGGCGCCGAAAATGAGTTCGGGGGCTCTGTAGTATCTAGAACAAATGTAAGACACG
TTGGGCTCGCCGGCAACGAGGATCTTGGCGGAACCAAAGTCACAAAGCTTCAAAACACCAGTCGCAGGGT
TGAGGAGCAAGTTTTGAGGCTTGATGTCTCGGTGGCAAATGCCGATGGAATGGATGTACGCCAAAGAGCG
GAAAAGCTGGTACATATAGAGTTTGACTTGGAGCATGGGCATTGCTTGCTTGAGCTTGGCATAATGACGA
GAAGCTCGGTAGACAGTCTCAGGTACTAATTCAAGCACAAGGTTGAGGTATACTTCGTCCTTCTTGTCGC
CGTTGGAGTAGAAGAATGCCCTAAGGTCGACAATGTTGGGATGATGGACTAGGCGCATGATTTGTAGTTC
TCGGTTCTACATCAAGTTAATAATCATCCCGCATATGTAAATCTCGCTCCTAACTGATTGAGGCATACCT
TGAATCGCTTGTCCTGCAACACCTTCTTAATAGCAATGTCCGATTCTGGCTCCTCAGACCCGTCTTCGTG
TTTCACAGGCGACATCTTGGCTGCAAAGACAACACCGAAACTTCCGTTACCGACAGCCTTGCAGTTGGTG
TAGCTGATGGTGGTGTCGGCGCCAGTTTTGCCCCATTGAGCACTGACGGTAATGACGCGGTTGGGGTCGT
CGGCTTACAAAAAAGTCAGACATACAGAGACAAAAGACAAAAGAACGTACTAGCGACCCTAACACCGTTC
ACGACTCCTGACA
Protein Sequence 
>gi|134108634|ref|XP_776970.1| hypothetical protein CNBB4980 [Cryptococcus neoformans var. neoformans B-3501A]
MSGVVNGVRVATDDPNRVITVSAQWGKTGADTTISYTNCKAVGNGSFGVVFAAKMSPVKHEDGSEEPESD
IAIKKVLQDKRFKNRELQIMRLVHHPNIVDLRAFFYSNGDKKDEVYLNLVLELVPETVYRASRHYAKLKQ
AMPMLQVKLYMYQLFRSLAYIHSIGICHRDIKPQNLLLNPATGVLKLCDFGSAKILVAGEPNVSYICSRY
YRAPELIFGATNYTTNIDIWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIKTMNPNYMEH
KFPQIKPHPFTKVFRPRTPADAISLISTLLEYTPSARYTAPEALVHPFFDELRVEGARLPNGKDMPELFN
FTHEELSSRPDLIRQLVPTHAEEELRSRGIDVNDFKPIPPEQLRVTLD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: It serves as an important link between sterol biosynthesis, oxygen sensing, CoCl2 sensitivity. The mutation showed no virulence in a mouse infection model (Chang et al., 2009).
References
Chang et al., 2009: Chang YC, Ingavale SS, Bien C, Espenshade P, Kwon-Chung KJ. Conservation of the sterol regulatory element-binding protein pathway and its pathobiological importance in Cryptococcus neoformans. Eukaryotic cell. 2009; 8(11); 1770-1779. [PubMed: 19749173].